DMTF1 (NM_021145) Human Untagged Clone

CAT#: SC107975

DMTF1 (untagged)-Human cyclin D binding myb-like transcription factor 1 (DMTF1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DMTF1
• Synonyms: DMP1; DMTF; hDMP1; MRUL
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC107975 sequence for NM_021145 edited (data generated by NextGen Sequencing)
  
  
  ATGAGCACAGTGGAAGAGGATTCTGACACAGTAACAGTAGAAACTGTGAACTCTGTGACTTTGACTCAGG
  ACACAGAAGGGAATCTCATTCTTCACTGCCCTCAGAATGAAGCGGATGAAATAGACTCAGAAGATAGTAT
  TGAACCTCCACATAAAAGGCTTTGTTTGTCCTCTGAGGATGATCAGAGTATTGATGATTCTACTCCTTGC
  ATATCAGTTGTTGCACTTCCACTTTCAGAAAATGATCAGAGCTTTGAAGTGACCATGACTGCGACCACAG
  AAGTAGCAGATGATGAGGTTACTGAGGGGACTGTGACACAGATACAGATTTTGCAGAATGAGCAACTAGA
  TGAAATATCTCCCTTGGGTAACGAGGAAGTTTCAGCAGTTAGCCAAGCATGGTTTACAACTAAAGAAGAT
  AAGGATTCTCTGACTAATAAAGGACATAAATGGAAGCAGGGGATGTGGTCCAAGGAAGAAATTGATATTT
  TGATGAACAATATTGAACGCTATCTTAAGGCACGCGGAATAAAAGATGCTACAGAAATCATCTTTGAGAT
  GTCAAAAGACGAAAGAAAAGATTTCTACAGGACTATAGCATGGGGTCTGAACCGGCCTTTGTTTGCAGTT
  TATAGAAGAGTGCTTCGCATGTATGATGACAGAAACCATGTGGGAAAATATACACCTGAAGAAATTGAGA
  AGCTCAAGGAGCTCCGGATAAAGCATGGCAATGACTGGGCAACAATAGGGGCGGCGCTAGGAAGAAGTGC
  ATCTTCTGTCAAAGATCGGTGCCGACTGATGAAGGATACTTGCAACACAGGGAAGTGGACAGAAGAAGAA
  GAAAAGAGACTTGCAGAAGTGGTTCATGAGTTGACAAGCACTGAGCCAGGTGACATAGTCACACAGGGTG
  TGTCTTGGGCAGCTGTGGCTGAACGAGTCGGTACCCGCTCAGAAAAGCAATGTCGTTCTAAATGGCTCAA
  CTACCTGAATTGGAAACAGAGTGGGGGTACTGAATGGACCAAGGAAGATGAAATCAATCTCATCCTCAGG
  ATAGCAGAACTTGATGTAGCTGATGAAAATGACATTAACTGGGATCTGTTAGCTGAGGGATGGAGTAGTG
  TCCGTTCACCACAATGGCTACGAAGTAAATGGTGGACCATCAAAAGGCAAATTGCAAACCATAAGGATGT
  TTCGTTCCCTGTCTTAATAAAAGGTCTTAAACAGTTACATGAGAACCAAAAAAACAACCCAACGCTTTTG
  GAGAATAAATCAGGATCTGGAGTTCCAAACAGTAATACCAATTCCAGTGTGCAGCATGTTCAGATAAGAG
  TTGCCCGCTTGGAAGATAATACAGCCATCTCTTCTAGCCCCATGGCAGCATTGCAGATTCCAGTCCAGAT
  CACCCATGTTTCTTCAGCAGACTCTCCTGCTACCGTTGACTCAGAAACAATAACACTAAACAGTGGAACA
  CTACAGACATTTGAGATTCTTCCCTCTTTCCATCTACAGCCCACTGGCACTCCAGGCACCTACCTACTTC
  AAACAAGCTCAAGCCAAGGCCTTCCCCTAACTCTGACTGCTAGTCCCACAGTAACCCTGACAGCTGCTGC
  TCCTGCTTCTCCTGAACAGATTATTGTTCATGCTTTATCCCCAGAACATTTGTTGAACACAAGTGATAAT
  GTTACAGTGCAGTGTCACACACCAAGAGTCATCATTCAGACTGTTGCCACAGAGGACATCACTTCTTCCA
  TATCCCAAGCAGAACTGACAGTCGATAGTGATATTCAGTCATCTGATTTTCCTGAGCCTCCAGACGCCCT
  AGAAGCAGACACTTTCCCAGATGAAATTCATCACCCTAAGATGACTGTGGAGCCATCATTTAATGATGCT
  CATGTATCCAAATTCAGTGACCAAAATAGCACAGAACTGATGAATAGTGTTATGGTCAGAACAGAAGAAG
  AAATCTCTGACACCGACCTTAAACAAGAGGAATCACCCTCTGATTTAGCCAGTGCTTATGTTACTGAGGG
  TTTAGAGTCTCCCACTATAGAAGAACAAGTTGATCAAACAATTGATGATGAAACAATACTTATCGTTCCT
  TCACCACATGGCTTTATCCAGGCATCTGATGTTATAGATACTGAATCTGTCTTGCCTTTGACAACACTAA
  CAGATCCCATACTCCAACATCATCAGGAAGAATCAAATATCATTGGATCATCCTTGGGCAGTCCTGTTTC
  AGAAGATTCAAAGGATGTCGAAGATTTGGTAAACTGTCATTAG
  
  Clone variation with respect to NM_021145.3
  273:g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021145 unedited
  TTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGGCCACTCTCGCCCGT
  GGCTGCTTCCTCCATCCTGGTATTTTTTGGAGCTTCCATCCTGGTTCTTCCAAAGTGCCC
  GGACCCAAAACAGGAAAGTGTTGCGGAGATAGGAACATGGGAGAGAAACAATCTGGGTAA
  CATGAAAGTGATGCTGGTTGCTAAGGGAAGGCAACTTGATTCTGTGGGAAGGGCTGTAGC
  TGATCCATCCGTTGTCTAGATTTGAGTATGAGCACAGTGGAAGAGGATTCTGACACAGTA
  ACAGTAGAAACTGTGAACTCTGTGACTTTGACTCAGGACACAGAAGGGAATCTCATTCTT
  CACTGCCCTCAGAATGAAGCGGATGAAATAGACTCAGAAGATAGTATTGAACCTCCACAT
  AAAAGGCTTTGTTTGTCCTCTGAGGATGATCAGAGTATTGATGATTCTACTCCTTGCATA
  TCAGTTGTTGCACTTCCACTTTCAGAAAATGATCAGAGCTTTGAAGTGACCATGACTGCG
  ACCACAGAAGTAGCAGATGATGAGGTTACTGAGGGGACTGTGACACAGATACAGATTTTG
  CAGAATGAGCAACTAGATGAAATATCTCCCTTGGGTAACGAGGAAGTTTCAGCAGTTAGC
  CAAGCATGGTTTACAACTAAAGAAGATAAGGATTCTCTGACTAATAAAGGACATANATGG
  AAGCAGGGGATGTGGTCCAAGGAAGAAATTGATATTTTGATGAAAATATTGAACGCTATC
  TTAAGGCACGCGNATAAAAGAGCTACAGAAATCATCTTTGAGATGTCANAAGACGAAGAA
  NAGATTCTACAGGATATAGCATGGGGTCTGAACCGGCCTTTGNTTGCAGTTATANAANAA
  GTGCTCGCATGTTGATGACAGAACCATGTGGGAAATATACC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021145 unedited
  GTCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTAAAACAAATATTCT
  TTTATTTCTGTTAAACTGAATATACAATTGTTCCCTAGGCAACCAACTTTTGCTTATAAC
  TACAATTTAATTTCACGTTGACAAAACACAGTGAAAAGACAACTTTGTGAAGATCTAATT
  ACAATAATAAATAAAATAATTTATACAAGGGTTTTTTTTTCTTGACTTTTCTATAGGGGT
  CATATTCATTAAAAAGCCCAAAAGGCTACCTTTGCCTTAACCCTTCTGTAGTACAGGAAT
  GATTCTTAAATTTGTTTCCTTTTGTTATAAAAGCAAATATTGTTTTTTTAAAATAGCCTG
  AGATGAGAGGTTATATTGTACCCCACCAGCTAACACACTAAGTGGATGACAAACTATTCT
  CTCGGTAATTTATATAGCAAAACATCTAATAAATGGTCATGGTATCAAGGATAGGTAACA
  TTACTTCCTTCCTCATTAAGTTTTACTTCAAAGTGCTAACTTTGTAAACTAATGACAGTG
  GTTTCTGAGGGGGTGAAAACTGCTTAGATTCTGGCGGGTTTTGTTACTATGCTTATCCAT
  ATTCCCTTTTAAAGTAACAAAAAACCTGTAGAGAATTTTAACTTTTAATGCTTTCCTGTT
  TACCTGGCTAAACCAGCTCAACTGCCCCCCATGGGTTAACCAAATGTACACCACAAAACC
  CCCCCTTACGCCTCTAACTTGGAATTCTGTCCACATATCAATCTAAACCTTTTCGAACAC
  CACCAGATCCCCCGTAAAGCCTCTCACCCTTTTTAGAACCTTGTCCACAAAACCCTTTCG
  ACCTCAACCCACCCTCTAGAGACCACCACCCTCTCTCTCTTCCTTACAACACCTCTCTTC
  CCTACCCACCCACCCTTCCGTCTCATCACACCCTCTCTGGCTAACTACG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021145
• ORF Size: 2283 bp
• Insert Size: 3870
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_021145.2, NP_066968.2
• RefSeq Size: 4052
• RefSeq ORF: 2283
• Locus ID: 9988
• Domains: myb_DNA-binding
• Protein Families: Transcription Factors
• Gene Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
  Transcript Variant: This variant (1) encodes the longer isoform (a, also known as DMP1alpha). Variants 1 and 2 encode the same isoform.