Menin (MEN1) (NM_130799) Human Untagged Clone

CAT#: SC109429

MEN1 (untagged)-Human multiple endocrine neoplasia I (MEN1), transcript variant 2


  "NM_130799" in other vectors (6)

Reconstitution Protocol

USD 1,040.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol MEN1
Synonyms MEAI; SCG2
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC109429 sequence for NM_130799 edited (data generated by NextGen Sequencing)
ATGGGGCTGAAGGCCGCCCAGAAGACGCTGTTCCCGCTGCGCTCCATCGACGACGTGGTG
CGCCTGTTTGCTGCCGAGCTGGGCCGAGAGGAGCCGGACCTGGTGCTCCTTTCCTTGGTG
CTGGGCTTCGTGGAGCATTTTCTGGCTGTCAACCGCGTCATCCCTACCAACGTTCCCGAG
CTCACCTTCCAGCCCAGCCCCGCCCCCGACCCGCCTGGCGGCCTCACCTACTTTCCCGTG
GCCGACCTGTCTATCATCGCCGCCCTCTATGCCCGCTTCACCGCCCAGATCCGAGGCGCC
GTCGACCTGTCCCTCTATCCTCGAGAAGGGGGTGTCTCCAGCCGTGAGCTGGTGAAGAAG
GTCTCCGATGTCATATGGAACAGCCTCAGCCGCTCCTACTTCAAGGATCGGGCCCACATC
CAGTCCCTCTTCAGCTTCATCACAGGCACCAAATTGGACAGCTCCGGTGTGGCCTTTGCT
GTGGTTGGGGCCTGCCAGGCCCTGGGTCTCCGGGATGTCCACCTCGCCCTGTCTGAGGAT
CATGCCTGGGTAGTGTTTGGGCCCAATGGGGAGCAGACAGCTGAGGTCACCTGGCACGGC
AAGGGCAACGAGGACCGCAGGGGCCAGACAGTCAATGCCGGTGTGGCTGAGCGGAGCTGG
CTGTACCTGAAAGGATCATACATGCGCTGTGACCGCAAGATGGAGGTGGCGTTCATGGTG
TGTGCCATCAACCCTTCCATTGACCTGCACACCGACTCGCTGGAGCTTCTGCAGCTGCAG
CAGAAGCTGCTCTGGCTGCTCTATGACCTGGGACATCTGGAAAGGTACCCCATGGCCTTA
GGGAACCTGGCAGATCTAGAGGAGCTGGAGCCCACCCCTGGCCGGCCAGACCCACTCACC
CTCTACCACAAGGGCATTGCCTCAGCCAAGACCTACTATCGGGATGAACACATCTACCCC
TACATGTACCTGGCTGGCTACCACTGTCGCAACCGCAATGTGCGGGAAGCCCTGCAGGCC
TGGGCGGACACGGCCACTGTCATCCAGGACTACAACTACTGCCGGGAAGACGAGGAGATC
TACAAGGAGTTCTTTGAAGTAGCCAATGATGTCATCCCCAACCTGCTGAAGGAGGCAGCC
AGCTTGCTGGAGGCGGGCGAGGAGCGGCCGGGGGAGCAAAGCCAGGGCACCCAGAGCCAA
GGTTCCGCCCTCCAGGACCCTGAGTGCTTCGCCCACCTGCTGCGATTCTACGACGGCATC
TGCAAATGGGAGGAGGGCAGTCCCACGCCTGTGCTGCACGTGGGCTGGGCCACCTTTCTT
GTGCAGTCCCTAGGCCGTTTTGAGGGACAGGTGCGGCAGAAGGTGCGCATAGTGAGCCGA
GAGGCCGAGGCGGCCGAGGCCGAGGAGCCGTGGGGCGAGGAAGCCCGGGAAGGCCGGCGG
CGGGGCCCACGGCGGGAGTCCAAGCCAGAGGAGCCCCCGCCGCCCAAGAAGCCAGCACTG
GACAAGGGCCTGGGCACCGGCCAGGGTGCAGTGTCAGGACCCCCCCGGAAGCCTCCTGGG
ACTGTCGCTGGCACAGCCCGAGGCCCTGAAGGTGGCAGCACGGCTCAGGTGCCAGCACCC
GCAGCATCACCACCGCCGGAGGGTCCAGTGCTCACTTTCCAGAGTGAGAAGATGAAGGGC
ATGAAGGAGCTGCTGGTGGCCACCAAGATCAACTCGAGCGCCATCAAGCTGCAACTCACG
GCACAGTCGCAAGTGCAGATGAAGAAGCAGAAAGTGTCCACCCCTAGTGACTACACTCTG
TCTTTCCTCAAGCGGCAGCGCAAAGGCCTCTGA

Clone variation with respect to NM_130799.2
>OriGene 5' read for NM_130799 unedited
AAATTTCCCGCCCGTTGCCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG
CAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGC
GAATTCGGCACGAGGGGCCGCCGCCCACCGCCCGCCGCCATGGGGCTGAAGGCCGCCCAG
AAGACGCTGTTCCCGCTGCGCTCCATCGACGACGTGGTGCGCCTGTTTGCTGCCGAGCTG
GGCCGAGAGGAGCCGGACCTGGTGCTCCTTTCCTTGGTGCTGGGCTTCGTGGAGCATTTT
CTGGCTGTCAACCGCGTCATCCCTACCAACGTTCCCGAGCTCACCTTCCAGCCCAGCCCC
GCCCCCGACCCGCCTGGCGGCCTCACCTACTTTCCCGTGGCCGACCTGTCTATCATCGCC
GCCCTCTATGCCCGCTTCACCGCCCAGATCCGAGGCGCCGTCGACCTGTCCCTCTATCCT
CGAGAAGGGGGTGTCTCCAGCCGTGAGCTGGTGAAGAAGGTCTCCGATGTCATATGGAAC
AGCCTCAGCCGCTCCTACTTCAAGGATCGGGCCCACATCCAGTCCCTCTTCAGCTTCATC
ACAGGCACCAAATTGGACAGCTCCGGTGTGGCCTTTGCTGTGGATGGGGCCTGCCAGGCC
CTGNGTCTCCGGGATGTCCACCTCGCCCTGTCTGAGGATCATGCCTGGGTAGTGTTTGGG
CCCAATGGNGAGCAGACAGCTGAGGTCACCTGGCACGGCCAGGGCAACGAGGACCGCAGG
NGCCAGACAGTCATGCCTGTGTGGCTGAGCGGAGCTGGCTGTACCTGCACAGATCATACA
TGCGCTGTGACCGCAGCAGGNAGTNGCGATCATGGTGTGTGCCATCAACCCTTNCATTGA
CCTGCACACCGACTCGCTGGAGCTTCTGCAGCTGCAGCAGAAGCTGCTCTGGCTGCTT
>OriGene 3' read for NM_130799 unedited
NGGGAATCTATGNACCGCGCCGCATTCTAGNGATCGATTTTTTTTTTTTTTTTTTAACAA
ATGTATTCATCTTTCTTGGAACTGAAAAAAAATCTATGTACAAAACAGGAAGAGATCAGG
CTCTTGTCACCCACTCCTAACCCTCTGCAGATTTCCTCCGGGATGCTCCGAGATGGGCTG
GACCTCTGGGAGGTTCCCAGAGGGTCGGAAGGGAGGTCCTGCTCTGATCCGGGGCCAGAC
TCGTCAGGAAGAGGGCGGGGCTCAGGATGCTCATAGGCTGGGGGCGGAGTTTTGTGTCCC
AGACTCGGGATACGAAGGAGAGGAAACTAGGATTTCCAAATTCTGGAGCAGGACTGAAGT
TATTTGGGGCAGGGAGCTTGGATTCGCAAGATATGGAATTCTGAAGTGCGGAAATATACT
CCTAGGGGCTGAGTGGTCCTAGGCTCCCGGGCTGGAGGTGGGACCTGTGCTCCTTGGGTT
AAGGGTGAAACCTCAGCTCCTACAAGCTGGGAGGAGCCCTGAGTAACGTTGGTCTGGCTC
TAGGTGAGCGGTTCCGAGGAGGAGCTTGGGTTTCTAGGGGCTGGGCCTTTAAAGACTGGT
AATTAGGACCCAGCGTGAGGTTTCCATTGGCCGGCTGGGATTCTGGGAGAAGAGACCTAT
ATTCTAACGACTGGGGCAGAGCCCTGGGTTCTGAGCTGGAGAAAATCGTGGGTTTGATAC
AGACTGTACTCGGGACCGGGAACCTNAGGTTTGGGTAGAGGTGAGGCCTGTCCCCTTTGG
GCTGGGGGCAGAACATGGGCTCAGNATTATGGGACTAAAGGCGGAGCCTGGGGTCCCACA
AGCGGTCCGAAATTCCCAGTAGTTCANAGGCTTTGCGCTGCCGCTTGAGAAAGAAGAAT
Restriction Sites NotI-NotI     
ACCN NM_130799
Insert Size 2850 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_130799.1, NP_570711.1
RefSeq Size 2772 bp
RefSeq ORF 1833 bp
Locus ID 4221
Cytogenetics 11q13.1
Domains Menin
Protein Families Druggable Genome, Transcription Factors
Gene Summary 'This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]'
Transcript Variant: This variant (2) differs from variant 1 by using an alternative splice site in exon 2. Use of this splice site results in the loss of 15 nt at the end of exon 2. Isoform 2 is missing an internal 5 aa as compared to isoform 1. Variants 2, 4, 5, and 6 all encode the same isoform (2).

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