NFAT2 (NFATC1) (NM_172388) Human Untagged Clone

CAT#: SC109490

NFATC1 (untagged)-Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 4


  "NM_172388" in other vectors (6)

Reconstitution Protocol

USD 600.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol NFATC1
Synonyms NF-ATC; NF-ATc1.2; NFAT2; NFATc
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_172388, the custom clone sequence may differ by one or more nucleotides


ATGCTGCAGCTTTTCATTGGGACGGCGGACGACCGCCTGCTGCGCCCGCACGCCTTCTACCAGGTGCACC
GCATCACAGGGAAGACCGTGTCCACCACCAGCCACGAGGCCATCCTCTCCAACACCAAAGTCCTGGAGAT
CCCACTCCTGCCGGAGAACAGCATGCGAGCCGTCATTGACTGTGCCGGAATCCTGAAACTCAGAAACTCC
GACATTGAACTTCGGAAAGGAGAGACGGACATCGGGAGGAAGAACACACGGGTACGGCTGGTGTTCCGCG
TTCACGTCCCGCAACCCAGCGGCCGCACGCTGTCCCTGCAGGTGGCCTCCAACCCCATCGAATGCTCCCA
GCGCTCAGCTCAGGAGCTGCCTCTGGTGGAGAAGCAGAGCACGGACAGCTATCCGGTCGTGGGCGGGAAG
AAGATGGTCCTGTCTGGCCACAACTTCCTGCAGGACTCCAAGGTCATTTTCGTGGAGAAAGCCCCAGATG
GCCACCATGTCTGGGAGATGGAAGCGAAAACTGACCGGGACCTGTGCAAGCCGAATTCTCTGGTGGTTGA
GATCCCGCCATTTCGGAATCAGAGGATAACCAGCCCCGTTCACGTCAGTTTCTACGTCTGCAACGGGAAG
AGAAAGCGAAGCCAGTACCAGCGTTTCACCTACCTTCCCGCCAACGTTCCAATTATAAAAACAGAACCCA
CTGATGATTATGAGCCTGCTCCAACCTGTGGACCGGTGAGCCAGGGGTTAAGTCCTCTCCCAAGACCATA
CTACAGCCAGCAGCTCGCGATGCCACCCGACCCCAGCTCCTGCCTCGTGGCCGGCTTCCCGCCCTGTCCG
CAGAGAAGCACCCTGATGCCAGCGGCCCCTGGCGTGAGCCCCAAGCTCCACGACCTTTCTCCCGCTGCCT
ACACCAAGGGCGTTGCCAGCCCGGGCCACTGTCACCTCGGACTCCCGCAGCCGGCCGGAGAGGCCCCCGC
CGTCCAGGACGTGCCCAGGCCAGTGGCCACGCACCCCGGCTCGCCCGGGCAGCCACCCCCGGCCCTGCTG
CCACAGCAGTAA


>OriGene 5' read for NM_172388 unedited
NGTTTCGGCATTTTNGTATACGATCTCACTATAGGGCGGCCGCGATTCGGCACGAGGAAC
CGAACCCCTGGCGGCCGCGACCCCGGCTCCCGCCCCGGCCCCGGCCCCGGCCCGACCCGC
CATGACGGGGCTGGAGGACCAGGAGTTCGACTTCGAGTTCCTCTTCGAGTTTAACCAGCG
CGACGAGGGCGCCGCCGCGGCCGCCCCAGCCCGACCCTGCCCGCCCTGGACTGGCAGCTG
CCGTCCCACTCAGGCCCGTATGAGCTTCGGATTGAGGTGCAGCCCAAGTCCCACCACCGA
GCCCACTACGAGACGGAGGGCAGCCGGGGGGCCGTGAAGGCGTCGGCCGGAGGACACCCC
ATCGTGCAGCTGCATGGCTACTTGGAGAATGAGCCGCTGATGCTGCAGCTTTTCATTGGG
ACGGCGGACGACCGCCTGCTGCGCCCGCACGCCTTCTACCAGGTGCACCGCATCACAGGG
AAGACCGTGTCCACCACCAGCCACGAGGCCATCCTCTCCAACACCAAAGTCCTGGAGATC
CCACTCCTGCCGGAGAACAGCATGCGAGCCGTCATTGACTGTGCCGGAATCCTGAAACTC
AGAAACTCCGACATTGAACTTCGGAAAGGAGAGACGGACATCGGGAGGAAGAACACACGG
GTACGGCTGGTGTTCCGCGTTCACGTCCCGCAACCCAGCGGCCGCACGCTGTCCCTGCAG
GTGGCCTCCAACCCCATCGAATGCTCCCAGCGCTCAGCTCAGGAGCTGCCTCTGGTGGAG
AAGCAGAGCACGGACAGCTATCCGTTCGTGGGCGGNAAGAAGATGGCCCTGTCCGGCCAC
ACTTTCTGCAGGACTCCAAGGTCATTTNCGTGGAGAAAGCCCAGATGGCCACCTGTCTGG
AAGATGGAGCGAAACTGACCGGGCCTGTGCAAGCGCATTTCTGTGG
>OriGene 3' read for NM_172388 unedited
GTACCGCGCCGCAATCTAGTAGTCGAGNNNTTTTTTTTTTTTTTTTTTTTTTACAGCAAA
AAAAACGGCTTTATTGGATCTATTTCCTAACTACAAAGACAGCTGACACAGACATCAAAC
GTTTCCTTTTCAATGACAGTCCCCTGAAAAAGGCTGCACGTGACTCCTACAGTGCCGGGT
GCAGGGTACCCAGCCGCAGGGGGGACGCGGCCACACGTCTTCACGGTTACGTGCAGACCG
ACGGGATGGCCTTCAGGTTGTTTCTTTCCGTGAGTGAAACACAAGAGACGCGATTGTGCC
GGAGCGCACGGTACAGGCCGTTCCTTCTGCGGGAGCCCTTTTTCCATCAGCGACGTTCTG
TTCAGGGACTTCACAGCCGAAGCCTCCACCCGCAGGGGCATTTTAGGCAGGTCCCATAGA
GGGGCTTTATTTTCTAAGGCCCTAGTCCAGGCCCCCCCGGCTTCAATGAATAACACCTGC
CTCCCGCGCTTCCGGACCACTAGATCGTTGGGAGTATTCTTGCCTGCTAACCCCCTCTTT
GGCCTTAGTGCCCCCCATCGCCTCTACACCTCTACCGGAGCCTTGTCCCCTTCGCACCAC
ACCCTCCCCCGTCCCCTCACCAATCCCGCGTCACCGGAATTCCCTACCCAATTCACCCCG
TTCTGTCTTCTGGTCCCTCCAACCTGAGTCCCCCTGCCTCCTTCCTTTATCATGCTCCAC
AAGTTCGGACCCCCTCGGTCTCCCCGATGCCTTCATTATTGTTATATTTCTCATGTTTAG
TTCTCGCAACCTCCCGACCTCCAGCTACCGAGCTTCATGAGTTTCGCCTGTTACAGGGCA
ACTACATCCCTACGCACCCCTCACCGCTCTATTGCCCACCCGCCGTTTTTCCTCGCCCAT
TCGTCCTTCCCACCCGCTCCTATTATGTGCCCTACTCCCGCGCACCGGAGCTGGGTCCAC
CGAGTATATGGCATCTCTTACTGACCATATCATTG
Restriction Sites NotI-NotI     
ACCN NM_172388
Insert Size 3250 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_172388.1, NP_765976.1
RefSeq Size 3671 bp
RefSeq ORF 1062 bp
Locus ID 4772
Cytogenetics 18q23
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Axon guidance, B cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway
Gene Summary 'The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]'
Transcript Variant: This variant (4) lacks an internal exon in the 5' region, which results in a downstream translation start codon, and has an alternate splice site in the 3' coding region, compared to variant 6. The encoded isoform (D) is shorter at both the N- and C- termini, compared to isoform F.

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