IGLL1 (NM_152855) Human Untagged Clone

CAT#: SC108252

IGLL1 (untagged)-Human immunoglobulin lambda-like polypeptide 1 (IGLL1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IGLL1
• Synonyms: 14.1; AGM2; CD179b; IGL1; IGL5; IGLJ14.1; IGLL; IGO; IGVPB; VPREB2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_152855 edited
  GAATTCGGCACCAGTGCCAGCGAGAGGGACCAGGGCACCACTCTCTAGGGAGCCCACACT
  GCAAGTCAGGCCACAAGGACCTCTGACCCTGAGGGCCGATGAGGCCAGGGACAGGCCAGG
  GGGGCCTTGAGGCCCCTGGTGAGCCAGGCCCCAACCTCAGGCAGCGCTGGCCCCTGCTGC
  TGCTGGGTCTGGCCGTGGTAACCCATGGCCTGCTGCGCCCAACAGCTGCATCGCAGAGCA
  GGGCCCTGGGCCCTGGAGCCCCTGGAGGAAGCAGCCGGTCCAGCCTGAGGAGCCGGTGGG
  GCAGGTTCCTGCTCCAGCGCGGCTCCTGGACTGGCCCCAGGTGCTGGCCCCGGGGGTTTC
  AATCCAAGCATAACTCAGTGACGCATGTGTTTGGCAGCGGGACCCAGCTCACCGTTTTAA
  GTCAGCCCAAGGCCACCCCCTCGGTCACTCTGTTCCCGCCGTCCTCTGAGGAGCTCCAAG
  CCAACAAGGCTACACTGGTGTGTCTCATGAATGACTTTTATCCGGGAATCTTGACGGTGA
  CCTGGAAGGCAGATGGTACCCCCATCACCCAGGGCGTGGAGATGACCACGCCCTCCAAAC
  AGAGCAACAACAAGTACGCGGCCAGCAGCTACCTGAGCCTGACGCCCGAGCAGTGGAGGT
  CCCGCAGAAGCTACAGCTGCCAGGTCATGCACGAAGGGAGCACCGTGGAGAAGACGGTGG
  CCCCTGCAGAATGTTCATAGGTTCCCAGCCCCGACCCCACCCAAAGGGGCCTGGAGCTGC
  AGGATCCCAGGGGAAGGGTCTCTCTCTGCATCCCAAGCCATCCAGCCCTTCTCCCTGTAC
  CCAGTAAACCCTAAATAAATACCCTCTTTGTCAACCAGAAAAAAAAAAAAAAAAAAAAAA
  AACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_152855 unedited
  NTAAAGTTCAGGATTTTGTAATACGACTCACTATAGGGGCGGCGCGCGAATTCGCACCAG
  TGCCAGCGAGAGGGACCAGGGCACCACTCTGTGGGGAGCCCACACTGCAAGTCAGGCCAC
  AAGGACCTCTGACCCTGAGGGCCGATGAGGCCAGGGACAGGCCAGGGGGGCCTTGAGGCC
  CCTGGTGAGCCAGGCCCCAACCTCAGGCAGCGCTGGCCCCTGCTGCTGCTGGGTCTGGCC
  GTGGTAACCCAGGGGCTGCTGCGCCCAACAGCTGCATCGCAGAGCAGGGCCCTGGGCCCT
  GGAGCCCCTGGAGGAAGCAGCCGGTCCAGCCTGAGGAGCCGGTGGGGCAGGTTCCTGCTC
  CAGCGCGGCTCCTGGACTGGCCCCAGGTGCTGGCCCCGGGGGTTTCAATCCAAGCATAAC
  TCAGTGACGCATGTGTTTGGCAGCGGGACCCAGCTCACCGTTTTAAGTCAGCCCAAGGCC
  ACCCCCTCGGTCACTCTGTTCCCGCCGTCCTCTGAGGAGCTCCAAGCCAACAAGGCTACA
  CTGGTGTGTCTCATGAATGACTTTTATCCGGGAATCTTGACGGTGACCTGGAAGGCAGAT
  GGTACCCCCATCACCCAGGGCGTGGAGATGACCACGCCCTCCAAACAGAGCAACAACAAG
  TACGCGGCCAGCAGCTACCTGAGCCTGACGCCCGAGCAGTGGAGGTCCCGCAGAAGCTAC
  AGCTGCCAGGTCATGCACGAAGGGAGCACCGTGGAGAAGACGGTGGCCCCTGCAGAAGTT
  CATAGGTTCCCAGCCCCGACCCACCCAAAGGGGCCTGGAGCTGCAGGATCCCAGGGGAGG
  GTGTCTCTCTGCATCCCAAGCCATCCAGCCCTTCTCCTGTACCCAGTAAACCTAAAAAAT
  ACCCTCTTA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_152855 unedited
  CNATTTTATATCTTTTTTTTTTTTTTTTCGGTTGACAAAAAGGTATTTATTTAGGGTTTA
  CTGGGTACAGGGAGAAGGGCTGGATGGCTTGGGATGCAGAGAGAGACCCTTCCCCTGGGA
  TCCTGCAGCTCCAGGCCCCTTTGGGTGGGGTCGGGGCTGGGAACCTATGAACATTCTGCA
  GGGGCCACCGTCTTCTCCACGGTGCTCCCTTCGTGCATGACCTGGCAGCTGTAGCTTCTG
  CGGGACCTCCACTGCTCGGGCGTCAGGCTCAGGTAGCTGCTGGCCGCGTACTTGTTGTTG
  CTCTGTTTGGAGAGGCGTGGTCATCTCCACGCCCTGGGTGATGGGGGTACCATCTGCCTT
  CCAGGTCACCGTCAAGATTCCCGGATAAAAGTCATTCATGAGACACACCAGTGTAGCCTT
  GTTGGCTTGGAGCTCCTCAGAGGACGGCGGGAACAGAGTGACCGAGGGGGTGGCCTTGGG
  CTGACTTAAAACGGTGAGCTGGGTCCCGCTGCCAAACACATGCGTCACTGAGTTATGCTT
  GGATTGAAACCCCCGGGGCCAGCACCTGGGGCCAGTCCAGGAGCCGCGCTGGAGCAGGAA
  CCTGCCCCACCGGCTCCTCAGGCTGGACCCGCTGCTTCCTGCAGGGGCTCCAGGGCCCAG
  GGCCCTGCTCTGCGATGCAACTGTTGGGCGCAACATGCCTGGGGTTACCACGGGCAGACC
  CAGCAGCACCGGGGGCCAACGCTGCCTGAGGTTGGGGCCTGGTTCACCAGGGCCCTAAGG
  GCCCCCTGGCCTGTCCCTGGCCTCATAGA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_152855
• Insert Size: 1000 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_152855.1, NP_690594.1
• RefSeq Size: 785 bp
• RefSeq ORF: 255 bp
• Locus ID: 3543
• Cytogenetics: 22q11.23
• Protein Families: Secreted Protein
• Protein Pathways: Primary immunodeficiency
• Gene Summary: 'The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, which causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.