PAX6 (NM_001604) Human Untagged Clone

CAT#: SC109551

PAX6 (untagged)-Human paired box 6 (PAX6), transcript variant 2


  "NM_001604" in other vectors (6)

Reconstitution Protocol

USD 740.00

In Stock*

Size
    • 10 ug

Product Images

Other products for "PAX6"

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PAX6
Synonyms AN; AN2; ASGD5; D11S812E; FVH1; MGDA; WAGR
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC109551 sequence for NM_001604 edited (data generated by NextGen Sequencing)
ATGCAGAACAGTCACAGCGGAGTGAATCAGCTCGGTGGTGTCTTTGTCAACGGGCGGCCA
CTGCCGGACTCCACCCGGCAGAAGATTGTAGAGCTAGCTCACAGCGGGGCCCGGCCGTGC
GACATTTCCCGAATTCTGCAGACCCATGCAGATGCAAAAGTCCAAGTGCTGGACAATCAA
AACGTGTCCAACGGATGTGTGAGTAAAATTCTGGGCAGGTATTACGAGACTGGCTCCATC
AGACCCAGGGCAATCGGTGGTAGTAAACCGAGAGTAGCGACTCCAGAAGTTGTAAGCAAA
ATAGCCCAGTATAAGCGGGAGTGCCCGTCCATCTTTGCTTGGGAAATCCGAGACAGATTA
CTGTCCGAGGGGGTCTGTACCAACGATAACATACCAAGCGTGTCATCAATAAACAGAGTT
CTTCGCAACCTGGCTAGCGAAAAGCAACAGATGGGCGCAGACGGCATGTATGATAAACTA
AGGATGTTGAACGGGCAGACCGGAAGCTGGGGCACCCGCCCTGGTTGGTATCCGGGGACT
TCGGTGCCAGGGCAACCTACGCAAGATGGCTGCCAGCAACAGGAAGGAGGGGGAGAGAAT
ACCAACTCCATCAGTTCCAACGGAGAAGATTCAGATGAGGCTCAAATGCGACTTCAGCTG
AAGCGGAAGCTGCAAAGAAATAGAACATCCTTTACCCAAGAGCAAATTGAGGCCCTGGAG
AAAGAGTTTGAGAGAACCCATTATCCAGATGTGTTTGCCCGAGAAAGACTAGCAGCCAAA
ATAGATCTACCTGAAGCAAGAATACAGGTATGGTTTTCTAATCGAAGGGCCAAATGGAGA
AGAGAAGAAAAACTGAGGAATCAGAGAAGACAGGCCAGCAACACACCTAGTCATATTCCT
ATCAGCAGTAGTTTCAGCACCAGTGTCTACCAACCAATTCCACAACCCACCACACCGGTT
TCCTCCTTCACATCTGGCTCCATGTTGGGCCGAACAGACACAGCCCTCACAAACACCTAC
AGCGCTCTGCCGCCTATGCCCAGCTTCACCATGGCAAATAACCTGCCTATGCAACCCCCA
GTCCCCAGCCAGACCTCCTCATACTCCTGCATGCTGCCCACCAGCCCTTCGGTGAATGGG
CGGAGTTATGATACCTACACCCCCCCACATATGCAGACACACATGAACAGTCAGCCAATG
GGCACCTCGGGCACCACTTCAACAGGACTCATTTCCCCTGGTGTGTCAGTTCCAGTTCAA
GTTCCCGGAAGTGAACCTGATATGTCTCAATACTGGCCAAGATTACAGTAA

Clone variation with respect to NM_001604.4
>OriGene 5' read for NM_001604 unedited
GTCACAATTTGTATACGACTCACTATAGGCGGCCGCGAAATTCGCACGAGGCCTCGTGCC
GAATTCGGCACGAGGCACACACCAACCCAGCAACATCCGTGGAGAAAACTCTCACCAGCA
ACTCCTTTAAAACACCGTCATTTCAAACCATTGTGGTCTTCAAGCAACAACAGCAGCACA
AAAAACCCCAACCAAACAAAACTCTTGACAGAAGCTGTGACAACCAGAAAGGATGCCTCA
TAAAGGGGGAAGACTTTAACTAGGGGCGCGCAGATGTGTGAGGCCTTTTATTGTGAGAGT
GGACAGACATCCGAGATTTCAGAGCCCCATATTCGAGCCCCGTGGAATCCCGCGGCCCCC
AGCCAGAGCCAGCATGCAGAACAGTCACAGCGGAGTGAATCAGCTCGGTGGTGTCTTTGT
CAACGGGCGGCCACTGCCGGACTCCACCCGGCAGAAGATTGTAGAGCTAGCTCACAGCGG
GGCCCGGCCGTGCGACATTTCCCGAATTCTGCAGACCCATGCAGATGCAAAAGTCCAAGT
GCTGGACAATCAAAACGTGTCCAACGGATGTGTGAGTAAAATTCTGGGCAGGTATTACGA
GACTGGCTCCATCAGACCCAGGGCAATCGGTGGTAGTAAACCGAGAGTAGCGACTCCAGA
AGTTGTAAGCAAAATAGCCCAGTATAAGCGGGAGTGCCCGTCCATCTTTGCTTGGGAAAT
CCGAGACAGATTACTGTCCCGAGGGGTCTGTACCAACGATAACATACCAAGCGTGTCATC
AATAAAACAGAGTCTTCGCACCCTGGCTAGCGAAAAGCACCAGATGGGCCCAGACCGGAT
GTATGATTAACTAAAGATGTTGAACGGGCAAACCCGAAGCTGGGGCACCCGCCCTGGTTG
GTATCCGGGGGACTTCGGTGCCACGGCAN
>OriGene 3' read for NM_001604 unedited
CCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTACTGTAATCTTG
GCCAGTATTGAGACATATCAGGTTCACTTCCGGGAACTTGAACTGGAACTGACACACCAG
GGGAAAATGAGTCCTGTTGAAGTGGTGCCCGAGGTGCCCATTGGCTGACTGTTCATGTGT
GTCTGCATATGTGGGGGGGTGTAGGTATCATAACTCCGCCCATTCACCGAAGGGCTGGTG
GGCAGCATGCAGGAGTATGAGGAGGTCTGGCTGGGGACTGGGGGTTGCATAGGCAGGTTA
TTTGCCATGGTGAAGCTGGGCATAGGCGGCAGAGCGCTGTAGGTGTTTGTGAGGGCTGTG
TCTGTTCGGCCCAACATGGAGCCAGATGTGAAGGAGGAAACCGGTGTGGTGGGTTGTGGA
ATTGGTTGGTAGACACTGGTGCTGAAACTACTGCTGATAGGAATATGACTAGGTGTGTTG
CTGGCCTGTCTTCTCTGATTCCTCAGTTTTTCTTCTCTTTTCCATTTGGCCCTTCGATTA
GAAAACCATACCTGTATTCTTGCTTCAGGTAGATCTATTTTGGCTGCTAGTCTTTCTCGG
GCAAACACATCTGGATAATGGGTTCTCTCAAACTCTTTTTCCAGGGCCTTAATTTGCTCT
TGGTAAAGGATGTTCTATTTTTTTGCAGCTTCCGCTTCAGCTGAAATCGCATTTGAGCCT
AATCTGAATCTTCTCCGCTTGAACTGATGGGATTTGTTATTCTTTCCCCCTTCTTTCTTG
TTGCTGGCAGCCTTCTTGCGTAAGGTTCGCCTGGGCACCGAAATCCCCCGTAAACCAACC
ACGGGCGGGTTGCCCCAGCTTTCGGGTCTGCCCCGTCAACAATCCTTTATTTTTATAACT
GCCGTGTGCGCCCTTTTGTGGTTTTTCCTTACCAGTTGCCAACAATCTTTTTATTGTTTA
ACCCT
Restriction Sites NotI-NotI     
ACCN NM_001604
Insert Size 1710 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001604.3, NP_001595.2
RefSeq Size 2781 bp
RefSeq ORF 1311 bp
Locus ID 5080
Cytogenetics 11p13
Domains homeobox, PAX
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, Transcription Factors
Protein Pathways Maturity onset diabetes of the young
Gene Summary 'This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]'
Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. It initiates from the B (P1) promoter. The encoded isoform (b, also known as 5a) is longer than isoform a. Variants 2, 4, 5, 8, and 17-19 all encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Other Versions

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.