IL15RA (NM_002189) Human Untagged Clone

CAT#: SC109344

IL15RA (untagged)-Human interleukin 15 receptor, alpha (IL15RA), transcript variant 1


  "NM_002189" in other vectors (6)

Reconstitution Protocol

USD 660.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IL15RA
Synonyms CD215
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC109344 sequence for NM_002189 edited (data generated by NextGen Sequencing)
ATGGCCCCGCGGCGGGCGCGCGGCTGCCGGACCCTCGGTCTCCCGGCGCTGCTACTGCTG
CTGCTGCTCCGGCCGCCGGCGACGCGGGGCATCACGTGCCCTCCCCCCATGTCCGTGGAA
CACGCAGACATCTGGGTCAAGAGCTACAGCTTGTACTCCAGGGAGCGGTACATTTGTAAC
TCTGGTTTCAAGCGTAAAGCCGGCACGTCCAGCCTGACGGAGTGCGTGTTGAACAAGGCC
ACGAATGTCGCCCACTGGACAACCCCCAGTCTCAAATGCATTAGAGACCCTGCCCTGGTT
CACCAAAGGCCAGCGCCACCCTCCACAGTAACGACGGCAGGGGTGACCCCACAGCCAGAG
AGCCTCTCCCCTTCTGGAAAAGAGCCCGCAGCTTCATCTCCCAGCTCAAACAACACAGCG
GCCACAACAGCAGCTATTGTCCCGGGCTCCCAGCTGATGCCTTCAAAATCACCTTCCACA
GGAACCACAGAGATAAGCAGTCATGAGTCCTCCCACGGCACCCCCTCTCAGACAACAGCC
AAGACCTGGGAACTCACAGCATCCGCCTCCCACCAGCCGCCAGGTGTGTATCCACAGGGC
CACAGCGACACCACTGTGGCTATCTCCACGTCCACTGTCCTGCTGTGTGGGCTGAGCGCT
GTGTCTCTCCTGGCATGCTACCTCAAGTCAAGGCAAACTCCCCCGCTGGCCAGCGTTGAA
ATGGAAGCCATGGAGGCTCTGCCGGTGACTTGGGGGACCAGCAGCAGAGATGAAGACTTG
GAAAACTGCTCTCACCACCTATGA

Clone variation with respect to NM_002189.3
545 a=>c
>OriGene 5' read for NM_002189 unedited
GGATTTTGTAATACGACTCACTATAGGGCGGCCCGCGAATTCGCACGAGGGGAGTCCAGC
GGTGTCCTGTGGAGCTGCCGCCATGGCCCCGCGGCGGGCGCGCGGCTGCCGGACCCTCGG
TCTCCCGGCGCTGCTACTGCTGCTGCTGCTCCGGCCGCCGGCGACGCGGGGCATCACGTG
CCCTCCCCCCATGTCCGTGGAACACGCAGACATCTGGGTCAAGAGCTACAGCTTGTACTC
CAGGGACCGGTACATTTGTAACTCTGGTTTCAAGCGTAAAGCCGGCACGTCCAGCCTGAC
GGAGTGCGTGTTGAACAAGGCCACGAATGTCGCCCACTGGACAACCCCCAGTCTCAAATG
CATTAGAGACCCTGCCCTGGTTCACCAAAGGCCAGCGCCACCCTCCACAGTAACGACGGC
AGGGGTGACCCCACAGCCAGAGAGCCTCTCCCCTTCTGGAAAAGAGCCCGCAGCTTCATC
TCCCAGCTCAAACAACACAGCGGCCACAACAGCAGCTATTGTCCCGGGCTCCCAGCTGAT
GCCTTCAAAATCACCTTCCACAGGAACCACAGAGATAAGCAGTCATGAGTCCTCCCACGG
CACCCCCTCTCAGACAACAGCCAAGACCTGNGAACTCACAGCATCCGCCTCCCACCAGCC
GCCAGGTGTGTATCCACAGGGCCACAGCGACACCACTGTGGCTATCTCCACGTCCACTGT
CCTGCTGTGTGGGCTGAGCGCTGTGTCTCTCCTGGCATGCTACCTCAAGTCAAGGCANAC
TCCCCCCGCTGCCAGCGTTGAAATGGAAGCCATGGNAGCTCTGNNCGTGACTTGNGGGAC
CAGCAGCAGAGATGAAGACTTGGAANACTGCTCTCACACCTATGAAACTCGNGAAACCAG
NCCAGCTAGTCCGNAGTGAGGAGCTCTCTGCTTTACTAAGACACTGAAAGAGTGCAGGAA
GCGGNCTCAGACAGCTACCAGCNTAAAGTCCACAGATTACGACTGTCGGTCGGCCT
>OriGene 3' read for NM_002189 unedited
AAGGAGGCGCCTAGGNGAATGGCACTTTCCAGGNCCAGNAAAGCACTGGGGNAGGGTCAC
AGGATGCCACCCGGGAATTCTGTTCAGGAAAACAGCTATGACCGCGGCCGCAATCTAGAG
TCGAGTTTTTTTTTTTTTTTTTTTATTGAAAATAGATGTTTTATTTTGTTTATACAAGGT
ACAATGTCAAAATACAAATAATATATAATGTATAGATATAATAGACAAGGAAGTATAAAT
ATAAACGCATATATTCGTAAAATGGCACTGAGTTGAGTTTTCTTCTTCCTGAATCCTTCA
ATGGAGAGGATTCGCTGGGCTCAGCATCTCTCCCACCTTTCCCAGGTCCCTGTCCATGTG
TGCAGAGCAGCTGGAGACAGGGTGGTTAGAAGCCCAAACGCTGGTGTCTTCCCTGTAGAC
GTCTCCCACGCCAGGAGAAGCCTTGTAATTGACAGAGAGCTTTGGGTATGTCACTTTTCT
CTGTGAACTGCAAGTTAGGATGAGGGACGGAAGATTCGGGGCAGGGTTTTCATTTCATCA
CCACATGTATTCCAAGCAGCTCACACTGTAATGAAATAAAAATCCTGCTCAGAAGCCTTT
GGTCTCTCCTGGGAAGCTGGGCCCTGGGTCCAAGGCACGACAGGCAGGCAAGTGGTGCCC
ATGGGAAAGCGGAGAACCTGCTCCTTCGCGCAGGAAGCGCCGAACCCGCAGTCCGGGAAT
CCTGCTGGAATTTTAAAAAGCCTGGTGAACTTGTTCCTGAAACCCGCCTCATTGCAACTA
TTTCTAATACACTTTTACTAAAGCAAAAAAGCTCCTTTTTTCCCAAATTATCTTGGATGG
CTTCACCAAATTTTAAAATTGTGGAGAACATTTTCCACAGTCTCACTTGN
Restriction Sites NotI-NotI     
ACCN NM_002189
Insert Size 1600 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002189.2, NP_002180.1
RefSeq Size 1610 bp
RefSeq ORF 804 bp
Locus ID 3601
Cytogenetics 10p15.1
Domains CCP
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Gene Summary 'This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]'
Transcript Variant: This variant (1) lacks an alternate in-frame 5' coding exon, compared to variant 4. This results in a shorter isoform (1), compared to isoform 4.

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