TDP1 (NM_018319) Human Untagged Clone

CAT#: SC111344

TDP1 (untagged)-Human tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TDP1
• Synonyms: FLJ11090; MGC104252
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111344 sequence for NM_018319 edited (data generated by NextGen Sequencing)
  ATGTCTCAGGAAGGCGATTATGGGAGGTGGACCATATCTAGTAGTGATGAAAGTGAGGAA
  GAAAAGCCAAAACCAGACAAGCCATCTACCTCTTCTCTTCTCTGTGCCAGGCAAGGAGCA
  GCAAATGAGCCCAGGTACACCTGTTCCGAGGCCCAGAAAGCTGCACACAAGAGGAAAATA
  TCACCTGTGAAATTCAGCAATACAGATTCAGTTTTACCTCCCAAAAGGCAGAAAAGCGGT
  TCCCAGGAGGACCTCGGCTGGTGTCTGTCCAGCAGTGATGATGAGCTGCAACCAGAAATG
  CCGCAGAAGCAGGCTGAGAAAGTGGTGATCAAAAAGGAGAAAGACATCTCTGCTCCCAAT
  GACGGCACTGCCCAAAGAACTGAAAATCATGGCGCTCCCGCCTGCCACAGGCTCAAAGAG
  GAGGAAGACGAGTATGAGACATCAGGGGAGGGCCAGGACATTTGGGACATGCTGGATAAA
  GGGAACCCCTTCCAGTTTTACCTCACTAGAGTCTCTGGAGTTAAGCCAAAGTATAACTCT
  GGAGCCCTCCACATCAAGGATATTTTATCTCCTTTATTTGGGACGCTTGTTTCTTCAGCT
  CAGTTTAACTACTGCTTTGACGTGGACTGGCTCGTAAAACAGTATCCACCAGAGTTCAGG
  AAGAAGCCAATCCTGCTTGTGCATGGTGATAAGCGAGAGGCTAAGGCTCACCTCCATGCC
  CAGGCCAAGCCTTACGAGAACATCTCTCTCTGCCAGGCAAAGTTGGATATTGCGTTTGGA
  ACACACCACACGAAAATGATGCTGCTGCTCTATGAAGAAGGCCTCCGGGTTGTCATACAC
  ACCTCCAACCTCATCCATGCTGACTGGCACCAGAAAACTCAAGGAATATGGTTGAGCCCC
  TTATACCCACGAATTGCTGATGGAACCCACAAATCTGGAGAGTCGCCAACACATTTTAAA
  GCTGATCTCATCAGTTACTTGATGGCTTATAATGCCCCTTCTCTCAAGGAGTGGATAGAT
  GTCATTCACAAGCACGATCTCTCTGAAACAAATGTTTATCTTATTGGTTCAACCCCAGGA
  CGCTTTCAAGGAAGTCAAAAAGATAATTGGGGACATTTTAGACTTAAGAAGCTTCTGAAA
  GACCATGCCTCATCCATGCCTAACGCAGAGTCCTGGCCTGTCGTAGGTCAGTTTTCAAGC
  GTTGGCTCCTTGGGAGCCGATGAATCAAAGTGGTTATGTTCTGAGTTTAAAGAGAGCATG
  CTGACACTGGGGAAGGAAAGCAAGACTCCAGGAAAAAGCTCTGTTCCTCTTTACTTGATC
  TATCCTTCTGTGGAAAATGTGCGGACCAGTTTAGAAGGATATCCTGCTGGGGGCTCTCTT
  CCCTATAGCATCCAGACAGCTGAAAAACAGAATTGGCTGCATTCCTATTTTCACAAATGG
  TCAGCTGAGACTTCTGGCCGCAGCAATGCCATGCCACATATTAAGACATATATGAGGCCT
  TCTCCAGACTTCAGTAAAATTGCTTGGTTCCTTGTCACAAGCGCAAATCTGTCCAAGGCT
  GCCTGGGGAGCATTGGAGAAGAATGGCACCCAGCTGATGATCCGCTCCTACGAGCTCGGG
  GTCCTTTTCCTCCCTTCAGCATTTGGTCTAGACAGTTTCAAAGTGAAACAGAAGTTCTTC
  GCTGGCAGCCAGGAGCCAATGGCCACCTTTCCTGTGCCATATGATTTGCCTCCAGAACTG
  TATGGAAGTAAAGATCGGCCATGGATATGGAACATTCCTTATGTCAAAGCACCGGATACG
  CATGGGAACATGTGGGTGCCCTCCTGA
  
  Clone variation with respect to NM_018319.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018319 unedited
  NGGGTCACATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGCCGAGGCA
  AGCGTTGGTTCTGTGCGCCTCAGGAGTATAATGTCTCAGGAAGGCGATTATGGGAGGTGG
  ACCATATCTAGTAGTGATGAAAGTGAGGAAGAAAAGCCAAAACCAGACAAGCCATCTACC
  TCTTCTCTTCTCTGTGCCAGGCAAGGAGCAGCAAATGAGCCCAGGTACACCTGTTCCGAG
  GCCCAGAAAGCTGCACACAAGAGGAAAATATCACCTGTGAAATTCAGCAATACAGATTCA
  GTTTTACCTCCCAAAAGGCAGAAAAGCGGTTCCCAGGAGGACCTCGGCTGGTGTCTGTCC
  AGCAGTGATGATGAGCTGCAACCAGAAATGCCGCAGAAGCAGGCTGAGAAAGTGGTGATC
  AAAAAGGAGAAAGACATCTCTGCTCCCAATGACGGCACTGCCCAAAGAACTGAAAATCAT
  GGCGCTCCCGCCTGCCACAGGCTCAAAGAGGAGGAAGACGAGTATGAGACATCAGGGGAG
  GGCCAGGACATTTGGGACATGCTGGATAAAGGGAACCCCTTCCAGTTTTACCTCACTAGA
  GTCTCTGGAGTTAAGCCAAAGTATAACTCTGGAGCCCTCCACATCAAGGATATTTTATCT
  CCTTTATTTGGGACGCTTGTTTCTTCAGCTCAGTTTAACTACTGCTTTGACGTGGACTGG
  CTCGTAAAACAGTATCCACCAGAGTTCANGAAGAAGCCAATCCTGCTTGTGCATGGTGAT
  AAGCGAGAGGCTAAGGCTCACCTNCATGCCCCAGCCAAGCCTTACGAGAACATCTCTCTC
  TGCCAGNCAAAGNTGGGATATTGCGTTNGGAACACACCACACGAAAATGATGCTGCTGCT
  CTATGAAAANGGCCTCNCGGNNTGTCATACACACCTNNCAACTCATNCATGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_018319 unedited
  AAATAGGGGTTNCGATTCCTTTTTAAAAAGACAGACACACAAAATACATACAACACCCCA
  TAAATGTCCTTTACAGAATCCCAGTATGTACAACAGATACAGCAGAGCCTGTCTGTTGGA
  AGGTGGGAGGCCCTGCAGCCCTGTCTCCCTGCCTCCTGCTCTATCGCCACACCCCCACTG
  CAGCCTACAAGGTTCCTAAGGTACTTTTGGAAAATCCTAGGCCTCTGAGGAACAGTTTGA
  AAGACTACTTTAGAAAATCTTTCAAGACTAACGTTCAACTCTATCCTAAATTATAAGATA
  AAGAGGTTGATGACAAACTGGAAATCAGCCTCATGCAGAAGAAAACAAACAGGGTCTAAA
  GCACCCTAGGGAGAACACAATGTACACAAAGCACAAAGACACTCAAGCTCTGAGCCCCGC
  TCACTGTGTGACCCTGGGGACATCCTTAACCTTCTAGGCCTTAGCTTCCTCACTTGTGAA
  TTTAAGGCATCAAATTAAGTCACCTTTTAGGATTTTTTCCCAAAATACTTGTGTGCTTTT
  GTATGTTTCTATGAGCTGCTTCCTCTGAAAGTTTCTGGGGATAGAAGAGACACCCATTTA
  CCCTAAGCAGGTGTTTGGGTTTGGTGGGACCTGTCTGTCAGCAGTGAGGCAGCCAGCATG
  GTGCCCGGGAGAGATGAGAAACCTCCTAAAAGCTAAGCTGAAAGCTATGAAAAGCCGCTG
  TGAGGACAGTCAATACAATTCTTAACTGCAGGGGGCTGAAACAAGCCATTGGTCTCAAAG
  ACAGATCCCTAGATTCACCTCCAGCACCCCAGAAAACTTACTTCAAAAACCTTAAAGAAG
  GCATCCGTGGAAAAAGAAAAGATCGTGTTCTTACCGGGAAAAATTTCTGCGGGCAAGAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018319
• ORF Size: 1827 bp
• Insert Size: 3780
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_018319.3, NP_060789.2
• RefSeq Size: 3763
• RefSeq ORF: 1827
• Locus ID: 55775
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]
  Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform.