TCIRG1 (NM_006053) Human Untagged Clone

CAT#: SC110144

TCIRG1 (untagged)-Human T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (TCIRG1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TCIRG1
• Synonyms: a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TIRC7; Vph1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006053 edited
  GAATTCGGCACGAGGGACGGAGCGCCTGGCCCAGGAGCTGCGGGATGTGCGGGGCAACCA
  GCAGGCCCTGCGGGCCCAGCTGCACCAGCTGCAGCTCCACGCCGCCGTGCTACGCCAGGG
  CCATGAACCTCAGCTGGCAGCCGCCCACACAGATGGGGCCTCAGAGAGGACGCCCCTGCT
  CCAGGCCCCCGGGGGGCCGCACCAGGACCTGAGGGTCAACTTTGTGGCAGGTGCCGTGGA
  GCCCCACAAGGCCCCTGCCCTAGAGCGCCTGCTCTGGAGGGCCTGCCGCGGCTTCCTCAT
  TGCCAGCTTCAGGGAGCTGGAGCAGCCGCTGGAGCACCCCGTGACGGGCGAGCCAGCCAC
  GTGGATGACCTTCCTCATCTCCTACTGGGGTGAGCAGATCGGACAGAAGATCCGCAAGAT
  CACGGACTGCTTCCACTGCCACGTCTTCCCGTTTCTGCAGCAGGAGGAGGCCCGCCTCGG
  GGCCCTGCAGCAGCTGCAACAGCAGAGCCAGGAGCTGCAGGAGGTCCTCGGGGAGACAGA
  GCGGTTCCTGAGCCAGGTGCTAGGCCGGGTGCTGCAGCTGCTGCCGCCAGGGCAGGTGCA
  GGTCCACAAGATGAAGGCCGTGTACCTGGCCCTGAACCAGTGCAGCGTGAGCACCACGCA
  CAAGTGCCTCATTGCCGAGGCCTGGTGCTCTGTGCGAGACCTGCCCGCCCTGCAGGAGGC
  CCTGCGGGACAGCTCGATGGAGGAGGGAGTGAGTGCCGTGGCTCACCGCATCCCCTGCCG
  GGACATGCCCCCCACACTCATCCGCACCAACCGCTTCACGGCCAGCTTCCAGGGCATCGT
  GGATGCCTACGGCGTGGGCCGCTACCAGGAGGTCAACCCCGCTCCCTACACCATCATCAC
  CTTCCCCTTCCTGTTTGCTGTGATGTTCGGGGATGTGGGCCACGGGCTGCTCATGTTCCT
  CTTCGCCCTGGCCATGGTCCTTGCGGAGAACCGACCGGCTGTGAAGGCCGCGCAGAACGA
  GATCTGGCAGACTTTCTTCAGGGGCCGCTACCTGCTCCTGCTTATGGGCCTGTTCTCCAT
  CTACACCGGCTTCATCTACAACGAGTGCTTCAGTCGCGCCACCAGCATCTTCCCCTCGGG
  CTGGAGTGTGGCCGCCATGGCCAACCAGTCTGGCTGGAGTGATGCATTCCTGGCCCAGCA
  CACGATGCTTACCCTGGATCCCAACGTCACCGGTGTCTTCCTGGGACCCTACCCCTTTGG
  CATCGATCCTATTTGGAGCCTGGCTGCCAACCACTTGAGCTTCCTCAACTCCTTCAAGAT
  GAAGATGTCCGTCATCCTGGGCGTCGTGCACATGGCCTTTGGGGTGGTCCTCGGAGTCTT
  CAACCACGTGCACTTTGGCCAGAGGCACCGGCTGCTGCTGGAGACGCTGCCGGAGCTCAC
  CTTCCTGCTGGGACTCTTCGGTTACCTCGTGTTCCTAGTCATCTACAAGTGGCTGTGTGT
  CTGGGCTGCCAGGGCCGCCTCGGCCCCCAGCATCCTCATCCACTTCATCAACATGTTCCT
  CTTCTCCCACAGCCCCAGCAACAGGCTGCTCTACCCCCGGCAGGAGGTGGTCCAGGCCAC
  GCTGGTGGTCCTGGCCTTGGCCATGGTGCCCATCCTGCTGCTTGGCACACCCCTGCACCT
  GCTGCACCGCCACCGCCGCCGCCTGCGGAGGAGGCCCGCTGACCGACAGGAGGAAAACAA
  GGCCGGGTTGCTGGACCTGCCTGACGCATCTGTGAATGGCTGGAGCTCCGATGAGGAAAA
  GGCAGGGGGCCTGGATGATGAAGAGGAGGCCGAGCTCGTCCCCTCCGAGGTGCTCATGCA
  CCAGGCCATCCACACCATCGAGTTCTGCCTGGGCTGCGTCTCCAACACCGCCTCCTACCT
  GCGCCTGTGGGCCCTGAGCCTGGCCCACGCCCAGCTGTCCGAGGTTCTGTGGGCCATGGT
  GATGCGCATAGGCCTGGGCCTGGGCCGGGAGGTGGGCGTGGCGGCTGTGGTGCTGGTCCC
  CATCTTTGCCGCCTTTGCCGTGATGACCGTGGCTATCCTGCTGGTGATGGAGGGACTCTC
  AGCCTTCCTGCACGCCCTGCGGCTGCACTGGGTGGAATTCCAGAACAAGTTCTACTCAGG
  CACGGGCTACAAGCTGAGTCCCTTCACCTTCGCTGCCACAGATGACTAGGGCCCACTGCA
  GGTCCTGCCAGACCTCCTTCCTGACCTCTGAGGCAGGAGAGGAATAAAGACGGTCCGCCC
  TGGCAGTGXXXXXXXXXXXXXXXXXXXXXXXXXAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006053 unedited
  GTTCAAATTTGTATACGACTCATATAGGCGGCCGCGNAATCGGCACGAGGGACGGAGCGC
  CTGGCCCAGNAGCTGCGGGATGTGCGGGGCAACCAGCAGGCCCTGCGGGCCCAGCTGCAC
  CAGCTGCAGCTCCACGCCGCCGTGCTACGCCAGGGCCATGAACCTCAGCTGGCAGCCGCC
  CACACAGATGGGGCCTCAGAGAGGACGCCCCTGCTCCAGGCCCCCGGGGGGCCGCACCAG
  GACCTGAGGGTCAACTTTGTGGCAGGTGCCGTGGAGCCCCACAAGGCCCCTGCCCTAGAG
  CGCCTGCTCTGGAGGGCCTGCCGCGGCTTCCTCATTGCCAGCTTCAGGGAGCTGGAGCAG
  CCGCTGGAGCACCCCGTGACGGGCGAGCCAGCCACGTGGATGACCTTCCTCATCTCCTAC
  TGGGGTGAGCAGATCGGACAGAAGATCCGCAAGATCACGGACTGCTTCCACTGCCACGTC
  TTCCCGTTTCTGCAGCAGGAGGAGGCCCGCCTCGGGGCCCTGCAGCAGCTGCAACAGCAG
  AGCCAGGAGCTGCAGGAGGTCCTCGGGGAGACAGAGCGGTTCCTGAGCCAGGTGCTAGGC
  CGGGTGCTGCAGCTGCTGCCGCCAGGGCAGGTGCAGGTCCACAAGATGAAGGCCGTGTAC
  CTGGCCCTGAACCAGTGCAGCGTGAGCACCACGCACAAGTGCCTCATTGCCGAGGCCTGG
  TGCTCTGTGCGAGACCTGCCCGCCCTGCAGGAGGCCCTGCGGGACAGCTCGATGGAGGAG
  GGAGTGAGTGCCGTGGCTCACCGCATCCCCTGCCGGGACATGCCCNCCACACTCATCCGC
  ACCAACCGCTTCACGGNCAGCTTCCCAGGCATCGTGGATGCCTACGGCGTGGGCCGCTAC
  CAGAAGGTCAACCCCGCTTCCTACACCAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006053 unedited
  TGGGACGGACCGCCTTTTTTCCTCTCCTGCCTCANAGTCAGGNAAGAGGTCTGGCAGGAC
  CTGCAGTGGGCCCTAGTCATCTGTGGCAGCGAAGGTGAAGGGACTCAGCTTGTAGCCCGT
  GCCTGAGTAGAACTTGTTCTGGAATTCCACCCAGTGCAGCCGCAGGGCGTGCAGGAAGGC
  TGAGAGTCCCTCCATCACCAGCAGGATAGCCACGGTCATCACGGCAAAGGCGGCAAAGAT
  GGGGACCAGCACCACAGCCGCCACGCCCACCTCCCGGCCCAGGCCCAGGCCTATGCGCAT
  CACCATGGCCCACAGAACCTCGGACAGCTGGGCGTGGGCCAGGCTCAGGGCCCACAGGCG
  CAGGTAGGAGGCGGTGTTGGAGACGCAGCCCAGGCAGAACTCGATGGTGTGGATGGCCTG
  GTGCATGAGCACCTTGGAGGGGACGAGCTCGGCCTCCTCTTCATCATCCAGGCCCCCTGC
  CTTTTCCTCATCGGAGCTNCAGCCATTCACAGATGCGTCAGGCAGGTCCAGCAACCCGGC
  CTTGTTTTCCTCCTGTCGGTCAGCGGGCCTCCTCCGCATGCGGNGGCGGTGGCGGTGCAC
  CATGTGCACGGGTGTGCCAAGCAGCATGATGGGCACCATGGCCAAGGCCAGAACCACCAG
  CGTGGCCTGGGACACCTCCTGCCCGGGGTTGAGNANCCTGTTGCTGGGGCTGCGGGAGAA
  GAGGACATGTCTGTGAATTGGATGGAGATGCTTGGGGCCGAGGCGGCCCTGNNACCCACC
  ACCCCCTGCACCTTGGTTAGACTAGAACACAGCAGTAACCTAAGATTCCCACAAGGAAGG
  CATGCTTCTGTATGTTTCCTATCACTCCCCGTGCCTTTGGGTCAATGGAACTTGGTTNAN
  ACCTCCTGGTCACCCCTAAGCGCTGTCAACTATCCACTNCTACCGCTCCTCCTCTTTACG
  GTTTGTACACGCCTGTCCCACTCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006053
• ORF Size: 1845 bp
• Insert Size: 2500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_006053.2, NP_006044.1
• RefSeq Size: 2480
• RefSeq ORF: 1845
• Locus ID: 10312
• Domains: V_ATPase_sub_a
• Protein Families: Transmembrane
• Protein Pathways: Epithelial cell signaling in Helicobacter pylori infection, Lysosome, Metabolic pathways, Oxidative phosphorylation, Vibrio cholerae infection
• Gene Summary: This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
  Transcript Variant: This variant (2) encodes isoform b, also known as the TCIR7 protein. This protein is expressed in T lymphocytes and is essential for normal T cell activation. This variant uses a transcription start site that is within exon 5 of variant 1, and it also includes the following intron as part of its 5' UTR. The encoded isoform (b) is shorter than isoform a.