PXR (NR1I2) (NM_003889) Human Untagged Clone

CAT#: SC109997

NR1I2 (untagged)-Human nuclear receptor subfamily 1, group I, member 2 (NR1I2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NR1I2
• Synonyms: BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_003889, the custom clone sequence may differ by one or more nucleotides
  
  
  CTGGAGGTGAGACCCAAAGAAAGCTGGAACCATGCTGACTTTGTACACTGTGAGGACACAGAGTCTGTTC
  CTGGAAAGCCCAGTGTCAACGCAGATGAGGAAGTCGGAGGTCCCCAAATCTGCCGTGTATGTGGGGACAA
  GGCCACTGGCTATCACTTCAATGTCATGACATGTGAAGGATGCAAGGGCTTTTTCAGGAGGGCCATGAAA
  CGCAACGCCCGGCTGAGGTGCCCCTTCCGGAAGGGCGCCTGCGAGATCACCCGGAAGACCCGGCGACAGT
  GCCAGGCCTGCCGCCTGCGCAAGTGCCTGGAGAGCGGCATGAAGAAGGAGATGATCATGTCCGACGAGGC
  CGTGGAGGAGAGGCGGGCCTTGATCAAGCGGAAGAAAAGTGAACGGACAGGGACTCAGCCACTGGGAGTG
  CAGGGGCTGACAGAGGAGCAGCGGATGATGATCAGGGAGCTGATGGACGCTCAGATGAAAACCTTTGACA
  CTACCTTCTCCCATTTCAAGAATTTCCGGCTGCCAGGGGTGCTTAGCAGTGGCTGCGAGTTGCCAGAGTC
  TCTGCAGGCCCCATCGAGGGAAGAAGCTGCCAAGTGGAGCCAGGTCCGGAAAGATCTGTGCTCTTTGAAG
  GTCTCTCTGCAGCTGCGGGGGGAGGATGGCAGTGTCTGGAACTACAAACCCCCAGCCGACAGTGGCGGGA
  AAGAGATCTTCTCCCTGCTGCCCCACATGGCTGACATGTCAACCTACATGTTCAAAGGCATCATCAGCTT
  TGCCAAAGTCATCTCCTACTTCAGGGACTTGCCCATCGAGGACCAGATCTCCCTGCTGAAGGGGGCCGCT
  TTCGAGCTGTGTCAACTGAGATTCAACACAGTGTTCAACGCGGAGACTGGAACCTGGGAGTGTGGCCGGC
  TGTCCTACTGCTTGGAAGACACTGCAGGTGGCTTCCAGCAACTTCTACTGGAGCCCATGCTGAAATTCCA
  CTACATGCTGAAGAAGCTGCAGCTGCATGAGGAGGAGTATGTGCTGATGCAGGCCATCTCCCTCTTCTCC
  CCAGACCGCCCAGGTGTGCTGCAGCACCGCGTGGTGGACCAGCTGCAGGAGCAATTCGCCATTACTCTGA
  AGTCCTACATTGAATGCAATCGGCCCCAGCCTGCTCATAGGTTCTTGTTCCTGAAGATCATGGCTATGCT
  CACCGAGCTCCGCAGCATCAATGCTCAGCACACCCAGCGGCTGCTGCGCATCCAGGACATACACCCCTTT
  GCTACGCCCCTCATGCAGGAGTTGTTCGGCATCACAGGTAGCTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003889 unedited
  CCCGTTAGGAATTGTAAACGACTCATATAGGCGGCCTGCGAATTCGCACCAGCCTATGAC
  TAGGACGGGAAGAGGAAGCACTGCCTTTACTTCAGTGGGAATCTCGGCCTCAGCCTGCAA
  GCCAAGTGTTCACAGTGAGAAAAGCAAGAGAATAAGCTAATACTCCTGTCCTGAAAAAGG
  CAGCGGCTCCTTGGTAAAGCTACTCCTTGATCGATCCTTTGCACCGGATTGTTCAAAGTG
  GACCCCAGGGGAGAAGTCGGAGCAAAGAACTTACCACCAAGCAGTCCAAGAGGCCCAGAA
  GCAAACCTGGAGGTGAGACCCAAAGAAAGCTGGAACCATGCTGACTTTGTACACTGTGAG
  GACACAGAGTCTGTTCCTGGAAAGCCCAGTGTCAACGCAGATGAGGAAGTCGGAGGTCCC
  CAAATCTGCCGTGTATGTGGGGACAAGGCCACTGGCTATCACTTCAATGTCATGACATGT
  GAAGGATGCAAGGGCTTTTTCAGGAGGGCCATGAAACGCAACGCCCGGCTGAGGTGCCCC
  TTCCGGAAGGGCGCCTGCGAGATCACCCGGAAGACCCGGCGACAGTGCCAGGCCTGCCGC
  CTGCGCAAGTGCCTGGAGAGCGGCATGAAGAAGGAGATGATCATGTCCGACGAGGCCGTG
  GAGGAGAGGCGGGCCTTGATCAAGCGGAAGAGAAGTGAACGGACAGGGACTCAGCCACTG
  NGAGTGCAGGGGCTGACAGAGGAGCAGCTGATGATGATCAGGGAGCTGATGGACGCTCAG
  ATGAAAACCTTTGACACTACCTTCTCCCATTTCAAGAATTTCCTGCTGCCAGGGGTGCTT
  AGCAGTGGCTGCGAGTTGCCAGAGTCTCTGCAGGCCCCATCTGAGGAAAGAAGCTGCCTA
  GTGTAGCCAGGTCTGGAAAGATCTGTGCTCTTTGAAGGTCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003889 unedited
  CCCCCCCATTAGTGTAGNCNCGCGGNCCGCTATTCTAGACNCGACTTTTTTTTTTTTTTT
  TTTTTAGCCAAAGTACATTATTTAATTCCTTTTGCCTTGATTTGACATTAAACCCAGGGC
  TACATTTCCCAAAACTAGTTCTTAGGTGTGGAATGCCTTATATAAAGTATAATTTGTGAA
  AATGCAAAAAAATTTTTACTCACAAGTGGCTATAAACAAGGCAGGCACTTTCATACCCTT
  TAGCTTTGAGAATAGATGTGTACACAGAAATATAAGGTGCATGTAAATGGTTCTTCTCCG
  GTGTGTTTAACTGATTGTCAGCGTAGCCTTGTCACAGAGCATACCCAGCATTCCAGCCCC
  AGGAACAAACCCAGGCCCCATCAAGTGGCAAACAGACCTACCTACACCAAATCACACACA
  CGCACTCACAGCTGCAGTTTGTGCCCTTGCTCCTACAGACTCATGTCCTCGGGAACCTTC
  ACTTGGGTACCCAGTGCCCGCCATCACAGCTCAGCATCCACACAGGGAAATTCCTTGTGC
  TGCTTTTGCCACTTATCATTTCTCCTTTTGATCCACAACGTTTGTGTTTCTGTTTGTTTT
  TTTAACTATAAACTCTGTGAGCTCAGGATCTATATCTGAGTCAATGCTGTATACCCCACA
  GCAGGCTACCTATTATCGGTGCTTAATAATGGGTTCAAATGGATGCAGAGACCAGAATGA
  CGTGGCCGGAATGAGGCCATGCCCAGCTTCTGACATTTGGTGCCGGCACTCCTGGCTTCT
  CATCTTTCTAGAGGACGTCCCACCGAACTTATGCCCCTGCCGATGAGTACAGGCCTGGAG
  CCCCAAAGCAGTTGGAAGAGAGGGAAACCAATGGAACATGGAGACGCACTATTACAGTTA
  GCATGAAAAAN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003889
• ORF Size: 1305 bp
• Insert Size: 2930
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003889.2, NP_003880.3
• RefSeq Size: 4446
• RefSeq ORF: 1305
• Locus ID: 8856
• Domains: HOLI, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Gene Summary: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) contains an alternate 5' terminal exon compared to transcript variant 2, and initiates translation from an in-frame, downstream non-AUG (CUG) codon, resulting in a shorter isoform (1) with a different N-terminus compared to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.