NUDT15 (NM_018283) Human Untagged Clone

CAT#: SC113594

NUDT15 (untagged)-Human nudix (nucleoside diphosphate linked moiety X)-type motif 15 (NUDT15)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NUDT15
• Synonyms: MTH2; NUDT15D
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC113594 sequence for NM_018283 edited (data generated by NextGen Sequencing)
  ATGACGGCCAGCGCACAGCCGCGCGGGCGGCGGCCAGGAGTCGGAGTCGGAGTCGTGGTG
  ACCAGCTGCAAGCATCCGCGTTGCGTCCTCCTGGGGAAGAGGAAAGGCTCGGTTGGAGCT
  GGCAGTTTCCAACTCCCTGGAGGTCATCTGGAGTTCGGTGAAACCTGGGAAGAATGTGCT
  CAAAGGGAAACCTGGGAAGAAGCAGCTCTTCACCTGAAAAATGTTCACTTTGCCTCAGTT
  GTGAATTCTTTCATTGAGAAGGAGAATTACCATTATGTTACTATATTAATGAAAGGAGAA
  GTGGATGTGACTCATGATTCAGAACCAAAGAATGTAGAGCCTGAAAAAAATGAAAGTTGG
  GAGTGGGTTCCTTGGGAAGAACTACCTCCCCTGGACCAGCTTTTCTGGGGACTGCGTTGT
  TTAAAAGAACAAGGCTATGATCCATTTAAAGAAGATCTGAACCATCTGGTGGGATACAAA
  GGAAATCATCTCTAG
  
  Clone variation with respect to NM_018283.1
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018283 unedited
  TGTCACATTTGTATACGACTCCTATAGGCGGCCGCGNAATTCGCACGAGGCCCGCGCGCT
  ATGACGGCCAGCGCACAGCCGCGCGGGCGGCGGCCAGGAGTCGGAGTCGGAGTCGTGGTG
  ACCAGCTGCAAGCATCCGCGTTGCGTCCTCCTGGGGAAGAGGAAAGGCTCGGTTGGAGCT
  GGCAGTTTCCAACTCCCTGGAGATCATCTGGAGTTCGGTGAAACCTGGGAAGAATGTGCT
  CAAAGGGAAACCTGGGAAGAAGCAGCTCTTCACCTGAAAAATGTTCACTTTGCCTCAGTT
  GTGAATTCTTTCATTGAGAAGGAGAATTACCATTATGTTACTATATTAATGAAAGGAGAA
  GTGGATGTGACTCATGATTCAGAACCAAAGAATGTAGAGCCTGAAAAAAATGAAAGTTGG
  GAGTGGGTTCCTTGGGAAGAACTACCTCCCCTGGACCAGCTTTTCTGGGGACTGCGTTGT
  TTAAAAGAACAAGGCTATGATCCATTTAAAGAAGATCTGAACCATCTGGTGGGATACAAA
  GGAAATCATCTCTAGGTGGCCAAGAAGATTTGATTTTCTTTAAAAAGACAAGAATAAGGT
  CTGGTTAGGGAATGAAAAATGTATACATTTCGGAACAACTCCATTTTATCTAAAAAAGTT
  CTTGTGATTGCCAGTTTATTTGCAGTCTCTTATGTATCCCCCCTCTTTCAGCCAGTACTT
  GAGAAAATTTTTCTGAATATGTCATTGAATTGTATTCCAGACACAGAATACATGATAAAT
  ACTGATATTATGGGTAATCTGCTTCCATATTTACTATGATATTACTGTGCAGNTTGNATT
  ACTAGCTGCATGGAGTAGATGCATCAAATTGCCTTAGTGTTTCTGTCAATAGAGACCCTG
  ATCAATTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_018283 unedited
  GCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TAATTTCTTAAAATTTTTATTAATCATTTGCAAGTAACAAGAACCAAGTTTATATAAACA
  CATAAAAACATTTTTGGCAAATAGCTAATTTTATTTTTTTCACATATTAAAACCCACTAA
  AAATAACCATTTTTCTAACTAACCACAACAAAAATTAGGGAGAAAAGTACTGGTGCTTTA
  CATTTCTCCAAATCTCTTCAATGTCTGATGACAGACGAAAGCTGGAATCTTGGATCTGCT
  TTTGCATTCAGCCTATTACAATATCACACCAGATAGCCTCTTGAAAACTCCTCTGCATAC
  TCATGAAAAAATGAGGGAAAAAGATAAATGATGGCTGGGCGTTGGGGCTCATACCTGTAA
  TCCCAGCACTTTGGGAGGCTGAAATGGGCAAATCACTTGAGCTCAGGAGTTCCAGACCAG
  CCTGGCCAACATGGGGAAACCCCGTCTCCACTAAAAATACAAAAATTAGCCAGGTGTGGG
  GGTGGGTGCCTATAATCCCAGCTACTCGGGAAGCTGAGGTAGGAGAATTGCTTGAACCCA
  GGTGGCGGAGGCTGCAATGAGCTGAGATCGCGCCACTGCACTCCAATGTGGGCACCAGAG
  CAAGACTCCTTCTAAAATAAAAAAAGGGAAAGCTATAAATAGCGAAATGATGTCTTAGTG
  TTATAAAAACAGTTTTGACCCAAAAAACCCTTGAAGGCTTTTGAGGCCCCCCCAGACCAA
  ATTTTGACACCCACTGTTCTAGACGAATCTCTTCATATAAAGAAACCTTTCATAATAAGA
  ACCCCTGGCCTCAAAAAGAAGTAGTGGGAAACTCACCTCCAAGCCTTTAAAAGCCTGAAC
  AGAATATAAAGGGTTGCCCAACTCTTTTGGTTTAAATCCTACATGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018283
• ORF Size: 495 bp
• Insert Size: 2000
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_018283.1, NP_060753.1
• RefSeq Size: 2022
• RefSeq ORF: 495
• Locus ID: 55270
• Domains: NUDIX
• Gene Summary: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
  Transcript Variant: This variant (1) encodes the longer isoform (1).