TEM8 (ANTXR1) (NM_053034) Human Untagged Clone

CAT#: SC110684

ANTXR1 (untagged)-Human anthrax toxin receptor 1 (ANTXR1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ANTXR1
• Synonyms: ATR; GAPO; TEM8
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_053034, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCACGGCGGAGCGGAGAGCCCTCGGCATCGGCTTCCAGTGGCTCTCTTTGGCCACTCTGGTGCTCA
  TCTGCGCCGGGCAAGGGGGACGCAGGGAGGATGGGGGTCCAGCCTGCTACGGCGGATTTGACCTGTACTT
  CATTTTGGACAAATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTTGGCT
  CACAAATTCATCAGCCCACAGTTGAGAATGTCCTTTATTGTTTTCTCCACCCGAGGAACAACCTTAATGA
  AACTGACAGAAGACAGAGAACAAATCCGTCAAGGCCTAGAAGAACTCCAGAAAGTTCTGCCAGGAGGAGA
  CACTTACATGCATGAAGGATTTGAAAGGGCCAGTGAGCAGATTTATTATGAAAACAGACAAGGGTACAGG
  ACAGCCAGCGTCATCATTGCTTTGACTGATGGAGAACTCCATGAAGATCTCTTTTTCTATTCAGAGAGGG
  AGGCTAATAGGTCTCGAGATCTTGGTGCAATTGTTTACTGTGTTGGTGTGAAAGATTTCAATGAGACACA
  GCTGGCCCGGATTGCGGACAGTAAGGATCATGTGTTTCCCGTGAATGACGGCTTTCAGGCTCTGCAAGGC
  ATCATCCACTCAATTTTGAAGAAGTCCTGCATCGAAATTCTAGCAGCTGAACCATCCACCATATGTGCAG
  GAGAGTCATTTCAAGTTGTCGTGAGAGGAAACGGCTTCCGACATGCCCGCAACGTGGACAGGGTCCTCTG
  CAGCTTCAAGATCAATGACTCGGTCACACTCAATGAGAAGCCCTTTTCTGTGGAAGATACTTATTTACTG
  TGTCCAGCGCCTATCTTAAAAGAAGTTGGCATGAAAGCTGCACTCCAGGTCAGCATGAACGATGGCCTCT
  CTTTTATCTCCAGTTCTGTCATCATCACCACCACACACTGTTCTGACGGTTCCATCCTGGCCATCGCCCT
  GCTGATCCTGTTCCTGCTCCTAGCCCTGGCTCTCCTCTGGTGGTTCTGGCCCCTCTGCTGCACTGTGATT
  ATCAAGGAGGTCCCTCCACCCCCTGCCGAGGAGAGTGAGGAAAATAAAATAAAATAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_053034 unedited
  GCACGAGGCCCGGACCGAGGCAGCCCTCCCCTTTAAAAGAAGCGGAGGACAGGATTGGGA
  TCCTTGAAACCCGAAACCCAGAAACAGCATCGGAGCGGAAACCAGAGGGGAAACCTTGAA
  CTCCTCCAGACAATTGCTTCCGGGGAGTTGCGAGGGAGCGAGGGGGAATAAAGGACCCGC
  GAGGAAGGGCCCGCGGATGGCGCGTCCCTGAGGGTCGTGGCGAGTTCGCGGAGCGTGGGA
  AGGAGCGGACCCTGCTCTCCCCGGGCTGCGGGCCATGGCCACGGCGGAGCGGAGAGCCCT
  CGGCATCGGCTTCCAGTGGCTCTCTTTGGCCACTCTGGTGCTCATCTGCGCCGGGCAAGG
  GGGACGCAGGGAGGATGGGGGTCCAGCCTGCTACGGCGGATTTGACCTGTACTTCATTTT
  GGACAAATCAGGAAGTGTGCTGCACCACTGGAATGAAATCTATTACTTTGTGGAACAGTT
  GGCTCACAAATTCATCAGCCCACAGTTGAGAATGTC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_053034
• ORF Size: 1107 bp
• Insert Size: 5000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_053034.1, NP_444262.1
• RefSeq Size: 1454
• RefSeq ORF: 1107
• Locus ID: 84168
• Domains: VWA
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
  Transcript Variant: This variant (2) has an alternative 3' coding region and 3' UTR segment and lacks multiple segments, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.