TRM1 (TRMT1) (NM_017722) Human Untagged Clone

CAT#: SC114002

TRMT1 (untagged)-Human TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) (TRMT1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRMT1
• Synonyms: MRT68; TRM1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC114002 sequence for NM_017722 edited (data generated by NextGen Sequencing)
  ATGCAAGGATCGTCTCTGTGGCTAAGCCTCACTTTCCGCTCCGCCCGGGTGCTCTCTAGA
  GCCCGGTTTTTCGAGTGGCAGTCTCCAGGGCTGCCGAATACAGCAGCGATGGAGAACGGC
  ACCGGGCCCTACGGAGAAGAACGTCCACGTGAAGTCCAGGAGACGACAGTCACCGAGGGG
  GCTGCCAAAATCGCCTTTCCCAGTGCCAACGAGGTCTTTTATAACCCGGTGCAGGAATTC
  AATCGGGACCTGACATGTGCTGTGATCACCGAGTTTGCTCGCATTCAGCTTGGGGCCAAA
  GGAATCCAGATCAAGGTTCCAGGAGAGAAGGACACGCAAAAAGTGGTCGTGGACTTGTCA
  GAGCAAGAGGAGGAAAAGGTTGAACTGAAAGAGAGTGAAAACCTGGCCTCAGGAGACCAA
  CCTCGCACAGCGGCCGTGGGGGAGATCTGTGAGGAAGGCCTGCATGTGCTGGAAGGCCTG
  GCAGCTTCAGGCCTACGTTCCATTCGATTTGCCCTAGAGGTGCCTGGGCTCAGATCTGTG
  GTTGCAAACGATGCCTCCACCCGGGCTGTGGATCTCATACGCCGGAATGTCCAGCTCAAT
  GACGTGGCCCACCTGGTACAGCCGAGCCAAGCAGATGCCCGGATGCTGATGTACCAGCAC
  CAGAGGGTGTCGGAGAGGTTTGACGTCATCGATCTGGACCCCTATGGCAGCCCAGCCACC
  TTCCTGGATGCAGCTGTGCAGGCTGNNNGTGCAGGAGGGTTGCTGTGTGTGACCTGCACA
  GACATGGCGGTGTTGGCGGGGAACAGCGGGGAGACGTGCTACAGCAAGTACGGGGCCATG
  GCCCTCAAGAGCCGGGCCTGCCACGAGATGGCCCTGAGAATCGTCCTGCACAGCCTGGAC
  CTCCGCGCCAACTGCTACCAGCGCTTCGTGGTGCCGCTGCTCAGCATCAGCGCTGACTTC
  TACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGGCCAAGGTCAAGGCCTCAGCCAGC
  AAGCAGGCGCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGC
  AAAGCGTCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTCTGCAGCCTGTGGTCCCCCTGTG
  ACCCCCGAGTGTGAACACTGTGGGCAACGACACCAGCTTGGTGGCCCCATGTGGGCAGAG
  CCCATCCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGC
  CGCTTCCACACCTCGGAGCGGATCCGAGGGGTCCTGAGCGTCATCACTGAGGAGCTCCCG
  GACGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCACTGCAACACACCA
  AGCCTCCTGCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCAC
  GCCTGTAAGAACGCTGTGAAGACGGATGCCCCTGCCTCTGCCCTCTGGGACATCATGCGT
  TGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGACTATCAGAGACTAGCCCAGCGTTC
  CGCATTCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAAC
  CCCAGCTCCCGACAGCGAGGACTCAAGCGCTTCCAGGCTAACCCGGAGGCCAACTGGGGT
  CCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCCGACGAAGCTATGGAGGAGAGACGC
  AGGCTGCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGG
  CTCAAGACATTTCCTTGCAAGAGGTTTAAGGAGGGCACCTGTCAACGCGGGGACCAGTGC
  TGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCTGCTGATGCTGCCCCTGACTGTCCA
  GAGACCTCCAACCAGACCCCCCCTGGACCTGGGGCTGCCGCTGGGCCAGGCATAGACTGA
  
  Clone variation with respect to NM_017722.3
  746 t=>n;747 g=>n;748 a=>n;752 a=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_017722 unedited
  CACATTTGTATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGGNAAACGTGCA
  CCTTGACTAATTCGGTTTTCTGTGGCTACGAGAGCAGGCTTGGCGGGCGGAGGCGCCAGC
  GGATGTCTCATGCAAGGATCGTCTCTGTGGCTAAGCCTCACTTTCCGCTCCGCCCGGGTG
  CTCTCTAGAGCCCGGTTTTTCGAGTGGCAGTCTCCAGGGCTGCCGAATACAGCAGCGATG
  GAGAACGGCACCGGGCCCTACGGAGAAGAACGTCCACGTGAAGTCCAGGAGACGACAGTC
  ACCGAGGGGGCTGCCAAAATCGCCTTTCCCAGTGCCAACGAGGTCTTTTATAACCCGGTG
  CAGGAATTCAATCGGGACCTGACATGTGCTGTGATCACCGAGTTTGCTCGCATTCAGCTT
  GGGGCCAAAGGAATCCAGATCAAGGTTCCAGGAGAGAAGGACACGCAAAAAGTGGTCGTG
  GACTTGTCAGAGCAAGAGGAGGAAAAGGTTGAACTGAAAGAGAGTGAAAACCTGGCCTCA
  GGAGACCAACCTCGCACAGCGGCCGTGGGGGAGATCTGTGAGGAAGGCCTGCATGTGCTG
  GAAGGCCTGGCAGCTTCAGGCCTACGTTCCATTCGATTTGCCCTAGAGGTGCCTGGGCTC
  AGATCTGTGGTTGCAAACGATGCCTCCACCCGGGCTGTGGATCTCATACGCCGGAATGTC
  CAGCTCAATGACGTGGCCCACCTGGTACAGCCGAGCCAAGCAGATGCCCGGATGCTGATG
  TACCAGCACCAGNAGGTGTCGGAGAAGTTTGACGTCATCGATCTGGACCCCTATGGCAGC
  CCAGCCACCTTCCTGNATGCANCTGTGCANGCTGGNTGCTGTGTGTGACCTGCACGACAT
  GNNCGTGTTNNGCGGNGACANCGNGNAGACGTGCTACAGCAGTACGGNGCCATGGNCCTC
  CAGACCNGGCCTN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_017722 unedited
  NNNNNTTACTTGNACCCGGCCGCATNCTANNGATCGGTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTGACGTGACATCTCTTTATTGGTTCAGTCTATGCCTGGCCCAGCGGCAGCCCC
  AGGTCCAGGGGGGGTCTGGTTGGAGGTCTCTGGACAGTCAGGGGCAGCATCAGCAGAAAC
  CCTGGGTGTCGGGGGGCTGTGGGAGTAGCAGCACTGGTCCCCGCGTTGACAGGTGCCCTC
  CTTAAACCTCTTGCAAGGAAATGTCTTGAGCCGGGCAGCCCGCTGGGCCACATCTTCCGG
  CGGCTCCTTCCGCTTGTTCTGAAGCAGCCTGCGTCTCTCCTCCATAGCTTCGTCGGCCGC
  CTTGCCCCCTGGCCGGGCACGAGGCCGGGGACCCCAGTTGGCCTCCGGGTTAGCCTGGAA
  GCGCTTGAGTCCTCGCTGTCGGGAGCTGGGGTTGGCATCTTCCCGGATGGTGAAGTTGGC
  CTGCAGCCTGGGCTCCACACTGAGAATGCGGAACGCTGGGCTAGTCTCTGATAGTCGCTC
  CCGTTTCACCGGACATTCCTTCTCCCAGCAACGCATGATGTCCCAGAGGGCAAAGGCAGG
  GGCATCCGTCTTCACAGCGTTCTTACAGGCGTGGGAGAGTGAGACCCGGAAGTCAGCGTG
  GAGGAGGGCCGACCGCAACTGCAGGAGGCTTGGTGTGTTGCAGTGGATGGTGCTGCTCAN
  CTGGTCCAGGGTGTAGTACAGAGGCACGTCCGGGAGCTCCTGCGATGGGGGACAGGATGG
  GCATGAGTGGAGATGGACCGGCACAGGTGGAGCCCCCCTCCCCGTCACAGGCCGGTTCTC
  ACCTTAGAGATGACGCTCAGGACCCCTCGGATCCGGTCCCGAGTGTGGAAGCGCCCGGGG
  T
  
• Restriction Sites: NotI-NotI
• ACCN: NM_017722
• ORF Size: 1980 bp
• Insert Size: 2640
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_017722.2, NP_060192.1
• RefSeq Size: 2217
• RefSeq ORF: 1980
• Locus ID: 55621
• Domains: zf-CCCH, TRM
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
  Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).