Ku70 (XRCC6) (NM_001469) Human Untagged Clone

CAT#: SC110901

XRCC6 (untagged)-Human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6)


  "NM_001469" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol XRCC6
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC110901 sequence for NM_001469 edited (data generated by NextGen Sequencing)
ATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCGATGAAGAAGCAGAGGAAGAACAA
GAAGAGAACCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTTTT
TTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTT
GACATGAGCATCCAGTGTATCCAAAGTGTGTACATCAGTAAGATCATAAGCAGTGATCGA
GATCTCTTGGCTGTGGTGTTCTATGGTACCGAGAAAGACAAAAATTCAGTGAATTTTAAA
AATATTTACGTCTTACAGGAGCTGGATAATCCAGGTGCAAAACGAATTCTAGAGCTTGAC
CAGTTTAAGGGGCAGCAGGGACAAAAACGTTTCCAAGACATGATGGGCCACGGATCTGAC
TACTCACTCAGTGAAGTGCTGTGGGTCTGTGCCAACCTCTTTAGTGATGTCCAATTCAAG
ATGAGTCATAAGAGGATCATGCTGTTCACCAATGAAGACAACCCCCATGGCAATGACAGT
GCCAAAGCCAGCCGGGCCAGGACCAAAGCCGGTGATCTCCGAGATACAGGCATCTTCCTT
GACTTGATGCACCTGAAGAAACCTGGGGGCTTTGACATATCCTTGTTCTACAGAGATATC
ATCAGCATAGCAGAGGATGAGGACCTCAGGGTTCACTTTGAGGAATCCAGCAAGCTAGAA
GACCTGTTGCGGAAGGTTCGCGCCAAGGAGACCAGGAAGCGAGCACTCAGCAGGTTAAAG
CTGAAGCTCAACAAAGATATAGTGATCTCTGTGGGCATTTATAATCTGGTCCAGAAGGCT
CTCAAGCCTCCTCCAATAAAGCTCTATCGGGAAACAAATGAACCAGTGAAAACCAAGACC
CGGACCTTTAATACAAGTACAGGCGGTTTGCTTCTGCCTAGCGATACCAAGAGGTCTCAG
ATCTATGGGAGTCGTCAGATTATACTGGAGAAAGAGGAAACAGAAGAGCTAAAACGGTTT
GATGATCCAGGTTTGATGCTCATGGGTTTCAAGCCGTTGGTACTGCTGAAGAAACACCAT
TACCTGAGGCCCTCCCTGTTCGTGTACCCAGAGGAGTCGCTGGTGATTGGGAGCTCAACC
CTGTTCAGTGCTCTGCTCATCAAGTGTCTGGAGAAGGAGGTTGCAGCATTGTGCAGATAC
ACACCCCGCAGGAACATCCCTCCTTATTTTGTGGCTTTGGTGCCACAGGAAGAAGAGTTG
GATGACCAGAAAATTCAGGTGACTCCTCCAGGCTTCCAGCTGGTCTTTTTACCCTTTGCT
GATGATAAAAGGAAGATGCCCTTTACTGAAAAAATCATGGCAACTCCAGAGCAGGTGGGC
AAGATGAAGGCTATCGTTGAGAAGCTTCGCTTCACATACAGAAGTGACAGCTTTGAGAAC
CCCGTGCTGCAGCAGCACTTCAGGAACCTGGAGGCCTTGGCCTTGGATTTGATGGAGCCG
GAACAAGCAGTGGACCTGACATTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCC
TTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT
ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCA
GAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATG
CTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG
GAAGCCCTCACCAAGCACTTCCAGGACTGA

Clone variation with respect to NM_001469.3
>OriGene 5' read for NM_001469 unedited
TTTGTAATACGACTTACTATAGGGCGGCCGCGAATTCGGCACGAGGGTTGGTCGCTTCCC
TGCGCCAAAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAACCGAGGG
CGATGAAGAAGCAGAGGAAGAACAAGAAGAGAACCTTGAAGCAAGTGGAGACTATAAATA
TTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCA
GAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGTGTATCCAAAGTGTGTACAT
CAGTAAGATCATAAGCAGTGATCGAGATCTCTTGGCTGTGGTGTTCTATGGTACCGAGAA
AGACAAAAATTCAGTGAATTTTAAAAATATTTACGTCTTACAGGAGCTGGATAATCCAGG
TGCAAAACGAATTCTAGAGCTTGACCAGTTTAAGGGGCAGCAGGGACAAAAACGTTTCCA
AGACATGATGGGCCACGGATCTGACTACTCACTCAGTGAAGTGCTGTGGGTCTGTGCCAA
CCTCTTTAGTGATGTCCAATTCAAGATGAGTCATAAGAGGATCATGCTGTTCACCAATGA
AGACAACCCCCATGGCAATGACAGTGCCAAAGCCAGCCGGGCCAGGACCAAAGCCGGTGA
TCTCCGAGATACAGGCATCTTCCTTGACTTGATGCACCTGAAGAAACCTGGGGGCTNTGA
CATATNNCTTGNTCTACAGAGATATCATCAGCATAGCAGAGGATGANGGACCTCAGGGNT
TCACTTTNGAGAAATCCAGCAGCTANAAGACCTGTTGCCGGAAGGGTCGCGCCAAGGAGA
CCCAGAAGCGAGCACTCAGCAGGTTAAAGCTGAAGCTCACAAAGATTTATGATCTCTTGG
GCATTTATATC
>OriGene 3' read for NM_001469 unedited
CTATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTATAGTACAAAC
TTAGGGCTCTTTATTCAGGCAGTAAAGTAAGGAACAGCAAAGTGGGAGGGCTACACCATC
ACCATGGCAACAGAAAGCCTCAAAAACATAAAGTCCCTCGACTTATGTCGGGTAGACTCT
TCCTAGCTCAGGAGAAACACATTTTAACTGGCTGAGGACAAGGCCAGGCAGCCTGGCCAC
ACTGCGGAAGGGCAGCTGGACGCGCGGCCTCTGGTCAGTCCTGGAAGTGCTTGGTGAGGG
CTTCCAGCAGCTCCTGCTTCTTCAGCCCACTCTTCAGCCCGTAAGCCCGGCAGGCCTCTT
TCAGCATGGGCACAGTGAACTTGCCCAGCGTACCCTTGCTGATGTGGGTCTTCAGCTCCT
CTTCTGAATACTCCACCTTGGGCCTTTTGCTTCCAGAACCTTCATTATCGTGTTTTCTCT
TGGTAACTTTCCCTTCAGGATTGTAATCTGGTGGGTAAACAAGCTCCTTAAACTCATCCA
CCAAGGAGCCCAGTCTTTTATTCATTGCTTCAACCTTGGGCAATGTCAGGTCCACTGCTT
GTTCCGGCTCCATCAAATCCAAGGCCAAGGCCTNCAGGTTCCTGAAGTGCTGCTGCAGCA
CGGNGTTCTCANAGCTGTCACTTCTGTATGTGAAGCGAAGCTTCTCAACGATAGCCTTCA
TCTTGCCCACCTGCGTCTGGAGTGCCATGATTNTTTCAGTAAAGGGCATCTTCCTTTTAT
CATCAGCAAAGGGTAAAAAGACCAGCTGGAAGCCTGGAGGAGTCACCTNNGAATTTCTGG
TCATCCAACTCTTNCTTCTGTGGGCACCAAAGCCACAATAAGGAGGGATGTNCCTGCGGG
TGTGTATCTGCACATGCTGCACCCTCTTTNCAGACACTGAGAGCANACACTGNACAGGTT
GAGCNCCCATACAGC
Restriction Sites NotI-NotI     
ACCN NM_001469
Insert Size 2240 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001469.3, NP_001460.1
RefSeq Size 2156 bp
RefSeq ORF 1830 bp
Locus ID 2547
Cytogenetics 22q13.2
Domains SAP, Ku_C, Ku_N, ku
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Non-homologous end-joining
Gene Summary 'The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). Variants 1 and 2 encode the same protein.

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