B7-2 (CD86) (NM_006889) Human Untagged Clone

CAT#: SC111929

CD86 (untagged)-Human CD86 molecule (CD86), transcript variant 2


  "NM_006889" in other vectors (4)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CD86
Synonyms B7-2; B7.2; B70; CD28LG2; LAB72
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_006889 edited
GAATTCGGCACGAGGGGAAGGCTTGCACAGGGTGAAAGCTTTGCTTCTCTGCTGCTGTAA
CAGGGACTAGCACAGACACACGGATGAGTGGGGTCATTTCCAGATATTAGGTCACAGCAG
AAGCAGCCAAAATGGATCCCCAGTGCACTATGGGACTGAGTAACATTCTCTTTGTGATGG
CCTTCCTGCTCTCTGGTGCTGCTCCTCTGAAGATTCAAGCTTATTTCAATGAGACTGCAG
ACCTGCCATGCCAATTTGCAAACTCTCAAAACCAAAGCCTGAGTGAGCTAGTAGTATTTT
GGCAGGACCAGGAAAACTTGGTTCTGAATGAGGTATACTTAGGCAAAGAGAAATTTGACA
GTGTTCATTCCAAGTATATGGGCCGCACAAGTTTTGATTCGGACAGTTGGACCCTGAGAC
TTCACAATCTTCAGATCAAGGACAAGGGCTTGTATCAATGTATCATCCATCACAAAAAGC
CCACAGGAATGATTCGCATCCACCAGATGAATTCTGAACTGTCAGTGCTTGCTAACTTCA
GTCAACCTGAAATAGTACCAATTTCTAATATAACAGAAAATGTGTACATAAATTTGACCT
GCTCATCTATACACGGTTACCCAGAACCTAAGAAGATGAGTGTTTTGCTAAGAACCAAGA
ATTCAACTATCGAGTATGATGGTATTATGCAGAAATCTCAAGATAATGTCACAGAACTGT
ACGACGTTTCCATCAGCTTGTCTGTTTCATTCCCTGATGTTACGAGCAATATGACCATCT
TCTGTATTCTGGAAACTGACAAGACGCGGCTTTTATCTTCACCTTTCTCTATAGAGCTTG
AGGACCCTCAGCCTCCCCCAGACCACATTCCTTGGATTACAGCTGTACTTCCAACAGTTA
TTATATGTGTGATGGTTTTCTGTCTAATTCTATGGAAATGGAAGAAGAAGAAGCGGCCTC
GCAACTCTTATAAATGTGGAACCAACACAATGGAGAGGGAAGAGAGTGAACAGACCAAGA
AAAGAGAAAAAATCCATATACCTGAAAGATCTGATGAAGCCCAGCGTGTTTTTAAAAGTT
CGAAGACATCTTCATGCGACAAAAGTGATACATGTTTTTAATTAAAGAGTAAAGCCCATA
CAAGTATTCATTTTTTCTACCCTTTCCTTTGTAAGTTCCTGGGCAACCTTTTTGATTTCT
TCCAGAAGGCAAAAAGACATTACCATGAGTAATAAGGGGGCTCCAGGACTCCCTCTAAGT
GGAATAGCCTCCCTGTAACTCCAGCTCTGCTCCGTATGCCAAGAGGAGACTTTAATTCTC
TTACTGCTTCTTTTCACTTCAGAGCACACTTATGGGCCAAGCCCAGCTTAATGGCTCATG
ACCTGGAAATAAAATTTAGGACCAATACCTCCTCCAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_006889 unedited
AGCATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGGGAAGGCTT
GCACAGGGTGAAAGCTTTGCTTCTCTGCTGCTGTAACAGGGACTAGCACAGACACACGGA
TGAGTGGGGTCATTTCCAGATATTAGGTCACAGCAGAAGCAGCCAAAATGGATCCCCAGT
GCACTATGGGACTGAGTAACATTCTCTTTGTGATGGCCTTCCTGCTCTCTGGTGCTGCTC
CTCTGAAGATTCAAGCTTATTTCAATGAGACTGCAGACCTGCCATGCCAATTTGCAAACT
CTCAAAACCAAAGCCTGAGTGAGCTAGTAGTATTTTGGCAGGACCAGGAAAACTTGGTTC
TGAATGAGGTATACTTAGGCAAAGAGAAATTTGACAGTGTTCATTCCAAGTATATGGGCC
GCACAAGTTTTGATTCGGACAGTTGGACCCTGAGACTTCACAATCTTCAGATCAAGGACA
AGGGCTTGTATCAATGTATCATCCATCACAAAAGAGCCCACAGGAATGATTCGCATCCAC
CAGATGAATTCTGAACTGTCAGTGCTTGCTAACTTCAGTCAACCTGAAATAGTACCAATT
TCTAATATAACAGAAAATGTGTACATAAATTTGACCTGCTCATCTATACACGGTTACCCA
GAACCTAAGAAGATGAGTGTTTTGCTAAGAACCAAGAATTCAACTATCGAGTATGATGGT
ATTATGCAGAAATCTCAAGATAATGTCACAGAACTGTACGACGTTTCCATCAGCNTTGTC
TGTTTCATTCCCTGATGTTACGAGCCATATGACCATCTTCTGTATTCTGGANACTGACAG
ACGCGGCTTTTATCTTCACCTTTCTCTATAGAGCTTGAGGACCCTCAGCCTCCCCAGACA
CATTCCTTGGATTACAGCTGACTTNCACAGTATAATGGGGGAAGAGGGTNTCTGTCTAAT
CTATGAN
>OriGene 3' read for NM_006889 unedited
CCGTANGGTTATGGTCCTAATTTTATTTNCCAGNTCATGNAGCCATTAAGCTGGGCTTGG
NCCCATAAGTGTGCTNNCTGAAGTGAAAAAAAGCAGTAAGAGAATTAAAGTCTCCTCTTG
GCATACGGAGCAGAGCTGGAGTTACAGGGAGGCTATTCCACTTAGAGGGAGTCCTGGAGC
CCCCTTATTACTCATGGTAATGTCTTTTTGCCTTCTGGAAGAAATCAAAAAGGTTGCCCA
GGAACTTACAAAGGAAAGGGTAGAAAAAATGAATACTTGTATGGGCTTTACTCTTTAATT
AAAAACATGTATCACTTTTGTCGCATGAAGATGTCTTCGAACTTTTAAAAACACGCTGGG
CTTCATCAGATCTTTCAGGTATATGGATTTTTTCTCTTTTCTTGGTCTGTTCACTCTCTT
CCCTCTCCATTGTGTTGGTTCCACATTTATAAGAGTTGCGAGGCCGCTTCTTCTTCTTCC
ATTTCCATAGAATTAGACAGAAAACCATCACACATATAATAACTGTTGGAAGTACAGCTG
TAATCCAAGGAATGTGGTCTGGGGGAGGCTGAGGGTCCTCAAGCTCTATAGAGAAAGGTG
AAGATAAAAGCCGCGTCTTGTCAGTTTCCAGAATACAGAAGATGGTCATATTGCTCGTAA
CATCAGGGAATGAAACAGACAAGCTGATGGAAACGTCGTACAGTTCTGTGACATTATCTT
GAGATTTCTGCATAATACCATCATACTCGATAGTTGAATTCTTGGGGTCTTAGCCAACAC
TCATCTTCTTTAGTGCTGGGTAACCGTGTATAGATGAGCAAGTCAAATTTATGTACACAT
TTTTCTGTTATATTAGAAATTGGGACTATTTTCAGGTTGACTGAAGTTAGCAAGCCCTGA
CAGTTCAAAATTCATCTGTTGGATGCGAATCATTCCTGGTGGGCTTTTGG
Restriction Sites NotI-NotI     
ACCN NM_006889
Insert Size 1440 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_006889.2, NP_008820.1
RefSeq Size 2794 bp
RefSeq ORF 2790 bp
Locus ID 942
Cytogenetics 3q13.33
Domains IGv, IG
Protein Families Druggable Genome, Transcription Factors, Transmembrane
Protein Pathways Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis
Gene Summary 'This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]'
Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR, resulting in the use of a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus than isoform 1.

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