Paxillin (PXN) (NM_002859) Human Untagged Clone

CAT#: SC108478

PXN (untagged)-Human paxillin (PXN), transcript variant 2


  "NM_002859" in other vectors (6)

Reconstitution Protocol

USD 760.00

In Stock*

Size
    • 10 ug

Product Images

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PXN
Synonyms FLJ16691
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC108478 sequence for NM_002859 edited (data generated by NextGen Sequencing)
ATGGACGACCTCGACGCCCTGCTGGCGGACTTGGAGTCTACCACCTCCCACATCTCCAAA
CGGCCTGTGTTCTTGTCGGAGGAGACCCCCTACTCATACCCAACTGGAAACCACACATAC
CAGGAGATTGCCGTGCCACCCCCCGTCCCCCCACCCCCGTCCAGCGAGGCCCTCAATGGC
ACAATCCTTGACCCCTTAGACCAGTGGCAGCCCAGCGGCTCCCGATTCATCCACCAGCAG
CCTCAGTCCTCATCACCTGTGTACGGCTCCAGTGCCAAAACTTCCAGTGTCTCCAACCCT
CAGGACAGTGTTGGCTCTCCGTGCTCCCGAGTGGGTGAGGAGGAGCACGTCTACAGCTTC
CCCAACAAGCAGAAATCAGCTGAGCCTTCACCCACCGTAATGAGCACGTCCCTGGGCAGC
AACCTTTCTGAACTCGACCGCCTGCTGCTGGAACTGAACGCTGTACAGCATAACCCGCCA
GGCTTCCCTGCAGATGAGGCCAACTCAAGCCCCCCGCTTCCTGGGGCCCTGAGCCCCCTC
TATGGTGTCCCAGAGACTAACAGCCCCTTGGGAGGCAAAGCTGGGCCCCTGACGAAAGAG
AAGCCTAAGCGGAATGGGGGCCGGGGCCTGGAGGACGTGCGGCCCAGTGTGGAGAGTCTC
TTGGATGAACTGGAGAGCTCCGTGCCCAGCCCCGTCCCTGCCATCACTGTGAACCAGGGC
GAGATGAGCAGCCCGCAGCGCGTCACCTCCACCCAACAGCAGACACGCATCTCGGCCTCC
TCTGCCACCAGGGAGCTGGACGAGCTGATGGCTTCGCTGTCGGATTTCAAGTTCATGGCC
CAGGGGAAGACAGGGAGCAGCTCACCCCCTGGGGGGCCCCCGAAGCCCGGGAGCCAGCTG
GACAGCATGCTGGGGAGCCTGCAGTCTGACCTGAACAAGCTGGGGGTCGCCACAGTCGCC
AAAGGAGTCTGCGGGGCCTGCAAGAAGCCCATCGCCGGGCAGGTTGTGACCGCCATGGGG
AAGACGTGGCACCCCGAGCACTTCGTCTGCACCCACTGCCAGGAGGAGATCGGATCCCGG
AACTTCTTCGAGCGGGATGGACAGCCCTACTGTGAAAAGGACTACCACAACCTCTTCTCC
CCGCGCTGCTACTACTGCAACGGCCCCATCCTGGATAAAGTGGTGACAGCCCTTGACCGG
ACGTGGCACCCTGAACACTTCTTCTGTGCACAGTGTGGAGCCTTCTTTGGTCCCGAAGGG
TTCCACGAGAAGGACGGCAAGGCCTACTGTCGCAAGGACTACTTCGACATGTTCGCACCC
AAGTGTGGCGGCTGCGCCCGGGCCATCCTGGAGAACTATATCTCAGCCCTCAACACGCTG
TGGCATCCTGAGTGCTTTGTGTGCCGGGAATGCTTCACGCCATTCGTGAACGGCAGCTTC
TTCGAGCACGACGGGCAGCCCTACTGTGAGGTGCACTACCACGAGCGGCGCGGCTCGCTG
TGTTCTGGCTGCCAGAAGCCCATCACCGGCCGCTGCATCACCGCCATGGCCAAGAAGTTC
CACCCCGAGCACTTCGTCTGTGCCTTCTGCCTCAAGCAGCTCAACAAGGGCACCTTCAAG
GAGCAGAACGACAAGCCTTACTGTCAGAACTGCTTCCTCAAGCTCTTCTGCTAG

Clone variation with respect to NM_002859.3
217 a=>g
>OriGene 5' read for NM_002859 unedited
NAAAAAAAGAGAAAAAAACTTNNNNTNNNNNNNNNGTTTTTACCCCGCCCCTTGCCCCAA
AGGGCGGTAGGCGTGTACGGTGGGAAGTCTATATAAGCAGAGCTCATTTAGGTGACACTA
TAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGCTCGCGGC
GGAAAAGTTGCGGGGCATAGACGAGCGGCCCCGGGACGGGCAGCTAGCGCGACCCTGAGC
CGGCGCCCGTGGTCCGGCCATGGACGACCTCGACGCCCTGCTGGCGGACTTGGAGTCTAC
CACCTCCCACATCTCCAAACGGCCTGTGTTCTTGTCGGAGGAGACCCCCTACTCATACCC
AACTGGAAACCACACATACCAGGAGATTGCCGTGCCACCCCCCGTCCCCCCACCCCCGTC
CAGCGAGGCCCTCAATGGCACAATCCTTGACCCCTTAGACCAGTGGCAGCCCAGCGGCTC
CCGATTCATCCACCAGCAGCCTCAGTCCTCATCACCTGTGTACGGCTCCAGTGCCAAAAC
TTCCAGTGTCTCCAACCCTCAGGACAGTGTTGGCTCTCCGTGCTCCCGAGTGGGTGAGGA
GGAGCACGTCTACAGCTTCCCCAACAAGCAGAAATCAGCTGAGCCTTCACCCACCGTAAT
GAGCACGTCCCTGNGCAGCAACCTTTCTGAACTCGACCGCCTGCTGCTGGAACTGAACGC
TGTACAGCATAACCCGCCAGGCTTCCCTGCAGATGAGGCCAACTCAAGCCCCCCGCTTTC
TGGGGCCCCTGAGCCCCCTCTATGGTGTCCCAGAGACCTACAGCCCCTTGGGNAGCAAAG
CTGGCCCCCTGACGAAAGAGAAGCCTAAGCGGAATGGGGGCCGGGGCCTNGAAGNACGTG
CCGCCCCATGTGGNAGAGTCTCTTGGATGAACTGAAGAGCTCGTGCCCCACCCCGTTCCT
GCCT
>OriGene 3' read for NM_002859 unedited
GGGGAATCAGCGTGNACAGGCCCGTTAGCGANGATCGAAAACCTTTTTTTTTTTTTGAAA
ACATGGGCAAACTTTATTGGGGCATAAATCACAGGGAATTTGAAATGGGGAAAAGCCAGC
TTGGAAGTTTACAGGAGAAAAAATAAAATCAAAATCAAATTTTCAAATAACCACTGACTC
AGAGAATGGACCCCAGAAACCCCAGTCCCTCTTGGGGTAATATTTAGGGTGGGTCACTAT
AAACAGAGCGGTAAGGCCTGCGGGTGAAAGTGGAGACATCAGACCTTTGGAGGGGCTGGG
CTGACCTTCCCCCAAAAAGGAGGGACCCTCTTCGGAGACCCCAGCACACTCGGCTTCTGC
CAGGAGGCCAGTGGAGTGGTTTGGACTGTCACCATTAGACCCCGGTGGGGCCCCTTTCTC
CTCATCAGGAGCCCAAGGCCTGGCTCCTCTTTCATCCTTGGTAAAGAGCTCTGGGGGGTT
TCCCCAGAGGAGCCTGTCCCTCTGCCCCAAATCCTATCATGCTCCCTTATGACCTTCTTT
CCAGACCCCCTGAGTGCCGATCCCACCTGTGAAAGGGGAGGAGCAGATCTGGGGAAGGGA
TATGCCCAGAGGAAATCAACAAGACCAAAGAGACGTCAGAGTCCTGATGGCCAAAATCAG
ACACCAGCTTTCCTGAGAAGGCAGAAGAGAGAGCCCCATAAAAGCAGTGGGGGCTCAGAA
GGTTCAGTGGGTTCACAGGGGAGCAAGGCTCCTGAGGGCTACTCAGACAGAAGCACCCCC
CAAAAATACTTCCCCTTTTCCTCCCCGGAAACAGACAGATAAGGTTCAAAATTTAGGCCC
CAAAGGGGGCACACCCTTCAACCAATTCTATGAAAAACTTGTTGGCCCGG
Restriction Sites NotI-NotI     
ACCN NM_002859
Insert Size 4000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002859.1, NP_002850.1
RefSeq Size 3595 bp
RefSeq ORF 1674 bp
Locus ID 5829
Cytogenetics 12q24.23
Domains LIM, Paxillin
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, VEGF signaling pathway
Gene Summary 'This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]'
Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as isoform alpha).

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