RRM1 (NM_001033) Human Untagged Clone

CAT#: SC111007

RRM1 (untagged)-Human ribonucleotide reductase M1 (RRM1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RRM1
• Synonyms: R1; RIR1; RR1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111007 sequence for NM_001033 edited (data generated by NextGen Sequencing)
  ATGCATGTGATCAAGCGAGATGGCCGCCAAGAACGAGTCATGTTTGACAAAATTACATCT
  CGAATCCAGAAGCTTTGTTATGGACTCAATATGGATTTTGTTGATCCTGCTCAGATCACC
  ATGAAAGTAATCCAAGGCTTGTACAGTGGGGTCACCACAGTGGAACTAGATACTTTGGCT
  GCTGAAACAGCTGCAACCTTGACTACTAAGCACCCTGACTATGCTATCCTGGCAGCCAGG
  ATCGCTGTCTCTAACTTGCACAAAGAAACAAAGAAAGTGTTCAGTGATGTGATGGAAGAC
  CTCTATAACTACATAAATCCACATAATGGCAAACACTCTCCCATGGTGGCCAAGTCAACA
  TTGGATATTGTTCTGGCCAATAAAGATCGCCTGAATTCTGCTATTATCTATGACCGAGAT
  TTCTCTTACAATTACTTCGGCTTTAAGACGCTAGAGCGGTCTTATTTGTTGAAGATCAAT
  GGAAAAGTGGCTGAAAGACCACAACATATGTTGATGAGAGTATCTGTTGGGATCCACAAA
  GAAGACATTGATGCAGCAATTGAAACATATAATCTTCTTTCTGAGAGGTGGTTTACTCAT
  GCTTCGCCCACTCTCTTCAATGCTGGTACCAACCGCCCACAACTTTCTAGCTGTTTTCTT
  CTGAGTATGAAAGATGACAGCATTGAAGGCATTTATGACACTCTAAAGCAATGTGCATTG
  ATTTCTAAGTCTGCTGGAGGAATTGGTGTTGCTGTGAGTTGTATTCGGGCTACTGGCAGC
  TACATTGCTGGGACTAATGGCAATTCCAATGGCCTTGTACCGATGCTGAGAGTATATAAC
  AACACAGCTCGATATGTGGATCAAGGTGGGAACAAGCGTCCTGGGGCATTTGCTATTTAC
  CTGGAGCCTTGGCATTTAGACATCTTTGAATTCCTTGATTTAAAGAAGAACACAGGAAAG
  GAAGAGCAGCGTGCCAGAGATCTTTTCTTTGCTCTTTGGATTCCGGATCTCTTCATGAAA
  CGAGTGGAGACTAATCAGGACTGGTCTTTGATGTGTCCAAATGAGTGTCCTGGTCTGGAT
  GAGGTTTGGGGAGAGGAATTTGAGAAACTATATGCAAGTTATGAGAAACAAGGTCGTGTC
  CGCAAAGTTGTAAAAGCTCAGCAGCTTTGGTATGCCATCATTGAGTCTCAGACGGAAACA
  GGCACCCCGTATATGCTCTACAAAGATTCCTGTAATCGAAAGAGCAACCAGCAGAACCTG
  GGAACCATCAAATGCAGCAACCTGTGCACAGAAATAGTGGAGTACACCAGCAAAGATGAG
  GTTGCTGTTTGTAATTTGGCTTCCCTGGCCCTGAATATGTATGTCACATCAGAACACACA
  TACGACTTTAAGAAGTTGGCTGAAGTCACTAAAGTCGTTGTCCGAAACTTGAATAAAATT
  ATTGATATAAACTACTATCCTGTACCAGAGGCATGCCTATCAAATAAACGCCATCGCCCC
  ATTGGAATTGGGGTACAAGGTCTGGCAGATGCTTTTATCCTGATGAGATACCCTTTTGAG
  AGTGCAGAAGCCCAGTTACTGAATAAGCAGATCTTTGAAACTATTTATTATGGTGCTCTG
  GAAGCCAGCTGTGACCTTGCCAAGGAGCAGGGCCCATACGAAACCTATGAGGGCTCTCCA
  GTTAGCAAAGGAATTCTTCAGTATGATATGTGGAATGTTACTCCTACAGACCTATGGGAC
  TGGAAGGTTCTCAAGGAGAAGATTGCAAAGTATGGTATAAGAAACAGTTTACTTATTGCC
  CCGATGCCTACAGCTTCCACTGCTCAGATCCTGGGGAATAATGAGTCCATTGAACCTTAC
  ACCAGCAACATCTATACTCGCAGAGTCTTGTCAGGAGAATTTCAGATTGTAAATCCTCAC
  TTATTGAAAGATCTTACCGAGCGGGGCCTATGGCATGAAGAGATGAAAAACCAGATTATT
  GCATGCAATGGCTCTATTCAGAGCATACCAGAAATTCCTGATGACCTGAAGCAACTTTAT
  AAAACTGTGTGGGAAATCTCTCAGAAAACTGTTCTCAAGATGGCAGCTGAGAGAGGTGCT
  TTCATTGATCAAAGCCAATCTTTGAACATCCACATTGCTGAGCCTAACTATGGCAAACTC
  ACTAGTATGCACTTCTACGGCTGGAAGCAGGGTTTGAAGACTGGGATGTATTATTTAAGG
  ACAAGACCAGCAGCTAATCCAATCCAGTTCACTCTAAATAAGGAGAAGCTAAAAGATAAA
  GAAAAGGTATCAAAAGAGGAAGAAGAGAAGGAGAGGAACACAGCAGCCATGGTGTGCTCT
  TTGGAGAATAGAGATGAATGTCTGATGTGTGGATCCTGA
  
  Clone variation with respect to NM_001033.3
  2232 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001033 unedited
  GCACGAGGGCCTCTGCTCTGAAGAAGTGCTGTCTGGCTCCAACTCCAGTTCTTTCCCCTG
  AGCAGCGCCTGGAACCTAACCCTTCCCACTCTGTCACCTTCTCGATCCCGCCGGCGCTTT
  AGAGCCGCAGTCCAGTCTTGGATCCTTCAGAGCCTCAGCCACTAGCTGCGATGCATGTGA
  TCAAGCGAGATGGCCGCCAAGAACGAGTCATGTTTGACAAAATTACATCTCGAATCCAGA
  AGCTTTGTTATGGACTCAATATGGATTTTGTTGATCCTGCTCAGATCACCATGAAAGTAA
  TCCAAGGCTTGTACAGTGGGGTCACCACAGTGGAACTAGATACTTTGGCTGCTGAAACAG
  CTGCAACCTTGACTACTAAGCACCCTGACTATGCTATCCTGGCAGCCAGGATCGCTGTCT
  CTAACTTGCACAAAGAAACAAAGAAAGTGTTCAGTGATGTGATGGAAGACCTCTATAACT
  ACATAAATCCACATAATGGCAAACACTCTCCCATGGTGGCCAAGTCAACATTGGATATTG
  TTCTGGCCAATAAAGATCGCCTGAATTCTGCTATTATCTATGACCGAGATTTCTCTTACA
  ATTACTTC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001033 unedited
  CCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCAAAAGCTTATTTTGGT
  GAAAATCCCAATATATGAGTTTAAAAAAAAATCATTAACATCATTAACAGTACTTTAAAT
  CAATTACTCCTTTTGCCTGCAACAGGGTCCAGCAAAGCCTTACCACCTCAAGCAAACCCA
  CTATACCTATCTATGCTCAAGAAGTAGTTTGGCTACTGAAGACATGCTGGTCTCTTCCAA
  GTCTTTCCTCAGGATCCACACATCAGACATTCATCTCTATTCTCCAAAGAGCACACCATG
  GCTGCTGGGTTCCTCTCCTTCTCTTCTTCCTCTTTGGATACCTTTTCTTTATCTTTTAGC
  TTCTCCTTATTTAGAGTGAACTGGATTGGATTAGCTGCTGGTCTTGTCCTTAAATAATAC
  ATCCCAGTCTTCAAACCCTGCTTCCAGCCGTAGAAGTGCATACTAGTGAGTTTGCCATAG
  TTAGGCTCAGCAATGTGGATGTTCAAAGATTGGCTTTGATCAATGAAAGCACCTCTCTCA
  GCTGCCATCTTGAGAACAGTTTTCTGAGAGATTTCCCACACAGTTCTATAAAGTTGCTTC
  AGGTCATCAGGAATTTCCTGGTATGCTCTGAATAGAGCCATTGCATGGCATAATCTGGTT
  TTTCATCTCTTCATGCCATAGGCCCCGCTCGGGAAGACCTTTAATTAGTGAGGATTTACA
  TTCTGAAATCCTCCTGACCAGACCCTGCAAGTATAGATGTGCTGTGGTAGGGTCCAAGGA
  CCCATTATTCCCACGACTGAACAGGGGACCCGATAGCTCCGGGCAATAATAAACGGTTCT
  TAACCATACTTGCAATTTTTCCTGGAAACCTCCAGTCCATAGGCTGTAGGGGACCTTCCC
  AATTAACCGGAAATTCCTTGCACCGGAAGCCCTAAGGTTTTATGCCTTGTCCTGGAAGGG
  ACCCGGCTTCAAGCCATAAAAAGTAAAAACGGTTTTAAACGGGCTGGCCCCAAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001033
• ORF Size: 2379 bp
• Insert Size: 2930
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_001033.2, NP_001024.1
• RefSeq Size: 3117
• RefSeq ORF: 2379
• Locus ID: 6240
• Domains: ribonuc_red_lg, ATP-cone
• Protein Families: Druggable Genome
• Protein Pathways: Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism
• Gene Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).