Menin (MEN1) (NM_130799) Human Untagged Clone

CAT#: SC109429

MEN1 (untagged)-Human multiple endocrine neoplasia I (MEN1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MEN1
• Synonyms: MEAI; SCG2
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109429 sequence for NM_130799 edited (data generated by NextGen Sequencing)
  ATGGGGCTGAAGGCCGCCCAGAAGACGCTGTTCCCGCTGCGCTCCATCGACGACGTGGTG
  CGCCTGTTTGCTGCCGAGCTGGGCCGAGAGGAGCCGGACCTGGTGCTCCTTTCCTTGGTG
  CTGGGCTTCGTGGAGCATTTTCTGGCTGTCAACCGCGTCATCCCTACCAACGTTCCCGAG
  CTCACCTTCCAGCCCAGCCCCGCCCCCGACCCGCCTGGCGGCCTCACCTACTTTCCCGTG
  GCCGACCTGTCTATCATCGCCGCCCTCTATGCCCGCTTCACCGCCCAGATCCGAGGCGCC
  GTCGACCTGTCCCTCTATCCTCGAGAAGGGGGTGTCTCCAGCCGTGAGCTGGTGAAGAAG
  GTCTCCGATGTCATATGGAACAGCCTCAGCCGCTCCTACTTCAAGGATCGGGCCCACATC
  CAGTCCCTCTTCAGCTTCATCACAGGCACCAAATTGGACAGCTCCGGTGTGGCCTTTGCT
  GTGGTTGGGGCCTGCCAGGCCCTGGGTCTCCGGGATGTCCACCTCGCCCTGTCTGAGGAT
  CATGCCTGGGTAGTGTTTGGGCCCAATGGGGAGCAGACAGCTGAGGTCACCTGGCACGGC
  AAGGGCAACGAGGACCGCAGGGGCCAGACAGTCAATGCCGGTGTGGCTGAGCGGAGCTGG
  CTGTACCTGAAAGGATCATACATGCGCTGTGACCGCAAGATGGAGGTGGCGTTCATGGTG
  TGTGCCATCAACCCTTCCATTGACCTGCACACCGACTCGCTGGAGCTTCTGCAGCTGCAG
  CAGAAGCTGCTCTGGCTGCTCTATGACCTGGGACATCTGGAAAGGTACCCCATGGCCTTA
  GGGAACCTGGCAGATCTAGAGGAGCTGGAGCCCACCCCTGGCCGGCCAGACCCACTCACC
  CTCTACCACAAGGGCATTGCCTCAGCCAAGACCTACTATCGGGATGAACACATCTACCCC
  TACATGTACCTGGCTGGCTACCACTGTCGCAACCGCAATGTGCGGGAAGCCCTGCAGGCC
  TGGGCGGACACGGCCACTGTCATCCAGGACTACAACTACTGCCGGGAAGACGAGGAGATC
  TACAAGGAGTTCTTTGAAGTAGCCAATGATGTCATCCCCAACCTGCTGAAGGAGGCAGCC
  AGCTTGCTGGAGGCGGGCGAGGAGCGGCCGGGGGAGCAAAGCCAGGGCACCCAGAGCCAA
  GGTTCCGCCCTCCAGGACCCTGAGTGCTTCGCCCACCTGCTGCGATTCTACGACGGCATC
  TGCAAATGGGAGGAGGGCAGTCCCACGCCTGTGCTGCACGTGGGCTGGGCCACCTTTCTT
  GTGCAGTCCCTAGGCCGTTTTGAGGGACAGGTGCGGCAGAAGGTGCGCATAGTGAGCCGA
  GAGGCCGAGGCGGCCGAGGCCGAGGAGCCGTGGGGCGAGGAAGCCCGGGAAGGCCGGCGG
  CGGGGCCCACGGCGGGAGTCCAAGCCAGAGGAGCCCCCGCCGCCCAAGAAGCCAGCACTG
  GACAAGGGCCTGGGCACCGGCCAGGGTGCAGTGTCAGGACCCCCCCGGAAGCCTCCTGGG
  ACTGTCGCTGGCACAGCCCGAGGCCCTGAAGGTGGCAGCACGGCTCAGGTGCCAGCACCC
  GCAGCATCACCACCGCCGGAGGGTCCAGTGCTCACTTTCCAGAGTGAGAAGATGAAGGGC
  ATGAAGGAGCTGCTGGTGGCCACCAAGATCAACTCGAGCGCCATCAAGCTGCAACTCACG
  GCACAGTCGCAAGTGCAGATGAAGAAGCAGAAAGTGTCCACCCCTAGTGACTACACTCTG
  TCTTTCCTCAAGCGGCAGCGCAAAGGCCTCTGA
  
  Clone variation with respect to NM_130799.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_130799 unedited
  AAATTTCCCGCCCGTTGCCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG
  CAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGC
  GAATTCGGCACGAGGGGCCGCCGCCCACCGCCCGCCGCCATGGGGCTGAAGGCCGCCCAG
  AAGACGCTGTTCCCGCTGCGCTCCATCGACGACGTGGTGCGCCTGTTTGCTGCCGAGCTG
  GGCCGAGAGGAGCCGGACCTGGTGCTCCTTTCCTTGGTGCTGGGCTTCGTGGAGCATTTT
  CTGGCTGTCAACCGCGTCATCCCTACCAACGTTCCCGAGCTCACCTTCCAGCCCAGCCCC
  GCCCCCGACCCGCCTGGCGGCCTCACCTACTTTCCCGTGGCCGACCTGTCTATCATCGCC
  GCCCTCTATGCCCGCTTCACCGCCCAGATCCGAGGCGCCGTCGACCTGTCCCTCTATCCT
  CGAGAAGGGGGTGTCTCCAGCCGTGAGCTGGTGAAGAAGGTCTCCGATGTCATATGGAAC
  AGCCTCAGCCGCTCCTACTTCAAGGATCGGGCCCACATCCAGTCCCTCTTCAGCTTCATC
  ACAGGCACCAAATTGGACAGCTCCGGTGTGGCCTTTGCTGTGGATGGGGCCTGCCAGGCC
  CTGNGTCTCCGGGATGTCCACCTCGCCCTGTCTGAGGATCATGCCTGGGTAGTGTTTGGG
  CCCAATGGNGAGCAGACAGCTGAGGTCACCTGGCACGGCCAGGGCAACGAGGACCGCAGG
  NGCCAGACAGTCATGCCTGTGTGGCTGAGCGGAGCTGGCTGTACCTGCACAGATCATACA
  TGCGCTGTGACCGCAGCAGGNAGTNGCGATCATGGTGTGTGCCATCAACCCTTNCATTGA
  CCTGCACACCGACTCGCTGGAGCTTCTGCAGCTGCAGCAGAAGCTGCTCTGGCTGCTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_130799 unedited
  NGGGAATCTATGNACCGCGCCGCATTCTAGNGATCGATTTTTTTTTTTTTTTTTTAACAA
  ATGTATTCATCTTTCTTGGAACTGAAAAAAAATCTATGTACAAAACAGGAAGAGATCAGG
  CTCTTGTCACCCACTCCTAACCCTCTGCAGATTTCCTCCGGGATGCTCCGAGATGGGCTG
  GACCTCTGGGAGGTTCCCAGAGGGTCGGAAGGGAGGTCCTGCTCTGATCCGGGGCCAGAC
  TCGTCAGGAAGAGGGCGGGGCTCAGGATGCTCATAGGCTGGGGGCGGAGTTTTGTGTCCC
  AGACTCGGGATACGAAGGAGAGGAAACTAGGATTTCCAAATTCTGGAGCAGGACTGAAGT
  TATTTGGGGCAGGGAGCTTGGATTCGCAAGATATGGAATTCTGAAGTGCGGAAATATACT
  CCTAGGGGCTGAGTGGTCCTAGGCTCCCGGGCTGGAGGTGGGACCTGTGCTCCTTGGGTT
  AAGGGTGAAACCTCAGCTCCTACAAGCTGGGAGGAGCCCTGAGTAACGTTGGTCTGGCTC
  TAGGTGAGCGGTTCCGAGGAGGAGCTTGGGTTTCTAGGGGCTGGGCCTTTAAAGACTGGT
  AATTAGGACCCAGCGTGAGGTTTCCATTGGCCGGCTGGGATTCTGGGAGAAGAGACCTAT
  ATTCTAACGACTGGGGCAGAGCCCTGGGTTCTGAGCTGGAGAAAATCGTGGGTTTGATAC
  AGACTGTACTCGGGACCGGGAACCTNAGGTTTGGGTAGAGGTGAGGCCTGTCCCCTTTGG
  GCTGGGGGCAGAACATGGGCTCAGNATTATGGGACTAAAGGCGGAGCCTGGGGTCCCACA
  AGCGGTCCGAAATTCCCAGTAGTTCANAGGCTTTGCGCTGCCGCTTGAGAAAGAAGAAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_130799
• Insert Size: 2850 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_130799.1, NP_570711.1
• RefSeq Size: 2772 bp
• RefSeq ORF: 1833 bp
• Locus ID: 4221
• Cytogenetics: 11q13.1
• Domains: Menin
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: 'This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]'
  Transcript Variant: This variant (2) differs from variant 1 by using an alternative splice site in exon 2. Use of this splice site results in the loss of 15 nt at the end of exon 2. Isoform 2 is missing an internal 5 aa as compared to isoform 1. Variants 2, 4, 5, and 6 all encode the same isoform (2).