FACL4 (ACSL4) (NM_022977) Human Untagged Clone

CAT#: SC109208

ACSL4 (untagged)-Human acyl-CoA synthetase long-chain family member 4 (ACSL4), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ACSL4
• Synonyms: ACS4; FACL4; LACS4; MRX63; MRX68
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109208 sequence for NM_022977 edited (data generated by NextGen Sequencing)
  ATGAAACTTAAGCTAAATGTGCTCACCATTATTTTGCTGCCTGTCCACTTGTTAATAACA
  ATATACAGTGCCCTTATATTTATTCCATGGTATTTTCTTACCAATGCCAAGAAGAAAAAC
  GCTATGGCAAAGAGAATAAAAGCTAAGCCCACTTCAGACAAACCTGGAAGTCCATATCGC
  TCTGTCACACACTTCGACTCACTAGCTGTAATAGACATCCCTGGAGCAGATACTCTGGAT
  AAATTATTTGACCATGCTGTATCCAAGTTTGGGAAGAAGGACAGCCTTGGGACCAGGGAA
  ATCCTAAGTGAAGAAAATGAAATGCAGCCAAATGGAAAAGTTTTTAAGAAGTTAATTCTT
  GGGAATTATAAATGGATGAACTATCTTGAAGTGAATCGCAGAGTGAATAACTTTGGTAGT
  GGACTCACTGCACTGGGACTAAAACCAAAGAACACCATTGCCATCTTCTGTGAGACCAGG
  GCCGAATGGATGATTGCAGCACAGACCTGCTTTAAGTACAACTTTCCTCTTGTGACTTTA
  TATGCCACACTTGGCAAAGAAGCAGTAGTTCATGGGCTAAATGAATCTGAGGCTTCCTAT
  CTGATTACCAGTGTTGAACTTCTGGAAAGTAAACTTAAGACTGCATTGTTAGATATCAGT
  TGTGTTAAACATATCATTTATGTGGACAATAAGGCTATCAATAAAGCAGAGTACCCTGAA
  GGATTTGAGATTCACAGCATGCAATCAGTAGAAGAGTTGGGATCTAACCCAGAAAACTTG
  GGCATTCCTCCAAGTAGACCAACGCCTTCAGACATGGCCATTGTTATGTATACTAGTGGT
  TCTACTGGCCGACCTAAGGGAGTGATGATGCATCATAGCAATTTGATAGCTGGAATGACA
  GGCCAGTGTGAAAGAATACCTGGACTGGGACCGAAGGACACATATATTGGCTACTTGCCT
  TTGGCTCATGTGCTAGAACTGACAGCAGAGATATCTTGCTTTACCTATGGCTGCAGGATT
  GGATATTCTTCTCCGCTTACACTCTCTGACCAGTCCAGCAAAATTAAAAAAGGAAGCAAA
  GGAGACTGTACTGTACTGAAGCCCACACTTATGGCTGCTGTTCCGGAAATCATGGATAGA
  ATTTATAAGAATGTTATGAGCAAAGTCCAAGAGATGAATTATATTCAGAAAACTCTGTTC
  AAGATAGGGTATGATTACAAATTGGAACAGATCAAAAAGGGATATGATGCACCTCTTTGC
  AATCTGTTACTGTTTAAAAAGGTCAAGGCCCTGCTGGGAGGGAATGTCCGCATGATGCTG
  TCTGGAGGGGCCCCGCTATCTCCTCAGACACACCGATTCATGAATGTCTGCTTCTGCTGC
  CCAATTGGCCAGGGTTATGGACTGACAGAATCATGTGGTGCTGGGACAGTTACTGAAGTA
  ACTGACTATACTACTGGCAGAGTTGGAGCACCTCTTATTTGCTGTGAAATTAAGCTAAAA
  GACTGGCAAGAAGGCGGTTATACAATTAATGACAAGCCAAACCCCAGAGGTGAAATCGTA
  ATTGGTGGACAGAACATCTCCATGGGATATTTTAAAAATGAAGAGAAAACAGCAGAAGAT
  TATTCTGTGGATGAAAATGGACAAAGGTGGTTTTGCACTGGTGATATTGGAGAATTCCAT
  CCCGATGGATGTTTACAGATTATAGATCGTAAGAAAGATCTAGTGAAGTTACAAGCAGGA
  GAGTATGTATCTCTTGGGAAAGTAGAAGCTGCACTGAAGAATTGTCCACTTATTGACAAC
  ATCTGTGCTTTTGCCAAAAGTGATCAGTCCTATGTGATCAGTTTTGTGGTTCCTAACCAG
  AAAAGGTTGACACTTTTGGCACAACAGAAAGGGGTAGAAGGAACTTGGGTTGATATCTGC
  AATAATCCTGCTATGGAAGCTGAAATACTGAAAGAAATTCGAGAAGCTGCAAATGCCATG
  AAATTGGAGCGATTTGAAATTCCAATCAAGGTTCGATTAAGCCCAGAGCCATGGACCCCT
  GAAACTGGTTTGGTAACTGATGCTTTCAAACTGAAAAGGAAGGAGCTGAGGAACCATTAC
  CTCAAAGACATTGAACGAATGTATGGGGGCAAATAA
  
  Clone variation with respect to NM_022977.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_022977 unedited
  AGCATTTTGTAATACGACTCACTTATAGGGCGGCCGCGATTCGGCACCAGGCCGCTGCGG
  CTTTTTCTCTGGCCTCCGCCGCGCGCTCCTCCTCGTCCCAGCGCTAGCGGGCACGCGGTT
  CCTTTTTGCGAGCTTTCCGAGTGCCAGGCGCCGGCCGGCTGCGAAGACGCGGTGGGCCGC
  CCCTCCGGCGTACTTTATTGTCGGCTTCCAAAGATTACTAACTTTTATCTGTATCACTAA
  GATTGAACTGCCTTGGCTGTACTGCTATTCTTACTGCTGCTTCTATTATTGCCTTCTTCA
  GCACAATAAGGCTTTCAAAAGCCAAAGAATAACAAGAAATAAGCACCATTTTAGAAGCCT
  TTCCACTATGAAACTTAAGCTAAATGTGCTCACCATTATTTTGCTGCCTGTCCACTTGTT
  AATAACAATATACAGTGCCCTTATATTTATTCCATGGTATTTTCTTACCAATGCCAAGAA
  GAAAAACGCTATGGCAAAGAGAATAAAAGCTAAGCCCACTTCAGACAAACCTGGAAGTCC
  ATATCGCTCTGTCACACACTTCGACTCACTAGCTGTAATAGACATCCCTGGAGCAGATAC
  TCTGGATAAATTATTTGACCATGCTGTATCCAAGTTTGGGAAGAAGGACAGCCTTGGGAC
  CAGGGAAATCCTAAGTGAAGAAAATGAAATGCAGCCAAATGGAAAAGTTNTTAAGAAGTT
  AATTCTTGGGAATTATAAATGGATGAACTATCTTGAAGTGAATCGCAGAGTGAATAACTT
  TGGTAGTGGACTCACTGCACTGNGACTAANACCAAAGACACCATTGCCATCTTCTGTGAG
  AACCAGGCCGAATGGATGATTGCAGCACAGACCTGCTNTAAGTACAAACTTNCTCTTGTG
  ACTTTTATGCCACACTTGGCAAGAAGCAGTAGTTATGGGCTAATGATCTGAGCTTCTACT
  GAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_022977 unedited
  GCCGCAATTCACAGTCGAGCNCTTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAA
  ACATGGGGGGATTTATTTCTTAAAATTTGAGGGCAAACTTAAAAACCCGAACAAACAAAG
  CTTTTCATCCAGAATAAACACAAAATCTAAACAATTCTGCCATTCTGCCTTTCAACACAA
  AGCCCAAATCTCAACCCATTCTAACTTGCCCCTGCCCTCAAAACCCCAAATATTCGCTTC
  CCCCCCCCATAAGTCATACCCCTTTTCTCTGCCCCCCCCCCCCGCCCCTTCCCATTTTCC
  AAATCTGCTCCCCCCATAACAACCGCCCACTTCCCCCCCCCCGCCCTCCTCCCCAAACTA
  TTCCTTCCCCCCTCCACCTCCCTCCCTCCTTCATCCTATCTCCCCTCCCCGCCACACTGA
  CCTCGCCCCCTACCACTGCTCCCCTACCTATCCTCCCTCATCTTCTCTTCCTCCTCTCTA
  GCTCCCTTTTATCCCCCCACTCCCCCTTCAACCCCCCCCCCCAAACATACTCCCCCCCCC
  CATATACCCCCATACCTCCCCCTCTTCCCCCACTTCCCCTTTCCCTACTTTCTTCCCCCC
  CTACTCCCCCCCTTTTTTCCGCCCCCCCTCTCCCCCCCTTTCTCCCCCCCCTTTTTCCCC
  TCCCCACCCACCCTCTTCTTTCCTATTTTTTCGCCCCCCCCCCTCTAACCCCCATTTTCC
  CTTTCTCATTATCCACCCGCTTTTCCCTTCACACCTCCCCCCCCCCCATTTTCACCCTCT
  TATTCCCCCCATTTCCCATCCCCACTCAACTACTTTATCTCCCACCCACCTTTACCTTTT
  TCCTCCCACACGCCCCCCCCACTTTTTTTTCCACCATCCCCCACCTTTCCCTTTCCCACC
  CGTCACCGCGCCACCTTTCGACAATCAATTCAATCCCCACCCCCCTTCACCCCCGCGTTT
  TTCTATTCCCCCGCCCACATTCCCCCCCCCCCGTTTTATCCCCACCCCTTTCCTCTTTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_022977
• ORF Size: 2136 bp
• Insert Size: 5230
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_022977.1, NP_075266.1
• RefSeq Size: 5356
• RefSeq ORF: 2136
• Locus ID: 2182
• Domains: AMP-binding
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Fatty acid metabolism, Metabolic pathways, PPAR signaling pathway
• Gene Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
  Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).