UBE1C (UBA3) (NM_198195) Human Untagged Clone

CAT#: SC107764

UBA3 (untagged)-Human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 2


  "NM_198195" in other vectors (4)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol UBA3
Synonyms hUBA3; NAE2; UBE1C
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC107764 sequence for NM_198195 edited (data generated by NextGen Sequencing)
ATGGCGGATGGCGAGGAGCCAATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTGG
GAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCTGGACCCTTCACACACCCT
GATTTCGAACCGAGCACTGAATCTCTCCAGTTCTTGTTAGATACATGTAAAGTTCTAGTC
ATTGGAGCTGGCGGCTTAGGATGTGAGCTCCTGAAAAATCTGGCCTTGTCTGGTTTTAGA
CAGATTCATGTTATAGATATGGACACTATAGATGTTTCCAATCTAAATAGGCAGTTTTTA
TTTAGGCCTAAAGATATTGGAAGACCTAAGGCTGAAGTTGCTGCAGAATTTCTAAATGAC
AGAGTTCCTAATTGCAATGTAGTTCCACATTTCAACAAGATTCAAGATTTTAACGACACT
TTCTATCGACAATTTCATATTATTGTATGTGGACTGGACTCTATCATCGCCAGAAGATGG
ATAAATGGCATGCTGATATCTCTTCTAAATTATGAAGATGGTGTCTTAGATCCAAGCTCC
ATTGTCCCTTTGATAGATGGGGGGACAGAAGGTTTTAAAGGAAATGCCCGGGTGATTCTG
CCTGGAATGACTGCTTGTATCGAATGCACGCTGGAACTTTATCCACCACAGGTTAATTTT
CCCATGTGCACCATTGCATCTATGCCCAGGCTACCAGAACACTGTATTGAGTATGTAAGG
ATGTTGCAGTGGCCTAAGGAGCAGCCTTTTGGAGAAGGGGTTCCATTAGATGGAGATGAT
CCTGAACATATACAATGGATTTTCCAAAAATCCCTAGAGAGAGCATCACAATATAATATT
AGGGGTGTTACGTATAGGCTCACTCAAGGGGTAGTAAAAAGAATCATTCCTGCAGTAGCT
TCCACAAATGCAGTCATTGCAGCTGTGTGTGCCACTGAGGTTTTTAAAATAGCCACAAGT
GCATACATTCCCTTGAATAATTACTTGGTGTTTAATGATGTAGATGGGCTGTATACATAC
ACATTTGAAGCAGAAAGAAAGGAAAACTGCCCAGCTTGTAGCCAGCTTCCTCAAAATATT
CAGTTTTCTCCATCAGCTAAACTACAGGAGGTTTTGGATTATCTAACCAATAGTGCTTCT
CTGCAAATGAAATCTCCAGCCATCACAGCCACCCTAGAGGGAAAAAATAGAACACTTTAC
TTACAGTCGGTAACCTCTATTGAAGAACGAACAAGGCCAAATCTCTCCAAAACATTGAAA
GAATTGGGGCTTGTTGATGGACAAGAACTGGCGGTTGCTGATGTCACCACCCCACAGACT
GTACTATTCAAACTTCATTTTACTTCTTAA

Clone variation with respect to NM_198195.1
>OriGene 5' read for NM_198195 unedited
NGGGTTCGGAATTTGTNATACGACTCCTCTNAGGCGGCCGCGNAATTCGCACGAGGACAA
TATGGCGGATGGCGAGGAGCCATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTGG
GAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCTGGACCCTTCACACACCCT
GATTTCGAACCGAGCACTGAATCTCTCCAGTTCTTGTTAGATACATGTAAAGTTCTAGTC
ATTGGAGCTGGCGGCTTAGGATGTGAGCTCCTGAAAAATCTGGCCTTGTCTGGTTTTAGA
CAGATTCATGTTATAGATATGGACACTATAGATGTTTCCAATCTAAATAGGCAGTTTTTA
TTTAGGCCTAAAGATATTGGAAGACCTAAGGCTGAAGTTGCTGCAGAATTTCTAAATGAC
AGAGTTCCTAATTGCAATGTAGTTCCACATTTCAACAAGATTCAAGATTTTAACGACACT
TTCTATCGACAATTTCATATTATTGTATGTGGACTGGACTCTATCATCGCCAGAAGATGG
ATAAATGGCATGCTGATATCTCTTCTAAATTATGAAGATGGTGTCTTAGATCCAAGCTCC
ATTGTCCCTTTGATAGATGGGGGGACAGAAGGTTTTAAAGGAAATGCCCGGGTGATTCTG
CCTGGAATGACTGCTTGTATCGAATGCACGCTGGAACTTTATCCACCACAGGTTAATTTT
CCCATGTGCACCATTGCATCTATGCCCAGGCTACCAGAACACTGTATTGAGTATGTAAGG
ATGTTGCAGTGGCCTAAGAGCAGCCTTTTGGAAAGGNGTTNCATTAGATGGAGAGATCCT
GAACATTACATGGGATTTCCAAAAATCCCTAGANAAGCATN
>OriGene 3' read for NM_198195 unedited
GCACGCAATCTAGAATCGAGTTTTTTTTTTTTTTTTTTACACAATATATGATTTTATTAA
TAAATAGTGCAAAAGCATCAGTGATAACTGTTTGAACATTAAATTTTTTAAACAGCCATG
TCTTGGCATTAGTTAATATTGTGCATATTGGCCTCTATGGCACTACAAGTAAACAGATGA
AAATATTGCCCATTTTCATGCACAGGTATTCAGCTATAACACCATTTACAAATCATTATG
AACAAGATAAATTCTGCAATAATATTCATTTGGATGGCCACAATTAAATGAGTGTTATAT
CAAGAAATAGCCTATGTTCAATATACTCCAGATGTCAGATTGTAAAATGTAATGTTATTT
AAAACTTAATTCTTTATTTTCCTTAAAGGGACACCTTTTGTGTATTTGGGTACTCAAATG
AAAACTTAAGAATGCATTCTTTGACCATAATAACAAAATTCACACAAAAGAGGTTGTATG
CTTCCTCCTCTAAAAGAAGCAATACATTTGCTCATAATCTCTCTCTCCAGGTATCATTTC
TCATATTATTAATGAAAATGCTTACAAGCACCAACACCAAAATTCTGTCTTCAAGGGAAG
GTTACAAAGTTAAAAAAGAGTGGTTCATTATATAAAAAAAGACAAATCGTGGCAACACTA
TTGCTAAAAATGACATCGATTCAACTTCTTAGCATCCACAAAGTATATTATTTCCATGAG
TTCTCTATTATGTGGAGATCCTCCTTAAGAGTAAAATGAAGTTTGATAGTACAGTCTGTG
GAGTGGTGACATCAGCAACCGCCAGTTCTTGTCCATCAACAAGCCCCAATTNCTTCAATG
TTTTGGAGAGAATTAGCCCTTGNTCGTTCTTCAATAGAAGGTACCGACTGNTAGTAAAAG
TGTCTATTNTTTCCCTCTAGGNAGGCTGTGATGGCTGGAGATTNCATTGCAGAAAGCACT
ATTGGNTAGATATCCAAACCTNCCGTAGTTAAN
Restriction Sites NotI-NotI     
ACCN NM_198195
ORF Size 1350 bp
Insert Size 2010
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_198195.1, NP_937838.1
RefSeq Size 2094
RefSeq ORF 1350
Locus ID 9039
Protein Pathways Ubiquitin mediated proteolysis
Gene Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, as compared to variant 1. The encoded isoform (2) is thus missing an internal segment in the N-terminal region, as compared to isoform 1.

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