Caspase 4 (CASP4) (NM_001225) Human Untagged Clone

CAT#: SC111600

CASP4 (untagged)-Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha


  "NM_001225" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CASP4
Synonyms ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; TX
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC111600 sequence for NM_001225 edited (data generated by NextGen Sequencing)
ATGGCAGAAGGCAACCACAGAAAAAAGCCACTTAAGGTGTTGGAATCCCTGGGCAAAGAT
TTCCTCACTGGTGTTTTGGATAACTTGGTGGAACAAAATGTACTGAACTGGAAGGAAGAG
GAAAAAAAGAAATATTACGATGCTAAAACTGAAGACAAAGTTCGGGTCATGGCAGACTCT
ATGCAAGAGAAGCAACGTATGGCAGGACAAATGCTTCTTCAAACCTTTTTTAACATAGAC
CAAATATCCCCCAATAAAAAAGCTCATCCGAATATGGAGGCTGGACCACCTGAGTCAGGA
GAATCTACAGATGCCCTCAAGCTTTGTCCTCATGAAGAATTCCTGAGACTATGTAAAGAA
AGAGCTGAAGAGATCTATCCAATAAAGGAGAGAAACAACCGCACACGCCTGGCTCTCATC
ATATGCAATACAGAGTTTGACCATCTGCCTCCGAGGAATGGAGCTGACTTTGACATCACA
GGGATGAAGGAGCTACTTGAGGGTCTGGACTATAGTGTAGATGTAGAAGAGAATCTGACA
GCCAGGGATATGGAGTCAGCGCTGAGGGCATTTGCTACCAGACCAGAGCACAAGTCCTCT
GACAGCACATTCTTGGTACTCATGTCTCATGGCATCCTGGAGGGAATCTGCGGAACTGTG
CATGATGAGAAAAAACCAGATGTGCTGCTTTATGACACCATCTTCCAGATATTCAACAAC
CGCAACTGCCTCAGTCTGAAGGACAAACCCAAGGTCATCATTGTCCAGGCCTGCAGAGGT
GCAAACCGTGGGGAACTGTGGGTCAGAGACTCTCCAGCATCCTTGGAAGTGGCCTCTTCA
CAGTCATCTGAGAACCTAGAGGAAGATGCTGTTTACAAGACCCACGTGGAGAAGGACTTC
ATTGCTTTCTGCTCTTCAACGCCACACAACGTGTCCTGGAGAGACAGCACAATGGGCTCT
ATCTTCATCACACAACTCATCACATGCTTCCAGAAATATTCTTGGTGCTGCCACCTAGAG
GAAGTATTTCGGAAGGTACAGCAATCATTTGAAACTCCAAGGGCCAAAGCTCAAATGCCC
ACCATAGAACGACTGTCCATGACAAGATATTTCTACCTCTTTCCTGGCAATTGA

Clone variation with respect to NM_001225.3
>OriGene 5' read for NM_001225 unedited
NGGGTGCACATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGAACGCTG
TAAAAAAGACAGAGGCTGTTCCCTATGGCAGAAGGCAACCACAGNAAAAAAGCCACTTAA
GGTGTTGGAATCCCTGGGCAAAGATTTCCTCACTGGTGTTTTGGATAACTTGGTGGAACA
AAATGTACTGAACTGGAAGGAAGAGGAAAAAAAGAAATATTACGATGCTAAAACTGAAGA
CAAAGTTCGGGTCATGGCAGACTCTATGCAAGAGAAGCAACGTATGGCAGGACAAATGCT
TCTTCAAACCTTTTTTAACATAGACCAAATATCCCCCAATAAAAAAGCTCATCCGAATAT
GGAGGCTGGACCACCTGAGTCAGGAGAATCTACAGATGCCCTCAAGCTTTGTCCTCATGA
AGAATTCCTGAGACTATGTAAAGAAAGAGCTGAAGAGATCTATCCAATAAAGGAGAGAAA
CAACCGCACACGCCTGGCTCTCATCATATGCAATACAGAGTTTGACCATCTGCCTCCGAG
GAATGGAGCTGACTTTGACATCACAGGGATGAAGGAGCTACTTGAGGGTCTGGACTATAG
TGTAGATGTAGAAGAGAATCTGACAGCCAGGGATATGGAGTCAGCGCTGAGGGCATTTGC
TACCAGACCAGAGCACAAGTCCTCTGACAGCACATTCTTGGTACTCATGTCTCATGGCAT
CCTGGAGGGAATCTGCGGAACTGTGCATGATGAGAAAAAACCAGATGTGCTGCTTTATGA
CACCATCTTCCAGATATTCAACAAACCGCACTGCCTCAGTCTGAAGGACAAACCCAAGTC
ATCATTGTCCAGGCCTGCAGAAGTGCANACCGTGGGGAACNNTGTGGTCAGAGACTCTTC
AGCATCCTTGA
>OriGene 3' read for NM_001225 unedited
NCCTCTGTGNACCGCGCCGCATTCTANGATCGGTTTTTTTTTTTTTTTTTTGTCTTCACT
TTTATTGAAATACAAAATGTTAAATATGCAAGCTGTACTAATGAAGGTGCTCCTTGAAGT
TGATTAAGGAGGGCTGGGCTGCTTGTGGCTTCCATTTTCAATTGCCAGGAAAGAGGTAGA
AATATCTTGTCATGGACAGTCGTTCTATGGTGGGCATTTGAGCTTTGGCCCTTGGAGTTT
CAAATGATTGCTGTACCTTCCGAAATACTTCCTCTAGGTGGCAGCACCAAGAATATTTCT
GGAAGCATGTGATGAGTTGTGTGATGAAGATAGAGCCCATTGTGCTGTCTCTCCAGGACA
CGTTGTGTGGCGTTGAAGAGCAGAAAGCAATGAAGTCCTTCTCCACGTGGGTCTTGTAAA
CAGCATCTTCCTCCAGGTTCTCAGATGACTGTGAAGAGGCCACTTCCAAGGATGCTGGAG
AGTCTCTGACCCACAGTTCCCCACGGTTTGCACCTCTGCAGGCCTGGACAATGATGACCT
TGGGTTTGTCCTTCAGACTGAGGCAGTTGCGGTTGTTGAATATCTGGAAGATGGTGTCAT
AAAGCAGCACATCTGGTTTTTTCTCATCATGCACAGTTCCGCAGATTCCCTCCAGGATGC
CATGAGACATGAGTACCAAGAATGTGCTGTCAGAAGACTTGTGCTCTGGTCTGGTAGCAN
ATGCCCTCAGCGCTGACTCCATATCCCTGGCTGTCAGATTCTCTTCTACATCTACACTAT
AGTCCAGACCCCTCAGTAGCTCCTTCATCCCTGTGATGTCAAAGTCAGCTCCATTCCTCG
NAGGCAGATGGTCAAACTCTGTATTGCATATGATGAGAAGCCAGNCGTGTGCCGGGTGGT
TCTCTCCTTTATGGATAAGACTCTTCAGCTCTTTCTTTACATANNCTN
Restriction Sites NotI-NotI     
ACCN NM_001225
Insert Size 1290 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001225.3, NP_001216.1
RefSeq Size 1319 bp
RefSeq ORF 1134 bp
Locus ID 837
Cytogenetics 11q22.3
Domains CARD, CASc, ICE_p10, ICE_p20
Protein Families Druggable Genome, Protease
Gene Summary 'This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (alpha) encodes the longest isoform (alpha).

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