AIF (AIFM1) (NM_004208) Human Untagged Clone

CAT#: SC111098

AIFM1 (untagged)-Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AIFM1
• Synonyms: AIF; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111098 sequence for NM_004208 edited (data generated by NextGen Sequencing)
  ATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTG
  CGGACCGTGTGCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGGCAACTTGTTCCAG
  CGATGGCATGTTCCTCTAGAACTCCAGATGACAAGACAAATGGCTAGCTCTGGTGCATCA
  GGGGGCAAAATCGATAATTCTGTGTTAGTCCTTATTGTGGGCTTATCAACAGTAGGAGCT
  GGTGCCTATGCCTACAAGACTATGAAAGAGGATGAAAAAAGATACAATGAAAGAATTTCA
  GGGTTAGGGCTGACACCAGAACAGAAACAGAAAAAGGCCGCGTTATCTGCTTCAGAAGGA
  GAGGAAGTTCCTCAAGACAAGGCGCCAAGTCATGTTCCTTTCCTGCTAATTGGTGGAGGC
  ACAGCTGCTTTTGCTGCAGCCAGATCCATCCGGGCTCGGGATCCTGGGGCCAGGGTACTG
  ATTGTATCTGAAGATCCTGAGCTGCCGTACATGCGACCTCCTCTTTCAAAAGAACTGTGG
  TTTTCAGATGACCCAAATGTCACAAAGACACTGCGATTCAAACAGTGGAATGGAAAAGAG
  AGAAGCATATATTTCCAGCCACCTTCTTTCTATGTCTCTGCTCAGGACCTGCCTCATATT
  GAGAATGGTGGTGTGGCTGTCCTCACTGGGAAGAAGGTAGTACAGCTGGATGTGAGAGAC
  AACATGGTGAAACTTAATGATGGCTCTCAAATAACCTATGAAAAGTGCTTGATTGCAACA
  GGAGGTACTCCAAGAAGTCTGTCTGCCATTGATAGGGCTGGAGCAGAGGTGAAGAGTAGA
  ACAACGCTTTTCAGAAAGATTGGAGACTTTAGAAGCTTGGAGAAGATTTCACGGGAAGTC
  AAATCAATTACGATTATCGGTGGGGGCTTCCTTGGTAGCGAACTGGCCTGTGCTCTTGGC
  AGAAAGGCTCGAGCCTTGGGCACAGAAGTGATTCAACTCTTCCCCGAGAAAGGAAATATG
  GGAAAGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAAAAAGTCAGACGAGAGGGG
  GTTAAGGTGATGCCCAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCAAGTTACTT
  ATCAAGCTGAAAGACGGCAGGAAGGTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTG
  GAGCCCAATGTTGAGTTGGCCAAGACTGGTGGCCTGGAAATAGACTCAGATTTTGGTGGC
  TTCCGGGTAAATGCAGAGCTACAAGCACGCTCTAACATCTGGGTGGCAGGAGATGCTGCA
  TGCTTCTACGATATAAAGTTGGGAAGGAGGCGGGTAGAGCACCATGATCACGCTGTTGTG
  AGTGGAAGATTGGCTGGAGAAAATATGACTGGAGCTGCTAAGCCGTACTGGCATCAGTCA
  ATGTTCTGGAGTGATTTGGGCCCCGATGTTGGCTATGAAGCTATTGGTCTTGTGGACAGT
  AGTTTGCCCACAGTTGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCAAATCTGCC
  ACAGAGCAGTCAGGAACTGGTATCCGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAA
  ATTACTATTCCTCCCAGCACCCCGGCAGTTCCACAGGCTCCCGTCCAGGGGGAGGACTAC
  GGCAAAGGTGTCATCTTCTACCTCAGGGACAAAGTGGTCGTGGGGATTGTGCTATGGAAC
  ATCTTTAACCGAATGCCAATAGCAAGGAAGATCATTAAGGACGGTGAGCAGCATGAAGAT
  CTCAATGAAGTAGCCAAACTATTCAACATTCATGAAGACTGA
  
  Clone variation with respect to NM_004208.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004208 unedited
  TTTTAGGATTTTGTAATACGATCTCACTATAGGGCGGCCGCGAATCGGCACGAGGGAGAG
  GAAAGGGAAGGAGGAGGTCCCGAATAGCGGTCGCCGAAAGTTCCGGTGTGGAGGCCTGGC
  GGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTGCGGACCGTGTGCGTCCGAAGCCC
  GAGGCAGAGGAACCGGCTCCCAGGCAACTTGTTCCAGCGATGGCATGTTCCTCTAGAACT
  CCAGATGACAAGACAAATGGCTAGCTCTGGTGCATCAGGGGGCAAAATCGATAATTCTGT
  GTTAGTCCTTATTGTGGGCTTATCAACAGTAGGAGCTGGTGCCTATGCCTACAAGACTAT
  GAAAGAGGATGAAAAAAGATACAATGAAAGAATTTCAGGGTTAGGGCTGACACCAGAACA
  GAAACAGAAAAAGGCCGCGTTATCTGCTTCAGAAGGAGAGGAAGTTCCTCAAGACAAGGC
  GCCAAGTCATGTTCCTTTCCTGCTAATTGGTGGAGGCACAGCTGCTTTTGCTGCAGCCAG
  ATCCATCCGGGCTCGGGATCCTGGGGCCAGGGTACTGATTGTATCTGAAGATCCTGAGCT
  GCCGTACATGCGACCTCCTCTTTCAAAAGAACTGTGGTTTTCAGATGACCCACATGTCAC
  AAAGACACTGCGATTCAAACAGTGGAATGGAAAAGAGAGAAGCATATATTTCCAGCCACC
  TTCTTTCTATGTCTCTGCTCANGACCTGCCTCATATTGAGAATGGCGCTGTGGCTGTCCT
  CACTGTGAAGAAGTAGTACACCTGGATGTGACAGACAACAGGGTGAAACTTAATGATGGC
  TCTCCAATAACCTATGAAAAGTGCCTTGATTGCAACAAGTAGGTACTTCCAACAAGTCTG
  TCTTGCCATTGATACGCGCTGGAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004208 unedited
  ACCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTAGAAGAACAGAATTTAT
  TTCACTATGTGAACATTAAGAATTTACCTACATAGTTGAAAATATTCACAAAGGACTTGA
  TCATTCACACTCATACACAGAGAAAGTCTGCTGAATAAAAAAATGCTCCTTTACCCATTC
  GACCTCCTCTCAGGGGCTGCAGTGGGTTTGCCAATTCCACTGTGGGGCTTCAGTCTTCAT
  GAATGTTGAATAGTTTTGCTACCTCCATTGGAAACTTATGCTGGCCCCCCGGGCCTTAAA
  AGAACCCCCCTGCTTTTGGGGCTTGGGGAAAAAAAAGGTTCAAAAAAAAAACCCCCCCAA
  CCCTTTTTTCTCTGGGGGGAAAAAAAAAAAAACCTTTTTCGGGGAAACCCCCCCCCCCCC
  GAGGAGGGATCCTTTTTAATAACCCCGGGGGGGGGGGGGGGAGGAAAAAAAAAATTTTTG
  TGGGCGGGGGGGCTCTTTTTTTTTTTTTTTTTTTTGGAGGGCAACACCCCCCCTCTTTCT
  TTTTTTGAGAAAAAAAAAAGGGGGTGTGTTTTTACCCTCATTTCTTTTCCAAAAAAACAC
  CCCGCGCGGGGGTGTTCTCCTCCCCCAAAAAACAAAAACTAATTTTTTATTCGGTACGCG
  CGGGGGGCGCTCCACCACACACAAACGAATTAGTGGGGCGAGGGGGGGCCGGCGAATACC
  AACACACTATTTTTCTTTTTTTTTTCTCTCTCTCCCCTCCCCCCCACCCCACCCGAGACG
  GGGGGGGGTGGCGGGGCCCCCCCCCCCCCCTCCTCTTATNTTTACACCAAAACAACCCAC
  CCTCCTCCTCTCCTCCCCCACTCAGATACTATATATGCATTCGCCGTCTCTCTCCCACTC
  TAATAAACCAAAAACT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004208
• ORF Size: 1842 bp
• Insert Size: 2000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004208.2, NP_004199.1
• RefSeq Size: 2215
• RefSeq ORF: 1842
• Locus ID: 9131
• Domains: pyr_redox
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis
• Gene Summary: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
  Transcript Variant: This variant (1) encodes the longest isoform (AIF).