ACOX1 (NM_004035) Human Untagged Clone

CAT#: SC110818

ACOX1 (untagged)-Human acyl-CoA oxidase 1, palmitoyl (ACOX1), transcript variant 1


  "NM_004035" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ACOX1
Synonyms ACOX; PALMCOX; SCOX
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC110818 sequence for NM_004035 edited (data generated by NextGen Sequencing)
ATGAACCCGGACCTGCGCAGGGAGCGGGATTCCGCCAGCTTCAACCCGGAGCTGCTTACA
CACATCCTGGACGGCAGCCCCGAGAAAACCCGGCGCCGCCGAGAGATCGAGAACATGATC
CTGAACGACCCAGACTTCCAGCATGAGGACTTGAACTTCCTCACTCGCAGCCAGCGTTAT
GAGGTGGCTGTCAGGAAAAGTGCCATCATGGTGAAGAAGATGAGGGAGTTTGGCATCGCT
GACCCTGATGAAATTATGTGGTTTAAAAATTTTGTGCACCGAGGGCGGCCTGAGCCTCTG
GATCTTCACTTGGGCATGTTCCTGCCCACCTTGCTTCACCAGGCAACTGCGGAGCAGCAG
GAGCGCTTCTTCATGCCCGCCTGGAACTTGGAGATCATTGGCACTTATGCCCAGACAGAG
ATGGGTCATGGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACC
CAGGAGTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTT
GGAAAGACTTCAAATCATGCAATAGTTCTTGCCCAGCTCATCACTAAGGGGAAATGCTAT
GGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGA
ATTACCGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTC
AAAATGGACAACCATCGTATTCCCAGAGAAAACATGCTGATGAAGTATGCCCAGGTGAAG
CCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTT
GTCAGGTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCC
ATCCGATACAGCGCTGTGAGGCACCAGTCTGAAATCAAGCCAGGTGAACCAGAACCACAG
ATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCC
TTCCAGTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGT
CAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGCCCTCACCGCTGGACTGAAGGCTTTC
ACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGC
TATTCTCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTT
GAGGGAGAAAACACTGTCATGATGCTCCAGACGGCTAGGTTCCTGATGAAAAGTTATGAT
CAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGT
CAGCGCATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCC
GAAAGCCTAACCGAAGCATATAAACTCCGTGCAGCCAGATTAGTAGAAATTGCTGCAAAA
AACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCT
GTTGACCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCA
GAAAAACTCCTCAAAATTCAAGATAAAGCCATTCAAGCTGTCTTAAGGAGTTTATGTCTG
CTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATG
ACAGAGCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGC
TCAGATGCTGTTGCTTTGGTTGATGCATTTGATTTTCAGGATGTGACACTTGGCTCTGTG
CTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCA
CTGAACAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCCAAGCTC
TGA

Clone variation with respect to NM_004035.6
>OriGene 5' read for NM_004035 unedited
CAACATTTTGTAATACGAACTCACTATAGGGCGGCCGCGAATCGGCACCGGGTGCTTACT
TCGCTGCCAGCTGGTCGTCGCCATGAACCCGGACCTGCGCAGGGAGCGGGATTCCGCCAG
CTTCAACCCGGAGCTGCTTACACACATCCTGGACGGCAGCCCCGAGAAAACCCGGCGCCG
CCGAGAGATCGAGAACATGATCCTGAACGACCCAGACTTCCAGCATGAGGACTTGAACTT
CCTCACTCGCAGCCAGCGTTATGAGGTGGCTGTCAGGAAAAGTGCCATCATGGTGAAGAA
GATGAGGGAGTTTGGCATCGCTGACCCTGATGAAATTATGTGGTTTAAAAATTTTGTGCA
CCGAGGGCGGCCTGAGCCTCTGGATCTTCACTTGGGCATGTTCCTGCCCACCTTGCTTCA
CCAGGCAACTGCGGAGCAGCAGGAGCGCTTCTTCATGCCCGCCTGGAACTTGGAGATCAT
TGGCACTTATGCCCAGACAGAGATGGGTCATGGAACTCACCTTCGAGGCTTGGAAACCAC
AGCCACGTATGACCCTGAAACCCAGGAGTTCATTCTCAACAGTCCTACTGTGACCTCCAT
TAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCAGCT
CATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGG
GACCCATAAGCCTTTGCCAGGAATTACCGTTGGTGACATCGGCCCCAAATTTGGTTATGA
TGAGATAGACAATGGCTACCTCANAATGGGACACCATCGTATTCCCAGAGAAAACATGCT
GATGAAGTATGCCCCAGTGAAGCCTGATGGCACATACGTGAAACCGGCTGAGTAACAGCT
GACTTACGGGACCATGGTGGTTGTCANGGTCCTTCTTGTGGGAGAAGCTGCTCNGGCTCT
GTCTAAGCGTGCCN
>OriGene 3' read for NM_004035 unedited
TTATAATCTTTTTTTTTTTTTTTGACTTTAAGAAAAAATAATTAAGATGTATTTAACCTT
TAAGTATAGAATGATTGTATAAATTAGATTTCAACTGAAAGGACAATTAGCGATTCAGAG
AAAGCTCCTAGAAATAGACTGAAAACAAAGCCATACATAGAGTAAGAAATAGAACCTATG
GAACTTCCATTTTTCTAACTATAGTTTTTTGGTTTTGTTTTTTCCCAGTTGTTAAAAAAA
AAACAACTCACAGTTTCAATATTTTCTGAACCAAAAATCAGAACACATGGTTTGTGTCAA
AGGGTTTTTCTGTGCTACGTCTGGGAGTGCTGACCTAAGTGACATTTTTTTTTAATGCCA
AATACAGTAATCTCCAAGCTTTTAATGGCTTATGCCAAGATGACAGAATATGTGAAATCT
GATTGTCCCAGAGTTACACTCTGCACTCCAAAGCTACAACAGTGCCACAGCTGAGAGGTT
TCCCTATACTTCCTACTACTGTGACAATTTAGCAATCCTTCAAATGGAAAATTCCTAATT
ACACGAGACAATGGTCCTACAGTAGGCCCGTGCGGAATAAGTTCCCTCGTTGGAAAAATG
CTAGCATGAATAGTTTGATAAATGCAATCCATCAGCAAAGGAGAGCAAGCAGGCAGAGAC
TGTGCCAAGCAGAAACTCATTCGCATCAAGTTTTCCAAATAAGTTCCTCTCCCCCAGTCC
CCTTTTCTTCATTCCTGCTTTTAAGCCCAGCCCCCAGGTAAGTCTGGTAGAACACTGAGC
AGGAAAGCTTTGGAGGGTTCTACACCACTTTCAAAATACCTTTGGTTTATAAACACTTAT
TAGCCCGTGATTAGCAATTAACATGGGAAAATAATCAACTACCCCGAGAGTTGAATTCG
Restriction Sites NotI-NotI     
ACCN NM_004035
Insert Size 3250 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004035.4, NP_004026.2
RefSeq Size 3445 bp
RefSeq ORF 1983 bp
Locus ID 51
Cytogenetics 17q25.1
Domains ACOX, Acyl-CoA_dh
Protein Families Druggable Genome
Protein Pathways alpha-Linolenic acid metabolism, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism, Metabolic pathways, PPAR signaling pathway
Gene Summary 'The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (1) encodes isoform a, alternately referred to as ACOX1b per PMID: 17603022. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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