gamma Catenin (JUP) (NM_021991) Human Untagged Clone

CAT#: SC112564

JUP (untagged)-Human junction plakoglobin (JUP), transcript variant 2


  "NM_021991" in other vectors (4)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol JUP
Synonyms CTNNG; DP3; DPIII; PDGB; PKGB
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC112564 sequence for NM_021991 edited (data generated by NextGen Sequencing)
ATGGAGGTGATGAACCTGATGGAGCAGCCTATCAAGGTGACTGAGTGGCAGCAGACATAC
ACCTACGACTCGGGTATCCACTCGGGCGCCAACACCTGCGTGCCCTCCGTCAGCAGCAAG
GGCATCATGGAGGAGGATGAGGCCTGCGGGCGCCAGTACACGCTCAAGAAAACCACCACT
TACACCCAGGGGGTGCCCCCCAGCCAAGGTGATCTGGAGTACCAGATGTCCACAACAGCC
AGGGCCAAACGGGTGCGGGAGGCCATGTGCCCTGGTGTGTCAGGCGAGGACAGCTCGCTT
CTGCTGGCCACCCAGGTGGAGGGGCAGGCCACCAACCTGCAGCGACTGGCCGAGCCGTCC
CAGCTGCTCAAGTCGGCCATTGTGCATCTCATCAACTACCAGGACGATGCCGAGCTGGCC
ACTCGCGCCCTGCCCGAGCTCACCAAACTGCTCAACGACGAGGACCCGGTGGTGGTGACC
AAGGCGGCCATGATTGTGAACCAGCTGTCGAAGAAGGAGGCGTCGCGGCGGGCCCTGATG
GGCTCGCCCCAGCTGGTGGCCGCTGTCGTGCGTACCATGCAGAATACCAGCGACCTGGAC
ACAGCCCGCTGCACCACCAGCATCCTGCACAACCTCTCCCACCACCGGGAGGGGCTGCTC
GCCATCTTCAAGTCGGGTGGCATCCCTGCTCTGGTCCGCATGCTCAGCTCCCCTGTGGAG
TCGGTCCTGTTCTATGCCATCACCACGCTGCACAACCTGCTCCTGTACCAGGAGGGCGCC
AAGATGGCCGTGCGCCTGGCCGACGGGCTGCAAAAGATGGTGCCCCTGCTCAACAAGAAC
AACCCCAAGTTCCTGGCCATCACCACCGACTGCCTGCAGCTCCTGGCCTACGGCAACCAG
GAGAGCAAGCTGATCATCCTGGCCAATGGTGGGCCCCAGGCCCTCGTGCAGATCATGCGT
AACTACAGTTATGAAAAGCTGCTCTGGACCACCAGTCGTGTGCTCAAGGTGCTATCCGTG
TGTCCCAGCAATAAGCCTGCCATTGTGGAGGCTGGTGGGATGCAGGCCCTGGGCAAGCAC
CTGACCAGCAACAGCCCCCGCCTGGTGCAGAACTGCCTGTGGACCCTGCGCAACCTCTCA
GATGTGGCCACCAAGCAGGAGGGCCTGGAGAGTGTGCTGAAGATTCTGGTGAATCAGCTG
AGTGTGGATGACGTCAACGTCCTCACCTGTGCCACGGGCACACTCTCCAACCTGACATGC
AACAACAGCAAGAACAAGACGCTGGTGACACAGAACAGCGGTGTGGAGGCTCTCATCCAT
GCCATCCTGCGTGCTGGTGACAAGGACGACATCACGGAGCCTGCCGTCTGCGCTCTGCGC
CACCTCACTAGCCGCCACCCTGAGGCCGAGATGGCCCAGAACTCTGTGCGTCTCAACTAT
GGCATCCCAGCCATCGTGAAGCTGCTCAACCAGCCCAACCAGTGGCCACTGGTCAAGGCA
ACCATCGGCTTGATCAGGAATCTGGCCCTGTGCCCAGCCAACCATGCCCCGCTGCAGGAG
GCAGCGGTCATCCCCCGCCTCGTCCAACTGCTGGTGAAGGCCCACCAGGATGCCCAGCGC
CACGTAGCTGCAGGCACACAGCAGCCCTACACGGATGGTGTGAGGATGGAGGAGNNNNTG
GAGGGCTGCACCGGAGCACTGCACATCCTCGCCCGGGACCCCATGAACCGCATGGAGATC
TTCCGGCTCAACACCATTCCCCTGTTTGTGCAGCTCCTGTACTCGTCGGTGGAGAACATC
CAGCGCGTGGCTGCCGGGGTGCTGTGTGAGCTGGCCCAGGACAAGGAGGCGGCCGACGCC
ATTGATGCAGAGGGGGCCTCGGCCCCACTCATGGAGTTGCTGCACTCCCGCAACGAGGGC
ACTGCCACCTACGCTGCTGCCGTCCTGTTCCGCATCTCCGAGGACAAGAACCCAGACTAC
CGGAAGCGCGTGTCCGTGGAGCTCACCAACTCCCTCTTCAAGCATGACCCGGCTGCCTGG
GAGGCTGCCCAGAGCATGATTCCCATCAATGAGCCCTATGGAGATGACTTGGATGCCACC
TACCGCCCCATGTACTCCAGCGATGTGCCCCTTGACCCGCTGGAGATGCACATGGACATG
GATGGAGACTACCCCATCGACACCTACAGCGACGGCCTCAGGCCCCCGTACCCCACTGCA
GACCACATGCTGGCCTAG

Clone variation with respect to NM_021991.2
1675 a=>n;1676 t=>n;1677 t=>n;1678 g=>n;2089 a=>t
>OriGene 5' read for NM_021991 unedited
CTATCACCCGCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG
CAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCG
AATTCGGCACGAGGGTCCGGAGCAGCCGCCGCCCGACCGCGCCGAGCTCAGTTCGCTGTC
CGCGCCGGCTCCCACCCCGGCCCGACCCCGACCCGGCCCGGTCAGGCCCCATACTCAGTA
GCCACGATGGAGGTGATGAACCTGATGGAGCAGCCTATCAAGGTGACTGAGTGGCAGCAG
ACATACACCTACGACTCGGGTATCCACTCGGGCGCCAACACCTGCGTGCCCTCCGTCAGC
AGCAAGGGCATCATGGAGGAGGATGAGGCCTGCGGGCGCCAGTACACGCTCAAGAAAACC
ACCACTTACACCCAGGGGGTGCCCCCCAGCCAAGGTGACCTGGAGTACCAGATGTCCACA
ACAGCCAGGGCCAAACGGGTGCGGGAGGCCATGTGCCCTGGTGTGTCAGGCGAGGACAGC
TCGCTTCTGCTGGCCACCCAGGTGGAGGGGCAGGCCACCAACCTGCAGCGACTGGCCGAG
CCGTCCCAGCTGCTCAAGTCGGCCATTGTGCATCTCATCAACTACCAGGACGATGCCGAG
CTGGCCACTCGCGCCCTGCCCGAGCTCACCAAACTGCTCAACGACGAGGACCCGGTGGTG
GTGACCAANGCGGCCATGATTGTGAACCAGCTGTCGAAGAAGGAGCGTCGCGGCGGGCCC
TGATGGGCTCGCCCCAGCTGGTGGCCGCTGTCGTGCGTACCATGCAGAATACCAGCGACC
TGGACACAGNCCGCTGCACAACAGCATCCTGCACACCTCTCCCACACCGGGAGGGGCTGC
TCGCCATCTTCAAGTCGA
>OriGene 3' read for NM_021991 unedited
GGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCATCTGTGTTATTTTTATTTTC
TTTGCTTTGGTCTATACAAAAAAACCAATAACCAAAAACATAAAGCGATAATAATAAAAC
ACTCTGCTTGGACCTCCCCCAGCCCCCCACACCATGTGCGGGAAATGGGGGGGTCTGAAA
CAGGAAGGGGAAGAGAAAGCCCCTCACCACACACCAGAGGGGTCAGCCAAGAGCACTTCT
CGGGGTCAGCTAGGGCAGCTGTGTGGGTGGGACAGGGGTGTGAGGAAGCTGTCCCCAGAG
CTCCCTGGGGAGTGAGGGGTGGGCAAAGCCAACTAAGCACCCTGGAGAGAGAAGCTGGCA
TCTTCTGGAGCAGGTGACTCACTCCATATCTCCTCCCCATCTCCCCTGGACGGTCCCTGA
ACTTTTCAAGAGAAGTTTTGGATTTTGGGGGTTTGGGTCTCGAACCTGGGCCCTGGAGGC
CCTGAGGGCTTAGGGCAGTTGGTCGGTGGAGTTCAGTGAGAAAATCAGACCCAGAGAAGG
AACCAAAGCCCTTCCGGGGCCCAGGCAGCTGGAGACAGGGAGGCTGGAGGTTTGNAGGGG
CGTTGCTGGGGGAAACAGAATGGTACTTGAGTCTGAAGCTTTATTGCCCAGGCCCAGGGG
CGGGGAGGGGGGTGCATGCCCTGGCCCCTGCCCAGACAGAAAACAGGACAGACCCTTTCC
CAGAAAGACCCTCGGAGACCCTTGAAGCCCAGGTGCACCAGAATTACACCCCGTTCCCCA
GCTAGCATTTTTTGCTTGCCCTTGCCTGGACGAAACCTTTAAAGAGGAACGCACTGGGCC
ACGCCCCTAGCCACTTGTGGTTTCAATGGGGTCCCGGGCCCCGAGCCCCCCTTTTGGGTC
CAAGGGGGGACCCTCTCCTTTGCCGTGTTTTTCCC
Restriction Sites NotI-NotI     
ACCN NM_021991
Insert Size 3240 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_021991.1, NP_068831.1
RefSeq Size 3192 bp
RefSeq ORF 2238 bp
Locus ID 3728
Cytogenetics 17q21.2
Domains Armadillo_seg
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer
Gene Summary 'This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) lacks an alternate segment in the 3' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

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