TRAF6 (NM_004620) Human Untagged Clone

CAT#: SC109844

TRAF6 (untagged)-Human TNF receptor-associated factor 6 (TRAF6), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRAF6
• Synonyms: MGC:3310; RNF85
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004620 edited
  GAATTCGGCACGAGGAAGCAGTGGCGTCCGCAGCTGGGGCTTGGCCTGCGGGCGGCCAGC
  GAAGGTGGCGAAGGCTCCCACTGGATCCAGAGTTTGCCGTCCAAGCAGCCTCGTCTCGGC
  GCGCAGTGTCTGTGTCCGTCCTCTACCAGCGCCTTGGCTGAGCGGAGTCGTGCGGTTGGT
  GGGGGAGCCCTGCCCTCCTGGTTCGGCCTCCCCGCGCACTAGAACGAGCAAGTGATAATC
  AAGTTACTATGAGTCTGCTAAACTGTGAAAACAGCTGTGGATCCAGCCAGTCTGAAAGTG
  ACTGCTGTGTGGCCATGGCCAGCTCCTGTAGCGCTGTAACAAAAGATGATAGTGTGGGTG
  GAACTGCCAGCACGGGGAACCTCTCCAGCTCATTTATGGAGGAGATCCAGGGATATGATG
  TAGAGTTTGACCCACCCCTGGAAAGCAAGTATGAATGCCCCATCTGCTTGATGGCATTAC
  GAGAAGCAGTGCAAACGCCATGCGGCCATAGGTTCTGCAAAGCCTGCATCATAAAATCAA
  TAAGGGATGCAGGTCACAAATGTCCAGTTGACAATGAAATACTGCTGGAAAATCAACTAT
  TTCCAGACAATTTTGCAAAACGTGAGATTCTTTCTCTGATGGTGAAATGTCCAAATGAAG
  GTTGTTTGCACAAGATGGAACTGAGACATCTTGAGGATCATCAAGCACATTGTGAGTTTG
  CTCTTATGGATTGTCCCCAATGCCAGCGTCCCTTCCAAAAATTCCATATTAATATTCACA
  TTCTGAAGGATTGTCCAAGGAGACAGGTTTCTTGTGACAACTGTGCTGCATCAATGGCAT
  TTGAAGATAAAGAGATCCATGACCAGAACTGTCCTTTGGCAAATGTCATCTGTGAATACT
  GCAATACTATACTCATCAGAGAACAGATGCCTAATCATTATGATCTAGACTGCCCTACAG
  CCCCAATTCCATGCACATTCAGTACTTTTGGTTGCCATGAAAAGATGCAGAGGAATCACT
  TGGCACGCCACCTACAAGAGAACACCCAGTCACACATGAGAATGTTGGCCCAGGCTGTTC
  ATAGTTTGAGCGTTATACCCGACTCTGGGTATATCTCAGAGGTCCGGAATTTCCAGGAAA
  CTATTCACCAGTTAGAGGGTCGCCTTGTAAGACAAGACCATCAAATCCGGGAGCTGACTG
  CTAAAATGGAAACTCAGAGTATGTATGTAAGTGAGCTCAAACGAACCATTCGAACCCTTG
  AGGACAAAGTTGCTGAAATCGAAGCACAGCAGTGCAATGGAATTTATATTTGGAAGATTG
  GCAACTTTGGAATGCATTTGAAATGTCAAGAAGAGGAGAAACCTGTTGTGATTCATAGCC
  CTGGATTCTACACTGGCAAACCCGGGTACAAACTGTGCATGCGCTTGCACCTTCAGTTAC
  CGACTGCTCAGCGCTGTGCAAACTATATATCCCTTTTTGTCCACACAATGCAAGGAGAAT
  ATGACAGCCACCTCCCTTGGCCCTTCCAGGGTACAATACGCCTTACAATTCTTGATCAGT
  CTGAAGCACCTGTAAGGCAAAACCACGAAGAGATAATGGATGCCAAACCAGAGCTGCTTG
  CTTTCCAGCGACCCACAATCCCACGGAACCCAAAAGGTTTTGGCTATGTAACTTTTATGC
  ATCTGGAAGCCCTAAGACAAAGAACTTTCATTAAGGATGACACATTATTAGTGCGCTGTG
  AGGTCTCCACCCGCTTTGACATGGGTAGCCTTCGGAGGGAGGGTTTTCAGCCACGAAGTA
  CTGATGCAGGGGTATAGCTTGCCCTCACTTGCTCAAAAACAACTACCTGGAGAAAACAGT
  GCCTTTCCTTGCCCTGTTCTCAATAACATGCAAACAAACAAGCCACGGGAAATATGTAAT
  ATCTACTAGTGAGTGTTGTTAGAGAGGTCACTTACTATTTCTTCCTGTTACAAATGATCT
  GAGGCAGTTTTTTCCTGGGAATCCACACGTTCCATGCTTTTTCAGAAATGTTAGGCCTGA
  AGTGCCTGTGGCATGTTGCAGCAGCTATTTTGCCAGTTAGTATACCTCTTTGTTGTACTT
  TCTTGGGCTTTTGCTCTGGTGTATTTTATTGTCAGAAAGTCCAGACTCAAGAGTACTAAA
  CTTTTAATAATAATGGATTTTCCTTAAAACTTCAGTCTTTTTGTAGTATTATATGTAATA
  TATTAAAAGTGAAAATCACTACCGCCTTGTGCTAGTGCCCTCGAGAAGAGTTATTGCTCT
  AGAAAGTTGAGTTCTCATTTTTTTAACCTGTTATAGATTTCAGAGGATTTGAACCATAAT
  CCTTGGAAAACTTAAGTTCTCATTCACCCCAGTTTTTCCTCCAGGTTGTTACTAAGGATA
  TTCAGGGATGAGTTTAAACCCTAAATATAACCTTAATTATTTAGTGTAAACATGTCTGTT
  GAATAATACTTGTTTAAGTGTTCCTTCTGCCTTGCTTACTTATTTCCTTGAGGTTACGAA
  GTAGCNTCTTCCCCAGAGTTTATAATGCTGAGAACCACGTGGATACCAACTGCTCATTGT
  TATGCTATGTAACCCTTTTTGTCTATTCAGTGCAGAGTGAATTTCACAGCTCTGCATATG
  TCTTCATTTGTTTAATGCTTACAAGACAGGAGATGCACACATACAATCAGCAACATAAAA
  ATTANAAGTGACCCAAGTAGTCAGCGCATGTGGCATCTCATTGGTGGTGACAGAAGCTAT
  GTGAGCCAGANGTTTTCAGCTCTXXXXXXXXXXXXXXXXXXXXXXXXXCAGCTCAAAAAA
  GGAAATGATATTTAAAAGCTTCCTGGTCAGATTTCTATTAAAAGCACTGGCTGTGCATTA
  GATACAAAGAGGAGTCATTTCCTGCCTTGGTGATACTATTTTTTTCTACTAACTCAAGAG
  TCTTTATTAAAAAAAAAGTTGTTTTGCCTAATTTCAGCTTTTAGCAAGCTTCCCATCTGT
  AAAATGATTTGGACCAGATATTTCTAGAGTCCCCTCCAGCCATAACATTCTGTCTCAAAT
  TAAGTTCCAACCAGCAGAACACTGACAATACTTAGGAAAGTATTTTGCCAGTATAAAATG
  TCTTTAACTTACTCTTTGCTGACACTGATACTTTCCTCTAATTTAGTGTCTATCAGCTGG
  GTCACATCTTAAGTAAAATGAGCAATTTTAACCCCCAACATTTGGCATTTTGTCATAAAC
  CAGCCAGTTATTTTATGCTGGTCATTCATCTTGACTACAAAGTAGAATAGTCAAGCTGTC
  ATTCCAAATAGAAAACTTTTTACTTCAATCAGAATTAAGCCTTAACCTGGAAAGTTGGTT
  TCTTCCTTACATTTTCCCAATCTCCTACTCTATTCTTAAACATGCTAGTTTCACTCAGTT
  GGGTATACAAGCCTTTGGGCTTTATGTTGTATGTTACTAACCACCTTTTACCATATTTAT
  CTTTTGGCATCATTCTGGGACATTGCTAAATTAAAAAAGAAATTGTTTCCACTTTTTTCT
  GGAGATGTTCAACTAAAGGTTGTTTTGTTTTGTTTTTTGTTTTGAGACAGTCTCACCACT
  GCACTCCAGTCTGGGCAACAGAGCGAGACTCCTTCTCAAAAAAAAAAAAAAAAAAAAAAC
  TCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004620 unedited
  GACTCACTATAGGGCGGCCGCGAATTCGCACGAGGAAGCAGTGGCGTCCGCAGCTGGGGC
  TTGGCCTGCGGGCGGCCAGCGAAGGTGGCGAAGGCTCCCACTGGATCCAGAGTTTGCCGT
  CCAAGCAGCCTCGTCTCGGCGCGCAGTGTCTGTGTCCGTCCTCTACCAGCGCCTTGGCTG
  AGCGGAGTCGTGCGGTTGGTGGGGGAGCCCTGCCCTCCTGGTTCGGCCTCCCCGCGCACT
  AGAACGAGCAAGTGATAATCAAGTTACTATGAGTCTGCTAAACTGTGAAAACAGCTGTGG
  ATCCAGCCAGTCTGAAAGTGACTGCTGTGTGGCCATGGCCAGCTCCTGTAGCGCTGTAAC
  AAAAGATGATAGTGTGGGTGGAACTGCCAGCACGGGGAACCTCTCCAGCTCATTTATGGA
  GGAGATCCAGGGATATGATGTAGAGTTTGACCCACCCCTGGAAAGCAAGTATGAATGCCC
  CATCTGCTTGATGGCATTACGAGAAGCAGTGCAAACGCCATGCGGCCATAGGTTCTGCAA
  AGCCTGCATCATAAAATCAATAAGGGNATGCAGGTCACAAATGTCCAGTTGACAATGAAA
  TACTGCTGGAAAATCAACTATTTCCAGACAATTTTGCAAAACGTGAGATTCTTTCTCTNG
  ATGGTGAAATGTCCAATGAAAGGTTGTTTGCACAAGATGGAACTGAGACATCTTNGAGGA
  TCATCAAGCACATTTGTGAGTTTGCTCTTATGGGATTGTNCCCATGCCAGCGTCCCTTCC
  AAAAATTCATATTATATTACATTCTGGAAAGATGTCCAGGGAACAGGGTTTCTTGTGACA
  CTGTGCTGCATCATGGCATTTGAGATAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004620 unedited
  GGTCTTCCTTGGCCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTTTTTGA
  GAAGAGTCTCGCTCTGTTGCCCAGACTGGAGTGCAGTGGTGAGACTGTCTCAAAACAAAA
  AACAAAACAAAACAACCTTTAGTTGAACATCTCCAGAAAAAAGTGGAAACAATTTCTTTT
  TTAATTTAGCAATGTCCCAGAATGATGCCAAAAGATAAATATGGTAAAAGGTGGTTAGTA
  ACATACAACATAAAGCCCAAAGGCTTGTATACCCAACTGAGTGAAACTAGCATGTTTAAG
  AATAGAGTAGGAGATTGGGAAAATGTAAGGAAGAAACCAACTTTCCAGGTTAAGGCTTAA
  TTCTGATTGAAGTAAAAAGTTTTCTATTTGGAATGACAGCTTGACTATTCTACTTTGTAG
  TCAAGATGAATGACCAGCATAAAATAACTGGCTGGTTTATGACAAAATGCCAAATGTTGG
  GGGTTAAAATTGCTCATTTTACTTAAGATGTGACCCAGCTGATAGACACTAAATTAGAGG
  AAAGTATCAGTGTCAGCAAAGAGTAAGTTAAAGACATTTTATACTGGCAAAATACTTTCC
  TAAGTATTGTCAGTGTTCTGCTGGTTGGAACTTAATTTGAGACAGAATGTTATGGCTGGA
  GGGGACTCTAGAAATATCTGGTCCAAATCATTTTACAGATGGGAAGCTTGCTAAAAGCTG
  AAATTANGCAAAACAACTTTNTTTTTAATAAAGACTCTTGAGTTAGTAGAAAAAAATAGT
  ATCACCAAAGCAGGAAATGACTCCTCTTTGTATCTAATGCACAGCCAGTGCTTTTAATAG
  AAATCTGACCAGGAAGCCTTTAAATATACTTTCCCTTTTTTGAGCTGGGGGCGTGGAGAT
  AAATTGTTTTGTGGCAACACTTAATT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004620
• ORF Size: 1569 bp
• Insert Size: 4470
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004620.2, NP_004611.1
• RefSeq Size: 2515
• RefSeq ORF: 1569
• Locus ID: 7189
• Domains: zf-TRAF, RING, MATH
• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, Toll-like receptor signaling pathway, Ubiquitin mediated proteolysis
• Gene Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]
  Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.