PILRA (NM_013439) Human Untagged Clone

CAT#: SC108389

PILRA (untagged)-Human paired immunoglobin-like type 2 receptor alpha (PILRA), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PILRA
• Synonyms: FDF03
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_013439, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGTCGGCCCCTGCTGCTGCCCCTACTGCCCTTGCTGCTGCCGCCAGCATTTCTGCAGCCTAGTGGCT
  CCACAGGATCTGGTCCAAGCTACCTTTATGGGGTCACTCAACCAAAACACCTCTCAGCCTCCATGGGTGG
  CTCTGTGGAAATCCCCTTCTCCTTCTATTACCCCTGGGAGTTAGCCACAGCTCCCGACGTGAGAATATCC
  TGGAGACGGGGCCACTTCCACAGGCAGTCCTTCTACAGCACAAGGCCGCCTTCCATTCACAAGGATTATG
  TGAACCGGCTCTTTCTGAACTGGACAGAGGGTCAGAAGAGCGGCTTCCTCAGGATCTCCAACCTGCAGAA
  GCAGGACCAGTCTGTGTATTTCTGCCGAGTTGAGCTGGACACACGGAGCTCAGGGAGGCAGCAGTGGCAG
  TCCATCGAGGGGACCAAACTCTCCATCACCCAGGCTGTCACGACCACCACCCAGAGGCCCAGCAGCATGA
  CTACCACCTGGAGGCTCAGTAGCACAACCACCACAACCGGCCTCAGGGTCACACAGGGCAAACGACGCTC
  AGACTCTTGGCACATAAGTCTGGAGACTGCTGTGGGGGTGGCAGTGGCTGTCACTGTGCTCGGAATCATG
  ATTTTGGGACTGATCTGCCTCCTCAGGTGGAGGAGAAGGAAAGGTCAGCAGCGGACTAAAGCCACAACCC
  CAGCCAGGGAACCCTTCCAAAACACAGAGGAGCCATATGAGAATATCAGGAATGAAGGACAAAATACAGA
  TCCCAAGCTAAATCCCAAGGATGACGGCATCGTCTATGCTTCCCTTGCCCTCTCCAGCTCCACCTCACCC
  AGAGCACCTCCCAGCCACCGTCCCCTCAAGAGCCCCCAGAACGAGACCCTGTACTCTGTCTTAAAGGCCT
  AA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013439 unedited
  TCGGCTTTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCTCCACCCCTG
  GGAGGCAGAAGCCAGGCATAGCGCGCTGGCTAGGACTCCAGTACCGTGAAGGGAGGCAGT
  GAGAGCAGACATCTGTGCCTCATTCCTGATCTCAAGGGGAAAGCAAGAACAAGGGAGGCT
  TCCTCAGGATCTCGAACCTGCGGAAGGAGGACCAGTCTGTGTACTTCTGCCAAGTCCAGC
  TGGACATACAGATCAGGGAGGCTGTCGTGGCAGTCCATCAAGGGGACCCACCTCACCATC
  ACCCAGGCCCTCAGGCAGCCCCTCCACAGGGCCCCTCTCCTGCCTGGACAGCTCTGCTGG
  TCTCCCCGTCCCCTGGAGAAGAACAAGGCCATGGGTCGGCCCCTGCTGCTGCCCCTGCTG
  CTCCTGCTGCAGCCGCCAGCATTTCTGCAGCCTGGTGGCTCCACAGGATCTGGTCCAAGC
  TACCTTTATGGGGTCACTCAACCAAAACACCTCTCAGCCTCCATGGGTGGCTCTGTGGAA
  ATCCCCTTCTCCTTCTATTACCCCTGGGAGTTAGCCATAGTTCCCAACGTGAGAATATCC
  TGGAGACGGGGCCACTTCCACGGGCAGTCCTTCTACAGCACAAGGCCGCCTTCCATTCAC
  AAGGATTATGTGAACCGGCTCTTTCTGAACTGGACAGAGGGTCAGGAGAGCGGCTTCCTC
  AGGATCTCAAACCTGCGGAAGGAGGACCAGTCTGTGTATTTCTGCCGAGTCGAGCTGGAC
  ACCCGNAGATCAGGGAGGCAGCAGTTGCAGTCCATCAAGGGGACCAAACTCACCATCACC
  CCAGCTGTCACAACCACCACCACCTGGNAGGCCCAGCAGCACAACCACCATAGNCGGCCT
  CAGGNTCACAGAAAGCAAAGGGCACTCANAATCATGGCACCTAAGTCTGGCACTGCCATC
  AGGGNTGCATTGGCTGNCGCTGN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_013439 unedited
  NNTTTTTAGCTATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTT
  AAATTTGTTACTTTATTGTTAATATATATTTTTAACTAGAGATGGCATCTCGCTCCATTA
  TCAAAGCTGGCCCTGAACTCCTGGGCTCACTTGATTCTGCCTCAGGCTTCAGAGTAGCTG
  GGATTACAGGTGTGCGCCACTGTACCTGGCCTCACCATTCAGTCTTGAGAGGGCTGTCCA
  TTGGTTAGGCCTTTAAGACAGAGTACAGGGTCTCGTTCTGGGGGCTCTTGAGGGGACGGT
  GGCTGGGAGGTGCTCTGGGTGAGGTGGAGCTGGAGAGGGCAAGGGAAGCATAGACGATGC
  CGTCATCCTTGGGATTTAGCTTGGGATCTGTATTTTGTCCTTCATTCCTGATATTCTCAT
  ATGGCTCCTCTGTGTTTTGGAAGGGTTCCCTGGCTGGGGTTGTGGCTTTAGTCCGCTGCT
  GACCTTTCCTTCTCCTCCACCTGAGGAGGCAGATCAGTCCCAAAATCATGATTCCGAGCA
  CAGTGACAGCCACTGCCACCCCCACAGCAGTCTCCAGACTTATGTGCCAAGAGTCTGAGC
  GTCGTTTGCCCTGTGTGACCCTGAGGCCGGTTGTGGTGGTTGTGCTACTGAGCCTCCAGG
  TGGTAGTCATGCTGCTGGGCCTCTGGGTGGTGGTCGTGACAGCCTGNGTGATGGAGAGNT
  TGGGTCCCCTCGATGGACTGCCACTGCTGCCTCCCTGAGCTNNCGTGTGTCCAGCTAAAC
  TCGGCAGAAAACACAGACTGGTCCTGCTTTGCAGTTTGGGAGATCTGGAGAAGCCGCTCT
  CTGACCTCTGTCCAGTCAGAAGAAGACGGTCACATATCTGTGAAAGGAAAGCGNCCTGGC
  TTTNAAAGGCTCGGTCGTGAATGGGCCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_013439
• ORF Size: 912 bp
• Insert Size: 2190
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_013439.2, NP_038467.2
• RefSeq Size: 1323
• RefSeq ORF: 912
• Locus ID: 29992
• Domains: IG
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).