p18 INK4c (CDKN2C) (NM_001262) Human Untagged Clone

CAT#: SC107906

CDKN2C (untagged)-Human cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (CDKN2C), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CDKN2C
• Synonyms: INK4C; p18; p18-INK4C
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107906 sequence for NM_001262 edited (data generated by NextGen Sequencing)
  ATGGCCGAGCCTTGGGGGAACGAGTTGGCGTCCGCAGCTGCCAGGGGGGACCTAGAGCAA
  CTTACTAGTTTGTTGCAAAATAATGTAAACGTCAATGCACAAAATGGATTTGGAAGGACT
  GCGCTGCAGGTTATGAAACTTGGAAATCCCGAGATTGCCAGGAGACTGCTACTTAGAGGT
  GCTAATCCCGATTTGAAAGACCGAACTGGTTTCGCTGTCATTCATGATGCGGCCAGAGCA
  GGTTTCCTGGACACTTTACAGACTTTGCTGGAGTTTCAAGCTGATGTTAACATCGAGGAT
  AATGAAGGGAACCTGCCCTTGCACTTGGCTGCCAAAGAAGGCCACCTCCGGGTGGTGGAG
  TTCCTGGTGAAGCACACGGCCAGCAATGTGGGGCATCGGAACCATAAGGGGGACACCGCC
  TGTGATTTGGCCAGGCTCTATGGGAGGAATGAGGTTGTTAGCCTGATGCAGGCAAACGGG
  GCTGGGGGAGCCACAAATCTTCAATAA
  
  Clone variation with respect to NM_001262.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001262 unedited
  NNNNGGGAGANCNNCNNACCCTCCCCCCCCCCCGGTTCAGAATTTGTNATACGACTCACT
  ATAGGCGGCCGCGCGCATCACTCTCCTTCCTCGGGCTGCCGGGAGTCCCGGGACCTGGCG
  GGGCCGGCATGACGGGCTTCTCGGGGGCCCGCCGCACGCCCGGCAGCCTCCGGAGACGCG
  CGCCGAGCCCGGCTCCCACGGCCTCTGAGGCTCGGCGGGGCTGCGGCTGCCTGGCGGGCG
  GGCTCCGGAGCTTTCCTGAGCGGCATTAGCCCACGGCTTGGCCCGGACGCGACCAAAGGC
  TCTTCTGGAGAAGCCCAGAGCACTGGGCAATCGTTACGACCTGTAACTTGAGGGCCACCG
  AACTGCTACTCCCGTTCGCCTTTGGCGATCATCTTTTAACCCTCCGGAGCACGTCAGCAT
  CCAGCCACCGCGGCGCTCTCCCAGCAGCGGAGGACCCAGGACTATCCCTTCGGCGAGACG
  GATGGAAACCGAGCCCCCTGGAGGACCTGCCCCTGCAGTTCTGCCTCACACGGCTCAAGT
  CACCACCGTGAACAAGGGACCCTAAAGAATGGCCGAGCCTTGGGGGAACGAGTTGGCGTC
  CGCAGCTGCCAGGGGGGACCTAGAGCAACTTACTANGTTTGGTGCANAATAATGTAAACG
  TCAATGCACAAAATGGATNTGGAAGGACTGCGCTGCAGGTTATGAAACTTGGAAATCCCG
  AGATTGCCAGGAGACTGCTACTTTANAGGTGCTAAATCCCGATTTGAAAGACCGAACTGG
  GTTTCGCTGTCATTCATGATGCGGGCANAGCAGGTTTCCCTGGACACTTTACAGACCTTG
  CTGGGAGTTTCAAGCTGATGGTAACCTCGAGGATAATGGAAGGGAACCTGCCCTTGCACT
  TGGCTGCCAAAGAAGCCACTCCGGCTGGGGGGGAGGTCCCTGTGGAACC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001262 unedited
  NNGGGTTTACTATGNACCGCGCCGCAATCTANGATCGGTTTTTTTTTTTTTTTTTTCCTG
  TTTTGAAGTGTTTTAATTAGACAAAAGCATCAGGACAAACCATTTTAAAAACAAAGTCTT
  CAACTTGGGTGTTGAGATTGGCAAAAGGGGAAGCAAGGGAAAAGCCAAGGAAAGATAAAA
  TATTCAGAAGAAAGTCAAAGTTATCTGCAATTACATGTTAGAACAGATTTTGCAGGTTAA
  AAAGATGTTGCTTAAATATATTCATAAGCCTGTTGTAAGATTTTCACTTATGCAGTTTCA
  GAAAATTTAGCTGCTTAACATATGACAGAACTGTATTTTAACAAATGACATTAAAAGTCA
  GGAGAGCTACTCAGTTAATTGATAAAGTAGAGGCAACGTGGGGGAGCCCTCCCCACGTTT
  ATTGAAGATTTGTGGCTCCCCCAGCCCCGTTTGCCTGCATCAGGCTAACAACCTCATTCC
  TCCCATAGAGCCTGGCCAAATCACAGGCGGTGTCCCCCTTATGGTTCCGATGCCCCACAT
  TGCTGGCCGTGTGCTTCACCAGGAACTCCACCACCCGGAGGTGGCCTTCTTTGGCAGCCA
  AGTGCAAGGGCAGGTTCCCTTCATTATCCTCGATGTTAACATCAGCTTGAAACTCCAGCA
  AAGTCTGTAAAGTGTCCAGGAAACCTGCTCTGGCCGCATCATGAATGACAGCGAAACCAG
  TTCGGTCTTTCAAATCGGGATTAGCACCTCTAAGTAGCAGTCTCCTGGGCATCTCGGGAT
  TTCCAAGTTTTATAACCTGCAGCGCAGTCCTTCCAAATCCATTTTGTGCATTGACGTTTA
  CATTATTTTGCAACAAACTAGTAAGTTGCTCCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001262
• Insert Size: 1500 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001262.2, NP_001253.1
• RefSeq Size: 2104 bp
• RefSeq ORF: 507 bp
• Locus ID: 1031
• Cytogenetics: 1p32.3
• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle
• Gene Summary: 'The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (1) contains a different 5' UTR region, and encodes an identical protein, when compared to variant 2.