PTP epsilon (PTPRE) (NM_130435) Human Untagged Clone

CAT#: SC109677

PTPRE (untagged)-Human protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 2


  "NM_130435" in other vectors (4)

Reconstitution Protocol

USD 1,080.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PTPRE
Synonyms HPTPE; PTPE; R-PTP-EPSILON
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC109677 sequence for NM_130435 edited (data generated by NextGen Sequencing)
ATGAGCAACAGGAGTAGCTTTTCCCGGCTCACCTGGTTCAGGAAGCAGAGGAAAGCTGTG
GTCAGCACCAGCGACAAGAAGATGCCCAACGGAATCTTGGAGGAGCAAGAGCAGCAAAGG
GTGATGCTGCTCAGCAGGTCACCCTCAGGGCCCAAGAAGTATTTTCCCATCCCCGTGGAG
CACCTGGAGGAGGAGATCCGTATCAGATCCGCCGACGACTGCAAGCAGTTTCGGGAGGAG
TTCAACTCATTGCCATCTGGACACATACAAGGAACTTTTGAACTGGCAAATAAAGAAGAA
AACAGAGAAAAAAACAGATATCCCAACATCCTTCCCAATGACCATTCTAGGGTGATTCTG
AGCCAACTGGATGGAATTCCCTGTTCAGACTACATCAATGCTTCCTACATAGATGGTTAC
AAAGAGAAGAATAAATTCATAGCAGCTCAAGGTCCCAAACAGGAAACGGTTAACGACTTC
TGGAGAATGGTCTGGGAGCAAAAGTCTGCGACCATCGTCATGTTAACAAACTTGAAAGAA
AGGAAAGAGGAAAAGTGCCATCAGTACTGGCCCGACCAAGGCTGCTGGACCTATGGAAAC
ATCCGGGTGTGCGTGGAGGACTGCGTGGTTTTGGTCGACTACACCATCCGGAAGTTCTGC
ATACAGCCACAGCTCCCCGACGGCTGCAAAGCCCCCAGGCTGGTCTCACAGCTGCACTTC
ACCAGCTGGCCCGACTTCGGAGTGCCTTTTACCCCCATTGGGATGCTGAAGTTCCTCAAG
AAAGTAAAGACGCTCAACCCCGTGCACGCTGGGCCCATCGTGGTCCACTGTAGCGCGGGC
GTGGGCCGGACGGGCACCTTCATTGTGATCGATGCCATGATGGCCATGATGCACGCGGAG
CAGAAGGTGGATGTGTTTGAATTTGTGTCTCGAATCCGTAATCAGCGCCCTCAGATGGTT
CAAACGGATATGCAGTACACGTTCATCTACCAAGCCTTACTCGAGTACTACCTCTACGGG
GACACAGAGCTGGACGTGTCCTCCCTGGAGAAGCACCTGCAGACCATGCACGGCACCACC
ACCCACTTCGACAAGATCGGGCTGGAGGAGGAGTTCAGGAAATTGACAAATGTCCGGATC
ATGAAGGAGAACATGAGGACGGGCAACTTGCCGGCAAACATGAAGAAGGCCAGGGTCATC
CAGATCATCCCGTATGACTTCAACCGAGTGATCCTTTCCATGAAAAGGGGTCAAGAATAC
ACAGACTACATCAACGCATCCTTCATAGACGGCTACCGACAGAAGGACTATTTCATCGCC
ACCCAGGGGCCACTGGCACACACGGTTGAGGACTTCTGGAGGATGATCTGGGAATGGAAA
TCCCACACTATCGTGATGCTGACGGAGGTGCAGGAGAGAGAGCAGGATAAATGCTACCAG
TATTGGCCAACCGAGGGCTCAGTTACTCATGGAGAAATAACGATTGAGATAAAGAATGAT
ACCCTTTCAGAAGCCATCAGTATACGAGACTTTCTGGTCACTCTCAATCAGCCCCAGGCC
CGCCAGGAGGAGCAGGTCCGAGTAGTGCGCCAGTTTCACTTCCACGGCTGGCCTGAGATC
GGGATTCCCGCCGAGGGCAAAGGCATGATTGACCTCATCGCAGCCGTGCAGAAGCAGCAG
CAGCAGACAGGCAACCACCCCATCACCGTGCACTGCAGTGCCGGAGCTGGGCGAACAGGT
ACATTCATAGCCCTCAGCAACATTTTGGAGCGAGTAAAAGCCGAGGGACTTTTAGATGTA
TTTCAAGCTGTGAAGAGTTTACGACTTCAGAGACCACATATGGTGCAAACCCTGGAACAG
TATGAATTCTGCTACAAAGTGGTACAAGATTTTATTGATATATTTTCTGATTATGCTAAT
TTCAAATGA

Clone variation with respect to NM_130435.3
>OriGene 5' read for NM_130435 unedited
CGTTCACATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACCAGGTGGCTCAGC
CATGAGCAACAGGAGTAGCTTTTCCCGGCTCACCTGGTTCAGGAAGCAGAGGAAAGCTGT
GGTCAGCACCAGCGACAAGAAGATGCCCAACGGAATCTTGGAGGAGCAAGAGCAGCAAAG
GGTGATGCTGCTCAGCAGGTCACCCTCAGGGCCCAAGAAGTATTTTCCCATCCCCGTGGA
GCACCTGGAGGAGGAGATCCGTATCAGATCCGCCGACGACTGCAAGCAGTTTCGGGAGGA
GTTCAACTCATTGCCATCTGGACACATACAAGGAACTTTTGAACTGGCAAATAAAGAAGA
AAACAGAGAAAAAAACAGATATCCCAACATCCTTCCCAATGACCATTCTAGGGTGATTCT
GAGCCAACTGGATGGAATTCCCTGTTCAGACTACATCAATGCTTCCTACATAGATGGTTA
CAAAGAGAAGAATAAATTCATAGCAGCTCAAGGTCCCAAACAGGAAACGGTTAACGACTT
CTGGAGAATGGTCTGGGAGCAAAAGTCTGCGACCATCGTCATGTTAACAAACTTGAAAGA
AAGGAAAGAGGAAAAGTGCCATCAGTACTGGCCCGACCAAGGCTGCTGGACCTATGGAAA
CATCCGGGTGTGCGTGGAGGACTGCGTGGTTNTGGTCGACTACACCATCCGGAAGTTCTG
CATACAGCCACAGCTCCCCGACGGCTGCANAGCCCCCAGGCTGGTCTCACAGCTGCACTT
CACCAGCTGGCCCGACTTCGNAGTGCCTTTTACCCCCATTGGGATGCTGAAGTTCCCTCA
GAAAGTAAGACGCTCAACCCGTGCACGCTGGGCCCATCGTGGTCCACTGNTACGCGGGCG
TGGGCCGGNACGGCACCTCCATGTGATCGATCCCT
Restriction Sites NotI-NotI     
ACCN NM_130435
Insert Size 2200 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_130435.2, NP_569119.1
RefSeq Size 5002 bp
RefSeq ORF 1929 bp
Locus ID 5791
Cytogenetics 10q26.2
Domains Y_phosphatase, PTPc_motif
Protein Families Druggable Genome, Phosphatase, Transmembrane
Gene Summary 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]'
Transcript Variant: This variant (2) contains an alternate exon in place of the first 5 exons compared to variant 3. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 3. The encoded protein is a cytoplasmic isoform of this PTP.

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