CCR2 (NM_000648) Human Untagged Clone

CAT#: SC109082

CCR2 (untagged)-Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B


  "NM_000648" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CCR2
Synonyms CC-CKR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC109082 sequence for NM_000648 edited (data generated by NextGen Sequencing)
ATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAGCGGTGAAGAAGTC
ACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGACGTGAAGCAAATT
GGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGTGTTCATCTTTGGTTTTGTGGGCAAC
ATGCTGGTCATCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACATTTAC
CTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCCATTGTGGGCTCAC
TCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATTCACAGGGCTGTAT
CACATCGGTTATTTTGGCGGAATCTTCTTCATCATCCTCCTGACAATCGATAGATACCTG
GCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGGTGACA
AGTGTGATCACCTGGTTGGTGGCTGTGTTTGCTTCTGTCCCAGGAATCATCTTTACTAAA
TGCCAGAAAGAAGATTCTGTTTATGTCTGTGGCCCTTATTTTCCACGAGGATGGAATAAT
TTCCACACAATAATGAGGAACATTTTGGGGCTGGTCCTGCCGCTGCTCATCATGGTCATC
TGCTACTCGGGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGCATAGG
GCAGTGAGAGTCATCTTCACCATCATGATTGTTTACTTTCTCTTCTGGACTCCCTATAAT
ATTGTCATTCTCCTGAACACCTTCCAGGAATTCTTCGGCCTGAGTAACTGTGAAAGCACC
AGTCAACTGGACCAAGCCACGCAGGTGACAGAGACTCTTGGGATGACTCACTGCTGCATC
AATCCCATCATCTATGCCTTCGTTGGGGAGAAGTTCAGAAGGTATCTCTCGGTGTTCTTC
CGAAAGCACATCACCAAGCGCTTCTGCAAACAATGTCCAGTTTTCTACAGGGAGACAGTG
GATGGAGTGACTTCAACAAACACGCCTTCCACTGGGGAGCAGGAAGTCTCGGCTGGTTTA
TAA

Clone variation with respect to NM_000648.2
190 g=>a
>OriGene 5' read for NM_000648 unedited
GGGGGGGACCNNNNNCCCTTTCCCNCCCGGTTCAGATTTGTNATACGACTCACTATAGGC
GGCCGCGAATTCGCACGAGGCTGAACAGAGAAGTGGATTGAACAAGGACGCATTTCCCCA
GTACATCCACAACATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAG
CGGTGAAGAAGTCACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGA
CGTGAAGCAAATTGGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGTGTTCATCTTTGG
TTTTGTGGGCAACATGCTGGTCATCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTT
GACTGACATTTACCTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCC
ATTGTGGGCTCACTCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATT
CACAGGGCTGTATCACATCGGTTATTTTGGCGGAATCTTCTTCATCATCCTCCTGACAAT
CGATAGATACCTGGCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTT
TGGGGTGGTGACAAGTGTGATCACCTGGTTGGTGGCTGTNGTTGCTTCTGTCCCCAGAAT
CATCTTTACTAAATGCCAGANAGAAGATTCTGTTTATGTCTGTGGCCCTTTATTTCCACG
AGGATGGAAATATTNCACANCATTATGAGGAACATTNNTGNGCTGGTCCCTGCGCTGCTC
ATCATGGNCATCTGCTACTCGGNAATCCTGAAACCCTGCTTNCGTGTCGAAACGAGAAGA
AGAGCATAGGGCAGTGAGAGTCATCTTCACATCATNGATGTTACTTTCTCTTCTGGACTC
CCTATATATGNCATCTNNCTGACACTTNCAGNNATCTTCGNCTGAGTACTGTGAAGCACA
GTCACTGGACCAGCCGCAGTGACAGAACTCTGGGAGACTACTGCT
>OriGene 3' read for NM_000648 unedited
CTTTGGCCCGCGGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTCTTTTATCAA
CATAGTTATAGCATTGATTTATTTTCCAAATCATAGTTGTTAAAAACAGTATTTACATTT
CATCACCATCAACTTAACATTTTATGCATTCATTAGGATCATACAAATATATGAAGGTGA
AAGTTCTGCTCTGTCCCCACTTCTTTCTGAAACCTTCTTTAGCCATGTGGCCTGAAAGTA
GAGCCATAGTCCAGCTTGGGAGTCTAGTTCCCAAGTTGCCTGGTTCTAGAAGCCCAGTGT
TTCTTGCTTGCATCAGATCAGAAACACACTGGGCAACATAAGAACATTCTTAACTTGGCT
CGACTAAGAGGAAAGTCTTTGCTTACTTCAGGGAGCTTCTCCACCTTCCATTCTTTCCCA
ATAGGGTTTAAAAGCTTTGATTAGAAGCCAACTTGATTTAGGAGTTCCCACTGGCAAAAT
AGGGAACAATATGAGCATCAAGGACATCTGCGAAGCACTGAAACACTCGAATGTGATTAA
ACGCATGACTTCATAATGATACAAAACAAAACACAAAAGGCTTTTGGCAGCAAGCCTGAG
AGAATGGAGATCCAGCTGAGATGACAGCGATGGAGCGTATACTGTGATTCAAACGACATC
ATTACTTAGATGCTGCATGCACATAGGCTAATGTGCCCACAGATCACACACTTCCAACTC
CTGCCAATCAACAACTATTGGGGTTGACTCAGCAGTCTCCCAAACATACCACCTGCTCAA
AATTCTTAGCTCAAGCTAGATTATCTTGTGACTAATACAGATTTCACGTTTGACTGATAG
TACTCAACTAACTCTTACACATTACAAGTGCAGTTTCAGCTTAATTTATTTTACTATTAA
AAAAGCTGACTCTATGCTGTATCAAAAGAGGACTNAAGTAGTTGGAAAACTGTTCCACCC
ACTGGAGCCTCTCTT
Restriction Sites NotI-NotI     
ACCN NM_000648
ORF Size 1083 bp
Insert Size 3600
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_000648.1, NP_000639.1
RefSeq Size 1979
RefSeq ORF 1083
Locus ID 1231
Domains 7tm_1
Protein Families Druggable Genome, GPCR, Transmembrane
Gene Summary This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq]
Transcript Variant: This variant (B) lacks the 3' exon but has an alternate 3' segment, as compared to transcript A. It encodes the predominant isoform (B) which localizes to the plasma membrane. Isoform B has a distinct C-terminus and is 14 aa shorter than isoform A.

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