SMURF1 (NM_181349) Human Untagged Clone

CAT#: SC112098

SMURF1 (untagged)-Human SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SMURF1
• Synonyms: KIAA1625
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_181349 edited
  GAATTCGGCACGAGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACC
  CCGGGACACGCAGGAACGGCTCCAGCATCAAGATCCGTCTGACAGTGTTATGTGCCAAGA
  ACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTGTCGTGGATG
  GGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACC
  AGCACTATGATCTATATGTTGGGAAAACGGATTCGATAACCATTAGCGTGTGGAACCATA
  AGAAAATTCACAAGAAACAGGGAGCTGGCTTCCTGGGCTGTGTGCGGCTGCTCTCCAATG
  CCATCAGCAGATTAAAAGATACCGGATACCAGCGTTTGGATCTATGCAAACTAAACCCCT
  CAGATACTGATGCAGTTCGTGGCCAGATAGTGGTCAGTTTACAGACACGAGACAGAATAG
  GAACCGGCGGCTCGGTGGTGGACTGCAGAGGACTGTTAGAAAATGAAGGAACGGTGTATG
  AAGACTCGGGGCCTGGGAGGCCGCTCAGCTGCTTCATGGAGGAACCAGCCCCTTACACAG
  ATAGCACCGGTGCTGCTGCTGGAGGAGGGAATTGCAGGTTCGTGGAGTCCCCAAGTCAAG
  ATCAAAGACTTCAGGCACAGCGGCTTCGAAACCCTGATGTGCGAGGTTCACTACAGACGC
  CCCAGAACCGACCACACGGCCACCAGTCCCCGGAACTGCCCGAAGGCTACGAACAAAGAA
  CAACAGTCCAGGGCCAAGTTTACTTTTTGCATACACAGACTGGAGTTAGCACGTGGCACG
  ACCCCAGGATACCAAGAGACCTTAACAGTGTGAACTGTGATGAACTTGGACCACTGCCGC
  CAGGCTGGGAAGTCAGAAGTACAGTTTCTGGGAGGATATATTTTGTAGATCATAATAACC
  GAACAACCCAGTTTACAGACCCAAGGTTACACCACATCATGAATCACCAGTGCCAACTCA
  AGGAGCCCAGCCAGCCGCTGCCACTGCCCAGTGAGGGCTCTCTGGAGGACGAGGAGCTTC
  CTGCCCAGAGATACGAAAGAGATCTAGTCCAGAAGCTGAAAGTCCTCAGACACGAACTGT
  CGCTTCAGCAGCCCCAAGCTGGTCATTGCCGCATCGAAGTGTCCAGAGAAGAAATCTTTG
  AGGAGTCTTACCGCCAGATAATGAAGATGCGACCGAAAGACTTGAAAAAACGGCTGATGG
  TGAAATTCCGTGGGGAAGAAGGTTTGGATTACGGTGGTGTGGCCAGGGAGTGGCTTTACT
  TGCTGTGCCATGAAATGCTGAATCCTTATTACGGGCTCTTCCAGTATTCTACGGACAATA
  TTTACATGTTGCAAATAAATCCGGATTCTTCAATCAACCCCGACCACTTGTCTTATTTCC
  ACTTTGTGGGGCGGATCATGGGGCTGGCTGTGTTCCATGGACACTACATCAACGGGGGCT
  TCACAGTGCCCTTCTACAAGCAGCTGCTGGGGAAGCCCATCCAGCTCTCAGATCTGGAAT
  CTGTGGACCCAGAGCTGCATAAGAGCTTGGTGTGGATCCTAGAGAACGACATCACGCCTG
  TACTGGACCACACCTTCTGCGTGGAACACAACGCCTTCGGGCGGATCCTGCAGCATGAAC
  TGAAACCCAATGGCAGAAATGTGCCAGTCACAGAGGAGAATAAGAAAGAATACGTCCGGT
  TGTATGTAAACTGGAGGTTTATGAGAGGAATCGAAGCCCAGTTCTTAGCTCTGCAGAAGG
  GGTTCAATGAGCTCATCCCTCAACATCTGCTGAAGCCTTTTGACCAGAAGGAACTGGAGC
  TGATCATAGGCGGCCTGGATAAAATAGACTTGAACGACTGGAAGTCGAACACGCGGCTGA
  AGCACTGTGTGGCCGACAGCAACATCGTGCGGTGGTTCTGGCAAGCGGTGGAGACGTTCG
  ATGAAGAAAGGAGGGCCAGGCTCCTGCAGTTTGTGACTGGGTCCACGCGAGTCCCGCTCC
  AAGGCTTCAAGGCTTTGCAAGGTTCTACAGGCGCGGCAGGGCCCCGGCTGTTCACCATCC
  ACCTGATAGACGCGAACACAGACAACCTTCCGAAGGCCCATACCTGCTTTAACCGGATCG
  ACATTCCACCATATGAGTCCTATGAGAAGCTCTACGAGAAGCTGCTGACAGCCGTGGAGG
  AGACCTGCGGGTTTGCTGTGGAGTGAAAAGCAACCAAAGGCAACAGAGTCTAGCTCATGG
  CCACCAGACCAAAAAGCATCCAGCTTCTGTGCACCTCCTGCAAAGCTGGCAGAGGCCCTG
  GAATTCCAGATCACCTGAGGGGAAAGGGTTGTCTCTCTCCTTTCTGTTGGGGGAGGGGGA
  TGGGGGACTTTTGTTGGTGGCTCCCACCCATATATCCCTCCTTTACCATAGTACTCCCAC
  CCACTTCCATCACCCATCCAATAAAATGCAGCCAGGTTTAGCCTTTGGCTTTGGTCACAC
  AGGAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_181349 unedited
  AGCATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGCGCTGGATC
  CGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCA
  GCATCAAGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCA
  GGCTCCCTGACCCTTTTGCAAAGATTGTCGTGGATGGGTCTGGGCAGTGCCACTCAACCG
  ACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTATATGTTGGGA
  AAACGGATTCGATAACCATTAGCGTGTGGAACCATAAGAAAATTCACAAGAAACAGGGAG
  CTGGCTTCCTGGGCTGTGTGCGGCTGCTCTCCAATGCCATCAGCAGATTAAAAGATACCG
  GATACCAGCGTTTGGATCTATGCAAACTAAACCCCTCAGATACTGATGCAGTTCGTGGCC
  AGATAGTGGTCAGTTTACAGACACGAGACAGAATAGGAACCGGCGGCTCGGTGGTGGACT
  GCAGAGGACTGTTAGAAAATGAAGGAACGGTGTATGAAGACTCGGGGCCTGGGAGGCCGC
  TCAGCTGCTTCATGGAGGAACCAGCCCCTTACACAGATAGCACCGGTGCTGCTGCTGGAG
  GAGGGAATTGCAGGTTCGTGGAGTCCCCAAGTCAAGATCAAAGACTTCAGGCACAGCGGC
  TTCGAAACCCTGATGTGCGAGGNTCACTACAGACGCCCCAGAACCGACCACACGGNCACC
  AGTCCNCGGAACTGCCCCGAGGCTACGANACAAGACAACAGTCCAGGGCCAAGTTTACTT
  TNTGCATACACAGACTGGGAGTAGCACGTGGCACGACCCCCAGATACAAGAGACCTTACA
  GTGTGAACTGTGATGAACTTGGACCACTGCCGCCAGCCTGGGAAGTCAAAGTACAGTTTC
  G
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_181349 unedited
  ATGACCGCGGCCGCAATCTANAATCGAGTTTTTTTTTTTTTTTTTTCCTGTGTGACCAAA
  GCCAAAGGCTAAACCTGGCTGCATTTTATTGGATGGGTGATGGAAGTGGGTGGGAGTACT
  ATGGTAAAGGAGGGATATATGGGTGGGAGCCACCAACAAAAGTCCCCCATCCCCCTCCCC
  CAACAGAAAGGAGAGAGACAACCCTTTCCCCTCAGGTGATCTGGAATTCCAGGGCCTCTG
  CCAGCTTTGCAGGAGGTGCACAGAAGCTGGATGCTTTTTGGTCTGGTGGCCATGAGCTAG
  ACTCTGTTGCCTTTGGTTGCTTTTCACTCCACAGCAAACCCGCAGGTCTCCTCCACGGCT
  GTCAGCAGCTTCTCGTAGAGCTTCTCATAGGACTCATATGGTGGAATGTCGATCCGGTTA
  AAGCAGGTATGGGCCTTCGGAAGGTTGTCTGTGTTCGCGTCTATCAGGTGGATGGTGAAC
  AGCCGGGGCCCTGCCGCGCCTGTAGAACCTTGCAAAGCCTTGAAGCCTTGGAGCGGGACT
  CGCGTGGACCCAGTCACAAACTGCAGGAGCCTGGCCCTCCTTTCTTCATCGAACGTCTCC
  ACCGCTGGCCAGAACCACCGCACGATGTTGCTGTCGGCCACACAGTGCTTCAGCCGCGTG
  TTCGACTTCCAGTCGTTCAAGTCTATTTTATCCAGGCCCGCCTATGATCAGCTCCCAGTC
  CCTTTCTGGTCAAAAAGGCTTCACCAGATGTTGAGGGATGAGCTCATTGAACCCCTTCTG
  CAGAGCTAAGAACTGGGCTTCGATTCCTCTCATAACCTCCAGTTTCATACAACCGAACGT
  ATTCTTTCTAATCTCCTTTGTGACGGCACATTTCTGCCATTGGGTTCAATTCATGCTGCA
  GAACCGCCCGAGGCTTGGTGTCCACCCAAAGTTGGGTCCAAACAGGCGGAAGTCTTCTCT
  AGATCCCCCAATTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_181349
• ORF Size: 2196 bp
• Insert Size: 2440
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_181349.1, NP_851994.1
• RefSeq Size: 5659
• RefSeq ORF: 2196
• Locus ID: 57154
• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis
• Gene Summary: This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2010]
  Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. Isoform 2 is shorter than isoform 1.