RNase L (RNASEL) (NM_021133) Human Untagged Clone

CAT#: SC112978

RNASEL (untagged)-Human ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (RNASEL)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RNASEL
• Synonyms: PRCA1; RNS4
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_021133, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGAGCAGGGATCATAACAACCCCCAGGAGGGACCCACGTCCTCCAGCGGTAGAAGGGCTGCAGTGG
  AAGACAATCACTTGCTGATTAAAGCTGTTCAAAACGAAGATGTTGACCTGGTCCAGCAATTGCTGGAAGG
  TGGAGCCAATGTTAATTTCCAGGAAGAGGAAGGGGGCTGGACACCTCTGCATAACGCAGTACAAATGAGC
  AGGGAGGACATTGTGGAACTTCTGCTTCGTCATGGTGCTGACCCTGTTCTGAGGAAGAAGAATGGGGCCA
  CGCCTTTTATCCTCGCAGCGATTGCGGGGAGCGTGAAGCTGCTGAAACTTTTCCTTTCTAAAGGAGCAGA
  TGTCAATGAGTGTGATTTTTATGGCTTCACAGCCTTCATGGAAGCCGCTGTGTATGGTAAGGTCAAAGCC
  CTAAAATTCCTTTATAAGAGAGGAGCAAATGTGAATTTGAGGCGAAAGACAAAGGAGGATCAAGAGCGGC
  TGAGGAAAGGAGGGGCCACAGCTCTCATGGACGCTGCTGAAAAAGGACACGTAGAGGTCTTGAAGATTCT
  CCTTGATGAGATGGGGGCAGATGTAAACGCCTGTGACAATATGGGCAGAAATGCCTTGATCCATGCTCTC
  CTGAGCTCTGACGATAGTGATGTGGAGGCTATTACGCATCTGCTGCTGGACCATGGGGCTGATGTCAATG
  TGAGGGGAGAAAGAGGGAAGACTCCCCTGATCCTGGCAGTGGAGAAGAAGCACTTGGGTTTGGTGCAGAG
  GCTTCTGGAGCAAGAGCACATAGAGATTAATGACACAGACAGTGATGGCAAAACAGCACTGCTGCTTGCT
  GTTGAACTCAAACTGAAGAAAATCGCCGAGTTGCTGTGCAAACGTGGAGCCAGTACAGATTGTGGGGATC
  TTGTTATGACAGCGAGGCGGAATTATGACCATTCCCTTGTGAAGGTTCTTCTCTCTCATGGAGCCAAAGA
  AGATTTTCACCCTCCTGCTGAAGACTGGAAGCCTCAGAGCTCACACTGGGGGGCAGCCCTGAAGGATCTC
  CACAGAATATACCGCCCTATGATTGGCAAACTCAAGTTCTTTATTGATGAAAAATACAAAATTGCTGATA
  CTTCAGAAGGAGGCATCTACCTGGGGTTCTATGAGAAGCAAGAAGTAGCTGTGAAGACGTTCTGTGAGGG
  CAGCCCACGTGCACAGCGGGAAGTCTCTTGTCTGCAAAGCAGCCGAGAGAACAGTCACTTGGTGACATTC
  TATGGGAGTGAGAGCCACAGGGGCCACTTGTTTGTGTGTGTCACCCTCTGTGAGCAGACTCTGGAAGCGT
  GTTTGGATGTGCACAGAGGGGAAGATGTGGAAAATGAGGAAGATGAATTTGCCCGAAATGTCCTGTCATC
  TATATTTAAGGCTGTTCAAGAACTACACTTGTCCTGTGGATACACCCACCAGGATCTGCAACCACAAAAC
  ATCTTAATAGATTCTAAGAAAGCTGCTCACCTGGCAGATTTTGATAAGAGCATCAAGTGGGCTGGAGATC
  CACAGGAAGTCAAGAGAGATCTAGAGGACCTTGGACGGCTGGTCCTCTATGTGGTAAAGAAGGGAAGCAT
  CTCATTTGAGGATCTGAAAGCTCAAAGTAATGAAGAGGTGGTTCAACTTTCTCCAGATGAGGAAACTAAG
  GACCTCATTCATCGTCTCTTCCATCCTGGGGAACATGTGAGGGACTGTCTGAGTGACCTGCTGGGTCATC
  CCTTCTTTTGGACTTGGGAGAGCCGCTATAGGACGCTTCGGAATGTGGGAAATGAATCCGACATCAAAAC
  ACGAAAATCTGAAAGTGAGATCCTCAGACTACTGCAACCTGGGCCTTCTGAACATTCCAAAAGTTTTGAC
  AAGTGGACGACTAAGATTAATGAATGTGTTATGAAAAAAATGAATAAGTTTTATGAAAAAAGAGGCAATT
  TCTACCAGAACACTGTGGGTGATCTGCTAAAGTTCATCCGGAATTTGGGAGAACACATTGATGAAGAAAA
  GCATAAAAAGATGAAATTAAAAATTGGAGACCCTTCCCTGTATTTTCAGAAGACATTTCCAGATCTGGTG
  ATCTATGTCTACACAAAACTACAGAACACAGAATATAGAAAGCATTTCCCCCAAACCCACAGTCCAAACA
  AGCCTCAGTGTGATGGAGCTGGTGGGGCCAGTGGGTTGGCCAGCCCTGGGTGCTGA
  
  
• Restriction Sites: Please inquire
• ACCN: NM_021133
• Insert Size: 4700 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_021133.2, NP_066956.1
• RefSeq Size: 4166 bp
• RefSeq ORF: 2226 bp
• Locus ID: 6041
• Cytogenetics: 1q25.3
• Domains: pkinase, ANK, S_TKc, PUG
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: 'This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]'