FMRP (FMR1) (NM_002024) Human Untagged Clone

CAT#: SC110897

FMR1 (untagged)-Human fragile X mental retardation 1 (FMR1), transcript variant ISO1


  "NM_002024" in other vectors (6)

Reconstitution Protocol

USD 1,070.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol FMR1
Synonyms FMRP; FRAXA; POF; POF1; POFX
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_002024, the custom clone sequence may differ by one or more nucleotides


ATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACAAGGCATTTGTAAAGGATGTTC
ATGAAGATTCAATAACAGTTGCATTTGAAAACAACTGGCAGCCTGATAGGCAGATTCCATTTCATGATGT
CAGATTCCCACCTCCTGTAGGTTATAATAAAGATATAAATGAAAGTGATGAAGTTGAGGTGTATTCCAGA
GCAAATGAAAAAGAGCCTTGCTGTTGGTGGTTAGCTAAAGTGAGGATGATAAAGGGTGAGTTTTATGTGA
TAGAATATGCAGCATGTGATGCAACTTACAATGAAATTGTCACAATTGAACGTCTAAGATCTGTTAATCC
CAACAAACCTGCCACAAAAGATACTTTCCATAAGATCAAGCTGGATGTGCCAGAAGACTTACGGCAAATG
TGTGCCAAAGAGGCGGCACATAAGGATTTTAAAAAGGCAGTTGGTGCCTTTTCTGTAACTTATGATCCAG
AAAATTATCAGCTTGTCATTTTGTCCATCAATGAAGTCACCTCAAAGCGAGCACATATGCTGATTGACAT
GCACTTTCGGAGTCTGCGCACTAAGTTGTCTCTGATAATGAGAAATGAAGAAGCTAGTAAGCAGCTGGAG
AGTTCAAGGCAGCTTGCCTCGAGATTTCATGAACAGTTTATCGTAAGAGAAGATCTGATGGGTCTAGCTA
TTGGTACTCATGGTGCTAATATTCAGCAAGCTAGAAAAGTACCTGGGGTCACTGCTATTGATCTAGATGA
AGATACCTGCACATTTCATATTTATGGAGAGGATCAGGATGCAGTGAAAAAAGCTAGAAGCTTTCTCGAA
TTTGCTGAAGATGTAATACAAGTTCCAAGGAACTTAGTAGGCAAAGTAATAGGAAAAAATGGAAAGCTGA
TTCAGGAGATTGTGGACAAGTCAGGAGTTGTGAGGGTGAGGATTGAGGCTGAAAATGAGAAAAATGTTCC
ACAAGAAGAGGAAATTATGCCACCAAATTCCCTTCCTTCCAATAATTCAAGGGTTGGACCTAATGCCCCA
GAAGAAAAAAAACATTTAGATATAAAGGAAAACAGCACCCATTTTTCTCAACCTAACAGTACAAAAGTCC
AGAGGGTGTTAGTGGCTTCATCAGTTGTAGCAGGGGAATCCCAGAAACCTGAACTCAAGGCTTGGCAGGG
TATGGTACCATTTGTTTTTGTGGGAACAAAGGACAGCATCGCTAATGCCACTGTTCTTTTGGATTATCAC
CTGAACTATTTAAAGGAAGTAGACCAGTTGCGTTTGGAGAGATTACAAATTGATGAGCAGTTGCGACAGA
TTGGAGCTAGTTCTAGACCACCACCAAATCGTACAGATAAGGAAAAAAGCTATGTGACTGATGATGGTCA
AGGAATGGGTCGAGGTAGTAGACCTTACAGAAATAGGGGGCACGGCAGACGCGGTCCTGGATATACTTCA
GGAACTAATTCTGAAGCATCAAATGCTTCTGAAACAGAATCTGACCACAGAGACGAACTCAGTGATTGGT
CATTAGCTCCAACAGAGGAAGAGAGGGAGAGCTTCCTGCGCAGAGGAGACGGACGGCGGCGTGGAGGGGG
AGGAAGAGGACAAGGAGGAAGAGGACGTGGAGGAGGCTTCAAAGGAAACGACGATCACTCCCGAACAGAT
AATCGTCCACGTAATCCAAGAGAGGCTAAAGGAAGAACAACAGATGGATCCCTTCAGATCAGAGTTGACT
GCAATAATGAAAGGAGTGTCCACACTAAAACATTACAGAATACCTCCAGTGAAGGTAGTCGGCTGCGCAC
GGGTAAAGATCGTAACCAGAAGAAAGAGAAGCCAGACAGCGTGGATGGTCAGCAACCACTCGTGAATGGA
GTACCCTAA


>OriGene 5' read for NM_002024 unedited
AATTCGGCACGAGGCGGCGGCGGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGGCGGC
GGCTGGGCCTCGAGCGCCCGCAGCCCACCTCTCGGGGGCGGGCTCCCGGCGCTAGCAGGG
CTGAAGAGAAGATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACA
AGGCATTTGTAAAGGATGTTCATGAAGATTCAATAACAGTTGCATTTGAAAACAACTGGC
AGCCTGATAGGCAGATTCCATTTCATGATGTCAGATTCCCACCTCCTGTAGGTTATAATA
AAGATATAAATGAAAGTGATGAAGTTGAGGTGTATTCCAGAGCAAATGAAAAAGAGCCTT
GCTGTTGGTGGTTAGCTAAAGTGAGGATGATAAAGGGTGAGTTTTATGTGATAGAATATG
CAGCATGTGATGCAACTTACAATGAAATTGTCACAATTGAACGTCTAAGATCTGTTAATC
CCAACAAACCTGCCACAAAAGATACTTTCCATAAGATCAAGCTGGATGTGCCAGAAGACT
TACGGCAAATGTGTGCCAAAGAGGCGGCACATAAGGATTTTAAAAAGGCAGTTGGTGCCT
TTTCTGNTACTTATGATCCAGANAATTATCAGCTTGTCATTTTGTCCATCAATGAAGTCA
CCTCANAGCGAGCACATATGCTGATTGACATGCACTTTTCGAGTCTGCGCACTAAAGTGT
CTCTGNATATGAGAAATGAAGAAGCTAGNTAGCAGCTGGAGAGTTCAGGCAGCTTGCCTC
GAGATTCATGAACAGTTATCGTAGAAAAGATCTGATGGTCTAGCTATGGTACTCATGTGC
TATATTCAGCAGCTAGAAAGACTGGGGTCCTGCTATGACTAGAGAAATACTGCCATN
>OriGene 3' read for NM_002024 unedited
AGCTAAGGGATACAAACTCTTTGTTACTGCTTGCATACAAAATTATTGCACTATAACCAA
ACAAATGTCAACATAAAATCCAATCTGTTGTCGCTAATATGTACAGAGAATATTGCCCAA
GAGCAGTTACATTACAAGGTCATTCTACCTTGGTTAATTATCTACAGTATTTTAAAACCA
AACAGCTTACAGATGATGTGTGCAAGGTACCAATTTCTGTTTTCAAATACTATACATTCC
CAGAATAAATAACTAGAAATCAACATTAATGTTTGGCAATACTTTTTAAAAGACTTTTTA
ATATTTGTGAAATCATGTGCAGTTTGTTGCCATTTTATATGCTTGTTTGTATGCAAGGAA
AAGTAACTGTAAAATGAAAATTCAAAGAAACAAACTCACAAAATACATCAGAGGCAGAAC
TTCAGTTTTTACGGCTCTGTACAGATTCAGTGGTACCCCTACTAGGAGTTACTTTTTAAG
AAAAATATAACATCTTAGAGTGAAGGTCCTTCACATATTTTTCCTCAATAAATTTCACTT
AAAAAAAAAAGACTCAAAAAACAAAACCAAACCCCAACACTTCAAAAAACAAAAGAAAAA
AAGAAAAAAAAGTTGTTATTTGTTAACCGATCTTAGTCTTTTCCAATTCTGCTTAAACAT
TAGACCATATATTTCAAAGTTTACAAAACATTTAACCTGCTTCCAATGTTTCTTAGACAA
AGTACCTGTACTTTGCAGGATTATTATGCATACATGGAAATGACCTTNCTATCTCTCCAA
AATAAGCTTGAAATTAAAATATGAAAAATTTCACAAAACTTGGGNGCAGACAAAATTAAA
AAAAANAAGCTCTTAGTTAAAATTGGTCATCANGCCACAGAGCAGCATATCCTACTAACT
TTCGACCAGAAAGATNGTTCCTAGCTGAAAACATTTAC
Restriction Sites NotI-NotI     
ACCN NM_002024
Insert Size 3780 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002024.3, NP_002015.1
RefSeq Size 4362 bp
RefSeq ORF 1899 bp
Locus ID 2332
Cytogenetics Xq27.3
Domains KH
Protein Families Druggable Genome
Gene Summary 'The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]'
Transcript Variant: This variant (ISO1) represents the longest transcript and it encodes the longest protein (isoform ISO1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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