DIABLO (NM_138929) Human Untagged Clone

CAT#: SC110581

DIABLO (untagged)-Human diablo, IAP-binding mitochondrial protein (DIABLO), nuclear gene encoding mitochondrial protein, transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DIABLO
• Synonyms: DFNA64; DIABLO-S; SMAC; SMAC3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_138929, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGCTCTGAAGAGTTGGCTGTCGCGCAGCGTAACTTCATTCTTCAGGTACAGACAGTGTTTGTGTG
  TTCCTGTTGTGGCTAACTTTAAGAAGCGGTGTTTCTCAGAATTGATAAGACCATGGCACAAAACTGTGAC
  GATTGGCTTTGGAGTAACCCTGTGTGCGGTTCCTATTGCACAGGCTGTTTATACCTTAACTTCTCTTTAC
  CGACAATATACAAGTTTACTTGGGAAAATGAATTCAGAGGAGGAAGATGAAGTGTGGCAGGTGATCATAG
  GAGCCAGAGCTGAGATGACTTCAAAACACCAAGAGTACTTGAAGCTGGAAACCACTTGGATGACTGCAGT
  TGGTCTTTCAGAGATGGCAGCAGAAGCTGCATATCAAACTGGCGCAGATCAGGCCTCTATAACCGCCAGG
  AATCACATTCAGCTGGTGAAACTGCAGGTGGAAGAGGTGCACCAGCTCTCCCGGAAAGCAGAAACCAAGC
  TGGCAGAAGCACAGATAGAAGAGCTCCGTCAGAAAACACAGGAGGAAGGGGAGGAGCGGGCTGAGTCGGA
  GCAGGAGGCCTACCTGCGTGAGGATTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_138929 unedited
  TCAAATTTTGTAATACGACTCACTATTAGGGCGGCCGCGATTCGGCACGAGGGTCTGGCG
  TCCGCGCGCTGCACAATGGCGGCTCTGAAGATTGGCTGTCGCGCAGCGTAACTTCATTCT
  TCAGGTACAGACAGTGTTTGTGTGTTCCTGTTGTGGCTAACTTTAAGAAGCGGTGTTTCT
  CAGAATTGATAAGACCATGGCACAAAACTGTGACGATTGGCTTTGGAGTAACCCTGTGTG
  CGGTTCCTATTGCACAGAAATCAGAGCCTCATTCCCTTAGTAGTGAAGCATTGATGAGGA
  GAGCAGTGTCTTTGGTAACAGATAGCACCTCTACCTTTCTCTCTCAGACCACATATGCGT
  TGATTGAAGCTATTACTGAATATACTAAGGCTGTTTATACCTTAACTTCTCTTTACCGAC
  AATATACAAGTTTACTTGGGAAAATGAATTCAGAGGAGGAAGATGAAGTGTGGCAGGTGA
  TCATAGGAGCCAGAGCTGAGATGACTTCAAAACACCAAGAGTACTTGAAGCTGGAAACCA
  CTTGGATGACTGCAGTTGGTCTTTCAGAGATGGCAGCAGAAGCTGCATATCAAACTGGCG
  CAGATCAGGCCTCTATAACCGCCAGGAATCACATTCAGCTGGTGAAACTGCAGGTGGAAG
  AGGTGCACCAGCTCTCCCGGAAAGCAGAAACCAAGCTGGCAGAAGCACAGATAGAAGAGC
  TCCGTCAGAAACACAGNANGAAAGGGGAGGAGCGGGCTGAGTCNGAGCAGGAGGCCTACC
  TGCGTGAGGATTGAGGGCCTGAGCCACTGCCCTGTCTCCCACTCAGTGGGAAAGCAGGNG
  CAGATGCCACCCTGCCANGGGTTGCATGACTGTCTGTGCACCGAGAGAGGCCGCAGATCC
  TGNCCTGGNCATCAGCGAGAGCCTTTGNAGCTTGGAGTGCTNCTGTGGTCTAGGCTGCCT
  GGACCTGGTCTTANCCTTGGCC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_138929 unedited
  TCTGAACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTAAAACCCTGTTGATGTTAAACTCCTGTTGAAAAG
  CACCAGGTAAACACTCTGCACCCCTTTTTTTAAAAAAAAAAGGTTTTTCACTCCTTGGCC
  TCAGCTGTCCTCACAGGACAGGGGGGGCAGATCAAAAAACACATTCAAAAATACCTACAA
  AAAAATCGTACAAACTGGACAGGTTCCCCTCCCCCTGCCACAACTGGCATCCCAACAGAG
  GGAACAAGTCCTAAATCTTTTTTGACGACGTAAATAAAACTGAAAACAGGTTAAACAGTT
  GCTGAACTTAAGGGCATGACAAAAAGGACTCCTTTCTTTGACCCAGGTAGGCAAAATGCT
  TTGGGGGGGAGGAAAAAAAAATGGGTAAAACCAGCTGTCCAAAGGGGGGGGAAATGTTAA
  ACAGGGTGCAGGGCCCAAGGGCTAAAAACCAGGTCCAGCGCAAGCCTGAAACCACAGGAG
  GCACTCACAGCTCACAAAGGCGTTTTGCCTGATTGGCCAGGGCAGGATCTGCCGCCTCTT
  TTTGGTGCACAAACAGTCATGCCAACCCTGGGCAGGGTGGAATTTGCCCCTGTTTTCCCC
  ACTGAGTGGGGAAACAGGGCAGTGTGCCTCAGCCCTAATTCCTAACGCAGGTAGGCCCTC
  CTGTTCCAAATAAAACCCGTTTCTCCCCTTCCTCCTGTGTTTTTTGAGGGAGCTCTTTTA
  TTTGGGCTCCGGCCACACTGGTTTTTCGTTTTTCGGGAAAAGTGGGGCACCCTTTTCCCT
  CGGAGTTCCACCACCGAGAAGGAATCCCGGCCGGTTATAAACGCCCTGACTGCCCCCATT
  TAAATCCACCTTTGTTGCCCTTTCTAAAAACCACCTGGACTCCCCAGGTGTTCCCACTTC
  AAACCTTTTGAGGTTTGAAAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_138929
• ORF Size: 588 bp
• Insert Size: 1320
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_138929.2, NP_620307.1
• RefSeq Size: 1366
• RefSeq ORF: 588
• Locus ID: 56616
• Protein Families: Transmembrane
• Gene Summary: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  Transcript Variant: This variant (3) lacks an in-frame segment, compared to variant 1. The resulting isoform (3) is shorter than isoform 1 and retains only a small portion of the IAP-binding domain. The isoform was previously identified as Smac-delta.