TRIM68 (NM_018073) Human Untagged Clone

CAT#: SC108792

TRIM68 (untagged)-Human tripartite motif containing 68 (TRIM68)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRIM68
• Synonyms: GC109; RNF137; SS-56; SS56
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_018073, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGATCCCACAGCCTTGGTGGAAGCCATTGTGGAAGAAGTGGCCTGTCCCATCTGTATGACCTTCCTGA
  GGGAGCCCATGAGCATTGACTGTGGCCACAGCTTCTGCCACAGCTGTCTCTCTGGACTCTGGGAGATCCC
  AGGAGAATCCCAGAACTGGGGTTACACCTGTCCCCTCTGTCGAGCTCCTGTCCAGCCAAGGAACCTGCGG
  CCTAATTGGCAGCTGGCCAATGTTGTAGAAAAAGTCCGTCTGCTAAGGCTACATCCAGGAATGGGGCTGA
  AGGGTGACCTGTGTGAGCGCCATGGGGAAAAGCTGAAGATGTTCTGCAAAGAGGATGTCTTGATAATGTG
  TGAGGCCTGCAGCCAGTCCCCAGAGCATGAGGCCCACAGTGTTGTGCCAATGGAGGATGTTGCCTGGGAG
  TACAAGTGGGAACTTCATGAGGCCCTCGAACATCTGAAGAAAGAGCAAGAAGAGGCCTGGAAGCTTGAAG
  TTGGTGAAAGGAAACGAACTGCCACCTGGAAGATACAGGTGGAAACCCGAAAACAGAGTATTGTATGGGA
  GTTTGAAAAATACCAGCGATTACTAGAGAAAAAGCAGCCACCACATCGGCAGCTGGGGGCAGAGGTAGCA
  GCAGCTCTGGCCAGCCTACAGCGGGAGGCAGCGGAGACCATGCAGAAACTGGAGTTGAACCATAGCGAGC
  TCATCCAGCAGAGCCAGGTCCTGTGGAGGATGATTGCAGAGTTGAAAGAGAGGTCGCAGAGGCCTGTCCG
  CTGGATGTTGCAGGATATTCAGGAAGTGTTAAACAGGAGCAAATCTTGGAGCTTGCAGCAGCCAGAACCA
  ATCTCCCTGGAGTTGAAGACAGATTGCCGTGTGCTGGGGCTAAGAGAGATCCTGAAGACTTATGCAGCTG
  ATGTGCGCTTGGATCCAGATACTGCTTACTCCCGTCTCATCGTGTCTGAGGACAGAAAACGTGTGCACTA
  TGGAGACACCAACCAGAAACTGCCAGACAATCCTGAGAGATTTTACCGCTATAATATCGTCCTGGGAAGC
  CAGTGCATCTCCTCAGGCCGGCACTACTGGGAGGTGGAGGTGGGAGACAGGTCTGAGTGGGGCCTGGGAG
  TATGTAAGCAAAATGTAGACCGGAAGGAGGTGGTCTACTTATCCCCCCACTATGGATTCTGGGTGATAAG
  GCTGAGGAAGGGAAATGAGTACCGAGCAGGCACCGATGAGTACCCAATCCTGTCCTTGCCGGTCCCTCCT
  CGCCGGGTGGGAATCTTCGTGGATTATGAGGCCCATGACATTTCTTTCTACAATGTGACTGACTGTGGCT
  CCCACATCTTCACTTTCCCCCGCTATCCCTTCCCTGGGCGCCTCCTGCCCTATTTTAGTCCTTGCTACAG
  CATTGGAACCAACAACACTGCTCCTCTGGCCATCTGCTCCCTGGATGGGGAGGACTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_018073
• ORF Size: 1458 bp
• Insert Size: 4000
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_018073.7, NP_060543.5
• RefSeq Size: 3372
• RefSeq ORF: 1458
• Locus ID: 55128
• Domains: zf-B_box, RING, SPRY
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).