MASP2 (NM_139208) Human Untagged Clone

CAT#: SC110196

MASP2 (untagged)-Human mannan-binding lectin serine peptidase 2 (MASP2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MASP2
• Synonyms: MAP19; MASP-2; MASP1P1; sMAP
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_139208, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAGGCTGCTGACCCTCCTGGGCCTTCTGTGTGGCTCGGTGGCCACCCCCTTGGGCCCGAAGTGGCCTG
  AACCTGTGTTCGGGCGCCTGGCATCCCCCGGCTTTCCAGGGGAGTATGCCAATGACCAGGAGCGGCGCTG
  GACCCTGACTGCACCCCCCGGCTACCGCCTGCGCCTCTACTTCACCCACTTCGACCTGGAGCTCTCCCAC
  CTCTGCGAGTACGACTTCGTCAAGCTGAGCTCGGGGGCCAAGGTGCTGGCCACGCTGTGCGGGCAGGAGA
  GCACAGACACGGAGCGGGCCCCTGGCAAGGACACTTTCTACTCGCTGGGCTCCAGCCTGGACATTACCTT
  CCGCTCCGACTACTCCAACGAGAAGCCGTTCACGGGGTTCGAGGCCTTCTATGCAGCCGAGGACATTGAC
  GAGTGCCAGGTGGCCCCGGGAGAGGCGCCCACCTGCGACCACCACTGCCACAACCACCTGGGCGGTTTCT
  ACTGCTCCTGCCGCGCAGGCTACGTCCTGCACCGTAACAAGCGCACCTGCTCAGAGCAGAGCCTCTAG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_139208 unedited
  TTATGTAATCCGACTTACTATAGNNGGCGGCCGCGCAATTCGGCACCAGGCCAGCTGGAC
  GGGCACACCATGAGGCTGCTGACCCTCCTGGGCCTTCTGTGTGGCTCGGTGGCCACCCCC
  TTGGGCCCGAAGTGGCCTGAACCTGTGTTCGGGCGCCTGGCATCCCCCGGCTTTCCAGGG
  GAGTATGCCAATGACCAGGAGCGGCGCTGGACCCTGACTGCACCCCCCGGCTACCGCCTG
  CGCCTCTACTTCACCCACTTCGACCTGGAGCTCTCCCACCTCTGCGAGTACGACTTCGTC
  AAGCTGAGCTCGGGGGCCAAGGTGCTGGCCACGCTGTGCGGGCAGGAGAGCACAGACACG
  GAGCGGGCCCCTGGCAAGGACACTTTCTACTCGCTGGGCTCCAGCCTGGACATTACCTTC
  CGCTCCGACTACTCCAACGAGAAGCCGTTCACGGGGTTCGAGGCCTTCTATGCAGCCGAG
  GACATTGACGAGTGCCAGGTGGCCCCGGGAGAGGCGCCCACCTGCGACCACCACTGCCAC
  AACCACCTGNGCGGTTTCTACTGCTCCTGCCGCGCAGGCTACGTCCTGCACCGTAACAAG
  CGCACCTGCTCAGAGCAGAGCCTCTAGCCTCCCCTGGAGCTCCGGCCTGCCCAGCAGGTC
  AGAAGCCAGAGCCAGCCTGCTGGCCTCAGCTCCGGGTTGGGCTGAGATGGCTGTGCCCCA
  ACTTCCCATTCACCCACCATGGACCCATAATTAACCTGGCCCCACCCCANTAAAAAAAAA
  ANAAAAAACCCGACTCTAGATTGGCGCCCGCGTCATAGCTGTTTCCTGAAAAATCCCGGG
  TGGCATCCCTTGAACCCCTCCCAGAGCCTTTCCTGCCCTGNAAGTTGCCTCCCGTGCCAC
  CACCCTGNCCTATAAATTAGGTGCATCATTGTCTGACAGGGGCCTCCTAAATACGTGCGG
  GGGCGCGGGGCCCGCCCTCTACCCCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_139208 unedited
  NNAAAGATNTTTACTCTGNACCGCGGNCCCGCATTCNANGATCGAGTTTTTTTTTTTTTT
  TTTTTTTGGGGTGGGGCCGGTTTATATTGGGTCCTGGGGGGTGAATGGGAGTTGGGGCAC
  AGCCATCTCAGCCCAACCCGGAGCTGAGGCCAGCAGGCTGGCTCTGGCTTCTGACCTGCT
  GGGCAGGCCGGAGCTCCAGGGGAGGCTAGAGGCTCTGCTCTGAGCAGGTGCGCTTGTTAC
  GGTGCAAGACGTAGCCTGCGCGGCAGGAGCAGTAGAAACCGCCCAGGTGGTTGTGGCAGT
  GGTGGTCGCAAGTGGGCGCCTCTCCCGGGGCCACCTGGCACTCGTCAATGTCCTCGGCTG
  CATAGAAGGCCTCGAACCCCGTGAACGGCTTCTCGTTGGAGTAGTCGGAGCGGAAGGTAA
  TGTCCAGGCTGGAGCCCAGCGAGTAGAAAGTGTCCTTGCCAGGGGCCCGCTCCGTGTCTG
  TGCTCTCCTGCCCGCACAGCGTGGCCAGCACCTTGGCCCCCGAGCTCAGCTTGACGAAGT
  CGTACTCGCAGAGGTGGGAGAGCTCCAGGTCGAAGTGGGTGAAGTAAAGGCGCAGGCGGT
  AGCCGGGGGGTGCAGTCAGGGTCCAGCGCCGCTCCTGGTCATTGGCATACTCCCCTGGAA
  AGCCGGGGGATGCCAGGCGCCCGACACAGGTTCAGGCCACTTCGGGCCCAAGGGGGGTGG
  CCACCGAGCCACACAGAAGGCCCNAGNAGGTCAGCAGCCTCATGGTGTGCCCGTCCAGCT
  GGCCTGGTGCCGANATCCGGCCGCCTATAGTGAGTCGTATACAAATTCTGACGGTCACTA
  ACGAGCTCTGCTATATAGACTNCCACGTAACGCTACCGCCATTGCGTACGGGGCGGGGTA
  TACGACATTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_139208
• ORF Size: 558 bp
• Insert Size: 780
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_139208.1, NP_631947.1
• RefSeq Size: 738
• RefSeq ORF: 558
• Locus ID: 10747
• Domains: CUB, EGF_CA, EGF
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades
• Gene Summary: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
  Transcript Variant: This variant (2), also called MAp19, differs in the 3' UTR and 3' coding region compared to variant 1, resulting in a frameshift and upstream stop codon. Isoform 2 has a unique C-terminus and lacks the serine protease catalytic domain, compared to isoform 1.