RTN3 (NM_006054) Human Untagged Clone

CAT#: SC108563

RTN3 (untagged)-Human reticulon 3 (RTN3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RTN3
• Synonyms: ASYIP; HAP; NSPL2; NSPLII; RTN3-A1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC108563 sequence for NM_006054 edited (data generated by NextGen Sequencing)
  ATGGCGGAGCCGTCGGCGGCCACTCAGTCCCATTCCATCTCCTCGTCGTCCTTCGGAGCC
  GAGCCGTCCGCGCCCGGCGGCGGCGGGAGCCCAGGAGCCTGCCCCGCCCTGGGGACGAAG
  AGCTGCAGCTCCTCCTGTGCGGTGCACGATCTGATTTTCTGGAGAGATGTGAAGAAGACT
  GGGTTTGTCTTTGGCACCACGCTGATCATGCTGCTTTCCCTGGCAGCTTTCAGTGTCATC
  AGTGTGGTTTCTTACCTCATCCTGGCTCTTCTCTCTGTCACCATCAGCTTCAGGATCTAC
  AAGTCCGTCATCCAAGCTGTACAGAAGTCAGAAGAAGGCCATCCATTCAAAGCCTACCTG
  GACGTAGACATTACTCTGTCCTCAGAAGCTTTCCATAATTACATGAATGCTGCCATGGTG
  CACATCAACAGGGCCCTGAAACTCATTATTCGTCTCTTTCTGGTAGAAGATCTGGTTGAC
  TCCTTGAAGCTGGCTGTCTTCATGTGGCTGATGACCTATGTTGGTGCTGTTTTTAACGGA
  ATCACCCTTCTAATTCTTGCTGAACTGCTCATTTTCAGTGTCCCGATTGTCTATGAGAAG
  TACAAGACCCAGATTGATCACTATGTTGGCATCGCCCGAGATCAGACCAAGTCAATTGTT
  GAAAAGATCCAAGCAAAACTCCCTGGAATCGCCAAAAAAAAGGCAGAATAA
  
  Clone variation with respect to NM_006054.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006054 unedited
  GACCTTGGATTTTGTAACCGACTTACTATAGGGNCGGCACGCGCAATTCGGCACGAGGGT
  CAGTCAGTCTGTCGGAGTCTGGTCCTCGGACAGGCGGAGTAAAGGGACTTGAGCGAGCCA
  GTTGCCGGATTATTCTATTTCCCCTCCCTCTCTCCCGCCCCGTATCTCTTTTCACCCTTC
  TCCCACCCTCGCTCGCGTAGCCATGGCGGAGCCGTCGGCGGCCACTCAGTCCCATTCCAT
  CTCCTCGTCGTCCTTCGGAGCCGAGCCGTCCGCGCCCGGCGGCGGCGGGAGCCCAGGAGC
  CTGCCCCGCCCTGGGGACGAAGAGCTGCAGCTCCTCCTGTGCGGTGCACGATCTGATTTT
  CTGGAGAGATGTGAAGAAGACTGGGTTTGTCTTTGGCACCACGCTGATCATGCTGCTTTC
  CCTGGCAGCTTTCAGTGTCATCAGTGTGGTTTCTTACCTCATCCTGGCTCTTCTCTCTGT
  CACCATCAGCTTCAGGATCTACAAGTCCGTCATCCAAGCTGTACAGAAGTCAGAAGAAGG
  CCATCCATTCAAAGCCTACCTGGACGTAGACATTACTCTGTCCTCAGAAGCTTTCCATAA
  TTACATGAATGCTGCCATGGTGCACATCAACAGGGCCCTGAAACTCATTATTCGTCTCTT
  TCTGGTAGAAGATCTGGTTGACTCCTTGAAGCTGGCTGTCTTCATGTGGCTGATGACCTA
  TGTTGGTGCTGTTTTTAACGGAATCACCCTTCTAATTCTTGCTGAACTGCTCATTTTCAG
  TGTCCCGATTGTCTATGAGAAGTACCAGACCCAGATTGATCACTATGTTGGCATCGCCCG
  AGATCAGACCAAGTCAATTGNTGAAAAGATCCCAGCANNACTCCTGGNATCGCCAAAAAA
  AGGCAGNNATAGTACATGGAAACCCAGAATGCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006054 unedited
  AGCTTGTACGCGGCCGCAATTTANAGTCGAGTTTTTTTTTTTTTTTTTTGGGGTTTTTTT
  TTTTTTATTAATACCACATCAATTTGAAATTTTACAGGAACCAAGATTCAAGCTCCTTAG
  GGGCTACTGTATTTTTATGTTGCACGCACAGACACGTACACACAGTTTCATTAGTAATTT
  TTCATCTATAGGTTTTTCTTAAAAAAAAAAAAAATCCTGTGTGGCACAAAGATCTCTTCA
  ATTATCTAAACACAGCAGCAACAAAAGAAAAGAACTGGATGTGGCACTTCCACTGCAAAA
  GGTCCTTTGGAGGGGAAGCCCAAAAAGACAATCACTGACTTCCTGGGAGGGCAAAGGATG
  AGGATGGAAAATGCACTTCCTACTAGGACATGAAACCAGTTAAAACACTCAAAGGGGGCT
  AAGAAAATAAGATGGAGTAAGGCAAGGGTACCTTTTACCCATCCAAATTCCTAACTAATT
  TTTCCAAGACACGTAGACAATTTCCTTCCACTACTTTTTGCAGCTGCCGTACTTTGGGAC
  CATCAAATATCATAGCCCTTACTTTAAACTCGCCAGTGCATATTCCCTCTGAAGGATCAT
  GACTATGAGTGAGAACCTGAAGGAACTCACAGATGATTTTTCTTTCAAGTTCGCTGAATT
  CTCATATTGAAGGTGAAGAAAAAAACTTGCCCCCAAATGGGAAATCGAGATTTGAATCTC
  GGGAAAAGATCAAGAAAAAAAGGCTTCTGTATTTCACCTCTTGAGAAATGTTCCCCCCAG
  ACTGAGATAGGATCCCAAAAACTCATTAACTGGAGGAGCCACATGCACGGTTATTTTTTT
  CTCTAACCAGTTTACAGCAGTGCACAGCAGTTACAGACATTTATTTTTAGTAAAAAAGTT
  CACCCTTTTTTTTAACTTGAGGTGGCCAGGGAAAGGTAGAAACCCATTN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006054
• ORF Size: 711 bp
• Insert Size: 2620
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006054.2, NP_006045.1
• RefSeq Size: 2583
• RefSeq ORF: 711
• Locus ID: 10313
• Domains: Reticulon
• Protein Families: Transmembrane
• Gene Summary: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
  Transcript Variant: This variant (1) encodes isoform a.