ITCH (NM_031483) Human Untagged Clone

CAT#: SC108233

ITCH (untagged)-Human itchy E3 ubiquitin protein ligase homolog (mouse) (ITCH)


  "NM_031483" in other vectors (6)

Reconstitution Protocol

USD 1,750.00

4 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ITCH
Synonyms ADMFD; AIF4; AIP4; NAPP1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_031483, the custom clone sequence may differ by one or more nucleotides


ATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTG
TCATCTCAGCAAAACTTAAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGT
AGATGGACAGTCAAAGAAGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACA
GTTATCGTTACCCCTGTGAGTAAATTACATTTTCGTGTGTGGAGTCACCAGACACTGAAATCTGATGTTT
TGTTGGGAACTGCTGCATTAGATATTTATGAAACATTAAAGTCAAACAATATGAAACTTGAAGAAGTAGT
TGTGACTTTGCAGCTTGGAGGTGACAAAGAGCCAACAGAGACAATAGGAGACTTGTCAATTTGTCTTGAT
GGGCTACAGTTAGAGTCTGAAGTTGTTACCAATGGTGAAACTACATGTTCAGAAAGTGCTTCTCAGAATG
ATGATGGCTCCAGATCCAAGGATGAAACAAGAGTGAGCACAAATGGATCAGATGACCCTGAAGATGCAGG
AGCTGGTGAAAATAGGAGAGTCAGTGGGAATAATTCTCCATCACTCTCAAATGGTGGTTTTAAACCTTCT
AGACCTCCAAGACCTTCACGACCACCACCACCCACCCCACGTAGACCAGCATCTGTCAATGGTTCACCAT
CTGCCACTTCTGAAAGTGATGGGTCTAGTACAGGCTCTCTGCCGCCGACAAATACAAATACAAATACATC
TGAAGGAGCAACATCTGGATTAATAATTCCTCTTACTATATCTGGAGGCTCAGGCCCTAGGCCATTAAAT
CCTGTAACTCAAGCTCCCTTGCCACCTGGTTGGGAGCAGAGAGTGGACCAGCACGGGCGAGTTTACTATG
TAGATCATGTTGAGAAAAGAACAACATGGGATAGACCAGAACCTCTACCTCCTGGCTGGGAACGGCGGGT
TGACAACATGGGACGTATTTATTATGTTGACCATTTCACAAGAACAACAACGTGGCAGAGGCCAACACTG
GAATCCGTCCGGAACTATGAACAATGGCAGCTACAGCGTAGTCAGCTTCAAGGAGCAATGCAGCAGTTTA
ACCAGAGATTCATTTATGGGAATCAAGATTTATTTGCTACATCACAAAGTAAAGAATTTGATCCTCTTGG
TCCATTGCCACCTGGATGGGAGAAGAGAACAGACAGCAATGGCAGAGTATATTTCGTCAACCACAACACA
CGAATTACACAATGGGAAGACCCCAGAAGTCAAGGTCAATTAAATGAAAAGCCCTTACCTGAAGGTTGGG
AAATGAGATTCACAGTGGATGGAATTCCATATTTTGTGGACCACAATAGAAGAACTACCACCTATATAGA
TCCCCGCACAGGAAAATCTGCCCTAGACAATGGACCTCAGATAGCCTATGTTCGGGACTTCAAAGCAAAG
GTTCAGTATTTCCGGTTCTGGTGTCAGCAACTGGCCATGCCACAGCACATAAAGATTACAGTGACAAGAA
AAACATTGTTTGAGGATTCCTTTCAACAGATAATGAGCTTCAGTCCCCAAGATCTGCGAAGACGTTTGTG
GGTGATTTTTCCAGGAGAAGAAGGTTTAGATTATGGAGGTGTAGCAAGAGAATGGTTCTTTCTTTTGTCA
CATGAAGTGTTGAACCCAATGTATTGCCTGTTTGAATATGCAGGGAAGGATAACTACTGCTTGCAGATAA
ACCCCGCTTCTTACATCAATCCAGATCACCTGAAATATTTTCGTTTTATTGGCAGATTTATTGCCATGGC
TCTGTTCCATGGGAAATTCATAGACACGGGTTTTTCTTTACCATTCTATAAGCGTATCTTGAACAAACCA
GTTGGACTCAAGGATTTAGAATCTATTGATCCAGAATTTTACAATTCTCTCATCTGGGTTAAGGAAAACA
ATATTGAGGAATGTGATTTGGAAATGTACTTCTCCGTTGACAAAGAAATTCTAGGTGAAATTAAGAGTCA
TGATCTGAAACCTAATGGTGGCAATATTCTTGTAACAGAAGAAAATAAAGAGGAATACATCAGAATGGTA
GCTGAGTGGAGGTTGTCTCGAGGTGTTGAAGAACAGACACAAGCTTTCTTTGAAGGCTTTAATGAAATTC
TTCCCCAGCAATATTTGCAATACTTTGATGCAAAGGAATTAGAGGTCCTTTTATGTGGAATGCAAGAGAT
TGATTTGAATGACTGGCAAAGACATGCCATCTACCGTCATTATGCAAGGACCAGCAAACAAATCATGTGG
TTTTGGCAGTTTGTTAAAGAAATTGATAATGAGAAGAGAATGAGACTTCTGCAGTTTGTTACTGGAACCT
GCCGATTGCCAGTAGGAGGATTTGCTGATCTCATGGGGAGCAATGGACCACAGAAATTCTGCATTGAAAA
AGTTGGGAAAGAAAATTGGCTACCCAGAAGTCATACCTGTTTTAATCGCCTGGACCTGCCACCATACAAG
AGCTATGAGCAACTGAAGGAAAAGCTGTTGTTTGCCATAGAAGAAACAGAAGGATTTGGACAAGAGTAA


>OriGene 5' read for NM_031483 unedited
GGGCACATTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGATGCATTTCA
CAGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTC
AGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTA
GCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTTAAGGAAAATA
AGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGA
AGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTTATCG
TTACCCCTGTGAGTAAATTACATTTTCGTGTGTGGAGTCACCAGACACTGAAATCTGATG
TTTTGTTGGGAACTGCTGCATTAGATATTTATGAAACATTAAAGTCAAACAATATGAAAC
TTGAAGAAGTAGTTGTGACTTTGCAGCTTGGAGGTGACAAAGAGCCAACAGAGACAATAG
GAGACTTGTCAATTTGTCTTGATGGGCTACAGTTAGAGTCTGAAGTTGTTACCAATGGTG
AAACTACATGTTCAGAAAGTGCTTCTCAGAATGATGATGGCTCCAGATCCAAGGATGAAA
CAAGAGTGAGCACAAATGGATCAGATGACCCTGAAGATGCAAGAGCTGGTGAAAATAGGA
GAGTCAGTGGGAATAATTCTCCATCACTCTCAAATGGTGGTTTTAAACCTCTAGACCTCA
AGACCTTCACGACCACCACCACCCACCCCACGTAGACCAGCATCTGTCAATGGGTCACCA
TCCTGCCACTTTGAAAGTGAGGGTCTAGTACAAGCTCTCCTGCCCCGACAAAACCAATAC
AATACATCTGG
>OriGene 3' read for NM_031483 unedited
GCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTATTTATCCCCCACCACGCTGCCC
AAAAAAAAGAACAGGGTCTCCCTATGTTGCCCAGGCTGGTCTTTAACTCCTGGGCTAAAG
GGATCCTCCTGCCTCGGCCTCCCAGAGTGCTAGGATTACAGGTATGAGCCACCATGCCCG
GCCCTAGGTTAACTTCTTAAAACAATGAAGGAATCACAGTGTTAACATTGTTTGTAAAGT
GTAGTATTTGTCAGGCAACTGAAACAATCAGACTTCCAAATGAAGTCATTTGCAGGCTGT
GACCAACTTTTCCCTGAATTCAAATTGACAAAACTACTTTGTAGAGATGCAAGAGTCTTG
CCTCACTTCCAGGAATGATGTATGGATTCATGCGCCAGAAAGGAAAAACAATAGTCAAGT
CAGACTAAAATGAGAGGGAGAACACAAGCCCGAATTTTGCTCACATCCNCAGAAGCAGGA
GTAAGCTTGCACTTTTAACAAATGCCTCTTACCAAGAGGCTTAATAGGAAAATCTTGTAT
ATTGCAGTTACCAAAGGACTTCCCTGCATGTCTGCAGAATGTCTAANAGAAAAAACACTA
CTCCCAAGTGAGACTTTTGACACACATAANATATTGTGTTAAAGGAATAACTAGTGGAAT
AGACAAGGGCAATTCATTGTGTGTAAAATCTATGTTAGCAGGTTCTGACTAGTCATTGCA
GACCTGATTCTGGAACGCTGAGTGAAATCACTGGAGATAATCTAATGAGACATTATTTAC
TTCACTCAGATACTCTCTAAGACCCATTGTCATTTACAGATGTGCCACAGCANAAAAGAC
AAACATGCAATTAGTCCTGCCATTCATGTGCCAGTTTAAAGTACTCTGCCAATCCTCTGT
TTTCTATGCAACAAAGCTTNCTAGTGCTAAACTCTGGTGGGGCAGTCAGCGATAAACGGT
GACTCTGGACCATTTCTTCCACTTTCAGCAATTCTTGGCATGCTCCAGAAAACAACTC
Restriction Sites NotI-NotI     
ACCN NM_031483
ORF Size 2589 bp
Insert Size 3910
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_031483.3, NP_113671.3
RefSeq Size 6357
RefSeq ORF 2589
Locus ID 83737
Domains C2, HECT, WW
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Endocytosis, Ubiquitin mediated proteolysis
Gene Summary This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Both variants 2 and 5 encode the same isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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