Epoxide hydrolase (EPHX1) (NM_000120) Human Untagged Clone

CAT#: SC112331

EPHX1 (untagged)-Human epoxide hydrolase 1, microsomal (xenobiotic) (EPHX1), transcript variant 1


  "NM_000120" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol EPHX1
Synonyms EPHX; EPOX; HYL1; MEH
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC112331 sequence for NM_000120 edited (data generated by NextGen Sequencing)
ATGTGGCTAGAAATCCTCCTCACTTCAGTGCTGGGCTTTGCCATCTACTGGTTCATCTCC
CGGGACAAAGAGGAAACTTTGCCACTTGAAGATGGGTGGTGGGGGCCAGGCACGAGGTCC
GCAGCCAGGGAGGACGACAGCATCCGCCCTTTCAAGGTGGAAACGTCAGATGAGGAGATC
CACGACTTACACCAGAGGATCGATAAGTTCCGTTTCACCCCACCTTTGGAGGACAGCTGC
TTCCACTATGGCTTCAACTCCAACTACCTGAAGAAAGTCATCTCCTACTGGCGGAATGAA
TTTGACTGGAAGAAGCAGGTGGAGATTCTCAACAGATACCCTCACTTCAAGACTAAAATT
GAAGGGCTGGACATCCACTTCATCCACGTGAAGCCCCCCCAGCTGCCCGCAGGCCATACC
CCGAAGCCCTTGCTGATGGTGCACGGCTGGCCCGGCTCTTTCTACGAGTTTTATAAGATC
ATCCCACTCCTGACTGACCCCAAGAACCATGGCCTGAGCGATGAGCACGTTTTTGAAGTC
ATCTGCCCTTCCATCCCTGGCTATGGCTTCTCAGAGGCATCCTCCAAGAAGGGGTTCAAC
TCGGTGGCCACCGCCAGGATCTTTTACAAGCTGATGCTGCGGCTGGGCTTCCAGGAATTC
TACATTCAAGGAGGGGACTGGGGGTCCCTGATCTGCACTAATATGGCCCAGCTGGTGCCC
AGCCACGTGAAAGGCCTGCACTTGAACATGGCTTTGGTTTTAAGCAACTTCTCTACCCTG
ACCCTCCTCCTGGGACAGCGTTTCGGGAGGTTTCTTGGCCTCACTGAGAGGGATGTGGAG
CTGCTGTACCCCGTCAAGGAGAAGGTATTCTACAGCCTGATGAGGGAGAGCGGCTACATG
CACATCCAGTGCACCAAGCCTGACACCGTAGGCTCTGCTCTGAATGACTCTCCTGTGGGT
CTGGCTGCCTATATTCTAGAGAAGTTTTCTACCTGGACCAATACGGAATTCCGATACCTG
GAGGATGGAGGCCTGGAAAGGAAGTTCTCCCTGGACGACCTGCTGACCAACGTCATGCTC
TACTGGACAACAGGCACCATCATCTCCTCCCAGCGCTTCTACAAGGAGAACCTGGGACAG
GGCTGGATGACCCAGAAGCATGAGCGGATGAAGGTCTATGTGCCCACTGGCTTCTCTGCC
TTCCCTTTTGAGCTATTGCACACGCCTGAAAAGTGGGTGAGGTTCAAGTACCCAAAGCTC
ATCTCCTATTCCTACATGGTTCGTGGGGGCCACTTTGCGGCCTTTGAGGAGCCGGAGCTG
CTCGCCCAGGACATCCGCAAGTTCCTGTCGGTGCTGGAGCGGCAATGA

Clone variation with respect to NM_000120.3
357 g=>a;990 c=>t
>OriGene 5' read for NM_000120 unedited
GTTCAAATTTGTATACGACTCCTATAGGGCGGCCGCGATTCGGCACCAGGCAGAGCTCCC
AGCTCTCTTTCCCAAGGAGTAATCAGAGGGTGAGAACGTGGAGCCTGGTGGACAGGTGAA
AGCACTGGGATCTTTCTGCCCAGAAAGGGGAAAGTTGCACATTTATATCCTAGAGGGAAG
CGACAGCAGTGCTTCTCCCTGTGCTGAGGAGCCATGTGGCTAGAAATCCTCCTCACTTCA
GTGCTGGGCTTTGCCATCTACTGGTTCATCTCCCGGGACAAAGAGGAAACTTTGCCACTT
GAAGATGGGTGGTGGGGGCCAGGCACGAGGTCCGCAGCCAGGGAGGACGACAGCATCCGC
CCTTTCAAGGTGGAAACGTCAGATGAGGAGATCCACGACTTACACCAGAGGATCGATAAG
TTCCGTTTCACCCCACCTTTGGAGGACAGCTGCTTCCACTATGGCTTCAACTCCAACTAC
CTGAAGAAAGTCATCTCCTACTGGCGGAATGAATTTGACTGGAAGAAGCAGGTGGAGATT
CTCAACAGATACCCTCACTTCAAGACTAAAATTGAAGGGCTGGACATCCACTTCATCCAC
GTGAAGCCCCCCCAGCTGCCCGCAGGCCATACCCCGAAGCCCTTGCTGATGGTGCACGGC
TGGCCCGGCTCTTTCTACGAGTTTTATAAGATCATCCCACTCCTGACTGACCCCAAGAAC
CATGGCCTGAGCGATGAGCACGTTTTTGAAGTCATCTGCCCTTCCATCCCTGGCTATGGC
TTCTCAGAGGCATCCTCCAGAAGGNGTTCAACTCGGTGGCCACGCCAGGATCTTTTAAAG
CTGATGCTGNCGCTGNGCTTCCAGGAATTCTACATTCAGGGGAGGGACTGGGGTCCCTGA
TCTGCACTATATGGCCCNAGCTGTGCCCANCN
>OriGene 3' read for NM_000120 unedited
NTTCTTGNACCCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTTAGAGTAAAG
TCGTTTATCATCAAAGCCATGTTGCTTACCACACGGAGTTGGGGGTTGGGGAGTGAGCTT
GGAGGGGTGAGGGGGTGAGCGTGGGCTCCCAGCATGGGCAGGGGACGGAGGCAAACTCAT
TCCTCAGAAAAGGGGTATCTTCCCCAAGAAAAGCCTGGAGGGCACTTGTGGGGGGAGGTG
GCAGGCGGGGGGAGAGGGGTGGGTCATTGCCGCTCCAGCACCGACAGGAACTTGCGGATG
TCCTGGGCGAGCAGCTCCGGCTCCTCAAAGGCCGCAAAGTGGCCCCCACGAACCATGTAG
GAATAGGAGATGAGCTTTGGGTACTTGAACCTCACCCACTTTTCAGGCGTGTGCAATAGC
TCAAAAGGGAAGGCAGAGAAGCCAGTGGGCACATAGACCTTCATCCGCTCATGCTTCTGG
GTCATCCAGCCCTGTCCCAGGTTCTCCTTGTAAAAGCGCTGGGAGGAGATGATGGTGCCT
GTTGTCCAGTAGAGCATGACGTTGGTCAGCAGGTCGTCCAGGGAGAACTTCCTTTCCAGG
CCCTCATCCTTCAGGTATCGGAATTCCGTATTGGTCCAGGTAGAAAACTTCTCTAGAATA
TAGGCAGCCGGACCCACAGAGAGTCATTCAGAGCAGAACCTACCGTGTCAGGCTTGGTGC
ACTGGATGTGCATGTAACCGCTTTTCCTTATAAGGCTGTAAAATACCTCTTCTTTGACGG
GTACAGAAGTTCCCATTCCTTTTAATGAGGCCAAGAACCTTCCGAAACCCTGTCCCAGGA
GAAGGGTCAGGGTAAAAAATTTTGTTAAAACCAAAGCCTGTTCAGGGCCGGCCCTTACGG
GGTTGGGCCCACATGGGCCTATTATGGAATACAGGACCCC
Restriction Sites NotI-NotI     
ACCN NM_000120
Insert Size 2000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000120.2, NP_000111.1
RefSeq Size 1856 bp
RefSeq ORF 1368 bp
Locus ID 2052
Cytogenetics 1q42.12
Domains abhydrolase
Protein Families Druggable Genome, Protease
Protein Pathways Metabolism of xenobiotics by cytochrome P450
Gene Summary 'Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]'
Transcript Variant: This variant (1) is the longer transcript. Variants 1, 2 and 3 encode the same protein.

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