UBL4A (NM_014235) Human Untagged Clone

CAT#: SC111067

UBL4A (untagged)-Human ubiquitin-like 4A (UBL4A)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UBL4A
• Synonyms: DX254E; DXS254E; G6PD; GDX; GET5; MDY2; TMA24; UBL4
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111067 sequence for NM_014235 edited (data generated by NextGen Sequencing)
  ATGCAGCTGACGGTGAAGGCGCTGCAGGGCCGCGAGTGCAGCCTGCAGGTGCCAGAGGAC
  GAGCTGGTGTCCACGCTGAAGCAGCTGGTCTCCGAGAAGCTGAACGTCCCAGTGCGCCAG
  CAGCGGCTGCTGTTCAAGGGCAAGGCCCTGGCAGATGGGAAACGACTCTCGGATTATAGC
  ATCGGGCCCAACTCCAAGCTCAACCTAGTGGTCAAACCCCTGGAGAAGGTGCTACTAGAA
  GAAGGCGAGGCCCAGAGGCTGGCCGACTCCCCACCCCCGCAGGTCTGGCAGCTGATCTCC
  AAAGTCTTGGCCCGCCACTTCAGTGCGGCAGATGCCAGCAGGGTCCTGGAACAGCTACAG
  AGGGATTACGAGAGGTCCCTGAGTCGCCTGACGCTGGACGACATCGAACGGTTGGCCAGC
  CGCTTCCTGCACCCTGAAGTGACTGAGACAATGGAGAAGGGCTTCTCCAAATAG
  
  Clone variation with respect to NM_014235.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014235 unedited
  GCATTTGTATACGACTCACTATAGGGCGGCNCGCGAATTCGCACGAGGGACGCCGTCGCG
  ACCGCCATGCAGCTGACGGTGAAGGCGCTGCAGGGCCGCGAGTGCAGCCTGCAGGTGCCA
  GAGGACGAGCTGGTGTCCACGCTGAAGCAGCTGGTCTCCGAGAAGCTGAACGTCCCAGTG
  CGCCAGCAGCGGCTGCTGTTCAAGGGCAAGGCCCTGGCAGATGGGAAACGACTCTCGGAT
  TATAGCATCGGGCCCAACTCCAAGCTCAACCTAGTGGTCAAACCCCTGGAGAAGGTGCTA
  CTAGAAGAAGGCGAGGCCCAGAGGCTGGCCGACTCCCCACCCCCGCAGGTCTGGCAGCTG
  ATCTCCAAAGTCTTGGCCCGCCACTTCAGTGCGGCAGATGCCAGCAGGGTCCTGGAACAG
  CTACAGAGGGATTACGAGAGGTCCCTGAGTCGCCTGACGCTGGACGACATCGAACGGTTG
  GCCAGCCGCTTCCTGCACCCTGAAGTGACTGAGACAATGGAGAAGGGCCTTCTCCAAATA
  GAATTCTCGGAGCATGGGGAGGTGCCCAACGCCAGGCTACCGCTGCATGTCGCACTAAGT
  GTGTTCTCCCTGTGCAGTTGGGCTCATCATCATCATAGCTGGCATGTACCTGGCTCTGGC
  CAGGTGCTAGGCACTCCCTCACAGCTTGACCTGCGTTTGCTTCCACACCCTCAGAAGAGG
  AGAGCCGGCACAGCAGAAGCACCGGCGATGAAGTGGCACAGCCCCCATCCGGAATACAGC
  GGCTTTCTGTAAGTGCCTTGCTGTGACAAAGAGGATGGGCCCGCTTGGAAAGCTGGCCTC
  TTCGATGTCATGTTTAACCCCCCGAGAATAACCCTCAGTGACTCCTTCCGCTACTCGAAG
  GCAAGCACCTGTCCCTGACTCTGGCGGGTCCACATAGCCTTAGGTTACTTGCAGAAGGCA
  GTGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014235 unedited
  TTTTACTCTGNACCCGCGGCCGCATNCTAGNGATCGGTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTCTGACCACGAAAAAATGTTTATTTGCTGGGGGCATCTGAAACAGCAAAG
  GGGGTACACAAAAAAAATGCTGCTCTGGCAGTGAGGGAGGGATTCCGTGGAAGCTGCAGG
  CAGCCATCTTTTCATCCTCGGAGGGGGGGGCCTGGGATGTACCAAATACCAACGCAAAGG
  GAGGCAAAAAACACTGGGTGAAATTGCTCACCTGCTGCCAATGCCAATACCACTGGACTT
  TTCACTTTCATAAGCCAAAAAATTTCCGTTAACTGATTAAACAAATTGCCTTTATTGTTA
  AACCAATGATTGGATATCAAAAACAGCCTAGCTAATATAGCTCCTTTTGGATAAAAGTAA
  AAGCCTCACATTCACCTTTAATGTTATTTCACTTTTTCCAAAATCAATTTCCTGGCACCA
  CACAAACAAAAACACTGGTAAATGTATCACCTGAACTGCAGGCCACACATGCTCACGAGT
  GTGTCCCTGCCGTAGGTGGCTTTGAAGCCATATACATGGCTCTCCAGCTCTCGTGGGGGG
  CCAGGGGCTTCTGTGTGCTCTTCAAAGCCTTCACCCATTGGGCCTCTGTCCATCTTTCCA
  GCCTGGGGACCCAGTATTTGCCCCACAAGGCCCAGGCAGGAGGGCCTNCAGCACGCGCAG
  CCCTGCCACACTGTGAGCAGCTCACTTTGCAGGNNTGAAGGGCCCGNANTGGCGTCCTCC
  TGATGTGGCTTCCTTTCAGCCTCTACACCCCTGGGGGCCCTCCTCAGGGAGCAGGTGGTT
  AGATGTCCTTCTGTGGCACACACACGNAGGNTTGAAGGAAGATGAAACCGGACCCATNCA
  TGCTTTTGCCCCACCCTGCACCCNAGGTNTNTTCTAGGCACAAGGACCCCCAAGGGGACC
  CTGAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014235
• ORF Size: 474 bp
• Insert Size: 2350
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_014235.2, NP_055050.1
• RefSeq Size: 2322
• RefSeq ORF: 474
• Locus ID: 8266
• Domains: UBQ
• Protein Families: Druggable Genome
• Gene Summary: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). [UniProtKB/Swiss-Prot Function]