PILRA (NM_178272) Human Untagged Clone

CAT#: SC110417

PILRA (untagged)-Human paired immunoglobin-like type 2 receptor alpha (PILRA), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PILRA
• Synonyms: FDF03
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_178272, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGTCGGCCCCTGCTGCTGCCCCTACTGCCCTTGCTGCTGCCGCCAGCATTTCTGCAGCCTAGTGGCT
  CCACAGGATCTGGTCCAAGCTACCTTTATGGGGTCACTCAACCAAAACACCTCTCAGCCTCCATGGGTGG
  CTCTGTGGAAATCCCCTTCTCCTTCTATTACCCCTGGGAGTTAGCCACAGCTCCCGACGTGAGAATATCC
  TGGAGACGGGGCCACTTCCACAGGCAGTCCTTCTACAGCACAAGGCCGCCTTCCATTCACAAGGATTATG
  TGAACCGGCTCTTTCTGAACTGGACAGAGGGTCAGAAGAGCGGCTTCCTCAGGATCTCCAACCTGCAGAA
  GCAGGACCAGTCTGTGTATTTCTGCCGAGTTGAGCTGGACACACGGAGCTCAGGGAGGCAGCAGTGGCAG
  TCCATCGAGGGGACCAAACTCTCCATCACCCAGGGTCAGCAGCGGACTAAAGCCACAACCCCAGCCAGGG
  AACCCTTCCAAAACACAGAGGAGCCATATGAGAATATCAGGAATGAAGGACAAAATACAGATCCCAAGCT
  AAATCCCAAGGATGACGGCATCGTCTATGCTTCCCTTGCCCTCTCCAGCTCCACCTCACCCAGAGCACCT
  CCCAGCCACCGTCCCCTCAAGAGCCCCCAGAACGAGACCCTGTACTCTGTCTTAAAGGCCTAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_178272 unedited
  GCACGAGGGCTGGGTCCCTGAATCACCGACTGGAGGAGAGTTACCTACAAGAGCCTTCAT
  CCAGGAGCATCCACACTGCAATGATATAGGAATGAGGCGGCCCCTCCACAGGGCCCCTCT
  CCTGCCTGGACGGCTCTGCTGGTCTCCCCGTCCCCTGGAGAAGAACAAGGCCATGGGTCG
  GCCCCTGCTGCTGCCCCTACTGCCCCTGCTGCTGCCGCCAGCATTTCTGCAGCCTAGTGG
  CTCCACAGGATCTGGTCCAAGCTACCTTTATGGGGTCACTCAACCAAAACACCTCTCAGC
  CTCCATGGGTGGCTCTGTGGAAATCCCCTTCTCCTTCTATTACCCCTGGGAGTTAGCCAC
  AGCTCCCGACGTGAGAATATCCTGGAGACGGGGCCACTTCCACGGGCAGTCCTTCTACAG
  CACAAGGCCGCCTTCCATTCACAAGGATTATGTGAACCGGCTCTTTCTGAACTGGACAGA
  GGGTCAGAAGAGCGGTTTCCTCAGGATCTCCAACCTGCAGAAGCAGGACCAGTCTGTGTA
  TTTCTGCCGAGTTGAGCTGGACACACGGAGCTCAGGGAGGCAGCAGTGGCAGTCCATCGA
  GGGGACCAAACTCTCCATCACCCAGGGTCAGCAGCGGACTAAAGCCACAACCCCAGCCAG
  GGAACCCTTCCA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_178272
• ORF Size: 693 bp
• Insert Size: 1600
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_178272.1, NP_840056.1
• RefSeq Size: 1104
• RefSeq ORF: 693
• Locus ID: 29992
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) lacks a coding exon, compared to variant 1, resulting in a protein (isoform 2) with a missing internal segment, compared to isoform 1. Isoform 2 is thought to be a soluble protein, since it lacks the transmembrane domain found in isoform 1.