FE65 (APBB1) (NM_001164) Human Untagged Clone

CAT#: SC111588

APBB1 (untagged)-Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1


  "NM_001164" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol APBB1
Synonyms FE65; MGC:9072; RIR
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_001164, the custom clone sequence may differ by one or more nucleotides


ATGTCTGTTCCATCATCACTGAGCCAGTCGGCCATTAATGCCAACAGCCACGGAGGCCCCGCACTGAGCC
TACCCCTGCCTCTGCACGCTGCCCACAACCAGCTGCTCAACGCCAAGCTGCAGGCCACAGCTGTGGGACC
CAAGGACCTGCGCAGCGCCATGGGGGAGGGTGGTGGGCCTGAGCCAGGCCCTGCCAATGCCAAGTGGCTA
AAAGAGGGCCAGAACCAGCTCCGGCGGGCCGCCACGGCCCACCGTGACCAGAATCGCAATGTGACCTTGA
CCTTGGCGGAGGAGGCCAGCCAGGAGCCTGAGATGGCACCCTTGGGCCCCAAAGGCCTGATACACCTGTA
CTCTGAGCTGGAGCTCTCAGCTCACAACGCAGCCAACCGAGGCCTACGAGGACCTGGCCTGATCATCAGC
ACTCAAGAGCAGGGGCCAGATGAGGGAGAGGAGAAGGCGGCCGGGGAGGCCGAGGAGGAGGAGGAGGATG
ATGATGATGAAGAGGAGGAGGAGGACTTATCTTCTCCCCCAGGGCTGCCTGAGCCCCTGGAGAGTGTGGA
GGCCCCTCCCAGGCCCCAAGCCCTTACAGATGGCCCCCGGGAACACAGCAAGAGTGCCAGCCTCCTGTTT
GGCATGCGGAACAGTGCAGCCAGTGATGAGGACTCAAGCTGGGCTACCTTATCCCAGGGCAGCCCCTCCT
ATGGCTCCCCAGAGGACACAGATTCCTTCTGGAACCCCAACGCCTTCGAGACGGATTCCGACCTGCCGGC
TGGATGGATGAGGGTCCAGGACACCTCAGGGACCTATTACTGGCACATCCCAACAGGGACCACCCAGTGG
GAACCCCCCGGCCGGGCCTCCCCCTCACAGGGGAGCAGCCCCCAAGAGGAGTCCCAGCTCACCTGGACAG
GTTTTGCTCATGGAGAAGGCTTTGAGGATGGAGAATTTTGGAAGGATGAACCCAGTGATGAGGCCCCAAT
GGAGCTGGGACTGAAGGAACCTGAGGAGGGGACGTTGACCTTCCCAGCTCAGAGCCTCAGCCCAGAGCCG
TTGCCCCAAGAGGAGGAGAAGCTTCCCCCACGGAATACCAACCCAGGGATCAAGTGTTTCGCCGTGCGCT
CCCTAGGCTGGGTAGAGATGACCGAGGAGGAGCTGGCCCCTGGACGCAGCAGTGTGGCAGTCAACAATTG
CATCCGTCAGCTCTCTTACCACAAAAACAACCTGCATGACCCCATGTCTGGGGGCTGGGGGGAAGGAAAG
GATCTGCTACTGCAGCTGGAGGATGAGACACTAAAGCTAGTGGAGCCACAGAGCCAGGCACTGCTGCACG
CCCAACCCATCATCAGCATCCGCGTGTGGGGCGTCGGGCGGGACAGTGGAAGAGAGAGGGACTTTGCCTA
CGTAGCTCGTGATAAGCTGACCCAGATGCTCAAGTGCCACGTGTTTCGCTGTGAGGCACCTGCCAAGAAC
ATCGCCACCAGCCTGCATGAGATCTGCTCTAAGATCATGGCCGAACGGCGTAATGCCCGCTGCTTGGTAA
ATGGACTCTCCCTGGACCACTCTAAACTTGTGGATGTCCCTTTCCAAGTGGAATTCCCAGCGCCTAAGAA
TGAGTTGGTCCAGAAGTTCCAAGTCTATTACCTGGGGAATGTACCTGTTGCTAAACCTGTTGGGGTAGAT
GTGATTAATGGGGCCCTCGAGTCAGTCCTGTCCTCCAGCAGCCGTGAACAATGGACCCCAAGTCATGTCA
GTGTGGCCCCTGCTACCCTCACCATCTTGCACCAGCAGACAGAGGCAGTGCTGGGAGAGTGTCGGGTGCG
TTTCCTCTCCTTCCTGGCCGTGGGCAGAGATGTCCACACGTTTGCATTCATCATGGCTGCCGGCCCAGCC
TCCTTCTGCTGCCACATGTTCTGGTGCGAGCCCAATGCTGCCAGCCTCTCAGAGGCTGTGCAGGCTGCGT
GCATGCTTCGCTACCAGAAGTGTCTGGATGCCCGTTCCCAGGCCTCCACCTCCTGCCTCCCAGCACCCCC
TGCTGAGTCTGTGGCACGGCGTGTAGGGTGGACTGTCCGCAGGGGTGTTCAGTCGCTGTGGGGCTCCCTG
AAGCCCAAACGGCTGGGGGCCCATACCCCATGA


>OriGene 5' read for NM_001164 unedited
TTCAAATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGGAGCCCG
AACCCCGCAGCCTGAGCCACCTCCGTCATCTGGGCCCGGGGCCTCACCGCGCAGGAGCTG
CCAAGGCCATGTCTGTTCCATCATCACTGAGCCAGTCGGCCATTAATGCCAACAGCCACG
GAGGCCCCGCACTGAGCCTACCCCTGCCTCTGCACGCTGCCCACAACCAGCTGCTCAACG
CCAAGCTGCAGGCCACAGCTGTGGGACCCAAGGACCTGCGCAGCGCCATGGGGGAGGGTG
GTGGGCCTGAGCCAGGCCCTGCCAATGCCAAGTGGCTAAAAGAGGGCCAGAACCAGCTCC
GGCGGGCCGCCACGGCCCACCGTGACCAGAATCGCAATGTGACCTTGACCTTGGCGGAGG
AGGCCAGCCAGGAGCCTGAGATGGCACCCTTGGGCCCCAAAGGCCTGATACACCTGTACT
CTGAGCTGGAGCTCTCAGCTCACAACGCAGCCAACCGAGGCCTACGANGACCTGGCCTGA
TCATCAGCACTCAAGAGCAGGGGCCANATGANGGAGAAGAGAAAGCGGCCGGNGAAGCCC
ANNGAGANGANGANGATGATGATGATGAAAAAGATNGAGGAGACTTATCTTTCTTCCCCA
GGGCTGCCCTGAGCCCCTGGAGAGTGTGGAAGGCCCCTCCCAAGCCCCCAAGCCCTTTAC
AGAGGCCCCCCGGGAACCACAAGCAGAAGGCCAGCCCTCCTGTTTGGCATTGCGGAAAGT
GCACCCAGTGATGAAGACTTAACCTTGGCTACCTTATCCAAGGCAAGCCCTCTATGGTTC
CCAGAAGAAACAAAATCCTTTGGAACCCCACGCCTTCAAAACGTATCCAACCTGCGCCTT
TATGATAAAAGGTCCAACACACCTTAGGA
>OriGene 3' read for NM_001164 unedited
GTACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAGCAGTGCAGACAG
ACTTTATTAGTGATATCAATACAGCAGAGGTGCCCATGGAGCAGGGGGAAGGGACCCATG
CCTGGACCAGTCCCTTCCTCCTTCTGCCCCTGCTGGGTCCAGGAGGATGAGGCCTGGCCT
GGACCAGTTCCTCCTGTTCCACCTGAAACACATGGGGATGGAGAACCAGGGCTGGCCTTG
CTTCCTGCTCCTCTTGTTACCACTCCAGTGTTATCACTTCCTTGAAGGGATTAGATCTCT
CCCTCCCCAGCTCCTAGGCAGGGAACCGTAGCTACTGGGGAGGGGCATATTTGGGAGGCC
TGAGGCCTAGGAATAGCCTCTAGACCCCTCCCTGACCCACACCCTTTAGTTCCCTGGGGC
CCAACACAAGCAGGTGGAGGGAAGGTGGGGGCTTCTTCATGGGGTATGGGCCCCCAGCCG
TTTGGGCTTCAGGGAGCCCCACAGCGACTGAACACCCCTGCGGACAGTCCACCCTACACG
CCGTGCCACAGACTCAGCAGGGGGTGCTGGGAGGCAGGAGGTGGAGGCCTGGGAACGGGC
ATCCAGACACTTCTGGTAGCGAAGCATGCACGCAGCCTGCACAGCCTCTGAGAGGCTGGC
AGCATTGGGCTCGCACCAGAACATGTGGCAGCAGAAGGAGGCTGGGCCGGCAGCCATGAT
GAATGCAAACGTGTGGACATCTCTGCCCACGCCAGNAAGGAGAGGAAACGCACCCGACAC
TCTCCCAGCACTGGCTCTGTCTGCTGGTGCAAGATGGTGAGGGTAGCAGGGGCCACACTG
ACATGACTTGGNGTCCATTGTTCACGGCTGCTGGAGACCAGACTGACTCNAGGGCCCCAT
TATCACATCTACCCAACAGGTTTAGCACAGGTACATC
Restriction Sites NotI-NotI     
ACCN NM_001164
Insert Size 2680 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001164.2, NP_001155.1
RefSeq Size 2653 bp
RefSeq ORF 2133 bp
Locus ID 322
Cytogenetics 11p15.4
Domains WW, PID
Protein Families Transcription Factors
Protein Pathways Alzheimer's disease
Gene Summary 'The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]'
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as E9). This isoform is exclusively expressed in neurons.

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