Ku80 (XRCC5) (NM_021141) Human Untagged Clone

CAT#: SC112985

XRCC5 (untagged)-Human X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (XRCC5)


  "NM_021141" in other vectors (7)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol XRCC5
Synonyms KARP-1; KARP1; KU80; Ku86; KUB2; NFIV
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC112985 sequence for NM_021141 edited (data generated by NextGen Sequencing)
ATGGTGCGGTCGGGGAATAAGGCAGCTGTTGTGCTGTGTATGGACGTGGGCTTTACCATG
AGTAACTCCATTCCTGGTATAGAATCCCCATTTGAACAAGCAAAGAAGGTGATAACCATG
TTTGTACAGCGACAGGTGTTTGCTGAGAACAAGGATGAGATTGCTTTAGTCCTGTTTGGT
ACAGATGGCACTGACAATCCCCTTTCTGGTGGGGATCAGTATCAGAACATCACAGTGCAC
AGACATCTGATGCTACCAGATTTTGATTTGCTGGAGGACATTGAAAGCAAAATCCAACCA
GGTTCTCAACAGGCTGACTTCCTGGATGCACTAATCGTGAGCATGGATGTGATTCAACAT
GAAACAATAGGAAAGAAGTTTGAGAAGAGGCATATTGAAATATTCACTGACCTCAGCAGC
CGATTCAGCAAAAGTCAGCTGGATATTATAATTCATAGCTTGAAGAAATGTGACATCTCC
CTGCAATTCTTCTTGCCTTTCTCACTTGGCAAGGAAGATGGAAGTGGGGACAGAGGAGAT
GGCCCCTTTCGCTTAGGTGGCCATGGGCCTTCCTTTCCACTAAAAGGAATTACCGAACAG
CAAAAAGAAGGTCTTGAGATAGTGAAAATGGTGATGATATCTTTAGAAGGTGAAGATGGG
TTGGATGAAATTTATTCATTCAGTGAGAGTCTGAGAAAACTGTGCGTCTTCAAGAAAATT
GAGAGGCATTCCATTCACTGGCCCTGCCGACTGACCATTGGCTCCAATTTGTCTATAAGG
ATTGCAGCCTATAAATCGATTCTACAGGAGAGAGTTAAAAAGACTTGGACAGTTGTGGAT
GCAAAAACCCTAAAAAAAGAAGATATACAAAAAGAAACAGTTTATTGCTTAAATGATGAT
GATGAAACTGAAGTTTTAAAAGAGGATATTATTCAAGGGTTCCGCTATGGAAGTGATATA
GTTCCTTTCTCTAAAGTGGATGAGGAACAAATGAAATATAAATCGGAGGGGAAGTGCTTC
TCTGTTTTGGGATTTTGTAAATCTTCTCAGGTTCAGAGAAGATTCTTCATGGGAAATCAA
GTTCTAAAGGTCTTTGCAGCAAGAGATGATGAGGCAGCTGCAGTTGCACTTTCCTCCCTG
ATTCATGCTTTGGATGACTTAGACATGGTGGCCATAGTTCGATATGCTTATGACAAAAGA
GCTAATCCTCAAGTCGGCGTGGCTTTTCCTCATATCAAGCATAACTATGAGTGTTTAGTG
TATGTGCAGCTGCCTTTCATGGAAGACTTGCGGCAATACATGTTTTCATCCTTGAAAAAC
AGTAAGAAATATGCTCCCACCGAGGCACAGTTGAATGCTGTTGATGCTTTGATTGACTCC
ATGAGCTTGGCAAAGAAAGATGAGAAGACAGACACCCTTGAAGACTTGTTTCCAACCACC
AAAATCCCAAATCCTCGATTTCAGAGATTATTTCAGTGTCTGCTGCACAGAGCTTTACAT
CCCCGGGAGCCTCTACCCCCAATTCAGCAGCATATTTGGAATATGCTGAATCCTCCCGCT
GAGGTGACAACAAAAAGTCAGATTCCTCTCTCTAAAATAAAGACCCTTTTTCCTCTGATT
GAAGCCAAGAAAAAGGATCAAGTGACTGCTCAGGAAATTTTCCAAGACAACCATGAAGAT
GGACCTACAGCTAAAAAATTAAAGACTGAGCAAGGGGGAGCCCACTTCAGCGTCTCCAGT
CTGGCTGAAGGCAGTGTCACCTCTGTTGGAAGTGTGAATCCTGCTGAAAACTTCCGTGTT
CTAGTGAAACAGAAGAAGGCCAGCTTTGAGGAAGCGAGTAACCAGCTCATAAATCACATC
GAACAGTTTTTGGATACTAATGAAACACCGTATTTTATGAAGAGCATAGACTGCATCCGA
GCCTTCCGGGAAGAAGCCATTAAGTTTTCAGAAGAGCAGCGCTTTAACAACTTCCTGAAA
GCCCTTCAAGAGAAAGTGGAAATTAAACAATTAAATCATTTCTGGGAAATTGTTGTCCAG
GATGGAATTACTCTGATCACCAAAGAGGAAGCCTCTGGAAGTTCTGTCACAGCTGAGGAA
GCCAAAAAGTTTCTGGCCCCCAAAGACAAACCAAGTGGAGACACAGCAGCTGTATTTGAA
GAAGGTGGTGATGTGGACGATTTATTGGACATGATATAG

Clone variation with respect to NM_021141.3
>OriGene 5' read for NM_021141 unedited
AGTTTGGATTTTGTNATCCGACTTCATATAGGGCGGCCGCGCAATTCGCACGAGGCCTCG
TGCCGAATTCGGCACGAGGCCGGAAGCGAGTTGCGACACGGCAGGTTCCCGCCCGGAAGA
AGCGACCAAAGCGCCTGAGGACCGGCAACATGGTGCGGTCGGGGAATAAGGCAGCTGTTG
TGCTGTGTATGGACGTGGGCTTTACCATGAGTAACTCCATTCCTGGTATAGAATCCCCAT
TTGAACAAGCAAAGAAGGTGATAACCATGTTTGTACAGCGACAGGTGTTTGCTGAGAACA
AGGATGAGATTGCTTTAGTCCTGTTTGGTACAGATGGCACTGACAATCCCCTTTCTGGTG
GGGATCAGTATCAGAACATCACAGTGCACAGACATCTGATGCTACCAGATTTTGATTTGC
TGGAGGACATTGAAAGCAAAATCCAACCAGGTTCTCAACAGGCTGACTTCCTGGATGCAC
TAATCGTGAGCATGGATGTGATTCAACATGAAACAATAGGAAAGAAGTTTGAGAAGAGGC
ATATTGAAATATTCACTGACCTCAGCAGCCGATTCAGCAAAAGTCAGCTGGATATTATAA
TTCATAGCTTGAAGAAATGTGACATCTCCCTGCAATTCTTCTTGCCTTTCTCACTTGGCA
AGGAAGATGGAAGTGGGGACAGAGGAGATGGCCCCTTTCGCTTAGGTGGCCATGGGCCTT
CCTTTCCACTAAAAGGAATTACCGAACAGCANANAGAAGGTCTTGAGATAGTGAAAATGG
TGATGATATCTTTAGAAGGTGAAGATGGGTTGGNATGAAAATTTATTCATTCAGTGAGAG
TCTGANAAAACTGTGCGTCTTTCAGAAATTTGAGAGCATTCCATTCACTGGCCCTGCCGA
CTGACCATTGGCTCCATTTGTCT
>OriGene 3' read for NM_021141 unedited
NTTTAGCTTGNACGCGGCCGCATCTANGATCGGTTTTTTTTTTTTTTTTTTGAGTCATTT
ATGCCTTTAATGTTACATGTACAAAACTGTGTATTAGTGACGACTTATGAGGGTGCTGAA
GACAGAGGTGACTGGGTACCAAGAAGTCTGTACACCAAAGAGGAACTGGAACTCAAGGCA
AGAATGAGGACAAGAAAAAAAGAGAATAAGGGCTTTGTTATTTTCTTATTTAGTAAAGGA
GACACCATCCACAAAGATGAAAGCTGACTTAGGTAGAAATGGGAAAGACCGAAAAGTTAC
CTAAGTGTTTTAATATAACGAAACTTTCTCTCTTTGAGGCTTGCAAGTAGAGAACAGTGA
AGTGATATAATTCTAACTACTGTAGTAAATTTCTCAGTTTTTGAGTTTCTAAAGGTTCAC
TGATATGGCAGAGATTGGGCCAAAAGGTCTTTTCTTCATGAGACCACCACCATAACTCAC
TGCTTAAAAGGAGTATGAAGGGAAATTGTGCTCCCCTTCCCACCCCACTTAAAGAAAACC
ACCTATATACAGAGGCAGAGTAATGTGGTAACTAGAAGGCCTCAACTAAAAAGAGAAGTG
AGTCCGTCCTTACCCATGGTTTTCCTAACCCAGCTGCTTGTTGGGAGGAAGCAAATGCTA
CTGCTTGCTCAACACAAGTTGTGACAGCTGTTGGAGGATCAGGCAAAGGGAGACTCTGGA
AAGGGTTAAGAAACTCATCAATAACCATGCCATGTTTCCCATGAGACACTAATTACATCA
CAAGGGCTGCCACTGTCACTGATATACTACGTCAAGAAAGGACTACTTTCCAGAAACTTC
AAAGCTTGTTTGTGATTTTCAAAGATCTGGTAGACCCCGAAAAAATATACCCCACCCGGA
AATAACATGACTCTT
Restriction Sites NotI-NotI     
ACCN NM_021141
Insert Size 3460 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_021141.2, NP_066964.1
RefSeq Size 3310 bp
RefSeq ORF 2199 bp
Locus ID 7520
Cytogenetics 2q35
Domains VWA, Ku_C, Ku_N, ku
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Non-homologous end-joining
Gene Summary 'The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]'

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