DPP1 (CTSC) (NM_148170) Human Untagged Clone

CAT#: SC109065

CTSC (untagged)-Human cathepsin C (CTSC), transcript variant 2


  "NM_148170" in other vectors (4)

Reconstitution Protocol

USD 420.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CTSC
Synonyms CPPI; DPP-I; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_148170, the custom clone sequence may differ by one or more nucleotides


ATGGGTGCTGGGCCCTCCTTGCTGCTCGCCGCCCTCCTGCTGCTTCTCTCCGGCGACGGCGCCGTGCGCT
GCGACACACCTGCCAACTGCACCTATCTTGACCTGCTGGGCACCTGGGTCTTCCAGGTGGGCTCCAGCGG
TTCCCAGCGCGATGTCAACTGCTCGGTTATGGGACCACAAGAAAAAAAAGTAGTGGTGTACCTTCAGAAG
CTGGATACAGCATATGATGACCTTGGCAATTCTGGCCATTTCACCATCATTTACAACCAAGGCTTTGAGA
TTGTGTTGAATGACTACAAGTGGTTTGCCTTTTTTAAGGATGTCACTGATTTTATCAGTCATTTGTTCAT
GCAGCTGGGAACTGTGGGGATATATGATTTGCCACATCTGAGGAACAAACTGGTTATTAAATAG


>OriGene 5' read for NM_148170 unedited
CTTAGATTTGTAAACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGTCTTCACCTCT
TTTCTCAGCTCCCTGCAGCATGGGTGCTGGGCCCTCCTTGCTGCTCGCCGCCCTCCTGCT
GCTTCTCTCCGGCGACGGCGCCGTGCGCTGCGACACACCTGCCAACTGCACCTATCTTGA
CCTGCTGGGCACCTGGGTCTTCCAGGTGGGCTCCAGCGGTTCCCAGCGCGATGTCAACTG
CTCGGTTATGGGACCACAAGAAAAAAAAGTAGTGGTGTACCTTCAGAAGCTGGATACAGC
ATATGATGACCTTGGCAATTCTGGCCATTTCACCATCATTTACAACCAAGGCTTTGAGAT
TGTGTTGAATGACTACAAGTGGTTTGCCTTTTTTAAGGATGTCACTGATTTTATCAGTCA
TTTGTTCATGCAGCTGGGAACTGTGGGGATATATGATTTGCCACATCTGAGGAACAAACT
GGTTATTAAATAGAGCATCTGTTGAGGGACTCTTTTAAAACCACAGCCATGAACAGACGT
TGGGGCTAAGAGACAGAGCAGCCTGCGACAGTGTGGACCTACCTGTAGCAGCTAGCAAAG
GCCTCTAGCAGCTACAGTCCCTTCTGGAGTCTTTATTTGCATGCAAAATGCAAAGGAGTC
CTGGTGACCTACCTCCAAGGCAGCTGCCCTCCTGAACACTCCCTTGGAAAACAGTAAACA
TCATTTTGGAATGTGAACAACCAGAGACTACACAGGAGAAAGGAAAAAAAAAATTCTGAA
GATGCAAAATCTTGGGTGGCTTCACCGTTCAGTTTTTTAATAAAAGGAACAATNTACANA
AAAAAAAANAAAAACTCGACTCTAGATTGCNGCCGCGGTCATAGCTGTTTCCTGAACAGA
TCCCGGNTGGCATNCCTGTGNACCCTNNCCATGCCTNTNCTGGCCCTGNAAGTGCCACT
>OriGene 3' read for NM_148170 unedited
TAACTATGNAACCGCGGCCGCATNCTAGNGATCGATTTTTTTTTTTTTTTTTTGTATATT
GTTCCTTTTATTAAAAAACTGAACGGTGAAGCCACCCAAAATTTTGCATCTTCAGAATTT
TTTTTTTCCTTTCTCCTGTGTAGTCTCTGGTTGTTCACATTCCAAAATGATGTTTACTGT
TTTCCAAGGGAGTGTTCAGGAGGGCAGCTGCCTTGGAGGTAGGTCACCAGGACTCCTTTG
CATTTTGCATGCAAATAAAGACTCCAGAAGGGACTGTAGCTGCTAGAGGCCTTTGCTAGC
TGCTACAGGTAGGTCCACACTGTCGCAGGCTGCTCTGTCTCTTAGCCCCAACGTCTGTTC
ATGGCTGTGGTTTTAAAAGAGTCCCTCAACAGATGCTCTATTTAATAACCAGTTTGTTCC
TCAGATGTGGCAAATCATATATCCCCACAGTTCCCAGCTGCATGAACAAATGACTGATAA
AATCAGTGACATCCTTAAAAAAGGCAAACCACTTGTAGTCATTCAACACAATCTCAAAGC
CTTGGTTGTAAATGATGGTGAAATGGCCAGAATTGCCAAGGTCATCATATGCTGTATCCA
GCTTCTGAAGGTACACCACTACTTTTTTTTCTTGTGGTCCCATAACCGAGCAGTTGACAT
CGCGCTGGGAACCGCTGGAGCCCACCTGGAAGACCCCAGTGCCCAGCAAGTCAAGAATAG
TGCAGTTGGCAAGTGTGTCGCAACCACGGCGCCGTCGCCGGAAAAAACACCAGGAGGCGG
CCAGCACCAAGGAGGGCCCACCACCCTGCTGCAGGGAGCTGAAAAAAAAGTGAAGACCTT
CTGCCCAAATTCCGGCCGCCCTATATTGAGTCGTATACCAAAATTTGACGGTTCACTAAC
GAGCTCTGCTTATTAGACCTCCAACCTACCACCTACCC
Restriction Sites NotI-NotI     
ACCN NM_148170
Insert Size 800 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_148170.2, NP_680475.1
RefSeq Size 6131 bp
RefSeq ORF 414 bp
Locus ID 1075
Cytogenetics 11q14.2
Protein Families Druggable Genome, Protease
Protein Pathways Lysosome
Gene Summary 'This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]'
Transcript Variant: This variant (2) differs in the coding sequence and 3' UTR compared to variant 1. This results in an isoform (b) that is much shorter and contains a different C-terminus than isoform a. Isoform b may act as a negative regulator of a stable mature enzyme. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.

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