gamma Catenin (JUP) (NM_021991) Human Untagged Clone

CAT#: SC112564

JUP (untagged)-Human junction plakoglobin (JUP), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: JUP
• Synonyms: CTNNG; DP3; DPIII; PDGB; PKGB
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC112564 sequence for NM_021991 edited (data generated by NextGen Sequencing)
  ATGGAGGTGATGAACCTGATGGAGCAGCCTATCAAGGTGACTGAGTGGCAGCAGACATAC
  ACCTACGACTCGGGTATCCACTCGGGCGCCAACACCTGCGTGCCCTCCGTCAGCAGCAAG
  GGCATCATGGAGGAGGATGAGGCCTGCGGGCGCCAGTACACGCTCAAGAAAACCACCACT
  TACACCCAGGGGGTGCCCCCCAGCCAAGGTGATCTGGAGTACCAGATGTCCACAACAGCC
  AGGGCCAAACGGGTGCGGGAGGCCATGTGCCCTGGTGTGTCAGGCGAGGACAGCTCGCTT
  CTGCTGGCCACCCAGGTGGAGGGGCAGGCCACCAACCTGCAGCGACTGGCCGAGCCGTCC
  CAGCTGCTCAAGTCGGCCATTGTGCATCTCATCAACTACCAGGACGATGCCGAGCTGGCC
  ACTCGCGCCCTGCCCGAGCTCACCAAACTGCTCAACGACGAGGACCCGGTGGTGGTGACC
  AAGGCGGCCATGATTGTGAACCAGCTGTCGAAGAAGGAGGCGTCGCGGCGGGCCCTGATG
  GGCTCGCCCCAGCTGGTGGCCGCTGTCGTGCGTACCATGCAGAATACCAGCGACCTGGAC
  ACAGCCCGCTGCACCACCAGCATCCTGCACAACCTCTCCCACCACCGGGAGGGGCTGCTC
  GCCATCTTCAAGTCGGGTGGCATCCCTGCTCTGGTCCGCATGCTCAGCTCCCCTGTGGAG
  TCGGTCCTGTTCTATGCCATCACCACGCTGCACAACCTGCTCCTGTACCAGGAGGGCGCC
  AAGATGGCCGTGCGCCTGGCCGACGGGCTGCAAAAGATGGTGCCCCTGCTCAACAAGAAC
  AACCCCAAGTTCCTGGCCATCACCACCGACTGCCTGCAGCTCCTGGCCTACGGCAACCAG
  GAGAGCAAGCTGATCATCCTGGCCAATGGTGGGCCCCAGGCCCTCGTGCAGATCATGCGT
  AACTACAGTTATGAAAAGCTGCTCTGGACCACCAGTCGTGTGCTCAAGGTGCTATCCGTG
  TGTCCCAGCAATAAGCCTGCCATTGTGGAGGCTGGTGGGATGCAGGCCCTGGGCAAGCAC
  CTGACCAGCAACAGCCCCCGCCTGGTGCAGAACTGCCTGTGGACCCTGCGCAACCTCTCA
  GATGTGGCCACCAAGCAGGAGGGCCTGGAGAGTGTGCTGAAGATTCTGGTGAATCAGCTG
  AGTGTGGATGACGTCAACGTCCTCACCTGTGCCACGGGCACACTCTCCAACCTGACATGC
  AACAACAGCAAGAACAAGACGCTGGTGACACAGAACAGCGGTGTGGAGGCTCTCATCCAT
  GCCATCCTGCGTGCTGGTGACAAGGACGACATCACGGAGCCTGCCGTCTGCGCTCTGCGC
  CACCTCACTAGCCGCCACCCTGAGGCCGAGATGGCCCAGAACTCTGTGCGTCTCAACTAT
  GGCATCCCAGCCATCGTGAAGCTGCTCAACCAGCCCAACCAGTGGCCACTGGTCAAGGCA
  ACCATCGGCTTGATCAGGAATCTGGCCCTGTGCCCAGCCAACCATGCCCCGCTGCAGGAG
  GCAGCGGTCATCCCCCGCCTCGTCCAACTGCTGGTGAAGGCCCACCAGGATGCCCAGCGC
  CACGTAGCTGCAGGCACACAGCAGCCCTACACGGATGGTGTGAGGATGGAGGAGNNNNTG
  GAGGGCTGCACCGGAGCACTGCACATCCTCGCCCGGGACCCCATGAACCGCATGGAGATC
  TTCCGGCTCAACACCATTCCCCTGTTTGTGCAGCTCCTGTACTCGTCGGTGGAGAACATC
  CAGCGCGTGGCTGCCGGGGTGCTGTGTGAGCTGGCCCAGGACAAGGAGGCGGCCGACGCC
  ATTGATGCAGAGGGGGCCTCGGCCCCACTCATGGAGTTGCTGCACTCCCGCAACGAGGGC
  ACTGCCACCTACGCTGCTGCCGTCCTGTTCCGCATCTCCGAGGACAAGAACCCAGACTAC
  CGGAAGCGCGTGTCCGTGGAGCTCACCAACTCCCTCTTCAAGCATGACCCGGCTGCCTGG
  GAGGCTGCCCAGAGCATGATTCCCATCAATGAGCCCTATGGAGATGACTTGGATGCCACC
  TACCGCCCCATGTACTCCAGCGATGTGCCCCTTGACCCGCTGGAGATGCACATGGACATG
  GATGGAGACTACCCCATCGACACCTACAGCGACGGCCTCAGGCCCCCGTACCCCACTGCA
  GACCACATGCTGGCCTAG
  
  Clone variation with respect to NM_021991.2
  1675 a=>n;1676 t=>n;1677 t=>n;1678 g=>n;2089 a=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021991 unedited
  CTATCACCCGCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG
  CAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCG
  AATTCGGCACGAGGGTCCGGAGCAGCCGCCGCCCGACCGCGCCGAGCTCAGTTCGCTGTC
  CGCGCCGGCTCCCACCCCGGCCCGACCCCGACCCGGCCCGGTCAGGCCCCATACTCAGTA
  GCCACGATGGAGGTGATGAACCTGATGGAGCAGCCTATCAAGGTGACTGAGTGGCAGCAG
  ACATACACCTACGACTCGGGTATCCACTCGGGCGCCAACACCTGCGTGCCCTCCGTCAGC
  AGCAAGGGCATCATGGAGGAGGATGAGGCCTGCGGGCGCCAGTACACGCTCAAGAAAACC
  ACCACTTACACCCAGGGGGTGCCCCCCAGCCAAGGTGACCTGGAGTACCAGATGTCCACA
  ACAGCCAGGGCCAAACGGGTGCGGGAGGCCATGTGCCCTGGTGTGTCAGGCGAGGACAGC
  TCGCTTCTGCTGGCCACCCAGGTGGAGGGGCAGGCCACCAACCTGCAGCGACTGGCCGAG
  CCGTCCCAGCTGCTCAAGTCGGCCATTGTGCATCTCATCAACTACCAGGACGATGCCGAG
  CTGGCCACTCGCGCCCTGCCCGAGCTCACCAAACTGCTCAACGACGAGGACCCGGTGGTG
  GTGACCAANGCGGCCATGATTGTGAACCAGCTGTCGAAGAAGGAGCGTCGCGGCGGGCCC
  TGATGGGCTCGCCCCAGCTGGTGGCCGCTGTCGTGCGTACCATGCAGAATACCAGCGACC
  TGGACACAGNCCGCTGCACAACAGCATCCTGCACACCTCTCCCACACCGGGAGGGGCTGC
  TCGCCATCTTCAAGTCGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021991 unedited
  GGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCATCTGTGTTATTTTTATTTTC
  TTTGCTTTGGTCTATACAAAAAAACCAATAACCAAAAACATAAAGCGATAATAATAAAAC
  ACTCTGCTTGGACCTCCCCCAGCCCCCCACACCATGTGCGGGAAATGGGGGGGTCTGAAA
  CAGGAAGGGGAAGAGAAAGCCCCTCACCACACACCAGAGGGGTCAGCCAAGAGCACTTCT
  CGGGGTCAGCTAGGGCAGCTGTGTGGGTGGGACAGGGGTGTGAGGAAGCTGTCCCCAGAG
  CTCCCTGGGGAGTGAGGGGTGGGCAAAGCCAACTAAGCACCCTGGAGAGAGAAGCTGGCA
  TCTTCTGGAGCAGGTGACTCACTCCATATCTCCTCCCCATCTCCCCTGGACGGTCCCTGA
  ACTTTTCAAGAGAAGTTTTGGATTTTGGGGGTTTGGGTCTCGAACCTGGGCCCTGGAGGC
  CCTGAGGGCTTAGGGCAGTTGGTCGGTGGAGTTCAGTGAGAAAATCAGACCCAGAGAAGG
  AACCAAAGCCCTTCCGGGGCCCAGGCAGCTGGAGACAGGGAGGCTGGAGGTTTGNAGGGG
  CGTTGCTGGGGGAAACAGAATGGTACTTGAGTCTGAAGCTTTATTGCCCAGGCCCAGGGG
  CGGGGAGGGGGGTGCATGCCCTGGCCCCTGCCCAGACAGAAAACAGGACAGACCCTTTCC
  CAGAAAGACCCTCGGAGACCCTTGAAGCCCAGGTGCACCAGAATTACACCCCGTTCCCCA
  GCTAGCATTTTTTGCTTGCCCTTGCCTGGACGAAACCTTTAAAGAGGAACGCACTGGGCC
  ACGCCCCTAGCCACTTGTGGTTTCAATGGGGTCCCGGGCCCCGAGCCCCCCTTTTGGGTC
  CAAGGGGGGACCCTCTCCTTTGCCGTGTTTTTCCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021991
• Insert Size: 3240 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_021991.1, NP_068831.1
• RefSeq Size: 3192 bp
• RefSeq ORF: 2238 bp
• Locus ID: 3728
• Cytogenetics: 17q21.2
• Domains: Armadillo_seg
• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer
• Gene Summary: 'This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (2) lacks an alternate segment in the 3' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.