UHRF1 (NM_013282) Human Untagged Clone

CAT#: SC111252

UHRF1 (untagged)-Human ubiquitin-like with PHD and ring finger domains 1 (UHRF1), transcript variant 2


  "NM_013282" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol UHRF1
Synonyms hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106; TDRD22
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_013282, the custom clone sequence may differ by one or more nucleotides


ATGGGGGTTTTTGCTGTCCCTCCCCTCAGCGCCGACACCATGTGGATCCAGGTTCGGACCATGGACGGGA
GGCAGACCCACACGGTGGACTCGCTGTCCAGGCTGACCAAGGTGGAGGAGCTGAGGCGGAAGATCCAGGA
GCTGTTCCACGTGGAGCCAGGCCTGCAGAGGCTGTTCTACAGGGGCAAACAGATGGAGGACGGCCATACC
CTCTTCGACTACGAGGTCCGCCTGAATGACACCATCCAGCTCCTGGTCCGCCAGAGCCTCGTGCTCCCCC
ACAGCACCAAGGAGCGGGACTCCGAGCTCTCCGACACCGACTCCGGCTGCTGCCTGGGCCAGAGTGAGTC
AGACAAGTCCTCCACCCACGGTGAGGCGGCCGCCGAGACTGACAGCAGGCCAGCCGATGAGGACATGTGG
GATGAGACGGAATTGGGGCTGTACAAGGTCAATGAGTACGTCGATGCTCGGGACACGAACATGGGGGCGT
GGTTTGAGGCGCAGGTGGTCAGGGTGACGCGGAAGGCCCCCTCCCGGGACGAGCCCTGCAGCTCCACGTC
CAGGCCGGCGCTGGAGGAGGACGTCATTTACCACGTGAAATACGACGACTACCCGGAGAACGGCGTGGTC
CAGATGAACTCCAGGGACGTCCGAGCGCGCGCCCGCACCATCATCAAGTGGCAGGACCTGGAGGTGGGCC
AGGTGGTCATGCTCAACTACAACCCCGACAACCCCAAGGAGCGGGGCTTCTGGTACGACGCGGAGATCTC
CAGGAAGCGCGAGACCAGGACGGCGCGGGAACTCTACGCCAACGTGGTGCTGGGGGATGATTCTCTGAAC
GACTGTCGGATCATCTTCGTGGACGAAGTCTTCAAGATTGAGCGGCCGGGTGAAGGGAGCCCCATGGTTG
ACAACCCCATGAGACGGAAGAGCGGGCCGTCCTGCAAGCACTGCAAGGACGACGTGAACAGACTCTGCCG
GGTCTGCGCCTGCCACCTGTGCGGGGGCCGGCAGGACCCCGACAAGCAGCTCATGTGCGATGAGTGCGAC
ATGGCCTTCCACATCTACTGCCTGGACCCGCCCCTCAGCAGTGTTCCCAGCGAGGACGAGTGGTACTGCC
CTGAGTGCCGGAATGATGCCAGCGAGGTGGTACTGGCGGGAGAGCGGCTGAGAGAGAGCAAGAAGAAGGC
GAAGATGGCCTCGGCCACATCGTCCTCACAGCGGGACTGGGGCAAGGGCATGGCCTGTGTGGGCCGCACC
AAGGAATGTACCATCGTCCCGTCCAACCACTACGGACCCATCCCGGGGATCCCCGTGGGCACCATGTGGC
GGTTCCGAGTCCAGGTCAGCGAGTCGGGTGTCCATCGGCCCCACGTGGCTGGCATACACGGCCGGAGCAA
CGACGGAGCGTACTCCCTAGTCCTGGCGGGGGGCTATGAGGATGATGTGGACCATGGGAATTTTTTCACA
TACACGGGTAGTGGTGGTCGAGATCTTTCCGGCAACAAGAGGACCGCGGAACAGTCTTGTGATCAGAAAC
TCACCAACACCAACAGGGCGCTGGCTCTCAACTGCTTTGCTCCCATCAATGACCAAGAAGGGGCCGAGGC
CAAGGACTGGCGGTCGGGGAAGCCGGTCAGGGTGGTGCGCAATGTCAAGGGTGGCAAGAATAGCAAGTAC
GCCCCCGCTGAGGGCAACCGCTACGATGGCATCTACAAGGTTGTGAAATACTGGCCCGAGAAGGGGAAGT
CCGGGTTTCTCGTGTGGCGCTACCTTCTGCGGAGGGACGATGATGAGCCTGGCCCTTGGACGAAGGAGGG
GAAGGACCGGATCAAGAAGCTGGGGCTGACCATGCAGTATCCAGAAGGCTACCTGGAAGCCCTGGCCAAC
CGAGAGCGAGAGAAGGAGAACAGCAAGAGGGAGGAGGAGGAGCAGCAGGAGGGGGGCTTCGCGTCCCCCA
GGACGGGCAAGGGCAAGTGGAAGCGGAAGTCGGCAGGAGGTGGCCCGAGCAGGGCCGGGTCCCCGCGCCG
GACATCCAAGAAAACCAAGGTGGAGCCCTACAGTCTCACGGCCCAGCAGAGCAGCCTCATCAGAGAGGAC
AAGAGCAACGCCAAGCTGTGGAATGAGGTCCTGGCGTCACTCAAGGACCGGCCGGCGAGCGGCAGCCCGT
TCCAGTTGTTCCTGAGTAAAGTGGAGGAGACGTTCCAGTGTATCTGCTGTCAGGAGCTGGTGTTCCGGCC
CATCACGACCGTGTGCCAGCACAACGTGTGCAAGGACTGCCTGGACAGATCCTTTCGGGCACAGGTGTTC
AGCTGCCCTGCCTGCCGCTACGACCTGGGCCGCAGCTATGCCATGCAGGTGAACCAGCCTCTGCAGACCG
TCCTCAACCAGCTCTTCCCCGGCTACGGCAATGGCCGGTGA


>OriGene 5' read for NM_013282 unedited
NGGTCAGCATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGCAGCGTT
TGCCGAGCGGGCGCTCCGGGTCGCACGCAAGTCCGCGCGGGGTCCGGGCCACGCACGCGG
TTTCATCGCCATCCCCAGCCGGGCCACGCGCGCAGGCAGACAAGCTGTTCGCGGCGACCG
GAGAGCGCCGACACCATGTGGATCCAGGTTCGGACCATGGACGGGAGGCAGACCCACACG
GTGGACTCGCTGTCCAGGCTGACCAAGGTGGAGGAGCTGAGGCGGAAGATCCAGGAGCTG
TTCCACGTGGAGCCAGGCCTGCAGAGGCTGTTCTACAGGGGCAAACAGATGGAGGACGGC
CATACCCTCTTCGACTACGAGGTCCGCCTGAATGACACCATCCAGCTCCTGGTCCGCCAG
AGCCTCGTGCTCCCCCACAGCACCAAGGAGCGGGACTCCGAGCTCTCCGACACCGACTCC
GGCTGCTGCCTGGGCCAGAGTGAGTCAGACAAGTCCTCCACCCACGGTGAGGCGGCCGCC
GAGACTGACAGCAGGCCAGCCGATGAGGACATGTGGGATGAGACGGAATTGGGGCTGTAC
AAGGTCAATGAGTACGTCGATGCTCGGGACACGAACATGNGGGGCGTGGTTTGAGGCGCA
NGTGGTCAGGGTGACGCGGAAGGCCCCCTCCCGGGACGAGCCCTGCAGCTCCACGTCCAG
GCCGGCGCTGGNAGGAGACGTCATTTACCACGTGAAATACGACGACTACCCGGAGAACCG
GCGTGGTCCAGATGAACTCCAGGGACGTNCGAGCGCGCGCCCGCACCATCATCAAGTGGC
AGGACCTGGNAGTGGGCCCAGNTGGTCATGCTCAACTACAACCCCGGAAACCNCAAGGAG
CGGGGGCTTTTGGTAN
>OriGene 3' read for NM_013282 unedited
NNNTTTTGACTCTGGACCCGCGGCCGCATNCTAANGATCGGTTTTTTTTTTTTTTTTTTT
TTTTTTTATCTGGGAAAAACTTTATTCTGAGAATCTAAAATCTGGACAAAGTACTGGACT
TTAAAAAAAGCCTACACAAAATTGTCTCATTCTTCCCTAATACATTAATAATCTAAGAAT
AAGGAGGTGAAAAAAACCCTTTAAAAATAACATTGCTCCAGTTTGTCTGCAGGTATGTGA
TTTAAAATATCCCTGTTTTATTGAGGTATAGGCTGCAAACTTTGGTAAAATTAGAAAAAT
TAACAAACCCTTTCAAAAGAAAAAAAATACAAAAACAAAAACAACCAAACCCTAACGTTA
TATCTTTCTTGGTACATATACAGTAACTACAAAAAAAATTCATTTAAAAAATGTGTTCAT
TAAGAGAAAAAAAAATTTTAAAAAAACCCTCTTGTAAGTTCTCACTTGCTGAGTTAAAAA
AATTGAATGTAAATGATCTATAAGGCTCAAACGGTTCCCAAGCACCCATCCGGTGTCAGG
AAGAACTGGATGACCGCAGTTTCTAGAATCTGGTTGACATTTTCAATAATTCAGTGCTAA
CAACAAAGACTGGTCGTCTTTAGAAAGAAGGAACGAATCAAAGGCACTTGCACGTGACTT
TCGTGGCCTGGCCGTCCGGTCCGTTGGCCGCCTTCGTCGGACAGNGTCAGTCACACGCCC
TGGCCCCACGTGGAGCAAAATGCCCTTGGAGGCATTTTTTGGGGGGCCCCACCTCCCTGT
TTTCGTGGGGCAAGGACTTTCACCGCGGATCTTAGACGCTAACAGCCTGTGGGGGGGAGA
GGCTTTAGGGACAAGGGTTAAACCTCGCCCCAAAAGTTTCCCTTTTTCCTTGGAAAAATT
TTAAAAAAATTGAACCCCCCCTGCCCGGGCTTTCCCGGCCACCCAGGGA
Restriction Sites NotI-NotI     
ACCN NM_013282
ORF Size 2382 bp
Insert Size 3740
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_013282.2, NP_037414.2
RefSeq Size 3828
RefSeq ORF 2382
Locus ID 29128
Domains UBQ, RING, PHD, SRA
Protein Families Druggable Genome, Transcription Factors
Gene Summary This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is longer than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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