TMS1 (PYCARD) (NM_145182) Human Untagged Clone

CAT#: SC110404

PYCARD (untagged)-Human PYD and CARD domain containing (PYCARD), transcript variant 2


  "NM_145182" in other vectors (4)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PYCARD
Synonyms ASC; CARD5; TMS; TMS-1; TMS1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_145182 edited
GAATTCGGCACGAGGGGGGTGAGCGGCGGCAGCGGCCGGGGATCCTGGAGCCATGGGGCG
CGCGCGCGACGCCATCCTGGATGCGCTGGAGAACCTGACCGCCGAGGAGCTCAAGAAGTT
CAAGCTGAAGCTGCTGTCGGTGCCGCTGCGCGAGGGCTACGGGCGCATCCCGCGGGGCGC
GCTGCTGTCCATGGACGCCTTGGACCTCACCGACAAGCTGGTCAGCTTCTACCTGGAGAC
CTACGGCGCCGAGCTCACCGCTAACGTGCTGCGCGACATGGGCCTGCAGGAGATGGCCGG
GCAGCTGCAGGCGGCCACGCACCAGGGCTCTGGAGCCGCGCCAGCTGGGATCCAGGCCCC
TCCTCAGTCGGCAGCCAAGCCAGGCCTGCACTTTATAGACCAGCACCGGGCTGCGCTTAT
CGCGAGGGTCACAAACGTTGAGTGGCTGCTGGATGCTCTGTACGGGAAGGTCCTGACGGA
TGAGCAGTACCAGGCAGTGCGGGCCGAGCCCACCAACCCAAGCAAGATGCGGAAGCTCTT
CAGTTTCACACCAGCCTGGAACTGGACCTGCAAGGACTTGCTCCTCCAGGCCCTAAGGGA
GTCCCAGTCCTACCTGGTGGAGGACCTGGAGCGGAGCTGAGGCTCCTTCCCAGCAACACT
CCGGTCAGCCCCTGGCAATCCCACCAAATCATCCTGAATCTGATCTTTTTATACACAATA
TACGAAAAGCCAGCTTGAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_145182 unedited
GTTCAAAATTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGGGTG
AGCGGCGGCAGCGGCCGGGGATCCTGNGACCATGGGGCGCGCGCGCGACGCCATCCTGGA
TGCGCTGGAGAACCTGACCGCCGAGGAGCTCAAGAAGTTCAAGCTGAAGCTGCTGTCGGT
GCCGCTGCGCGAGGGCTACGGGCGCATCCCGCGGGGCGCGCTGCTGTCCATGGACGCCTT
GGACCTCACCGACAAGCTGGTCAGCTTCTACCTGGAGACCTACGGCGCCGAGCTCACCGC
TAACGTGCTGCGCGACATGGGCCTGCAGGAGATGGCCGGGCAGCTGCAGGCGGCCACGCA
CCAGGGCTCTGGAGCCGCGCCAGCTGGGATCCAGGCCCCTCCTCAGTCGGCAGCCAAGCC
AGGCCTGCACTTTATAGACCAGCACCGGGCTGCGCTTATCGCGAGGGTCACAAACGTTGA
GTGGCTGCTGGATGCTCTGTACGGGAAGGTCCTGACGGATGAGCAGTACCAGGCAGTGCG
GGCCGAGCCCACCAACCCAAGCAAGATGCGGAAGCTCTTCAGTTTCACACCAGCCTGGAA
CTGGACCTGCAAGGACTTGCTCCTCCAGGCCCTAAGGGAGTCCCAGTCCTACCTGGTGGA
GGACCTGGAGCGGAGCTGAGGCTCCTTCCCACAACACTCCGGTCAGCCCCTGGCAATCCC
ACCAAATCATCCTGAATCTGATCTTTNTATACACAATATACGAAAAGCCAGCTTGAAAAA
AAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAAAGATCC
CNGGTGGCATCCCTGTGACCCTNNCCGTGCCTCTTCTGGCCCTGGAAAGTGCACTNCAGT
GCCACCANNCTGTCTAATAAAATAAGTGCATCATTGCTGACTAGTGTCTATATATGG
>OriGene 3' read for NM_145182 unedited
TTTGGGTATTTTATGAACCGCGCCGCATTCTANNGATCGGTTTTTTTTTTTTTTTTTTCA
AGCTGGCTTTTCGTATATTGTGTATAAAAAGATCAGATTCAGGATGATTTGGTGGGATTG
CCAGGGGCTGACCGGAGTGTTGCTGGGAAGGAGCCTCAGCTCCGCTCCAGGTCCTCCACC
AGGTAGGACTGGGACTCCCTTAGGGCCTGGAGGAGCAAGTCCTTGCAGGTCCAGTTCCAG
GCTGGTGTGAAACTGAAGAGCTTCCGCATCTTGCTTGGGTTGGTGGGCTCGGCCCGCACT
GCCTGGTACTGCTCATCCGTCAGGACCTTCCCGTACAGAGCATCCAGCAGCCACTCAACG
TTTGTGACCCTCGCGATAAGCGCAGCCCGGTGCTGGTCTATAAAGTGCAGGCCTGGCTTG
GCTGCCGACTGAGGAGGGGCCTGGATCCCAGCTGGCGCGGCTCCAGAGCCCTGGTGCGTG
GCCGCCTGCAGCTGCCCGGCCATCTCCTGCAGGCCCATGTCGCGCAGCACGTTAGCGGTG
AGCTCGGCGCCGTAGGTCTCCAGGTAGAAGCTGACCAGCTTGTCGGTGAGGTCCAAGGCG
TCCATGGACAGCAGCGCGCCCCGCGGGATGCGCCCGTAGCCCTCGCGCAGCGGCACCGAC
CGCAGCTTCAGCTTGAACTTCTTGAGCTCCTCGGCGGTCAGGTTCTCCAGCGCATCCAGG
AAGGCGTCGCGCGCGCGCCCCATGGCTCCAGGATCCCCGGCCGGTGGCGCCGCTCACCCC
CCTTGACTCGAATTCGCGGCCGCCCTATTAGGAGTCGATTACAAAATTCTGACGGTTCAC
TAAACGAGCTCTGCTTTTATAGAACCTCCCCCGGTACCACCCT
Restriction Sites NotI-NotI     
ACCN NM_145182
ORF Size 531 bp
Insert Size 780
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_145182.1, NP_660183.1
RefSeq Size 879
RefSeq ORF 531
Locus ID 29108
Domains PAAD_DAPIN
Protein Families Druggable Genome
Protein Pathways Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway
Gene Summary This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (2) lacks an internal coding exon compared to variant 1. It maintains the same reading frame, and encodes a shorter isoform (b) missing a segment of 19 aa, compared to isoform a.

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