Adenylosuccinate Lyase (ADSL) (NM_000026) Human Untagged Clone

CAT#: SC110822

ADSL (untagged)-Human adenylosuccinate lyase (ADSL), transcript variant 1


  "NM_000026" in other vectors (5)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ADSL
Synonyms AMPS; ASASE; ASL
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_000026, the custom clone sequence may differ by one or more nucleotides


ATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGCTACCGCTCACCTCTTGCCTCCCGCTATGCCAGCC
CGGAGATGTGCTTCGTGTTTAGCGACAGGTATAAATTCCGGACATGGCGGCAGCTGTGGCTGTGGCTGGC
GGAGGCCGAGCAGACATTGGGTTTGCCTATCACAGATGAACAAATCCAGGAGATGAAATCAAACCTGGAG
AACATCGACTTCAAGATGGCAGCTGAGGAAGAGAAACGTTTACGACATGATGTGATGGCTCACGTGCACA
CATTTGGCCACTGCTGTCCAAAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCTTGCTATGTTGGAGA
CAATACTGACTTGATTATTCTTAGAAATGCACTTGACCTGCTTTTGCCAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTCCAGCCTGCAC
AGCTGACCACAGTTGGGAAACGTTGCTGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAA
GCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGTACCACTGGCACTCAGGCCAGTTTCCTGCAG
CTCTTTGAGGGAGATGACCATAAGGTAGAGCAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTTAAGA
GAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAG
CTTGGGGGCATCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAA
CCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGATGCCATATAAGCGGAATCCCATGCGTTCAGAACGTT
GCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAGACAGCATCTGTCCAGTGGTT
TGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGTTTGGCCGAGGCATTTCTTACCGCAGATACT
ATATTGAATACGCTGCAGAACATTTCTGAAGGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTC
GGCAAGAGCTGCCTTTCATGGCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCA
GGATTGCCATGAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTCTGTGGTTAAGCAGGAAGGGGGTGAC
AATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTGGATCATTTAC
TGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTCTTAGAAGAGGAGGTGTATCC
CCTGTTAAAACCATATGAAAGCGTGATGAAGGTGAAAGCAGAATTATGTCTGTAG


>OriGene 5' read for NM_000026 unedited
CGTCAGATTTGAACTCGACTCATATAGGCGGCCGCTNAATCGGCACGAGGCCTCGTGCCG
AATTCGGCACGAGGCAGGGTTGGGATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGC
TACCGCTCACCTCTTGCCTCCCGCTATGCCAGCCCGGAGATGTGCTTCGTGTTTAGCGAC
AGGTATAAATTCCGGACATGGCGGCAGCTGTGGCTGTGGCTGGCGGAGGCCGAGCAGACA
TTGGGTTTGCCTATCACAGATGAACAAATCCAGGAGATGAAATCAAACCTGGAGAACATC
GACTTCAAGATGGCAGCTGAGGAAGAGAAACGTTTACGACATGATGTGATGGCTCACGTG
CACACATTTGGCCACTGCTGTCCAAAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCT
TGCTATGTTGGAGACAATACTGACTTGATTATTCTTAGAAATGCACTTGACCTGCTTTTG
CCAAAGCTTGCCAGAGTGATCTCTCGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTA
CCCACATTAGGTTTCACACATTTCCAGCCTGCACAGCTGACCACAGTTGGGAAACGTTGC
TGTCTTTGGATTCAGGATCTTTGCATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGAC
CTGCGCTTCCGGGGAGTAAAGGGTACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTT
GAGGGAGATGACCATAANGTAGAGCAGCTTGACTAGATGGTGACAGACAAGGCAGGATTT
TAGAGAGCTTTCATCATCACAGGGCAGACATATACACGAAAAGTGGATAATGCAGTACTG
TCTGTGCTGGCTAGCTTGNGGNCATCAGTGCACAGATTTGCACTGACTACCCCTCTGCCA
AACTCAGGAGATGTAGCACCCTTTGAC
>OriGene 3' read for NM_000026 unedited
TCGACATATACAATGATTTTCGTTTAATTCTCTTCCAACTCTACATACATAATTCTGCTT
TCACCTTCATCACGCTTTCATATGGTTTTAACAGGGGATACACCTCCTCTTCTAAGAATC
TCTGCACCTGCTGGGAGGCACGACCAGTGAAAGAAGAAGGATCCAGTAAATGATCCAACT
GGGAGTGAATGGGACTGAAGTAGGCATCAACCTGGATACGCTCTATGAGGTCATTGTCAC
CCCCTTCCTGCTTAACCACAGAAGCTGCCTGCTGAGAAAGCACTCTGATTTTCTCATGGC
AATCCTGGCGGCTACCTCCAGCTTTGACCATGGCCATGATGATGTTCTCTGTGGCCATGA
AAGGCAGCTCTTGCCGAATGCGCCGTTCAATTACTTTGGGGTACACGACCAATCCTTCAG
AAATGTTCTGCAGCGTATTCAATATAGTATCTGCGGTAAGAAATGCCTCGGCCAAACAGA
TCCGTCGGTTGGCACTATCATCCAGTGTGCGTTCAAACCACTGGACAGATGCTGTCTGTA
GCGGGTCCATGACAAGGGTCATCATGTGGCGGGCAAGACTGCAGCAACGTTCTGAACGCA
TGGGATTCCGCTTATATGGCATCGCACTTGAGCCAATCTGCTGTTTTTCAAAGGGTTCCT
CCATCTNCTTGAGGTTGCCAGGAGGCGTATGTCGGTGCAAATCTTGTGCACTGATGCCCC
CAAGCTAGCCAGCACAGACAGTACTTAATATCCACTTTCCTGTATATGTCTGCCCTGTGA
TGATGATAGCTCTCTTTAATCCTGCCTTTTCTGTCACCATCTTGTCAAGCTGCTCTACCT
TATGGTCATTTCCCTAAAGGACTGCAAGAAACTGGCCCTGATGCCATTGTTTCCCTTTTC
TCCCAGGATCGCAGTTATCTCCGGCACGCTTAATGTCTGGAAATCCTCCAAATTCCTGAT
CCAAACACGTACGTTCCAACTGGGGCACN
Restriction Sites NotI-NotI     
ACCN NM_000026
Insert Size 1650 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000026.1, NP_000017.1
RefSeq Size 1692 bp
RefSeq ORF 1455 bp
Locus ID 158
Cytogenetics 22q13.1
Domains lyase_1
Protein Families Druggable Genome
Protein Pathways Alanine, aspartate and glutamate metabolism, Metabolic pathways, Purine metabolism
Gene Summary 'The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]'
Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (a).

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