SMURF 2 (SMURF2) (NM_022739) Human Untagged Clone

CAT#: SC112475

SMURF2 (untagged)-Human SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)


  "NM_022739" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SMURF2
Synonyms DKFZp686F0270; MGC138150
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_022739 edited
GAATTCGGCACGAGGGGAAGCGGCCGAGCCCAGAGTTCTGCTCCGGCGCCCCCGAGCACC
GCCCGCTTCAGCCGACCAGCCCCGTCGGCTACTGGGCCTCGCCGAGACGAGAGGAGGGAA
AGGCCTCGGCGGCCGCCGCCCCCGCCGCCGGGGACATGTCTAACCCCGGAGGCCGGAGGA
ACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGGATT
TTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATT
CTACAGATACTGTGAAGAATACGCTTGATCCAAAGTGGAATCAGCATTATGACCTGTATA
TTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGAAAC
AAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAG
ACACTGGTTATCAGAGGTTGGATTTATGCAAACTCGGGCCAAATGACAATGATACAGTTA
GAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAGTTG
TGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCG
CCTCTGGAAGAATCCAGTATCTAAACCATATAACAAGAACTACGCAATGGGAGCGCCCAA
CACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATGAGA
ACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGG
CAGAGAGGAGAGTCAGGTCACAACGACATAGAAATTACATGAGCAGAACACATTTACATA
CTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGTATT
TCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGGGATCTTA
GCAACATCAATTGTGAAGAGCTTGGTCCATTGCCTCCTGGATGGGAGATCCGTAATACGG
CAACAGGCAGAGTTTATTTCGTTGACCATAACAACAGAACAACACAATTTACAGATCCTC
GGCTGTCTGCTAACTTGCATTTAGTTTTAAATCGGCAGAACCAATTGAAAGACCAACAGC
AACAGCAAGTGGTATCGTTATGTCCTGATGACACAGAATGCCTGACAGTCCCAAGGTACA
AGCGAGACCTGGTTCAGAAACTAAAAATTTTGCGGCAAGAACTTTCCCAACAACAGCCTC
AGGCAGGTCATTGCCGCATTGAGGTTTCCAGGGAAGAGATTTTTGAGGAATCATATCGAC
AGGTCATGAAAATGAGACCAAAAGATCTCTGGAAGCGATTAATGATAAAATTTCGTGGAG
AAGAAGGCCTTGACTATGGAGGCGTTGCCAGGGAATGGTTGTATCTCTTGTCACATGAAA
TGTTGAATCCATACTATGGCCTCTTCCAGTATTCAAGAGATGATATTTATACATTGCAGA
TCAATCCTGATTCTGCAGTTAATCCGGAACATTTATCCTATTTCCACTTTGTTGGACGAA
TAATGGGAATGGCTGTGTTTCATGGACATTATATTGATGGTGGTTTCACATTGCCTTTTT
ATAAGCAATTGCTTGGGAAGTCAATTACCTTGGATGACATGGAGTTAGTAGATCCGGATC
TTCACAACAGTTTAGTGTGGATACTTGAGAATGATATTACAGGTGTTTTGGACCATACCT
TCTGTGTTGAACATAATGCATATGGTGAAATTATTCAGCATGAACTTAAACCAAATGGCA
AAAGTATCCCTGTTAATGAAGAAAATAAAAAAGAATATGTCAGGCTCTATGTGAACTGGA
GATTTTTACGAGGCATTGAGGCTCAATTCTTGGCTCTGCAGAAAGGATTTAATGAAGTAA
TTCCACAACATCTGCTGAAGACATTTGATGAGAAGGAGTTAGAGCTCATTATTTGTGGAC
TTGGAAAGATAGATGTTAATGACTGGAAGGTAAACACCCGGTTAAAACACTGTACACCAG
ACAGCAACATTGTCAAATGGTTCTGGAAAGCTGTGGAGTTTTTTGATGAAGAGCGACGAG
CAAGATTGCTTCAGTTTGTGACAGGATCCTCTCGAGTGCCTCTGCAGGGCTTCAAAGCAT
TGCAAGGTGCTGCAGGCCCGAGACTCTTTACCATACACCAGATTGATGCCTGCACTAACA
ACCTGCCGAAAGCCCACACTTGCTTCAATCGAATAGACATTCCACCCTATGAAAGCTATG
AAAAGCTATATGAAAAGCTGCTAACAGCCATTGAAGAAACATGTGGATTTGCTGTGGAAT
GACAAGCTTCAAGGATTTACCCAGGACTCTATTTATACAACCCTGACTGACAGCCTCCTT
TCAGCAGAGTTTCAAAGAATATGCTGAAATACAGGAAAACACTCCCCCCCCCCCTTTTTT
TTTTTTTTTTTTACATTTTAGGACACTGTGAGGGGAAAGGACAATTTTGAAATTCCTTTT
CAAGGAAAAAAAAGGTCTTTATGCTTTGCCATGAGGCCACATTCAGCTGCTATTTAAACT
TAATATCTTGAACCTAAAGAATGCTGACTTTTCCTACATTTCCAGAGTTAGGCAGTATTC
TACACTTAAAGACTACTACTATTTTTATAAAAGGTAATCTATTCAAATTTCTTCACAGAT
TTCAAGTCTCTCAAACATCAAGACAACTTCAGCAGTCGGTACAAGTCACATTTCATTTTG
ATTGAATACATGATCTTGAACAGCTCCTGTACTTGCTCTTTGTAAAAAAAAATAAAATTA
TTTTGAATTATTCTACCTTTGTAAACAATTGGCTAAAAGAATCATCTTTAAGAAATTAAG
CCATTTACATGTTTGTGTTTTTCTATAGCAGAGCATTATATTTTGCATTATATGTTTCAA
CCTAGTCTAAGTGGGTCTTTTTTACATTTTTCAAGAACGGATTTCCTGGAATACAGCGAT
ATAATTTTGGTTGTCAAATTCCTAATGCAACCATTTAGTCTAAACTTAGTCATTTATTTG
TGACAATAAGATGTGTTCAGGGGCTCCCTGTTTTTAAGAGACTCTTTTAAAAAAAAAAAA
ACCTAATGTTTTTATCTTGAGTCAATATGATTAGGTATTTTGGATTTACTTTTAATCTTA
AAATACTGCATTTTTATAGCTTCTCAGAGCATGTGGATGGGATGGGATTTTCGTTATTTT
GCTGGGTCAGCTTATCTXXXXXXXXXXXXXXXXXXXXXXXXXGAGATTGCAGTGAGCCGA
GATCGCACCACTGCACTCCAGCCTGGGCGACAAGAGTGAGACTCCGTCCCCGCCCAAAAA
AAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_022739 unedited
NGGCTTCTTACCCCCGCCCGTTGCCGCAATGGGCGGTAGGCGTGTACGGTGGGAAGGTCT
ATATAAGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAG
CGGCCGCGAATTCGGCACGAGGGGAAGCGGCCGAGCCCAGAGTTCTGCTCCGGCGCCCCC
GAGCACCGCCCGCTTCAGCCGACCAGCCCCGTCGGCTACTGGGCCTCGCCGAGACGAGAG
GAGGGAAAGGCCTCGGCGGCCGCCGCCCCCGCCGCCGGGGACATGTCTAACCCCGGAGGC
CGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAA
AAGGATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAA
TGCCATTCTACAGATACTGTGAAGAATACGCTTGATCCAAAGTGGAATCAGCATTATGAC
CTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCAT
AAGAAACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGC
CTCAAAGACACTGGTTATCAGAGGTTGGATTTATGCAAACTCGGGCCAAATGACAATGAT
ACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGA
CAAGTTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGG
AGAACCGCCTCTGGAAGATCCAGTNTCTAAACCATATAAACAGAACTANCGCATGGGAGC
GCCNAACACGACCGGCATCCCGATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGNTG
ATGAGAACACTCCCATTAGTGGAACAAT
Restriction Sites NotI-NotI     
ACCN NM_022739
ORF Size 2247 bp
Insert Size 5000
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_022739.3, NP_073576.1
RefSeq Size 3866
RefSeq ORF 2247
Locus ID 64750
Domains C2, HECT, WW
Protein Families Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways Allograft rejection, Antigen processing and presentation, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Endocytosis, Graft-versus-host disease, TGF-beta signaling pathway, Type I diabetes mellitus, Ubiquitin mediated proteolysis, Viral myocarditis
Gene Summary E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. [UniProtKB/Swiss-Prot Function]

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