TMPRSS3 (NM_032401) Human Untagged Clone

CAT#: SC110610

TMPRSS3 (untagged)-Human transmembrane protease, serine 3 (TMPRSS3), transcript variant B

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TMPRSS3
• Synonyms: DFNB8; DFNB8, DFNB10, ECHOS1, TADG12; DFNB10; ECHOS1; OTTHUMP00000109345; serine protease TADG12; TADG12; transmembrane protease, serine 3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110610 sequence for NM_032401 edited (data generated by NextGen Sequencing)
  ATGTGCTCCGATGACTGGAAGGGTCACTACRCAAATGTTGCCTGTGCCCAACTGGGTTTC
  CCAAGCTATGTGAGTTCAGATAACCTCAGAGTGAGCTCGCTGGAGGGGCAGTTCCGGGAG
  GAGTTTGTGTCCATCGATCACCTCTTGCCAGATGACAAGGTGACTGCATTACACCACTCA
  GTATATGTGAGGGAGGGATGTGCCTCTGGCCACGTGGTTACCTTGCAGTGCACAGCCTGT
  GGTCATAGAAGGGGCTACAGCTCACGCATCGTGGGTGGAAACATGTCCTTGCTCTCGCAG
  TGGCCCTGGCAGGCCAGCCTTCAGTTCCAGGGCTACCACCTGTGCGGGGGCTCTGTCATC
  ACGCCCCTGTGGATCATCACTGCTGCACACTGTGTTTATGACTTGTACCTCCCCAAGTCA
  TGGACCATCCAGGTGGGTCTAGTTTCCCTGTTGGACAATCCAGCCCCATCCCACTTGGTG
  GAGAAGATTGTCTACCACAGCAAGTACAAGCCAAAGAGGCTGGGCAATGACATCGCCCTT
  ATGAAGCTGGCCGGGCCACTCACGTTCAATGAAATGATCCAGCCTGTGTGCCTGCCCAAC
  TCTGAAGAGAACTTCCCCGATGGAAAAGTGTGCTGGACGTCAGGATGGGGGGCCACAGAG
  GATGGANNNGGTGACGCCTCCCCTGTCCTGAACCACGCGGCCGTCCCTTTGATTTCCAAC
  AAGATCTGCAACCACAGGGACGTGTACGGTGGCATCATCTCCCCCTCCATGCTCTGCGCG
  GGCTACCTGACGGGTGGCGTGGACAGCTGCCAGGGGGACAGCGGGGGGCCCCTGGTGTGT
  CAAGAGAGGAGGCTGTGGAAGTTAGTGGGAGCGACCAGCTTTGGCATCGGCTGCGCAGAG
  GTGAACAAGCCTGGGGTGTACACCCGTGTCACCTCCTTCCTGGACTGGATCCACGAGCAG
  ATGGAGAGAGACCTAAAAACCTGA
  
  Clone variation with respect to NM_032401.1
  31 g=>r;667 g=>n;668 c=>n;669 a=>n
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_032401 unedited
  NGGTTCANATTATGTATACGACTCCTATAGGCGGCCGGATTGGCCGAGGGAAGGGCTGTG
  TTTATGGGAAGCCAGTACACTGTGGCCTACTATCTCTTCCGTGGTGCCATCTACATTTTT
  GGGACTCGGGAATTATGAGGTAGAGGTGGAGGCGGAGCCGGATGTCAGAGGTCCTGAAAT
  AGTCACCATGGGGGAAAATGATCCGCCTGCTGTTGAAGCCCCCTTCTCATTCCGATCGCT
  TTTTGGCCTTGATGATTTGAAAATAAGTCCTGTTGCACCAGATGCAGATGCTGTTGCTGC
  ACAGATCCTGTCACTGCTGCCATTGAAGTTTTTTCCAATCATCGTCATTGGGATCATTGC
  ATTGATATTAGCACTGGCCATTGGTCTGGGCATCCACTTCGACTGCTCAGGGAAGTACAG
  ATGTCGCTCATCCTTTAAGTGTATCGAGCTGATAGCTCGATGTGACGGAGTCTCGGATTG
  CAAAGACGGGGAGGACGAGTACCGCTGTGTCCGGGTGGGTGGTCAGAATGCCGTGCTCCA
  GGTGTTCACAGCTGCTTCGTGGAAGACCATGTGCTCCGATGACTGGAAGGGTCACTACAC
  AAATGTTGCCTGTGCCCAACTGGGTTTCCCAAGCTATGTGAGTTCAGATAACCCTCAGAG
  TGAGCTCGCTGGAGGGGCAGTTCCGGGAGGAGTTTGTGTTCATCGATCACCTCTTGCCAG
  ATGAACAGGGTGACTGCATTACACCACTCCATATATGTGAGGGAAGGGATGTGCCTCTGG
  CCCACGTGTTTCACCTGCAGTGCACAGCCTGTGGTCATAACAACGCCTACCGCTCACGCA
  TCCGGGGTGGAAACATGTTCCTTCTCCTCGCATGGCCCTGGCAGGCCACCCTCTCATTCC
  AGGCTACCCCCTGGCG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_032401 unedited
  CTATGGAACGCGGCACGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGAGGGAAGGA
  AACATATTATTTGGAATCAAGGGCAATAATACGTCAAGCACCAAATGCTACAAAGAAATC
  ATGAAAATAGGCCTTAAACGAGTCATTCCTAGATTAACCTCCCCACATGTGAAAATAAGT
  CTTGGAAGTAGAAAGGGTGGGTTTGGTTCTGGTCCCTAGAGATGAAAACGTGCAGTGACT
  GCAGTTCTGCACTTCTGGGCTGGTGCGTCTTTTCTGAGTGGCTGTTGGTGGCTTTGCACG
  TGAGGTCACATAACTGCTTATCTCGTCAGGAATTTTGCAAGACCCTGGAGAGAAAACCAG
  ATGGACCAGTGGGAAAGGCCGCCCTTGCAAGTTGCTGCTTCTTTTGTTCTTAGTGAAGAT
  CAGAAAGGAGCGTGAGGCTAGGCGTGGTGGCCCATGCCTGTAATCCCAGCACTGTGGGAG
  GCTGAAGCAGGCACATCATTTGAGGTCAGGGGTTTGAGAGCAGCCTGGCCAACATGGTGA
  AACCCTGTCTCTACTAAAAATACAAAAATTAGTTGGGTGTGGTGGCGGGCACCTGTGGTC
  CCAGCTACTGGGGAAGCTGAGGCAAGAGAATCGCTTGAACCAGGGAAGCGGAGGCTGCAG
  TGAGCAGGNATTTCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCACCTCAAA
  AAACAAAAAACAAAAAGCAGCTTGAAAGCTGTGCTGGAATCAAATGGAAGGGTGCCTCTT
  TCGGGCCTGCTACTGGTGCCCGGACTCANAGCTCCAAGGTTGTCTGCTCGTGTGCAGGTT
  CCTCCCCGGAGTCCACGGGAGGAATCGGCTGGCTTCTCACCTCAGAACCAGGTGGCTACT
  TGCCCCCTCCTCTTCAGGTTTTAGGGCTCCTCCTCTGCCGCGGTCCAGCCAGAAGGAGGG
  ACCGGTTTCACCCAGCCTGGTACCTTGGCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_032401
• ORF Size: 984 bp
• Insert Size: 2290
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_032401.1, NP_115777.1
• RefSeq Size: 2554
• RefSeq ORF: 984
• Locus ID: 64699
• Domains: Tryp_SPc
• Protein Families: Druggable Genome, Protease, Transmembrane
• Gene Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
  Transcript Variant: This variant (B) lacks exons 1 and 2, but contains 384 nt of intron 2 preceding exon 3, possibly through the use of an alternative splice donor site. As a result, this variant lacks the exon 2 start codon and translation begins at a downstream in-frame start codon. The encoded protein has a 127 aa shorter N-terminus, as compared to isoform 1, and is identical to the protein encoded by variant C.