Cellular Apoptosis Susceptibility (CSE1L) (NM_001316) Human Untagged Clone

CAT#: SC109110

CSE1L (untagged)-Human CSE1 chromosome segregation 1-like (yeast) (CSE1L)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CSE1L
• Synonyms: CAS; CSE1; XPO2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109110 sequence for NM_001316 edited (data generated by NextGen Sequencing)
  ATGGAACTCAGCGATGCAAATCTGCAAACACTAACAGAATATTTAAAGAAAACACTTGAT
  CCTGATCCTGCCATCCGACGTCCAGCTGAGAAATTTCTTGAATCTGTTGAAGGAAATCAG
  AATTATCCACTGTTGCTTTTGACATTACTGGAGAAGTCCCAGGATAATGTTATCAAAGTA
  TGTGCTTCAGTAACATTCAAAAACTATATTAAAAGGAACTGGAGAATTGTTGAAGATGAA
  CCAAACAAAATTTGTGAAGCCGATCGAGTGGCCATTAAAGCCAACATAGTGCACTTGATG
  CTTAGCAGCCCAGAGCAAATTCAGAAGCAGTTAAGTGATGCAATTAGCATTATTGGCAGA
  GAAGATTTTCCACAGAAATGGCCTGACTTGCTGACAGAAATGGTGAATCGCTTTCAGAGT
  GGAGATTTCCATGTTATTAATGGAGTCCTCCGTACAGCACATTCATTATTTAAAAGATAC
  CGTCATGAATTTAAGTCAAACGAGTTATGGACTGAAATTAAGCTTGTTCTGGATGCCTTT
  GCTTTGCCTTTGACTAATCTTTTTAAGGCCACTATTGAACTCTGCAGTACCCATGCAAAT
  GATGCCTCTGCCCTGAGGATTCTGTTTTCTTCCCTGATCCTGATCTCAAAATTGTTCTAT
  AGTTTAAACTTTCAGGATCTCCCTGAATTTTTTGAAGATAATATGGAAACTTGGATGAAT
  AATTTTCATACTCTCTTAACATTGGATAATAAGCTTTTACAAACTGATGATGAAGAGGAA
  GCCGGCTTATTGGAGCTCTTAAAATCCCAGATTTGTGATAATGCCGCACTCTATGCACAA
  AAGTACGATGAAGAATTCCAGCGATACCTGCCTCGTTTTGTTACAGCCATCTGGAATTTA
  CTAGTTACAACGGGTCAAGAGGTTAAATATGATTTGTTGGTAAGTAATGCAATTCAATTT
  CTGGCTTCAGTTTGTGAGAGACCTCATTATAAGAATCTATTTGAGGACCAGAACACGCTG
  ACAAGTATCTGTGAAAAGGTTATTGTGCCTAACATGGAATTTAGAGCTGCTGATGAAGAA
  GCATTTGAAGATAATTCTGAGGAGTACATAAGGAGAGATTTGGAAGGATCTGATATTGAT
  ACTAGACGCAGGGCTGCTTGTGATCTGGTACGAGGATTATGCAAGTTTTTTGAGGGACCT
  GTGACAGGAATCTTCTCTGGTTATGTTAATTCCATGCTGCAGGAATACGCAAAAAATCCA
  TCTGTCAACTGGAAACACAAAGATGCAGCCATCTACCTAGTGACATCTTTGGCATCAAAA
  GCCCAAACACAGAAGCATGGAATTACACAAGCAAATGAACTTGTAAACCTAACTGAGTTC
  TTTGTGAATCACATCCTCCCTGATTTAAAATCAGCTAATGTGAATGAATTTCCTGTCCTT
  AAAGCTGACGGTATCAAATATATTATGATTTTTAGAAATCAAGTGCCAAAAGAACATCTT
  TTAGTCTCGATTCCTCTCTTGATTAATCATCTTCAAGCTGAAAGTATTGTTGTTCATACT
  TACGCAGCTCATGCTCTTGAACGGCTCTTTACTATGCGAGGGCCTAACAATGCCACTCTC
  TTTACAGCTGCAGAAATCGCACCGTTTGTTGAGATTCTGCTAACAAACCTTTTCAAAGCT
  CTCACACTTCCTGGCTCTTCAGAAAATGAATATATTATGAAAGCTATCATGAGAAGTTTT
  TCTCTCCTACAAGAAGCCATAATCCCCTACATCCCTACTCTCATCACTCAGCTTACACAG
  AAGCTATTAGCTGTTAGTAAGAACCCAAGCAAACCTCACTTTAATCACTACATGTTTGAA
  GCAATATGTTTATCCATAAGAATAACTTGCAAAGCTAACCCTGCTGCTGTTGTAAATTTT
  GAGGAGGCTTTGTTTTTGGTGTTTACTGAAATCTTACAAAATGATGTGCAAGAATTTATT
  CCATACGTCTTTCAAGTGATGTCTTTGCTTCTGGAAACACACAAAAATGACATCCCGTCT
  TCCTATATGGCCTTATTTCCTCATCTCCTTCAGCCAGTGCTTTGGGAAAGAACAGGAAAT
  ATTCCTGCTCTAGTGAGGCTTCTTCAAGCATTCTTAGAACGCGGTTCAAACACAATAGCA
  AGTGCTGCAGCTGACAAAATTCCTGGGTTACTAGGTGTCTTTCAGAAGCTGATTGCATCC
  AAAGCAAATGACCACCAAGGTTTTTATCTTCTAAACAGTATAATAGAGCACATGCCTCCT
  GAATCAGTTGACCAATATAGGAAACAAATCTTCATTCTGCTATTCCAGAGACTTCAGAAT
  TCCAAAACAACCAAGTTTATCAAGAGTTTTTTAGTCTTTATTAATTTGTATTGCATAAAA
  TATGGGGCACTAGCACTACAAGAAATATTTGATGGTATACAACCAAAAATGTTTGGAATG
  GTTTTGGAAAAAATTATTATTCCTGAAATTCAGAAGGTATCTGGAAATGTAGAGAAAAAG
  ATCTGTGCGGTTGGCATAACCAAATTACTAACAGAATGTCCCCCAATGATGGACACTGAG
  TATACCAAACTGTGGACTCCATTATTACAGTCTTTGATTGGTCTTTTTGAGTTACCCGAA
  GATGATACCATTCCTGATGAGGAACATTTTATTGACATAGAAGATACACCAGGATATCAG
  ACTGCCTTCTCACAGTTGGCATTTGCTGGGAAAAAAGAGCATGATCCTGTAGGTCAAATG
  GTGAATAACCCCAAAATTCACCTGGCACAGTCACTTCACAAGTTGTCTACCGCCTGTCCA
  GGAAGGGTTCCATCAATGGTGAGCACCAGCCTGAATGCAGAAGCGCTCCAGTATCTCCAA
  GGGTACCTTCAGGCAGCCAGTGTGACACTGCTTTAA
  
  Clone variation with respect to NM_001316.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001316 unedited
  TACTATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCGCGAGTTTGAATGT
  GAGGCGGAGCGGCGGCAGGAGCGGGTAGTGCCAGCTACGGTCCGCGGCTGGGGTTCCCTC
  CTCCGTTTCTGTATCCCCACGAGATCCTATAGCAATGGAACTCAGCGATGCAAATCTGCA
  AACACTAACAGAATATTTAAAGAAAACACTTGATCCTGATCCTGCCATCCGACGTCCAGC
  TGAGAAATTTCTTGAATCTGTTGAAGGAAATCAGAATTATCCACTGTTGCTTTTGACATT
  ACTGGAGAAGTCCCAGGATAATGTTATCAAAGTATGTGCTTCAGTAACATTCAAAAACTA
  TATTAAAAGGAACTGGAGAATTGTTGAAGATGAACCAAACAAAATTTGTGAAGCCGATCG
  AGTGGCCATTAAAGCCAACATAGTGCACTTGATGCTTAGCAGCCCAGAGCAAATTCAGAA
  GCAGTTAAGTGATGCAATTAGCATTATTGGCAGAGAAGATTTTCCACAGAAATGGCCTGA
  CTTGCTGACAGAAATGGTGAATCGCTTTCAGAGTGGAGATTTCCATGTTATTAATGGAGT
  CCTCCGTACAGCACATTCATTATTTAAAAGATACCGTCATGAATTTAAGTCAAACGAGTT
  ATGGACTGAAATTAAGCTTGTTCTGGATGCCTTTGCTTTGCCTTTGACTAATCTTTNTAA
  GGCCACTATTGAACTCTGCAGTACCCATGCANATGATGCCTCTGCCCCTGAGATCCTGTT
  TTCTTCCCTGATCCTGATCTCAAAATTGTTCTNATAGTTAAACCTTTCANGATCTCCCCT
  GAATTTTTGAAGAAATATGGAAACCTGGNATGATAATTTCATACTCTCTTACATNGNATA
  TAAGCTTTACAAACTGATGATGAAAGAGAAGCCCGCTTATTGGAGCTCTTAAACG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001316 unedited
  TTCCTTTTGCTCTGGACCGCGGCCCGCATNCTAGNGTCGAGTTTTTTTTTTTTTTTTTTC
  AGGTTAAAGCAACATTTAATATCCTTTACAAGATGGAATTCGTGACAAGTTCAAAAGGAA
  AACTTCCTTTGTTTTAATGCAGCTGTGCTCAAAAGCCTGTGATTTCCTAGGAAACCATCT
  GGGTTTAGCCCATTAGAAAAATGCAGTTTAAAGCAGTGTCACACTGGCTGCCTGAAGGTA
  CCCTTGGAGATACTGGAGCGCTTCTGCATTCAGGCTGGTGCTCACCATTGATGGAACCCT
  TCCTGGACAGGCGGTAGACAACTTGTGAAGTGACTGTGCCAGGTGAATTTTGGGGTTATT
  CACCATTTGACCTACAGGATCATGCTCTTTTTTCCCAGCAAATGCCAACTGTGAGAAGGC
  AGTCTGATATCCTGGTGTATCTTCTATGTCAATAAAATGTTCCTCATCAGGAATGGTATC
  ATCTTCGGGTAACTCAAAAAGACCAATCAAAGACTGTAATAATGGAGTCCACAGTTTGGT
  ATACTCAGTGTCCATCATTGGGGGACATTCTGTTAGTAATTTGGTTATGCCAACCGCACA
  GATCTTTTTCTCTACATTTCCAGATACCCTTCTGAATTTCAGGAATAATAATTNTTTCCA
  AAACCATTCCAAACATTGTTGGGTTGTATACCATCAAATATTTCTTGTAGTGCTAGGGCC
  CCATATTTTATGCATTACAAATTAATAAAGACTAAAAAACTCTTGATAAACTGGGTTGCT
  TTGGGATTTCTGGAGTCTCTGGAATAGCACAATGAAAATTTGTTTCCTATATTGGCCACT
  GGATTCAGGAGGCATGTGCTCTATTATACTGGTTAGAAGATAAACCCTTGCGGGCCATTG
  G
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001316
• Insert Size: 2930 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001316.2, NP_001307.2
• RefSeq Size: 3579 bp
• RefSeq ORF: 2916 bp
• Locus ID: 1434
• Cytogenetics: 20q13.13
• Domains: IBN_NT, CAS_CSE1
• Protein Families: Druggable Genome
• Gene Summary: 'Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]'
  Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).