TRIB1 (NM_025195) Human Untagged Clone

CAT#: SC110324

TRIB1 (untagged)-Human tribbles homolog 1 (Drosophila) (TRIB1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRIB1
• Synonyms: C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_025195 edited
  ATGCGGGTCGGTCCGGTGCGCTCTGCCATGAGCGGCGCCTCGCAGCCCCGCGGCCCGGCC
  CTGCTCTTCCCAGCCACCCGAGGCGTCCCGGCCAAACGCCTGCTGGACGCCGACGACGCG
  GCGGCTGTGGCGGCCAAGTGCCCGCGCCTCTCCGAGTGCTCCAGCCCCCCGGACTACCTC
  AGCCCCCCCGGCTCGCCCTGCAGCCCGCAGCCCCCGCCTGCCGCTCCGGGGGCCGGCGGA
  GGCTCCGGGAGCGCGCCGGGGCCCAGCCGCATCGCCGACTACCTGCTGCTGCCCCTAGCC
  GAGCGCGAGCATGTGTCCCGGGCGCTGTGCATCCACACTGGACGCGAGCTGCGCTGCAAG
  GTGTTTCCCATTAAACACTACCAGGACAAAATCAGGCCTTACATCCAGCTGCCATCGCAC
  AGCAACATTACTGGCATTGTGGAAGTGATCCTTGGGGAAACCAAGGCCTATGTCTTCTTT
  GAGAAGGACTTTGGGGACATGCACTCCTATGTGCGAAGCCGGAAGAGGCTGCGGGAAGAG
  GAAGCCGCCCGGCTCTTCAAGCAGATTGTCTCCGCCGTCGCCCACTGCCACCAGTCAGCC
  ATCGTGCTGGGGGACCTGAAGCTTAGGAAGTTCGTCTTCTCCACGGAGGAGAGAACCCAG
  CTTAGACTAGAAAGTCTAGAAGACACACACATAATGAAGGGGGAAGATGATGCTTTGTCA
  GACAAACATGGCTGCCCAGCCTACGTGAGCCCTGAGATCCTCAACACCACTGGGACCTAC
  TCCGGAAAGGCTGCGGACGTTTGGAGCCTGGGGGTGATGCTCTACACCCTTCTGGTTGGA
  CGATACCCCTTCCATGACTCAGACCCCAGTGCCCTTTTCTCCAAAATTCGGCGTGGACAG
  TTCTGCATTCCTGAGCACATTTCCCCCAAAGCCAGGTGCCTCATTCGCAGCCTCTTGAGA
  CGGGAGCCCTCCGAGAGACTCACTGCCCCCGAGATCCTACTGCACCCCTGGTTTGAGTCC
  GTCTTGGAACCCGGGTACATCGACTCAGAAATAGGAACTTCAGACCAGATTGTTCCAGAG
  TACCAGGAGGACAGTGACATTAGTTCCTTCTTCTGCTAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_025195 unedited
  GTAATACGATTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCAGTCTGCAAACTCCAT
  CCCGCCGGCTGGAAGAAGTCGCGGAGCCGGCACCAAACCCGCAGCGTCTTCCCGCGCGGA
  TCCCGGGACTTAAAAAGCCGGGGCCACCCCGGCCCAGGACGGGATGCGGGTCGGTCCGGT
  GCGCTCTGCCATGAGCGGCGCCTCGCAGCCCCGCGGCCCGGCCCTGCTCTTCCCAGCCAC
  CCGAGGCGTCCCGGCCAAACGCCTGCTGGACGCCGACGACGCGGCGGCTGTGGCGGCCAA
  GTGCCCGCGCCTCTCCGAGTGCTCCAGCCCCCCGGACTACCTCAGCCCCCCCGGCTCGCC
  CTGCAGCCCGCAGCCCCCGCCTGCCGCTCCGGGGGCCGGCGGAGGCTCCGGGAGCGCGCC
  GGGGCCCAGCCGCATCGCCGACTACCTGCTGCTGCCCCTAGCCGAGCGCGAGCATGTGTC
  CCGGGCGCTGTGCATCCACACTGGACGCGAGCTGCGCTGCAAGGTGTTTCCCATTAAACA
  CTACCAGGACAAAATCAGGCCTTACATCCAGCTGCCATCGCACAGCAACATTACTGGCAT
  TGTGGAAGTGATCCTTGGGGAAACCAAGGCCTATGTCTTCTTTGAGAAGGACTNTGGNGA
  CATGCACTCCTATGTGCGAAGCCGGAAGAGGCTGCCGGAAGAGGAAAGCGCCCGGCTCTT
  CAAGCAGATTGTCTCCGCCGTCGCCCACTGCCACCAGTCAGCCATCGTGCTGGGGGACCC
  TGAGCTAAGGAAGGTCGTCCTTCTCCACGGAGGAGAGACCCAGCTTAGACTATGAAGTCT
  AGAAGACCCCACATATTGAGGGGGGAAGAGATGCTTTGTCAGACAACATGGCTGCCCACC
  TACGGAGCCCTGAAACCTCACACCACTGGGACCTACTCGNAAGCTGTGNACTTTGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_025195 unedited
  GAGGCCGTAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTACGAAACCAGGTTTATTAAA
  ATTTCTCTACAAGTCAGAAACGGCCATCTCACTGTTCACATATATACACGTATGTACAGG
  AAGAACCTAGTGTTTCTAGCTTTCCCGGCAGAAGGCCCTGCCAGCCCAGAGTCCTTAGTC
  GGATAATGTATCACAGATACAACAGTGCGAGCAACCACGAGAGCGTTAGTGCGACAGAGG
  CCTCTGTCCTCCCTCTTCTCAAAGTCCCATGATTCTGTCAAGGTAATATTGCCAATAATC
  ATTCACATTTCACGTGGTTTTAGACACGCAGGTTATTCACACAGACACAGACCACAAACC
  AAGCCTTAAAGTCAGAACAAAACAAAACATAACAAAATTGAACATAGGTTTAAAAGGTTA
  AATATATGTGCAAAGTGCACAGTTCGTGAGGTATACACGGCATTTTCACAATGCATGTTC
  ACTACTCGTCTAGGTTTACGCCTTTAAGATGACTGCCTGTTTTTGTGCCATTGCTGAAAA
  TGCAGTGTATTGTGTCAACCCGATTAACTCACCTGATTTTAATACCTGCACAACACAGTC
  ACTGACATCGCATCCGAATCCGTGCCCCGATGCAAGTGTGGTTCCTCCGCGTCTAGTTTC
  CTACTTTTGTTATGGGATTGCACTTCCACTTATCGGTACCTATCTAACGCAGGCTGGTTT
  GTTCCCTTCTAAATAGCTGTAAAGGGGATTCTTGCCTTGGGAGTGGCTATTAGAAGCCGT
  ATATTGGTCCGCATGATGTCTAAGATTCTCTTCTCTTATAGATGCGGGGTCCGCTTGTTT
  CCTTGCTCACCTCTTCTCCCTCTTTTTTCATCTCCCCCTCTTTAGTTTTGCCCCTTGCCC
  TTCAACCTCTCAAGCGCCCCATCGTCAGGCCTTCCCTTCTGCTAGGGATGAAAACAATAT
  CG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_025195
• ORF Size: 1119 bp
• Insert Size: 3240
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_025195.2, NP_079471.1
• RefSeq Size: 3658
• RefSeq ORF: 1119
• Locus ID: 10221
• Domains: pkinase, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer transcript nd encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.