TLR5 (NM_003268) Human Untagged Clone

CAT#: SC112789

TLR5 (untagged)-Human toll-like receptor 5 (TLR5)


  "NM_003268" in other vectors (6)

Reconstitution Protocol

USD 760.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol TLR5
Synonyms MELIOS; SLE1; SLEB1; TIL3
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_003268 edited
CCTATAGTCTCAGGAACTGAAGTCTTTAAACAACCAGGGACCCTCTGCCCCTAGAATAAG
AACATACTAGAAGTCCCTTCTGCTAGGACAACGAGGATCATGGGAGACCACCTGGACCTT
CTCCTAGGAGTGGTGCTCATGGCCGGTCCTGTGTTTGGAATTCCTTCCTGCTCCTTTGAT
GGCCGAATAGCCTTTTATCGTTTCTGCAACCTCACCCAGGTCCCCCAGGTCCTCAACACC
ACTGAGAGGCTCCTGCTGAGCTTCAACTATATCAGGACAGTCACTGCTTCATCCTTCCCC
TTTCTGGAACAGCTGCAGCTGCTGGAGCTCGGGAGCCAGTATACCCCCTTGACTATTGAC
AAGGAGGCCTTCAGAAACCTGCCCAACCTTAGAATCTTGGACCTGGGAAGTAGTAAGATA
TACTTCTTGCATCCAGATGCTTTTCAGGGACTGTTCCATCTGTTTGAACTTAGACTGTAT
TTCTGTGGTCTCTCTGATGCTGTATTGAAAGATGGTTATTTCAGAAATTTAAAGGCTTTA
ACTCGCTTGGATCTATCCAAAAATCAGATTCGTAGCCTTTACCTTCATCCTTCATTTGGG
AAGTTGAATTCCTTAAAGTCCATAGATTTTTCCTCCAACCAAATATTCCTTGTATGTGAA
CATGAGCTCGAGCCCCTACAAGGGAAAACGCTCTCCTTTTTTAGCCTCGCAGCTAATAGC
TTGTATAGCAGAGTCTCAGTGGACTGGGGAAAATGTATGAACCCATTCAGAAACATGGTG
CTGGAGATACTAGATGTTTCTGGAAATGGCTGGACAGTGGACATCACAGGAAACTTTAGC
AATGCCATCAGCAAAAGCCAGGCCTTCTCTTTGATTCTTGCCCACCACATCATGGGTGCC
GGGTTTGGCTTCCATAACATCAAAGATCCTGACCAGAACACATTTGCTGGCCTGGCCAGA
AGTTCAGTGAGACACCTGGATCTTTCACATGGGTTTGTCTTCTCCCTGAACTCACGAGTC
TTTGAGACACTCAAGGATTTGAAGGTTCTGAACCTTGCCTACAACAAGATAAATAAGATT
GCAGATGAAGCATTTTACGGACTTGACAACCTCCAAGTTCTCAATTTGTCATATAACCTT
CTGGGGGAACTTTACAGTTCGAATTTCTATGGACTACCTAAGGTAGCCTACATTGATTTG
CAAAAGAATCACATTGCAATAATTCAAGACCAAACATTCAAATTCCTGGAAAAATTACAG
ACCTTGGATCTCCGAGACAATGCTCTTACAACCATTCATTTTATTCCAAGCATACCCGAT
ATCTTCTTGAGTGGCAATAAACTAGTGACTTTGCCAAAGATCAACCTTACAGCGAACCTC
ATCCACTTATCAGAAAACAGGCTAGAAAATCTAGATATTCTCTACTTTCTCCTACGGGTA
CCTCATCTCCAGATTCTCATTTTAAATCAAAATCGCTTCTCCTCCTGTAGTGGAGATCAA
ACCCCTTCAGAGAATCCCAGCTTAGAACAGCTTTTCCTTGGAGAAAATATGTTGCAACTT
GCCTGGGAAACTGAGCTCTGTTGGGATGTTTTTGAGGGACTTTCTCATCTTCAAGTTCTG
TATTTGAATCATAACTATCTTAATTCCCTTCCACCAGGAGTATTTAGCCATCTGACTGCA
TTAAGGGGACTAAGCCTCAACTCCAACAGGCTGACAGTTCTTTCTCACAATGATTTACCT
GCTAATTTAGAGATCCTGGACATATCCAGGAACCAGCTCCTAGCTCCTAATCCTGATGTA
TTTGTATCACTTAGTGTCTTGGATATAACTCATAACAAGTTCATTTGTGAATGTGAACTT
AGCACTTTTATCAATTGGCTTAATCACACCAATGTCACTATAGCTGGGCCTCCTGCAGAC
ATATATTGTGTGTACCCTGACTCGCTCTCTGGGGTTTCCCTCTTCTCTCTTTCCACGGAA
GGTTGTGATGAAGAGGAAGTCTTAAAGTCCCTAAAGTTCTCCCTTTTCATTGTATGCACT
GTCACTCTGACTCTGTTCCTCATGACCATCCTCACAGTCACAAAGTTCCGGGGCTTCTGT
TTTATCTGTTATAAGACAGCCCAGAGACTGGTGTTCAAGGACCATCCCCAGGGCACAGAA
CCTGATATGTACAAATATGATGCCTATTTGTGCTTCAGCAGCAAAGACTTCACATGGGTG
CAGAATGCTTTGCTCAAACACCTGGACACTCAATACAGTGACCAAAACAGATTCAACCTG
TGCTTTGAAGAAAGAGACTTTGTCCCAGGAGAAAACCGCATTGCCAATATCCAGGATGCC
ATCTGGAACAGTAGAAAGATCGTTTGTCTTGTGAGCAGACACTTCCTTAGAGATGGCTGG
TGCCTTGAAGCCTTCAGTTATGCCCAGGGCAGGTGCTTATCTGACCTTAACAGTGCTCTC
ATCATGGTGGTGGTTGGGTCCTTGTCCCAGTACCAGTTGATGAAACATCAATCCATCAGA
GGCTTTGTACAGAAACAGCAGTATTTGAGGTGGCCTGAGGATCTCCAGGATGTTGGCTGG
TTTCTTCATAAACTCTCTCAACAGATACTAAAGAAAGAAAAAGAAAAGAAGAAAGACAAT
AACATTCCGTTGCAAACTGTAGCAACCATCTCCTAATCAAAGGAGCAATTTCCAACTTAT
CTCAAGCCACAAATAACTCTTCACTTTGTATTTGCACCAAGTTATCATTTTGGGGTCCTC
TCTGGAGGTTTTTTTT
>OriGene 5' read for NM_003268 unedited
GGATTTTGGTATACGACTCACTATAGGGCGGCCCGCGAATCGGCACGAGGCCCAGAGTCT
CACTCTGCCGCCCAGGCTGGACTGCAGTGACACAATCTCGGCTGACTGCAACCACTGCCT
CCAGGGTTCAAGCGATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGATTGATG
TTCATGTTCCTGACACTACTACAAGATTCATACTCCTGATGCTACTGACAACGTGGCTTC
TCCACAGTCACCAAACCAGGGATGCTATACTGGACTTCCCTACTCTCATCTGCTCCAGCC
CCCTGACCTTATAGTTGCCCAGCTTTCCTGGCAATTGACTTTGCCCATCAATACACAGGA
TTTAGCATCCAGGGAAGATGTCGGAGCCTCAGATGTTAATTTTCTAATTGAGAATGTTGG
CGCTGTCCGAACCTGGAGACAGAGTATCAGCGCCTTTGCTTGCTGCTGTTTTTGCTGTTT
TTTGATGCTGGGAACCACCACCTAAAGATAGTAAAGAAAACACAGGAAGCTTTCCGGAAA
ACAAAAAGTCCTTTCTCCTGATTCACCAAAAAATAAAATACTGACTACCATCACTGTGAT
GAGATTCCTATAGTCTCAGGAACTGAAGTCTTTAAACAACCAGGGACCCTCTGCCCCTAG
AATAAGAACATACTAGAAGTCCCTTCTGCTAGGACAACGAGGATCATGGGAGACCACCTG
GACCTTCTCCTAGGAGTGGTGCTCATGGCCGGTCCTGTGTTTGGGATTCCTTCCTGCTCC
TTTGATGGCCGAATAGCCTTNTATCGNTTCTGNCACCTCNACCCAGTCCCNCCAGTCCTC
ACACCACTGAGAGGCTCCTGCTGAGCTTCACTATATCCAGACAGTCACTGCTTCATCCTT
CCCTTTTCTGNACAGCTGCAGCTGCTGGAGCTCGGNAGCCATATACCCCCTTGACTATGC
ACAGGNNAGGCTN
>OriGene 3' read for NM_003268 unedited
GCCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTGGCAGTTGCAATTTTCT
AGATCTATTATTTTCCATTTGGAGGTTAGTGAGACAGAACATGGTGTTGATACGAAAATT
GAGAGATTTATGTTGTTTTCATAGTAGCAAAAAGAAAAAAAAAACCTCCAGAGAGGACCC
CAAAATGATAACTTGGTGCAAATACAAAGTGAAGAGTTATTTGTGGCTTGAGATAAGTTG
GAAATTGCTCCTTTGATTAGGAGATGGTTGCTACAGTTTGCAACGGAATGTTATTGGCTT
TCTTCTTTTCTTTTTCTTTCTTTAGTATCTGTTGAGAGAGTTTATGAAGAAACCAGCCAA
CATCCTGGAGATCCTCAGGCCACCTCAAATACTGCTGTTTCTGTACAAAGCCTCTGATGG
ATTGATGTTTCATCAACTGGTACTGGGACAAGGACCCAACCACCACCATGATGAGAGCAC
TGTTAAGGTCAGATAAGCACCTGCCCTGGGCATAACTGAAGGCTTCAAGGCACCAGCCAT
CTCTAAGGAAGTGTCTGCTCACAAGACAAACGATCTTTCTACTGTTCCAGATGGCATCCT
GGATATTGGCAATGCGGTTTTCTCCTGGGACAAAGTCTCTTTCTTCAAAGCACAGGTTGA
ATCTGTTTTGGTCACTGTATTGAGTGTCCAGGTGTTTGAGCAAGCATTCTGCACCCATGT
GAAGTCTTTGCTGCTNGAGCACAATAGGCATCATATTTGTACTATCANGGNTCTGTGCCC
TGGGGATGGTCTTTGACACCAGTCTCTGGGCTGTCTTATACAAATAAACAGAGCCCCGGG
ACTTTGTGACTGTGAGGATGGTCATGAGGAACAGAGTCANATGACAGTGCATACATGAAA
AGGAGAACTTTAGACTTTAAGACTTCTCTCATACAACCTTCGGGAAAGAGAAAAGGAACC
CCNAGGCGGTCGGGTCCCCAATATGTTGGAGGAGCCCCCTTATGACATGGGGA
Restriction Sites NotI-NotI     
ACCN NM_003268
Insert Size 3600 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_003268.3, NP_003259.2
RefSeq Size 3369 bp
RefSeq ORF 2577 bp
Locus ID 7100
Cytogenetics 1q41
Domains TIR, LRRCT, LRR, LRR_TYP, LRR_SD22, LRR_PS
Protein Families Druggable Genome, Transmembrane
Protein Pathways Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway
Gene Summary 'This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]'

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