UBE1C (UBA3) (NM_198195) Human Untagged Clone

CAT#: SC107764

UBA3 (untagged)-Human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UBA3
• Synonyms: hUBA3; NAE2; UBE1C
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107764 sequence for NM_198195 edited (data generated by NextGen Sequencing)
  ATGGCGGATGGCGAGGAGCCAATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTGG
  GAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCTGGACCCTTCACACACCCT
  GATTTCGAACCGAGCACTGAATCTCTCCAGTTCTTGTTAGATACATGTAAAGTTCTAGTC
  ATTGGAGCTGGCGGCTTAGGATGTGAGCTCCTGAAAAATCTGGCCTTGTCTGGTTTTAGA
  CAGATTCATGTTATAGATATGGACACTATAGATGTTTCCAATCTAAATAGGCAGTTTTTA
  TTTAGGCCTAAAGATATTGGAAGACCTAAGGCTGAAGTTGCTGCAGAATTTCTAAATGAC
  AGAGTTCCTAATTGCAATGTAGTTCCACATTTCAACAAGATTCAAGATTTTAACGACACT
  TTCTATCGACAATTTCATATTATTGTATGTGGACTGGACTCTATCATCGCCAGAAGATGG
  ATAAATGGCATGCTGATATCTCTTCTAAATTATGAAGATGGTGTCTTAGATCCAAGCTCC
  ATTGTCCCTTTGATAGATGGGGGGACAGAAGGTTTTAAAGGAAATGCCCGGGTGATTCTG
  CCTGGAATGACTGCTTGTATCGAATGCACGCTGGAACTTTATCCACCACAGGTTAATTTT
  CCCATGTGCACCATTGCATCTATGCCCAGGCTACCAGAACACTGTATTGAGTATGTAAGG
  ATGTTGCAGTGGCCTAAGGAGCAGCCTTTTGGAGAAGGGGTTCCATTAGATGGAGATGAT
  CCTGAACATATACAATGGATTTTCCAAAAATCCCTAGAGAGAGCATCACAATATAATATT
  AGGGGTGTTACGTATAGGCTCACTCAAGGGGTAGTAAAAAGAATCATTCCTGCAGTAGCT
  TCCACAAATGCAGTCATTGCAGCTGTGTGTGCCACTGAGGTTTTTAAAATAGCCACAAGT
  GCATACATTCCCTTGAATAATTACTTGGTGTTTAATGATGTAGATGGGCTGTATACATAC
  ACATTTGAAGCAGAAAGAAAGGAAAACTGCCCAGCTTGTAGCCAGCTTCCTCAAAATATT
  CAGTTTTCTCCATCAGCTAAACTACAGGAGGTTTTGGATTATCTAACCAATAGTGCTTCT
  CTGCAAATGAAATCTCCAGCCATCACAGCCACCCTAGAGGGAAAAAATAGAACACTTTAC
  TTACAGTCGGTAACCTCTATTGAAGAACGAACAAGGCCAAATCTCTCCAAAACATTGAAA
  GAATTGGGGCTTGTTGATGGACAAGAACTGGCGGTTGCTGATGTCACCACCCCACAGACT
  GTACTATTCAAACTTCATTTTACTTCTTAA
  
  Clone variation with respect to NM_198195.1
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_198195 unedited
  NGGGTTCGGAATTTGTNATACGACTCCTCTNAGGCGGCCGCGNAATTCGCACGAGGACAA
  TATGGCGGATGGCGAGGAGCCATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTGG
  GAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCTGGACCCTTCACACACCCT
  GATTTCGAACCGAGCACTGAATCTCTCCAGTTCTTGTTAGATACATGTAAAGTTCTAGTC
  ATTGGAGCTGGCGGCTTAGGATGTGAGCTCCTGAAAAATCTGGCCTTGTCTGGTTTTAGA
  CAGATTCATGTTATAGATATGGACACTATAGATGTTTCCAATCTAAATAGGCAGTTTTTA
  TTTAGGCCTAAAGATATTGGAAGACCTAAGGCTGAAGTTGCTGCAGAATTTCTAAATGAC
  AGAGTTCCTAATTGCAATGTAGTTCCACATTTCAACAAGATTCAAGATTTTAACGACACT
  TTCTATCGACAATTTCATATTATTGTATGTGGACTGGACTCTATCATCGCCAGAAGATGG
  ATAAATGGCATGCTGATATCTCTTCTAAATTATGAAGATGGTGTCTTAGATCCAAGCTCC
  ATTGTCCCTTTGATAGATGGGGGGACAGAAGGTTTTAAAGGAAATGCCCGGGTGATTCTG
  CCTGGAATGACTGCTTGTATCGAATGCACGCTGGAACTTTATCCACCACAGGTTAATTTT
  CCCATGTGCACCATTGCATCTATGCCCAGGCTACCAGAACACTGTATTGAGTATGTAAGG
  ATGTTGCAGTGGCCTAAGAGCAGCCTTTTGGAAAGGNGTTNCATTAGATGGAGAGATCCT
  GAACATTACATGGGATTTCCAAAAATCCCTAGANAAGCATN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_198195 unedited
  GCACGCAATCTAGAATCGAGTTTTTTTTTTTTTTTTTTACACAATATATGATTTTATTAA
  TAAATAGTGCAAAAGCATCAGTGATAACTGTTTGAACATTAAATTTTTTAAACAGCCATG
  TCTTGGCATTAGTTAATATTGTGCATATTGGCCTCTATGGCACTACAAGTAAACAGATGA
  AAATATTGCCCATTTTCATGCACAGGTATTCAGCTATAACACCATTTACAAATCATTATG
  AACAAGATAAATTCTGCAATAATATTCATTTGGATGGCCACAATTAAATGAGTGTTATAT
  CAAGAAATAGCCTATGTTCAATATACTCCAGATGTCAGATTGTAAAATGTAATGTTATTT
  AAAACTTAATTCTTTATTTTCCTTAAAGGGACACCTTTTGTGTATTTGGGTACTCAAATG
  AAAACTTAAGAATGCATTCTTTGACCATAATAACAAAATTCACACAAAAGAGGTTGTATG
  CTTCCTCCTCTAAAAGAAGCAATACATTTGCTCATAATCTCTCTCTCCAGGTATCATTTC
  TCATATTATTAATGAAAATGCTTACAAGCACCAACACCAAAATTCTGTCTTCAAGGGAAG
  GTTACAAAGTTAAAAAAGAGTGGTTCATTATATAAAAAAAGACAAATCGTGGCAACACTA
  TTGCTAAAAATGACATCGATTCAACTTCTTAGCATCCACAAAGTATATTATTTCCATGAG
  TTCTCTATTATGTGGAGATCCTCCTTAAGAGTAAAATGAAGTTTGATAGTACAGTCTGTG
  GAGTGGTGACATCAGCAACCGCCAGTTCTTGTCCATCAACAAGCCCCAATTNCTTCAATG
  TTTTGGAGAGAATTAGCCCTTGNTCGTTCTTCAATAGAAGGTACCGACTGNTAGTAAAAG
  TGTCTATTNTTTCCCTCTAGGNAGGCTGTGATGGCTGGAGATTNCATTGCAGAAAGCACT
  ATTGGNTAGATATCCAAACCTNCCGTAGTTAAN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_198195
• ORF Size: 1350 bp
• Insert Size: 2010
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_198195.1, NP_937838.1
• RefSeq Size: 2094
• RefSeq ORF: 1350
• Locus ID: 9039
• Protein Pathways: Ubiquitin mediated proteolysis
• Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, as compared to variant 1. The encoded isoform (2) is thus missing an internal segment in the N-terminal region, as compared to isoform 1.