UBL4A (NM_014235) Human Untagged Clone

CAT#: SC111067

UBL4A (untagged)-Human ubiquitin-like 4A (UBL4A)


  "NM_014235" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol UBL4A
Synonyms DX254E; DXS254E; G6PD; GDX; GET5; MDY2; TMA24; UBL4
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC111067 sequence for NM_014235 edited (data generated by NextGen Sequencing)
ATGCAGCTGACGGTGAAGGCGCTGCAGGGCCGCGAGTGCAGCCTGCAGGTGCCAGAGGAC
GAGCTGGTGTCCACGCTGAAGCAGCTGGTCTCCGAGAAGCTGAACGTCCCAGTGCGCCAG
CAGCGGCTGCTGTTCAAGGGCAAGGCCCTGGCAGATGGGAAACGACTCTCGGATTATAGC
ATCGGGCCCAACTCCAAGCTCAACCTAGTGGTCAAACCCCTGGAGAAGGTGCTACTAGAA
GAAGGCGAGGCCCAGAGGCTGGCCGACTCCCCACCCCCGCAGGTCTGGCAGCTGATCTCC
AAAGTCTTGGCCCGCCACTTCAGTGCGGCAGATGCCAGCAGGGTCCTGGAACAGCTACAG
AGGGATTACGAGAGGTCCCTGAGTCGCCTGACGCTGGACGACATCGAACGGTTGGCCAGC
CGCTTCCTGCACCCTGAAGTGACTGAGACAATGGAGAAGGGCTTCTCCAAATAG

Clone variation with respect to NM_014235.3
>OriGene 5' read for NM_014235 unedited
GCATTTGTATACGACTCACTATAGGGCGGCNCGCGAATTCGCACGAGGGACGCCGTCGCG
ACCGCCATGCAGCTGACGGTGAAGGCGCTGCAGGGCCGCGAGTGCAGCCTGCAGGTGCCA
GAGGACGAGCTGGTGTCCACGCTGAAGCAGCTGGTCTCCGAGAAGCTGAACGTCCCAGTG
CGCCAGCAGCGGCTGCTGTTCAAGGGCAAGGCCCTGGCAGATGGGAAACGACTCTCGGAT
TATAGCATCGGGCCCAACTCCAAGCTCAACCTAGTGGTCAAACCCCTGGAGAAGGTGCTA
CTAGAAGAAGGCGAGGCCCAGAGGCTGGCCGACTCCCCACCCCCGCAGGTCTGGCAGCTG
ATCTCCAAAGTCTTGGCCCGCCACTTCAGTGCGGCAGATGCCAGCAGGGTCCTGGAACAG
CTACAGAGGGATTACGAGAGGTCCCTGAGTCGCCTGACGCTGGACGACATCGAACGGTTG
GCCAGCCGCTTCCTGCACCCTGAAGTGACTGAGACAATGGAGAAGGGCCTTCTCCAAATA
GAATTCTCGGAGCATGGGGAGGTGCCCAACGCCAGGCTACCGCTGCATGTCGCACTAAGT
GTGTTCTCCCTGTGCAGTTGGGCTCATCATCATCATAGCTGGCATGTACCTGGCTCTGGC
CAGGTGCTAGGCACTCCCTCACAGCTTGACCTGCGTTTGCTTCCACACCCTCAGAAGAGG
AGAGCCGGCACAGCAGAAGCACCGGCGATGAAGTGGCACAGCCCCCATCCGGAATACAGC
GGCTTTCTGTAAGTGCCTTGCTGTGACAAAGAGGATGGGCCCGCTTGGAAAGCTGGCCTC
TTCGATGTCATGTTTAACCCCCCGAGAATAACCCTCAGTGACTCCTTCCGCTACTCGAAG
GCAAGCACCTGTCCCTGACTCTGGCGGGTCCACATAGCCTTAGGTTACTTGCAGAAGGCA
GTGA
>OriGene 3' read for NM_014235 unedited
TTTTACTCTGNACCCGCGGCCGCATNCTAGNGATCGGTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTCTGACCACGAAAAAATGTTTATTTGCTGGGGGCATCTGAAACAGCAAAG
GGGGTACACAAAAAAAATGCTGCTCTGGCAGTGAGGGAGGGATTCCGTGGAAGCTGCAGG
CAGCCATCTTTTCATCCTCGGAGGGGGGGGCCTGGGATGTACCAAATACCAACGCAAAGG
GAGGCAAAAAACACTGGGTGAAATTGCTCACCTGCTGCCAATGCCAATACCACTGGACTT
TTCACTTTCATAAGCCAAAAAATTTCCGTTAACTGATTAAACAAATTGCCTTTATTGTTA
AACCAATGATTGGATATCAAAAACAGCCTAGCTAATATAGCTCCTTTTGGATAAAAGTAA
AAGCCTCACATTCACCTTTAATGTTATTTCACTTTTTCCAAAATCAATTTCCTGGCACCA
CACAAACAAAAACACTGGTAAATGTATCACCTGAACTGCAGGCCACACATGCTCACGAGT
GTGTCCCTGCCGTAGGTGGCTTTGAAGCCATATACATGGCTCTCCAGCTCTCGTGGGGGG
CCAGGGGCTTCTGTGTGCTCTTCAAAGCCTTCACCCATTGGGCCTCTGTCCATCTTTCCA
GCCTGGGGACCCAGTATTTGCCCCACAAGGCCCAGGCAGGAGGGCCTNCAGCACGCGCAG
CCCTGCCACACTGTGAGCAGCTCACTTTGCAGGNNTGAAGGGCCCGNANTGGCGTCCTCC
TGATGTGGCTTCCTTTCAGCCTCTACACCCCTGGGGGCCCTCCTCAGGGAGCAGGTGGTT
AGATGTCCTTCTGTGGCACACACACGNAGGNTTGAAGGAAGATGAAACCGGACCCATNCA
TGCTTTTGCCCCACCCTGCACCCNAGGTNTNTTCTAGGCACAAGGACCCCCAAGGGGACC
CTGAC
Restriction Sites NotI-NotI     
ACCN NM_014235
ORF Size 474 bp
Insert Size 2350
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_014235.2, NP_055050.1
RefSeq Size 2322
RefSeq ORF 474
Locus ID 8266
Domains UBQ
Protein Families Druggable Genome
Gene Summary As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). [UniProtKB/Swiss-Prot Function]

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