PHF8 (NM_015107) Human Untagged Clone

CAT#: SC107370

PHF8 (untagged)-Human PHD finger protein 8 (PHF8), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PHF8
• Synonyms: JHDM1F; KDM7B; MRXSSD; ZNF422
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_015107, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCTCGGTGCCGGTGTATTGCCTCTGCCGGCTGCCTTACGATGTGACCCGCTTCATGATCGAGTGTG
  ACATGTGCCAGGACTGGTTTCATGGCAGTTGTGTTGGTGTTGAAGAGGAGAAGGCTGCTGACATTGACCT
  CTACCACTGCCCCAACTGTGAAGTCTTGCATGGGCCCTCCATTATGAAAAAACGCCGTGGATCTTCAAAG
  GGGCATGATACACACAAGGGGAAACCAGTGAAGACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTA
  GGACTTTTGACAGCTCAGATGAAGTGATTCTGAAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGA
  AGAAAATAGCTTCAGTGTGCCCATCCTGGTCCTGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCA
  TCATTCACTGTGAGGGATGTTGAACACTATGTTGGTTCTGACAAAGAGATTGATGTGATTGATGTGACCC
  GCCAGGCTGACTGCAAGATGAAGCTTGGTGATTTTGTGAAATACTATTACAGCGGGAAGAGGGAGAAAGT
  CCTCAATGTCATTAGTTTGGAATTCTCTGATACCAGACTTTCTAACCTTGTGGAGACACCGAAGATTGTT
  CGAAAGCTGTCATGGGTCGAAAACTTGTGGCCAGAGGAATGTGTCTTTGAGAGACCCAATGTACAGAAGT
  ACTGCCTCATGAGTGTGCGAGATAGCTATACAGACTTTCACATTGACTTTGGTGGCACCTCTGTCTGGTA
  CCATGTACTCAAGGGTGAAAAGATCTTCTACCTGATCCGCCCAACAAATGCCAATCTGACTCTCTTTGAG
  TGCTGGAGCAGTTCCTCTAATCAGAATGAGATGTTCTTTGGGGACCAGGTGGACAAGTGCTACAAGTGTT
  CCGTGAAGCAAGGACAGACACTTTTCATTCCCACAGGGTGGATCCATGCTGTGCTGACGCCTGTGGACTG
  CCTTGCCTTTGGAGGGAACTTCTTACACAGCCTTAACATCGAGATGCAGCTCAAAGCCTATGAGATTGAG
  AAGCGGCTGAGCACAGCAGACCTCTTCAGATTCCCCAACTTTGAGACCATCTGTTGGTATGTGGGAAAGC
  ACATCCTGGACATCTTTCGCGGTTTGCGAGAGAACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGG
  CAAAGCCTTGAACTTGGCCTTTAGAGCCTGGACAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATC
  CCGGAGACAGTGCGAACCGTACAGCTCATTAAAGATCTGGCCAGGGAGATCCGCCTGGTGGAAGACATCT
  TCCAACAGAACGTTGGGAAGACGAGCAATATCTTTGGGCTGCAGAGGATCTTCCCAGCCGGCTCCATTCC
  CCTAACCAGGCCAGCCCATTCCACTTCAGTGTCCATGTCCAGGCTGTCACTGCCCTCCAAAAATGGTTCA
  AAGAAGAAAGGCCTGAAGCCCAAGGAACTCTTCAAGAAGGCAGAGCGAAAGGGCAAGGAGAGTTCAGCCT
  TGGGGCCTGCTGGCCAGTTGAGCTATAATCTCATGGACACATACAGTCATCAGGCACTGAAGACAGGCTC
  TTTCCAGAAAGCAAAGTTCAACATCACTGGTGCCTGCTTGAATGACTCAGATGACGACTCACCAGACTTG
  GACCTTGATGGAAATGAGAGCCCATTGGCCCTATTGATGTCTAACGGCAGTACGAAAAGGGTGAAGAGTT
  TATCCAAATCTCGGCGAACCAAGATAGCAAAGAAGGTAGACAAGGCTAGGCTGATGGCAGAACAGGTGAT
  GGAAGACGAATTTGACTTGGATTCAGATGATGAGCTGCAGATTGACGAGAGATTGGGAAAGGAGAAGGCG
  ACCCTGATAATAAGACCAAAATTTCCCCGGAAATTGCCCCGTGCGAAGCCTTGCTCTGACCCCAACCGAG
  TTCGTGAACCAGGAGAAGTTGAGTTTGACATTGAGGAGGACTATACAACAGATGAGGACATGGTGGAAGG
  GGTTGAAGGCAAGCTTGGGAATGGTAGTGGCGCTGGTGGCATTCTTGATCTGCTCAAGGCCAGCAGGCAG
  GTGGGGGGACCTGACTATGCTGCCCTCACCGAGGCCCCAGCTTCTCCCAGCACTCAGGAGGCCATCCAGG
  GCATGCTGTGCATGGCCAACCTGCAGTCCTCATCGTCCTCACCGGCTACCTCTAGCCTGCAGGCCTGGTG
  GACTGGGGGACAGGATCGAAGCAGTGGGAGCTCCAGCAGTGGGCTGGGCACAGTGTCTAACAGTCCTGCT
  TCCCAGCGCACCCCAGGGAAGCGGCCCATCAAGCGGCCAGCATACTGGAGAACCGAGAGCGAGGAGGAGG
  AGGAGAACGCCAGTCTGGATGAACAGGACAGCTTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCC
  TTCACTGGAGTCTGATGATGATGACCCTGCTTTGAAATCTCGACCCAAGAAAAAGAAGAATTCAGATGAT
  GCTCCATGGAGTCCTAAAGCCCGCGTGACCCCAACTCTGCCGAAGCAGGACCGTCCTGTGCGTGAGGGGA
  CCCGGGTAGCCTCTATTGAGACAGGTTTGGCTGCAGCAGCTGCAAAGCTGGCCCAGCAGGAGCTACAGAA
  GGCCCAAAAGAAGAAATATATCAAGAAGAAGCCTTTGCTGAAGGAGGTAGAACAGCCTCGCCCTCAAGAC
  TCCAATCTCAGTCTGACAGTACCAGCCCCCACTGTGGCTGCCACACCACAACTTGTCACCTCCTCCTCAC
  CCCTGCCTCCTCCTGAGCCTAAACAAGAGGCCCTGTCAGGAAGTCTCGCTGACCATGAGTACACCGCTCG
  TCCCAATGCCTTTGGCATGGCCCAGGCAAACCGCAGCACCACACCTATGGCCCCCGGTGTCTTCTTGACC
  CAGCGGCGCCCTTCAGTTGGCTCCCAGAGCAATCAGGCAGGACAAGGAAAGCGTCCCAAAAAGGGCCTGG
  CCACAGCAAAGCAGAGACTCGGCCGTATCCTGAAAATCCACAGAAATGGCAAACTACTTCTGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015107 unedited
  ATTACCCCCGCCCGTTGACGCAAAGGGCGGTCGGCGTGTACGGTGGGAGGTCTATATAAG
  CAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGC
  GAATTCGGCACGAGGGGACGAGCCTCCGCTGAGGCGCTTCGCAGTCCCGGAGCTAGCCCG
  GCTGCCGGCGTGTCGCTGGGGCTGAGCTCCGCGGGCGTGGAGTCCTTGCAGCCCAAAGCA
  TGAGGAGGTCCCTGTAGGATTCTGGACTGAAGACGTTCTTGTCAGGTTTGGGGCGTGAGG
  AGGTTCCTGTCAGTTGGGGAAGCGTTAAGAGTCCTCTATCGTCCAGAGAGGACGCGTGCT
  GCCGCCTCCCGCCCCTCTTGACACGACGAACCTGGCCGGCCGCAGAACGCTCCAGGGCCG
  AGCGAAGATGGCCTCGGTGCCGGTGTATTGCCTCTGCCGGCTGCCTTACGATGTGACCCG
  CTTCATGATCGAGTGTGACATGTGCCAGGACTGGTTTCATGGCAGCTGTGTTGGTGTTGA
  AGAGGAGAAGGCTGCTGACATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATGG
  GCCCTCCATTATGAAAAAACGCCGTGGATCTTCACAGGGGCATGATACACACAAGGGGAA
  ACCAGTGAAGACCGGGAGCCCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGACAG
  CTCAGATGAAGTGATTCTGAAGCCCACTGGCCATCAACTGACCGTGGCATTCCTGGCAGA
  CATAGCTTCAGTGTGCCCATCCTGGTCCTGAAGACGGANGGNTTGGGCATGACGCTGCCC
  TCGCCATCATTCACTGGNAGGGATGTTGAACCTCATGTTTGGTTCTGACAAGAGCATGAT
  GTGCACTGATGTGACCCGCCCAGCTGACTGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_015107
• ORF Size: 3075 bp
• Insert Size: 6000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_015107.1, NP_055922.1
• RefSeq Size: 5776
• RefSeq ORF: 3075
• Locus ID: 23133
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
  Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.